1,25-(OH)_2D_3 protects pancreatic beta cells against H_2O_2-induced apoptosis through inhibiting the PERK-ATF4-CHOP pathway

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成果类型：

期刊论文

作者：

Hu, Xiaobo;Hu, Cong;Liu, Jun;Wu, Zhuan;Duan, Tingting;...

通讯作者：

Cao, Z.

作者机构：

[Hu, Cong; Cao, Zhaohui; Hu, Xiaobo; Duan, Tingting; Liu, Jun; Wu, Zhuan] Univ South China, Hengyang Med Sch, Dept Biochem, Key Lab Ecol Environm & Crit Human Dis Prevent Hu, Hengyang 421001, Peoples R China.

[Hu, Cong; Cao, Zhaohui; Hu, Xiaobo; Duan, Tingting; Liu, Jun; Wu, Zhuan] Univ South China, Hengyang Med Sch, Dept Biochem, Hengyang 421001, Peoples R China.

[Hu, Cong; Cao, Zhaohui; Hu, Xiaobo; Duan, Tingting; Wu, Zhuan] Univ South China, Key Lab Typ Environm Pollut & Hlth Hazards, Hengyang 421001, Peoples R China.

[Hu, Cong] Yiyang Cent Hosp, Yiyang 413000, Peoples R China.

通讯机构：

[Cao, Z.] T

The Key Laboratory of Ecological Environment and Critical Human Diseases Prevention of Hunan Province Department of Education, China

语种：

英文

关键词：

1,25-(OH)2D3;MIN6 cells;PERK;diabetes;endoplasmic reticulum stress

期刊：

生物化学与生物物理学报

ISSN：

1672-9145

年：

2021

卷：

期：

页码：

46-53

DOI：

10.1093/abbs/gmaa138

基金类别：

Nature Science Fund of Hunan Province [14JJ3104, 2016JJ2113]; Science Fund of Hunan Provincial Education Department [16A186]; Graduate Education and Innovation Fund of University of South China [2017JG022, 2019JG029]

机构署名：

本校为第一机构

院系归属：

药学与生物科学学院

摘要：

Endoplasmic reticulum (ER) stress plays a critical role in pancreatic beta cell destruction which leads to the pathogenesis of type 1 diabetes mellitus (T1DM). Vitamin D (VD) has been reported to reduce the risk of T1DM; however, it remains unknown whether VD affects ER stress in pancreatic beta cells. In this study, we investigated the role of the active form of VD, 1,25-dihydroxyvitamin D3 [1,25-(OH)(2)D-3], in ER stress-induced beta cell apoptosis and explored its potential mechanism in mouse insulinoma cell line mouse insulinoma 6 (MIN6). The results of cell counting kit-8 (CCK8) and flow ...

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1,25-(OH)_2D_3 protects pancreatic beta cells against H_2O_2-induced apoptosis through inhibiting the PERK-ATF4-CHOP pathway

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