1,25-(OH)_2D_3 protects pancreatic beta cells against H_2O_2-induced apoptosis through inhibiting the PERK-ATF4-CHOP pathway

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成果类型：

期刊论文

作者：

Hu, Xiaobo;Hu, Cong;Liu, Jun;Wu, Zhuan;Duan, Tingting;...

通讯作者：

Zhaohui Cao

作者机构：

[Hu, Cong; Cao, Zhaohui; Hu, Xiaobo; Duan, Tingting; Liu, Jun; Wu, Zhuan] Univ South China, Hengyang Med Sch, Dept Biochem, Key Lab Ecol Environm & Crit Human Dis Prevent Hu, Hengyang 421001, Peoples R China.

[Hu, Cong; Cao, Zhaohui; Hu, Xiaobo; Duan, Tingting; Liu, Jun; Wu, Zhuan] Univ South China, Hengyang Med Sch, Dept Biochem, Hengyang 421001, Peoples R China.

[Hu, Cong; Cao, Zhaohui; Hu, Xiaobo; Duan, Tingting; Wu, Zhuan] Univ South China, Key Lab Typ Environm Pollut & Hlth Hazards, Hengyang 421001, Peoples R China.

[Hu, Cong] Yiyang Cent Hosp, Yiyang 413000, Peoples R China.

通讯机构：

[Zhaohui Cao] T

The Key Laboratory of Ecological Environment and Critical Human Diseases Prevention of Hunan Province Department of Education, Department of Biochemistry, Hengyang Medical School, University of South China , Hengyang 421001, China<&wdkj&>Department of Biochemistry, Hengyang Medical School, University of South China , Hengyang 421001, China<&wdkj&> The Key Laboratory of Typical Environmental Pollution and Health Hazards, University of South China , Hengyang 421001, China

语种：

英文

关键词：

1,25-(OH)2D3;MIN6 cells;PERK;diabetes;endoplasmic reticulum stress

期刊：

生物化学与生物物理学报

ISSN：

1672-9145

年：

2021

卷：

期：

页码：

46-53

DOI：

10.1093/abbs/gmaa138

基金类别：

This work was supported by the grants from the Nature Science Fund of Hunan Province (Nos. 14JJ3104 and 2016JJ2113), the Science Fund of Hunan Provincial Education Department (No. 16A186), and the Graduate Education and Innovation Fund of University of South China (Nos. 2017JG022 and 2019JG029).

机构署名：

本校为第一机构

院系归属：

药学与生物科学学院

摘要：

Endoplasmic reticulum (ER) stress plays a critical role in pancreatic beta cell destruction which leads to the pathogenesis of type 1 diabetes mellitus (T1DM). Vitamin D (VD) has been reported to reduce the risk of T1DM; however, it remains unknown whether VD affects ER stress in pancreatic beta cells. In this study, we investigated the role of the active form of VD, 1,25-dihydroxyvitamin D3 [1,25-(OH)(2)D-3], in ER stress-induced beta cell apoptosis and explored its potential mechanism in mouse insulinoma cell line mouse insulinoma 6 (MIN6). The results of cell counting kit-8 (CCK8) and flow ...

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1,25-(OH)_2D_3 protects pancreatic beta cells against H_2O_2-induced apoptosis through inhibiting the PERK-ATF4-CHOP pathway

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