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The causal association between serum metabolites and lung cancer based on multivariate Mendelian randomization.

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成果类型:
期刊论文
作者:
Sun, Tao;Chen, Xiaoyang;Yan, Hui;Liu, Jun
作者机构:
[Yan, Hui; Sun, Tao] Department of Hematology and Oncology Laboratory, The Affiliated Shaoyang Hospital, Hengyang Medical School, University of South China
[Chen, Xiaoyang] Department of Scientific Research and Teaching, The Affiliated Shaoyang Hospital, Hengyang Medical School, University of South China
[Liu, Jun] Department of Scientific Research, The First Affiliated Hospital of Shaoyang University, Shaoyang, Hunan Province, China
语种:
英文
期刊:
MEDICINE
ISSN:
0025-7974
年:
2024
卷:
103
期:
7
页码:
e37085
机构署名:
本校为第一机构
摘要:
This study seeks to understand the causal association between serum metabolites and different lung cancer types, an area yet to be extensively studied. We Used a two-sample Mendelian randomization (TSMR) approach, utilizing 486 blood metabolites as exposures and 3 distinct lung cancer types genome-wide association studies datasets as outcomes. We employed inverse variance weighting, MR-Egger, weighted median, simple mode, and weighted mode to estimate causal effects. We performed sensitivity analyses using Cochran Q test, MR-Egger intercept test, and MR-pleiotropy residual sum and outlier (MR-...

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