期刊论文

Liang, W.;He, J.;Fan, J.-B.

英文

JOURNAL OF CLINICAL INVESTIGATION

0021-9738

2021

131

10

10.1172/JCI145973

We thank all the participants for their generosity. This study was supported by the China National Science Foundation (nos. 82022048 and 81871893), the Key Project of Guangzhou Scientific Research Project (no. 201804020030), the National Key Research and Development Project (nos. 2017YFC0907903, 2017YFC1309002, and 2017YFC0112704), the Scheme of Guangzhou Economic and Technological Development District for Leading Talents in Innovation and Entrepreneurship (no. 2017-L152), the Scheme of Guangzhou for Leading Talents in Innovation and Entrepreneurship (no. 2016007), the Scheme of Guangzhou for Leading Team in Innovation (no. 201909010010), the Science and Technology Planning Project of Guangdong Province, Chi- na (no. 2017B020226005), the High-Level University Construction Project of Guangzhou Medical University (no. 20182737, 201721007, 201715907, 2017160107), and the Guangdong High Level Hospital Construction “Reaching Peak” Plan.

本校为其他机构

BACKGROUND. Current clinical management of patients with pulmonary nodules involves either repeated low-dose CT (LDCT)/CT scans or invasive procedures, yet causes significant patient misclassification. An accurate noninvasive test is needed to identify malignant nodules and reduce unnecessary invasive tests. METHOD. We developed a diagnostic model based on targeted DNA methylation sequencing of 389 pulmonary nodule patients’ plasma samples and then validation in 140 plasma samples independently. We tested the model in different stages and subt...