摘要：
Rationale: Peripheral arterial diseases (PADs) is defined as a systemic arterial disorders involving the lower extremity arteries, iliac, and carotid, which is developed more common in patients with chronic kidney disease (CKD) than individual with normal renal function. Concurrence of mesenteric artery disease and lower extremity artery disease (LEAD) is rare. The presence of PADs in patients receiving hemodialysis leads to a dramatic increase in risk of cardiovascular mortality. However, the early diagnosis of PADs in patient with CKD remains a challenge to nephrologists, which adds an adverse effect on prognosis. Patient concerns: A 48-year-old man received regular hemodialysis due to end-stage renal failure caused by type 2 diabetes mellitus (T2DM) for 7 years, who was admitted into hospital for acute, severe rest pain of the right lower extremity at the first time. The computed tomography angiography showed severe, diffuse stenosis of the distal third of femoral artery. After discharged, he was readmitted into hospital for abdominal pain and the recurred right lower limb pain. A diagnostic angiography confirmed the initial occlusion of superior mesenteric artery, severe obstruction of the distal segment of femoral artery and diffuse, irregular stenosis of arteria peronea and arteria tibialis posterior. Diagnosis: The patient was diagnosed as PADs including LEAD and mesenteric artery disease. Interventions: The percutaneous transulminal angioplasty (PTA) combined with antiplatelet therapy and beraprost were performed. Moreover, the cinacalcet and lanthanum carbonate were prescribed to control calcium-phosphorus- parathyroid hormone metabolism. Outcomes: The patient was free of abdominal pain and partly relieved from the ache of lower limb after PTA. However, he finally succumbed to acute myocardial infarction. Lessons: The incidence of PADs is higher in dialysis patients due to a unique set of biochemical and endocrine abnormalities. As there is a high uremic status and PADs burden in patients with hemodialysis, the short term risk of cardiovascular disesase mortality markedly increases. There is a need for nephrologists and cardiovascular physicians to identify these patients and then provide early and proper treatment.
摘要：
Heavy metal contamination of soils is a serious issue with various consequences in Hunan Province. Here, we aimed to determine the effect and action mechanisms of lychee biochar on the remediation of Pb, Cd, As, and Zn from soil using sunflower (Helianthus annuus). Different amounts of lychee biochar (2.5, 5, and 10%) were added to heavy metal-contaminated soil in the Shuikoushan mining area, Hunan Province. The effects of biochar on the biomass of sunflower plants, and the accumulation and distribution of Pb, Cd, As, and Zn in sunflower plants, and changes in Pb, Cd, As, and Zn concentrations in the rhizosphere soil were studied. The application of biochar stimulated the growth of the sunflower plants, with the maximum biomass recorded in the 5% biochar treatment; however, above this level, biochar inhibited plant growth. Pb, Cd, As, and Zn in sunflower plants were redistributed with biochar addition. The concentration of Pb, Cd, As, and Zn in the leaves and receptacles of sunflower plants increased with biochar application, but their concentration in the roots, stems, and seeds significantly decreased compared with the control. The total amount of accumulated Pb, Cd, and As in sunflower plants increased by 22.9-58.9%, 15.8-42.3%, and 67.9-110%, respectively, compared with that in the control. In the biochar treatments, the total amount of accumulated Zn in sunflowers decreased by 13.8-37.2%, compared with that in the control. The accumulated Pb, Cd, and As in sunflower plants have an antagonistic effect on Zn required by sunflowers. The sunflower plants significantly reduced the concentration of Pb, Cd, As, and Zn in contaminated soil (P<0.05), which decreased by 12.4, 11.0, 4.35, and 8.17%, respectively, compared with that before planting sunflower. The addition of biochar in heavy metal-contaminated soil significantly enhanced the heavy metal-remediation effect of sunflower. Compared with the control (0% biochar), 10% biochar application decreased the Pb, Cd, As, and Zn concentrations in the rhizosphere of sunflower plants, by 40.6, 31.6, 35.4, and 30.8%, respectively. In conclusion, lychee biochar enhanced the remediation of heavy metals in contaminated soil.
作者机构：
[Qiao, Yuchen; Quan, Meina; Fu, Yue; Zhao, Tan; Jia, Longfei; Tang, Yi; Qin, Qi; Jia, Jianping; Li, Yan; Wei, Cuibai; Wang, Fen] Capital Med Univ, Dept Neurol, Xuanwu Hosp, Innovat Ctr Neurol Disorders, Beijing 100053, Peoples R China.;[Jia, Jianping] Beijing Key Lab Geriatr Cognit Disorders, Beijing, Peoples R China.;[Jia, Jianping] Capital Med Univ, Clin Ctr Neurodegenerat Dis & Memory Impairment, Beijing, Peoples R China.;[Jia, Jianping] Beijing Inst Brain Disorders, Ctr Alzheimers Dis, Beijing, Peoples R China.;[Shi, Shengliang] Guangxi Med Univ, Affiliated Hosp2, Dept Neurol, Nanning, Peoples R China.
通讯机构：
[Jia, Jianping] C;Capital Med Univ, Dept Neurol, Xuanwu Hosp, Innovat Ctr Neurol Disorders, Beijing 100053, Peoples R China.
摘要：
China has the largest population of patients with dementia in the world, imposing a heavy burden on the public and health care systems. More than 100 epidemiological studies on dementia have been done in China, but the estimates of the prevalence and incidence remain inconsistent because of the use of different sampling methods. Despite improved access to health services, inadequate diagnosis and management for dementia is still common, particularly in rural areas. The Chinese Government issued a new policy to increase care facilities for citizens older than 65 years, but most patients with dementia still receive care at home. Western medicines for dementia symptoms are widely used in China, but many patients choose Chinese medicines even though they have little evidence supporting efficacy. The number of clinical trials of Chinese and western medicines has substantially increased as a result of progress in research on new antidementia drugs but international multicentre studies are few in number. Efforts are needed to establish a national system of dementia care enhance training in dementia for health professionals, and develop global collaborations to prevent and cure this disease.
摘要：
Circulating tumor DNA (ctDNA) has been frequently investigated to monitor tumor dynamics and measure tumor burden. This non-invasive method concerning ctDNA has been recognized as a promising biomarker. Recently, next generation sequencing has been used in ctDNA detection by researchers. However, those reports have been limited by modest sensitivity, and only a minority of patients with cancer were applicable. Additionally, a limited number of cases of liver cancer have been analyzed. A more precise method is required to be established to evaluate ctDNA noninvasively. In the present study, a novel method to design a liver cancer-associated chip region (spanning 211 kb, containing 159 genes) was performed with high specificity using International Cancer Genome Consortium datasets. Following evaluation with datasets from The Cancer Genome Atlas and data from 3 patients with liver cancer, the selected regions were demonstrated to be beneficial to locate specific somatic mutations associated with liver cancer therapy and to monitor cancer dynamics in the plasma samples of the patients. In addition to establishing performance benchmarks supporting direct clinical use, the chip designed and the high-resolution sequencing analyses pipeline would allow the development a set of patient specific markers that could monitor the process of cancer with high accuracy and low cost. Furthermore, the present study is essential to understanding the dynamics and providing insight into the basic mechanisms of liver cancer.
作者机构：
[Deng, Zhixiang; Fan, Dianyuan; Chen, Yu; Liu, Jun] Shenzhen Univ, Int Collaborat Lab 2D Mat Optoelect Sci & Technol, Key Lab Optoelect Devices & Syst, Minist Educ & Guangdong Prov,Coll Optoelect Engn, Shenzhen 518060, Peoples R China.;[Deng, Zhixiang] Univ South China, Sch Elect Engn, Hengyang 421001, Peoples R China.;[Liu, Jun] Aston Univ, Sch Engn & Appl Sci, Aston Inst Photon Technol, Birmingham B4 7ET, W Midlands, England.;[Zhao, Chujun] Hunan Univ, Sch Phys & Elect, IFSA Collaborat Innovat Ctr, Lab Micro Nanooptoelect Devices,Minist Educ, Changsha 410082, Hunan, Peoples R China.
通讯机构：
[Liu, Jun] S;[Liu, Jun] A;Shenzhen Univ, Int Collaborat Lab 2D Mat Optoelect Sci & Technol, Key Lab Optoelect Devices & Syst, Minist Educ & Guangdong Prov,Coll Optoelect Engn, Shenzhen 518060, Peoples R China.;Aston Univ, Sch Engn & Appl Sci, Aston Inst Photon Technol, Birmingham B4 7ET, W Midlands, England.
关键词：
Bright solitons;Dark solitons;Graded index fibers;Nonlinear effects;Space division multiplexing;Wave propagation
摘要：
In this paper, we illustrate how the periodically modulated nonlinear parameter induced by the spatial beam oscillation can be used to generate broadband resonant radiations, through a train of dark pulses in normally dispersive graded-index multimode fibers under the efficient quasi-phase-matching schemes. More precisely, we demonstrate that two co-propagating waves with equal intensities and certain temporal delays can induce the formation of a train of dark solitons, with each emitting multiple resonant radiation lines, which can possibly form multiple radiation continuums based on vast amount of excited dark solitons. The nonlinear-interaction-aided excitation of dark pulses and their radiations appear to occur through a deterministic pathway, in sharp contrast to the situation for bright pulses in the anomalous dispersion region. The quasi-phase-matching condition via periodic oscillation of spatial beam in the normal-dispersion regime adds a unique dimension to the physical design of multimode waveguides, allowing the spectrum to be engineered for specific applications. (C) 2019 Optical Society of America under the terms of the OSA Open Access Publishing Agreement
