通讯机构：
[Jun Liu] S;School of Material and Energy, Guangdong University of Technology, Guangzhou 510006, Guangdong, China<&wdkj&>School of Electrical Engineering, University of South China, Hengyang 421001, Hunan, China
摘要：
The design and fabrication of high-efficiency and low-cost bifunctional catalysts in overall water splitting is crucial for the industrial application of green and clean hydrogen energy. Herein, a three-dimensional (3D) self-supporting nickel sponge (SN) with many nickel synapses prepared by hydrothermal method was employed as the substrate. 2D CoFeLDH nanosheets were grown on nano-Ni synapses of SN by electro-deposition method. For comparison, CoFeLDH also was deposited on a nickel foam (NF) substrate using the same deposition process. The as-prepared CoFeLDH/SN exhibited excellent electrocatalytic performances with 208 mV at 10 mA cm(-2) for OER and 63 mV at 10 mA cm(-2) for HER in 1 M KOH alkaline solution, which is better than that of CoFeLDH/NF (276 mV at 10 mA cm(-2) for OER, and 173 mV at 10 mA cm(-2) for HER). The electrolytic cell using CoFeLDH/SN as both cathode and anode achieves a voltage of 1.52 V at current density of 10 mA cm(-2), which is better than that of most previously reported bifunctional catalysts. Our work provides a facile and inexpensive option for the design of bifunctional catalysts in overall water splitting. (C) 2022 Elsevier B.V. All rights reserved.
作者机构：
[Yang, Haiyan; Zeng, Liang; Li, Yizhi; Zhang, Yongchang; Yang, Nong; Liu, Lingli; Jiang, Wenjuan; Zhang, Xiangyu] Cent South Univ, Xiangya Sch Med, Lung Canc & Gastrointestinal Unit, Dept Med Oncol,Hunan Canc Hosp,Affiliated Canc Ho, Changsha 410013, Peoples R China.;[Zhang, Yongchang; Yang, Nong; Liu, Lingli] Univ South China, Grad Collaborat Training Base Hunan Canc Hosp, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.;[Zhang, Yongchang] Guangdong Prov Peoples Hosp, Guangdong Lung Canc Inst, Guangdong Prov Key Lab Translat Med Lung Canc, Guangzhou, Peoples R China.;[Zhang, Yongchang] Guangdong Acad Med Sci, Guangzhou, Peoples R China.;[Xu, Qinqin] Qinghai Prov Peoples Hosp, Dept Med Oncol, Xining 810000, Peoples R China.
通讯机构：
[Zhang, YC; Yang, N] C;[Zhang, YC; Yang, N] U;Cent South Univ, Xiangya Sch Med, Lung Canc & Gastrointestinal Unit, Dept Med Oncol,Hunan Canc Hosp,Affiliated Canc Ho, Changsha 410013, Peoples R China.;Univ South China, Grad Collaborat Training Base Hunan Canc Hosp, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.
关键词：
Advanced NSCLC;Bevacizumab combined with EGFR-TKI;Clinical features;Molecular features;Prediction Model
摘要：
BACKGROUND: The combination of bevacizumab and epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) could prolong progression-free survival (PFS) in patients with EGFR-mutant advanced non-small-cell lung cancer (NSCLC). Our study investigated the clinical and molecular factors that affect the efficacy of first-generation EGFR-TKI with or without bevacizumab and identify the subset of patients who can benefit from combination therapy. METHODS: Our study included 318 patients with EGFR-mutant locally advanced/advanced NSCLC treated with either first-generation EGFR-TKI combined with bevacizumab (A+T; n = 159) or EGFR-TKI monotherapy (T; n = 159). Two nomogram models to predict PFS and overall survival (OS), respectively, were constructed using two factors that impact EGFR-TKI efficacy: metastatic site and presence of concurrent mutations. The study cohort was stratified into 2 cohorts for training (n = 176) and validation (n = 142) of the nomogram model. Using the median score from the nomogram, the patients were stratified into two groups to analyze their survival outcome. RESULTS: The A+T group had significantly longer PFS (14.0 vs. 10.5 months; p < 0.001) and OS (37.0 vs. 26.0 months; p = 0.042) than the T group. Among the patients with concurrent mutations in tumor suppressor genes, those in the A+T group had significantly longer PFS and OS than the T group (PFS 14.5 vs. 8.0 months, p < 0.001; OS 39.0 vs. 20.0 months, p = 0.003). The higher scores from the nomograms were associated with the presence of brain/liver/pleural metastasis or concomitant gene mutations, which indicated a higher likelihood of shorter PFS and OS. The validation of the nomogram revealed that patients with lower scores had significantly longer PFS for the T group than those with higher scores (15.0 vs. 9.0 months, p = 0.002), but not for the A+T group (15.9 vs. 13.9 months, p = 0.256). CONCLUSIONS: Using a nomogram, our study demonstrated that the addition of bevacizumab may enhance the therapeutic effectiveness of EGFR-TKI by overcoming the negative impact of certain clinical and molecular factors on the efficacy of EGFR-TKI.
作者机构：
[Yang, Haiyan; Yang, Nong; Zhang, Xiangyu; Zhang, Yongchang] Cent South Univ, Dept Med Oncol, Lung Canc & Gastrointestinal Unit,Xiangya Sch Med, Hunan Canc Hosp,Affiliated Canc Hosp, Changsha 410013, Peoples R China.;[Yang, Nong; Zhang, Yongchang] Univ South China, Grad Sch, Hengyang 421001, Hunan, Peoples R China.;[Zhang, Ruiguang; Liu, Jun] Huazhong Univ Sci & Technol, Canc Ctr, Union Hosp, Tongji Med Coll, Wuhan 430022, Peoples R China.;[Xu, Qinqin] Qinghai Prov Peoples Hosp, Dept Med Oncol, Xining 810000, Peoples R China.;[Lizaso, Analyn] Burning Rock Biotech, Guangzhou 510300, Peoples R China.
通讯机构：
[Yang, Nong; Zhang, Yongchang] D;[Song, Zhengbo] C;[Zhang, Jiexia] N;Department of Medical Oncology, Lung Cancer and Gastrointestinal Unit, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, 410013, China.;Graduate School, University of South China, Hengyang, 421001, Hunan, China.
摘要：
BACKGROUND: ROS1-rearranged lung cancers benefit from first-line crizotinib therapy; however, clinical and molecular factors that could affect crizotinib efficacy in ROS1-rearranged lung cancers are not yet well-elucidated. Our retrospective study aimed to compare the efficacy of chemotherapy and crizotinib in the first-line treatment of ROS1-rearranged advanced lung cancer and evaluate various clinical and molecular factors that might impact crizotinib efficacy in real-world practice. METHODS: Treatment responses, survival outcomes, and patterns of disease progression were analyzed for 235 patients with locally advanced to advanced disease who received first-line chemotherapy (n = 67) or crizotinib (n = 168). RESULTS: The overall response rate was 85.7% (144/168) for first-line crizotinib and 41.8% (28/67) for chemotherapy. Patients treated with first-line crizotinib (n = 168) had significantly longer median progression-free survival (PFS) than chemotherapy (n = 67) (18.0 months vs. 7.0 months, p < 0.001). Patients harboring single CD74-ROS1 (n = 90) had significantly shorter median PFS with crizotinib than those harboring non-CD74 ROS1 fusions (n = 69) (17.0 months vs. 21.0 months; p = 0.008). Patients with baseline brain metastasis (n = 45) had a significantly shorter PFS on first-line crizotinib than those without brain metastasis (n = 123) (16.0 months vs. 22.0 months; p = 0.03). At progression, intracranial-only progression (n = 40), with or without baseline CNS metastasis, was associated with longer median PFS than those with extracranial-only progression (n = 64) (19.0 months vs. 13.0 months, p < 0.001). TP53 mutations were the most common concomitant mutation, detected in 13.1% (7/54) of patients with CD74-ROS1 fusions, and 18.8% (6/32) with non-CD74 ROS1 fusions. Patients with concomitant TP53 mutations (n=13) had significantly shorter PFS than those who had wild-type TP53 (n = 81) (6.5 months vs. 21.0 months; p < 0.001). PFS was significantly shorter for the patients who harbored concomitant driver mutations (n = 9) (11.0 months vs 24.0 months; p = 0.0167) or concomitant tumor suppressor genes (i.e., TP53, RB1, or PTEN) (n = 25) (9.5 months vs 24.0 months; p < 0.001) as compared to patients without concomitant mutations (n = 58). CONCLUSION: Our results demonstrate that baseline brain metastatic status and various molecular factors could contribute to distinct clinical outcomes from first-line crizotinib therapy of patients with ROS1-rearranged lung cancer. CLINICAL TRIALS REGISTRATION: CORE, NCT03646994.
作者机构：
[Liu, Yuelin] Univ South China, Key Discipline Lab Natl Def Biotechnol Uranium Mi, Hengyang 421001, Peoples R China.;[Liu, Yuelin] Hunan Univ Technol, Sch Civil Engn, Zhuzhou 412007, Peoples R China.;[Wu, Shanshan; Xie, Shuibo; Liu, Yingjiu] Univ South China, Hunan Prov Key Lab Pollut Control & Resources Reu, Hengyang 421001, Peoples R China.;[Liu, Jun] Hunan Univ Technol, Sch Life Sci & Chem, Hunan Key Lab Biomed Nanomat & Devices, Zhuzhou 412007, Peoples R China.;[Xie, Shuibo] Univ South China, Sch Civil Engn, Hengyang 421001, Peoples R China.
通讯机构：
[Xie, Shuibo] U;Univ South China, Hunan Prov Key Lab Pollut Control & Resources Reu, Hengyang 421001, Peoples R China.;Univ South China, Sch Civil Engn, Hengyang 421001, Peoples R China.
摘要：
Photocatalytic technology is a valid solution for the remediation of wastewater containing uranium. In this study, the synthesis of Z-scheme g-C3N4/TiO2 catalysts was made by a thermal synthetic approach for photocatalytic U(VI) reduction. The characterization results revealed the successful synthesis of g-C3N4/TiO2 nanostructures. The g-C3N4 surface was uniformly coated with TiO2 nanoparticles. The depletion of U(VI) in water evaluated the photocatalytic activity of g-C3N4/TiO2 under UV light irradiation. The photocatalytic tests showed that g-C3N4/TiO2 exhibited more effective photocatalytic activity than the raw materials (1.64 and 56.97 times higher than TiO2(P25) and g-C3N4, respectively). Besides, a pseudo-first-order model was followed by the experimental kinetic data for the photocatalytic process. Moreover, g-C3N4/TiO2 still presented high photocatalytic activity after four reacting cycles. Based on these experiment results, the improved photocatalytic activity could be attributed to the Z-scheme mechanism, which decreased the recombination of photo-produced electrons and holes. The synthesis of these g-C3N4/TiO2 nanomaterials provides a facile and inexpensive method for treating wastewater containing U(VI).
作者：
Chen, Xue-Kun;Hu, Xiao-Yan;Jia, Peng;Xie, Zhong-Xiang;Liu, Jun
期刊：
International Journal of Mechanical Sciences,2021年206:106576 ISSN：0020-7403
通讯作者：
Zhong-Xiang Xie<&wdkj&>Jun Liu
作者机构：
[Chen, Xue-Kun; Jia, Peng; Liu, Jun] Univ South China, Sch Math & Phys, Hengyang 421001, Peoples R China.;[Hu, Xiao-Yan] Univ South China, Sch Elect Engn, Hengyang 421001, Peoples R China.;[Xie, Zhong-Xiang] Hunan Inst Technol, Dept Math & Phys, Hengyang 421002, Peoples R China.
通讯机构：
[Zhong-Xiang Xie] D;[Jun Liu] S;Department of Mathematics and Physics, Hunan Institute of Technology, Hengyang 421002, China<&wdkj&>School of Mathematics and Physics, University of South China, Hengyang 421001, China
摘要：
Carbon foams (CFs) possess high storage capacity, good electronic conductivity and superb mechanical strength, which demonstrate promising applications in many engineering fields. Understanding thermal transport in CFs is critical for the design and reliability of functional electronic devices based on them. In this work, we systematically study anisotropic thermal transport in the CFs composed of sixfold-wing graphene nanoribbons by using equilibrium molecular dynamics simulations. The results showed that the remarkable anisotropic behavior reflecting geometric anisotropy can be attributed to the orientation-dependent group velocity of long wavelength phonons. Moreover, it is found that the anisotropic ratio could be effectively regulated by compress/tensile strains. Detailed spectral analysis revealed that the loading of strain would significantly modify the coupling level between the transverse and longitudinal vibrational modes, resulting in a change to the anisotropic ratio. For thermal management application, the interfacial thermal conductance (TBC) of CFs/silicon substrate is predicted to be about 35 MW/m(2) K-1, which is comparable to the TBC of the transferred metal films on silicon or SiO2 substrates. Furthermore, the TBC could be further enhanced by increasing ambient temperature or external stress. Our results might provide guidance for the development of thermal interfacial materials and thermal channeling devices.
作者：
Hu Xiao-Bo;Duan Ting-Ting;Liu Jun;Zhu Gao-Lu;Cao Zhao-Hui;...
期刊：
中华医学杂志(英文版),2021年134(1):41-43 ISSN：0366-6999
作者机构：
[Duan Ting-Ting; Zhu Gao-Lu] The Key Laboratory of Ecological Environment and Critical Human Diseases Prevention, Education Department of Hunan Province, Department of Biochemistry, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China;The Key Laboratory of Typical Environmental Pollution and Health Hazards, Hunan Province, University of South China, Hengyang, Hunan 421001, China;[Feng Shao-Long] The Institute of Preventive Medicine, School of Public Health, Guilin Medical University, Guilin, Guangxi 541004, China.;[Hu Xiao-Bo; Liu Jun; Cao Zhao-Hui] The Key Laboratory of Ecological Environment and Critical Human Diseases Prevention, Education Department of Hunan Province, Department of Biochemistry, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China<&wdkj&>The Key Laboratory of Typical Environmental Pollution and Health Hazards, Hunan Province, University of South China, Hengyang, Hunan 421001, China
摘要：
Type 1 diabetes (T1D) is an organ-specific autoimmune disease with loss of pancreatic β-cells, characterized by reduced insulin levels and increased blood glucose. The incidence of T1D is increasing by approximately 2% to 5% worldwide every year and becoming a global health problem. Vitamin D (VD) deficiency was reported to be a risk factor in the development of T1D. Recent studies showed that supplementation of VD alleviated disease symptoms in T1D patients. However, a few randomized controled trials (RCTs) demonstrated the clinical effect of VD treatment with inconsistent findings. This article aimed to evaluate the effect of VD supplementation in T1D, which is helpful to develop an adjuvant therapy for T1D.
作者机构：
[Hu, Cong; Cao, Zhaohui; Hu, Xiaobo; Duan, Tingting; Liu, Jun; Wu, Zhuan] Univ South China, Hengyang Med Sch, Dept Biochem, Key Lab Ecol Environm & Crit Human Dis Prevent Hu, Hengyang 421001, Peoples R China.;[Hu, Cong; Cao, Zhaohui; Hu, Xiaobo; Duan, Tingting; Liu, Jun; Wu, Zhuan] Univ South China, Hengyang Med Sch, Dept Biochem, Hengyang 421001, Peoples R China.;[Hu, Cong; Cao, Zhaohui; Hu, Xiaobo; Duan, Tingting; Wu, Zhuan] Univ South China, Key Lab Typ Environm Pollut & Hlth Hazards, Hengyang 421001, Peoples R China.;[Hu, Cong] Yiyang Cent Hosp, Yiyang 413000, Peoples R China.
通讯机构：
[Zhaohui Cao] T;The Key Laboratory of Ecological Environment and Critical Human Diseases Prevention of Hunan Province Department of Education, Department of Biochemistry, Hengyang Medical School, University of South China , Hengyang 421001, China<&wdkj&>Department of Biochemistry, Hengyang Medical School, University of South China , Hengyang 421001, China<&wdkj&> The Key Laboratory of Typical Environmental Pollution and Health Hazards, University of South China , Hengyang 421001, China
摘要：
Endoplasmic reticulum (ER) stress plays a critical role in pancreatic beta cell destruction which leads to the pathogenesis of type 1 diabetes mellitus (T1DM). Vitamin D (VD) has been reported to reduce the risk of T1DM; however, it remains unknown whether VD affects ER stress in pancreatic beta cells. In this study, we investigated the role of the active form of VD, 1,25-dihydroxyvitamin D3 [1,25-(OH)(2)D-3], in ER stress-induced beta cell apoptosis and explored its potential mechanism in mouse insulinoma cell line mouse insulinoma 6 (MIN6). The results of cell counting kit-8 (CCK8) and flow cytometric analyses showed that 1,25-(OH)(2)D-3 caused a significant increase in the viability of MIN6 cells injured by H2O2. The protein kinase like ER kinase (PERK) signal pathway, one of the most conserved branches of ER stress, was found to be involved in this process. H2O2 activated the phosphorylation of PERK, upregulated the activating transcription factor 4 (ATF4) and C/EBP homologous protein (CHOP) expression, and subsequently initiated cell apoptosis, which were significantly reversed by 1,25-(OH)(2)D-3 pretreatment. In addition, GSK2606414, a specific inhibitor of PERK, suppressed PERK phosphorylation and reduced the expressions of ATF4 and CHOP, leading to a significant decrease in beta cell apoptosis induced by H2O2. Taken together, the present findings firstly demonstrated that 1,25-(OH)(2)D-3 could prevent MIN6 cells against ER stress-associated apoptosis by inhibiting the PERK-ATF4-CHOP pathway. Therefore, our results suggested that 1,25-(OH)(2)D-3 might serve as a potential therapeutic target for preventing pancreatic beta cell destruction in T1DM.
作者机构：
[Zhang, Shuai; Cao, Jiantao] Xian Univ Sci & Technol, Coll Energy Sci & Engn, Xian 710054, Shaanxi, Peoples R China.;[Hong, Changshou; Cao, Jiantao; Liu, Yong] Univ South China, Hunan Prov Engn Res Ctr Radioact Control Technol, Hengyang 421001, Hunan, Peoples R China.;[Hong, Changshou; Cao, Jiantao; Liu, Yong] Univ South China, Hunan Prov Engn Technol Res Ctr Uranium Tailings, Hengyang 421001, Hunan, Peoples R China.;[Liu, Jun] Univ South China, Cooperat Innovat Ctr Nucl Fuel Cycle Technol & Eq, Hengyang 421001, Hunan, Peoples R China.;[Lei, Bo] Univ South China, Sch Resources Environm & Safety Engn, Hengyang 421001, Hunan, Peoples R China.
通讯机构：
[Cao, Jiantao] X;[Cao, Jiantao] U;Xian Univ Sci & Technol, Coll Energy Sci & Engn, Xian 710054, Shaanxi, Peoples R China.;Univ South China, Hunan Prov Engn Res Ctr Radioact Control Technol, Hengyang 421001, Hunan, Peoples R China.;Univ South China, Hunan Prov Engn Technol Res Ctr Uranium Tailings, Hengyang 421001, Hunan, Peoples R China.
摘要：
On the basis of reviewing the existing research status of cumulative damage of the rock mass and summarizing the existing engineering application fields of radon, this paper attempts to apply radon detection technology to the research field of rock damage mechanics so as to monitor the evolution process of cumulative damage of the rock mass. Based on the above research purposes, a test device for detecting cumulative damage of radioactive rocks by surface radon gas was designed, and the test results were obtained by integrating the system to implement the test scheme. Due to the limitation of the nonmetallic ultrasonic detector, a single blasting damage value of 25 detection points appears after a single blasting measurement, which is a surface longitudinal wave velocity characterization damage set, while the surface radon exhalation rate in the subsequent analysis process is an overall characterization value; that is, the existence of damage directly affects the whole body radon exhalation rate of the test block, and the data dimensions of the two are different. In order to solve this problem, we try to introduce three data evaluation methods, the average weighting method, grey prediction method, and K-means clustering algorithm, and compare the feasibility of these three methods. It is proved that there is a certain linear relationship between the radon exhalation rate and the cumulative damage, which further verifies the feasibility of using radon to detect cumulative damage. The results show that the cumulative damage of loaded radioactive rock test blocks can be reflected by surface radon detection technology, and finally, the correlation between the cumulative damage characteristics and the continuous change of the body radon exhalation rate is obtained. Based on the correlation, the body radon exhalation rate is introduced into the field of fractured rock mass damage characterization, which is mutually improved with common monitoring methods such as acoustic emission and microseismic monitoring, supplementing and enriching the means of rock mass damage evolution characterization, providing a theoretical basis for finely describing the whole process of fracture closure and initiation, and finally accurately ensuring the stability of surrounding rock under the action of deep underground engineering excavation disturbance.
作者机构：
[Liu, Jun] Univ South China, Hengyang Med Sch, Affiliated Hosp 2, Dept Urol, Hengyang 421001, Hunan, Peoples R China.;[Jiang, Xiaolong] Univ South China, Affiliated Nanhua Hosp, Dept Radiol, Hengyang 421002, Hunan, Peoples R China.
摘要：
This study was to discuss the application of multislice spiral computed tomography (CT) in the staging diagnosis of bladder cancer and the effect of ceramide glycosylation. The hybrid iterative reconstruction algorithm was applied. Immunohistochemistry and western blot were used to detect the normal bladder tissues (30 cases) of GCS in group 1 (100 cases) and group 2. The scanned images of all the research objects were obtained, the images with the iterative reconstruction algorithm were reconstructed, and statistical analysis on the CT value under the algorithm was conducted. The results showed that the image quality, blood vessel sharpness, average image score, signal-to-noise ratio, and radiation dose after the spiral CTand iterative reconstruction algorithm all increased, while the noise value decreased. optical density value of glucosylceramide synthase in group 2 patients increased by 71%, and the optical density value of group 1 increased by 29%. The optical density expression of glucosylceramide synthase in group 1 patients was significantly higher than that in the control group, and there was a statistical difference between the two (P < 0.05). Among the results of multislice spiral CT for tumor staging, the lesions larger than 5 cm and in the range of 1.1-2 cm in diameter were more sensitive. In 41 patients, there were multiple lesions. A total of 142 cancer lesions were found. The diameter of the tissue ranged from 0.5 to 6.8 cm, with an average diameter of 2.03 +/- 0.35 cm. The optical density of glucosylceramide synthase in the group 1 was 5526, and the optical density in group 2 was 2576. The OD expression of GCS in group 1 was greatly higher in contrast to that in group 2, and there was a statistical difference between the two groups (P < 0.05). The multislice spiral CT examination under this algorithm found that the diagnosis and staging accuracy of lesions with a diameter greater than 5 cm and tumor diameters in the range of 1.1 to 2 cm was higher. The image processed by the hybrid iterative reconstruction algorithm had good effect, high definition, and accuracy.
摘要：
The aim of the present study was to investigate a novel technology, requiring only a single portal and no special equipment, to perform endoscopic treatment of carpal tunnel (CT) syndrome (CTS). This novel technique involves a surgical approach and standard operating procedures and is designed to minimize the potential for complications. Patients with CTS were randomly assigned using a computer-generated random allocation and stratified by site to either the modified endoscopic CT release (MECTR) group (n=48) or open CT release (OCTR) group (n=46). Various medical indexes were compared between the two groups, including operative time, hospitalization time, the time required to resume a normal life or work, intraoperative complications, incision infection rate, the amelioration of symptoms (Kelly grading), post-operative scar pain score, recovery of grip strength and pinch strength, two-point discrimination and the presence of sympathetic dystrophy. The results revealed that all patients had grade A wound healing and the symptoms were completely relieved. No significant differences were observed between the two groups with regards to the incision infection rate, intraoperative complications, grip strength, pinch strength, two-point discrimination, presence of sympathetic dystrophy and clinical symptom amelioration. In addition, compared with the OCTR group, the MECTR group had a decreased operative and hospitalization time, post-operative scar pain score and time required to resume a normal lifestyle. Post-operative electromyographic examination also revealed that the median nerve sensory conduction speed increased compared with that prior to surgery in both groups. In conclusion, the use of MECTR for the treatment of CTS achieved higher patient satisfaction, a shorter operative time and hospitalization time, an earlier return to work time or resumption of a normal life, as well as less post-operative scar pain compared with OCTR. Thus, these results suggested that MECTR may be an effective method for the treatment of idiopathic CTS. Trial registration no. ChiCTR2000041165, retrospectively registered 20th December 2020.
期刊：
JOURNAL OF CLINICAL INVESTIGATION,2021年131(10) ISSN：0021-9738
通讯作者：
Liang, W.;He, J.;Fan, J.-B.
作者机构：
[Chen, Hanzhang; Wang, Jiaxuan; Yin, Weiqiang; Mo, Lili; Liu, Jun; Li, Caichen; He, Jianxing; Liang, Wenhua] Guangzhou Med Univ, Affiliated Hosp 1, China Natl Ctr Resp Med, China State Key Lab Resp Dis,Dept Thorac Surg & O, Guangzhou, Peoples R China.;[Chen, Hanzhang; Wang, Jiaxuan; Yin, Weiqiang; Mo, Lili; Liu, Jun; Li, Caichen; He, Jianxing; Liang, Wenhua] Natl Clin Res Ctr Resp Dis, Guangzhou, Peoples R China.;[Chen, Zhiwei; Tu, Xixiang; Zhao, Dezhi; Li, Hui; Fan, Jian-Bing; Tao, Jinsheng; Jiang, Zeyu] AnchorDx Med Co, Guangzhou, Peoples R China.;[Chen, Zhiwei; Liu, Xin] AnchorDx Inc, Fremont, CA USA.;[Cheng, Chao] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Thorac Surg, Guangzhou, Peoples R China.
通讯机构：
[Fan, J.-B.; Liang, W.; He, J.] D;Department of Pathology, 1838 ShaTai Road, China;Department of Thoracic Surgery and Oncology, 151 Yanjiang Road, China
作者机构：
[Deng, Zhixiang; Fan, Dianyuan; Chen, Yu; Liu, Jun] Shenzhen Univ, Minist Educ & Guangdong Prov, Key Lab Optoelect Devices & Syst,Coll Optoelect E, Int Collaborat Lab 2D Mat Optoelect Sci & Technol, Shenzhen 518060, Peoples R China.;[Deng, Zhixiang] Univ South China, Sch Elect Engn, Hengyang 421001, Peoples R China.;[Zhao, Chujun] Hunan Univ, Sch Phys & Elect, IFSA Collaborat Innovat Ctr, Minist Educ,Lab Micronanooptoelect Devices, Changsha 410082, Peoples R China.
通讯机构：
[Liu, Jun] S;Shenzhen Univ, Minist Educ & Guangdong Prov, Key Lab Optoelect Devices & Syst,Coll Optoelect E, Int Collaborat Lab 2D Mat Optoelect Sci & Technol, Shenzhen 518060, Peoples R China.
摘要：
The spectral analysis of the light propagating in normally dispersive graded-index multimode fibers is performed under initial noisy conditions. Based on the obtained spectra with multiple simulations in the presence of noise, we investigate the correlation in energy between the well-separated spectral sidebands through both the scattergrams and the frequency-dependent energy correlation map and find that conjugate couples are highly correlated while cross-combinations exhibit a very poor degree of correlation. These results reveal that the geometric parametric instability processes associated with each sideband pair occur independently from each other, which can provide significant insights into the fundamental dynamical effect of the geometric parametric instability and facilitate the future implementation of high-efficiency photon pair sources with reduced Raman decorrelations.
摘要：
Osteoarthritis (OA) is a common joint disorder characterized by progressive articular cartilage degeneration and destruction and results in gradual disability among middle-aged and elderly patients. Our previous study demonstrated that depletion of nuclear factor erythroid 2-related factor 2 (Nrf2) exacerbated cartilage erosion in an OA model and that activation of the Nrf2 pathway could counter this process. As a downstream target of Nrf2, heme oxygenase (HO) degrades heme to free iron, biliverdin and carbon monoxide (CO), which protects against oxidative stress. Ergosterol (ER), which is extracted from fungi, is a newly discovered Nrf2 activator and displayed efficacy against myocardial injury. The present study aimed to investigate the potential protective effects of ER against cartilage damage during OA. Primary mouse chondrocytes were treated with ER for in vitro assays. Furthermore, mice that underwent destabilization of the medial meniscus surgery were orally administered with ER. Western blotting suggested that ER increased protein expression of Nrf2 and HO-1 in primary chondrocytes and articular cartilage from knee joints. Cartilage damage in knee joints was significantly reduced by ER treatment. Western blotting and PCR analysis confirmed that ER could also suppress the expression of MMP-9 and MMP-13 in vivo and in vitro. The present findings suggested that ER effectively alleviated cartilage degradation and that activation of the Nrf2-heme oxygenase 1 pathway may play a role in ER-mediated cartilage protection against OA.
作者机构：
[Wang, Weishu; Song, Xiaoyong; Liu, Jun; Tian, Shujian; Yuan, Haoyun] North China Univ Water Resources & Elect Power, Sch Elect Power, Zhengzhou, Henan, Peoples R China.;[Li, Guozhuang] Univ South China, Sch Nucl Sci & Technol, Hengyang, Hunan, Peoples R China.
通讯机构：
[Tian, Shujian] N;North China Univ Water Resources & Elect Power, Sch Elect Power, Zhengzhou, Henan, Peoples R China.
关键词：
NAC-STC transport cask;AP1000 spent fuel assembly;thermal analysis;temperature distribution
摘要：
The heat transfer performance of the spent fuel transport cask is inseparably related to the safety of the whole reprocessing system. In this study, we carried out the thermal analysis on the NAC-STC transport cask for AP1000 spent fuel assembly to evaluate the thermal performance of transport cask by the finite element method software ANSYS. A computational dynamics model was developed to study the temperature distribution inside the transport cask and on the surface of the cask. The effectiveness of the numerical calculation is demonstrated by comparing with the theoretical results. The results show that transport cask can reach steady-state during transportation, and the highest temperature in the case is 328 degrees C, which is below the maximum safety limit of 400 degrees C Besides, the temperature of the fuel element baskets, sealing ring, photon shielding layer and neutron shielding layer in the cask are all within the safety limit.
