Progress in Understanding the Role and Therapeutic Targets of Polarized Subtypes of Macrophages in Pulmonary Fibrosis

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成果类型：

期刊论文

作者：

Sun, Yan;Xu, Hao;Lu, Tang;Li, Tong;Wang, Yaqi;...

通讯作者：

Liu, J

作者机构：

[Lu, Tang; Xu, Hao; Li, Tong; Cai, Meihan; Fan, Xinting; Liu, Jun; Sun, Yan; Wang, Yaqi; Jiang, Yuanyuan; He, Peishuang] Univ South China, Inst Cytol & Genet,Key Lab Ecol Environm & Crit Hu, Sch Basic Med Sci,Dept Cell Biol & Genet, Hengyang Med Sch,Hunan Prov Dept Educ, Hengyang 421001, Hunan, Peoples R China.

[Liu, Jun; Jiang, Yuanyuan] Univ South China, Sch Publ Hlth, Hengyang Med Sch, Key Lab Typ Environm Pollut & Hlth Hazards Hunan P, Hengyang 421001, Hunan, Peoples R China.

[Liu, Jun] Univ South China, Inst Cytol & Genet,Sch Basic Med Sci, Key Lab Hengyang City Ecol Impedance Technol Heavy, Hengyang Med Sch,Dept Cell Biol & Genet, Hengyang 421001, Hunan, Peoples R China.

[Liu, Jun] Univ South China, Inst Cytol & Genet, Sch Basic Med Sci,Key Lab Hengyang City Biol Toxic, Hengyang Med Sch,Dept Cell Biol & Genet, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Liu, J ] U

Univ South China, Inst Cytol & Genet,Key Lab Ecol Environm & Crit Hu, Sch Basic Med Sci,Dept Cell Biol & Genet, Hengyang Med Sch,Hunan Prov Dept Educ, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Sch Publ Hlth, Hengyang Med Sch, Key Lab Typ Environm Pollut & Hlth Hazards Hunan P, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Inst Cytol & Genet,Sch Basic Med Sci, Key Lab Hengyang City Ecol Impedance Technol Heavy, Hengyang Med Sch,Dept Cell Biol & Genet, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Inst Cytol & Genet, Sch Basic Med Sci,Key Lab Hengyang City Biol Toxic, Hengyang Med Sch,Dept Cell Biol & Genet, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

Macrophage polarization;M1 macrophages;M2 macrophages;Targeted therapy

期刊：

Cell Biochemistry and Biophysics

ISSN：

1085-9195

年：

2023

卷：

期：

页码：

673-682

DOI：

10.1007/s12013-023-01182-9

基金类别：

This work was supported by Hunan Key Laboratory of Typical Environmental Pollution and Health Hazards, School of Public Health, Hengyang 18Medical School, University of South China (2019TP1027); The Key Laboratory of Ecological Environment and Critical Human Diseases Prevention of Hunan Province Department of Education, School of Basic Medical Sciences, Hengyang Medical School, University of South China (2019–379); the Project of College Students’ Innovative Entrepreneurial Training of Hunan Province(S202010555147), and College Students’ Research Learning and Innovative Experimental Project of University of South China [grant number 2018XJXZ203, 2018XJXZ396, X202110555531 and X2019170].

机构署名：

本校为第一且通讯机构

院系归属：

公共卫生学院

摘要：

Pulmonary fibrosis represents the advanced phase of diverse pulmonary ailments, and at present, a definitive cure for these ailments is lacking. Furthermore, underlying mechanisms causative of these ailments remain elusive. Macrophages are immune cells that resist external stimuli in the early stages after birth. These cells can polarize into the classically (M1) and alternatively (M2) activated macrophages. When stimulated owing to the presence of toxic factors, M1 macrophages produce several pro-inflammatory factors, which mediate the inflammatory injury response of the alveolar tissue. The ...

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Progress in Understanding the Role and Therapeutic Targets of Polarized Subtypes of Macrophages in Pulmonary Fibrosis

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