通讯机构：
[Xu, F ; Dai, QH ] T;[He, JX ] G;Tsinghua Univ, Inst Brain & Cognit Sci, Beijing Natl Res Ctr Informat Sci & Technol, Sch Software, Beijing 100084, Peoples R China.;Tsinghua Univ, Inst Brain & Cognit Sci, Beijing Natl Res Ctr Informat Sci & Technol, Dept Automat, Beijing 100084, Peoples R China.;Guangzhou Med Univ, Dept Thorac Oncol & Surg, China State Key Lab Resp Dis, Guangzhou 510120, Peoples R China.
摘要：
Background Mediastinal neoplasms are typical thoracic diseases with increasing incidence in the general global population and can lead to poor prognosis. In clinical practice, the mediastinum's complex anatomic structures and intertype confusion among different mediastinal neoplasm pathologies severely hinder accurate diagnosis. To solve these difficulties, we organised a multicentre national collaboration on the basis of privacy-secured federated learning and developed CAIMEN, an efficient chest CT-based artificial intelligence (AI) mediastinal neoplasm diagnosis system. Methods In this multicentre cohort study, 7825 mediastinal neoplasm cases and 796 normal controls were collected from 24 centres in China to develop CAIMEN. We further enhanced CAIMEN with several novel algorithms in a multiview, knowledge-transferred, multilevel decision-making pattern. CAIMEN was tested by internal (929 cases at 15 centres), external (1216 cases at five centres and a real-world cohort of 11 162 cases), and human-AI (60 positive cases from four centres and radiologists from 15 institutions) test sets to evaluate its detection, segmentation, and classification performance. Findings In the external test experiments, the area under the receiver operating characteristic curve for detecting mediastinal neoplasms of CAIMEN was 0 & BULL;973 (95% CI 0 & BULL;969-0 & BULL;977). In the real-world cohort, CAIMEN detected 13 false-negative cases confirmed by radiologists. The dice score for segmenting mediastinal neoplasms of CAIMEN was 0 & BULL;765 (0 & BULL;738-0 & BULL;792). The mediastinal neoplasm classification top-1 and top-3 accuracy of CAIMEN were 0 & BULL;523 (0 & BULL;497-0 & BULL;554) and 0 & BULL;799 (0 & BULL;778-0 & BULL;822), respectively. In the human-AI test experiments, CAIMEN outperformed clinicians with top-1 and top-3 accuracy of 0 & BULL;500 (0 & BULL;383-0 & BULL;633) and 0 & BULL;800 (0 & BULL;700-0 & BULL;900), respectively. Meanwhile, with assistance from the computer aided diagnosis software based on CAIMEN, the 46 clinicians improved their average top-1 accuracy by 19 & BULL;1% (0 & BULL;345-0 & BULL;411) and top-3 accuracy by 13 & BULL;0% (0 & BULL;545-0 & BULL;616). Interpretation For mediastinal neoplasms, CAIMEN can produce high diagnostic accuracy and assist the diagnosis of human experts, showing its potential for clinical practice. Funding National Key R & D Program of China, National Natural Science Foundation of China, and Beijing Natural Science Foundation. Copyright & COPY; 2023 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 license.
通讯机构：
[Aixiang Wei] G;Guangdong Provincial Key Laboratory of Functional Soft Condensed Matter, School of Integrated Circuits, Guangdong University of Technology, Guangzhou 510006, Guangdong, China<&wdkj&>School of Information Science，Guangzhou Xinhua University, Dongguan 523133, Guangdong, China
摘要：
Rhenium diselenide (ReSe2) has attracted great interest due to its unique anisotropic structure and unusual in-plane anisotropic electrical and optical properties. However, efficient fabrication of large-area and high-quality 2D ReSe2 continuous films has become an increasingly important challenge. In this work, centimeter-scale 2D ReSe2 continuous films with the layer number varying from monolayer to 12 layers were successfully grown on a mica substrate using our space-confined CVD system via changing the position of the substrate. The fluorescence quenching effect and surface enhanced Raman scattering (SERS) effect on 2D ReSe2 films with different layer numbers were investigated using rhodamine 6G (R6G) dye molecules as a Raman probe. The large-area ReSe2 films show the layer-number-dependent nature of the SERS effect and a robust suppression effect of fluorescence. Our work explores the practical application of 2D ReSe2 films for molecular detection via the SERS technique.
摘要：
The reduction of soluble U(VI) to insoluble U(IV) by photocatalytic technology is considered to be a valid method to remove U(VI) from aqueous. Herein, g-C3N4/Ag/TiO2 Z-scheme heterojunction was synthesized for photocatalytic U(VI) reduction application. The SEM, XRD and XPS characterization results showed that the ternary g-C3N4/Ag/TiO2 composite photocatalyst was synthesized successfully. g-C3N4/Ag/TiO2 exhibited excellent photocatalytic reduction performance for U(VI) under visible light irradiation. After 30 min irradiation, the removal rate of U(VI) was above 99%. XPS indicated that the majority of U(VI) on the surface of g-C3N4/Ag/TiO2 was reduced to U(IV). In addition, the photocatalytic activity of g-C3N4/Ag/TiO2 has been kept significantly after five rounds of experiments, indicating the good stability. g-C3N4/Ag/TiO2 exhibited better photocatalytic reduction of U(VI) under visible light irradiation, which is mainly ascribed to Z-scheme photocatalytic mechanism assisted by the LSPR effect (Local Surface Plasmon Resonance). Ag with plasmon resonance effect on the loading has a strong absorption of photon energy. In addition, an intermediate charge transfer channel is formed between Ag and the semiconductor to inhibit the combination of photogenerated electrons and holes, resulting in a significant increase in the photocatalytic activity of the photocatalyst. This idea has some significance in design of other composite photocatalytic system.
期刊：
Drug Design, Development and Therapy,2022年16:2261-2274 ISSN：1177-8881
通讯作者：
Yang, G.;Zhang, H.
作者机构：
[Fu, Chengxiao; Yang, Guoping; Tan, Hongyi; Guo, Chengxian] Cent South Univ, Xiangya Hosp 3, Ctr Clin Pharmacol, Changsha, Peoples R China.;[Fu, Chengxiao; Yang, Bo] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Pharm, Hengyang, Peoples R China.;[Pei, Qi] Cent South Univ, Xiangya Hosp 3, Dept Pharm, Changsha, Peoples R China.;[Liang, Wu; Yang, Guoping; Tan, Hongyi; Guo, Chengxian] Cent South Univ, Res Ctr Drug Clin Evaluat, Changsha, Peoples R China.;[Li, Wei; Zhang, Hao; Liu, Jun] Cent South Univ, Xiangya Hosp 3, Dept Nephrol, Changsha, Peoples R China.
通讯机构：
[Zhang, H.] D;[Yang, G.] C;Center for Clinical Pharmacology, The Third Xiangya Hospital, Central South University, Changsha, People’s Republic of China<&wdkj&>Research Center of Drug Clinical Evaluation of Central South University, Changsha, People’s Republic of China
作者机构：
[Zhou, Wen] Cent South Univ, Xiangya Hosp 2, Clin Nursing Teaching & Res Sect, Changsha, Peoples R China.;[Zhao, Xin; Cao, Yanpeng; Liu, Jun] Univ South China, Affiliated Chenzhou Hosp, Hengyang Med Sch, Dept Limbs Foot & Hand Microsurg, Chenzhou, Peoples R China.;[Shi, Xin; Liu, Jun] Southern Med Univ, Sch Clin Med 1, Guangzhou, Peoples R China.;[Chen, Can] Cent South Univ, Xiangya Hosp, Dept Orthoped, Changsha, Peoples R China.
通讯机构：
[Yanpeng Cao; Xin Zhao; Jun Liu; Can Chen] D;[Wen Zhou] C;[Xin Shi] T;Department of Limbs (Foot and Hand) Microsurgery,Affiliated Chenzhou Hospital,Hengyang Medical School,China<&wdkj&>The First School of Clinical Medicine,Southern Medical University,Guangzhou,China<&wdkj&>Clinical Nursing Teaching and Research Section,The Second Xiangya Hospital,Central South University,China<&wdkj&>Department of Limbs (Foot and Hand) Microsurgery,Affiliated Chenzhou Hospital,Hengyang Medical School,China<&wdkj&>The First School of Clinical Medicine,Southern Medical University,Guangzhou,China<&wdkj&>Department of Orthopedics,Xiangya Hospital,Central South University,China
关键词：
Introduction;Materials and Methods;Results;Discussion;Conclusion;Abstract;Data Availability;Additional Points;Ethical Approval;Consent;Disclosure;Conflicts of Interests;Authors’ Contributions;Funding Statement;Acknowledgements;Acknowledgments;Supplementary Materials;Reference;Dataset Description;Dataset Files;Abstract;Introduction;Introduction and Materials;Introduction and Methods;Materials;Materials and Methods;Methods;Results;Discussion;Results and Discussion;Discussion and Conclusion;Results and Conclusion;Conclusion;Conclusions;Data Availability;Additional Points;Ethical Approval;Consent;Disclosure;Conflicts of Interest;Authors’ Contributions;Funding Statement;Acknowledgements;Supplementary Materials;References;Appendix;Abbreviations;Preliminaries;Introduction and Preliminaries;Notation;Proof of Theorem;Proofs;Analysis of Results;Examples;Numerical Example;Applications;Numerical Simulation;Model;Model Formulation;Systematic Palaeontology;Nomenclatural Acts;Taxonomic Implications;Experimental;Synthesis;Overview;Characterization;Background;Experimental;Theories;Calculations;Model Verification;Model Implementation;Geographic location;Study Area;Geological setting;Data Collection;Field Testing;Data and Sampling;Dataset;Literature Review;Related Works;Related Work;System Model;Methods and Data;Experimental Results;Results and Analysis;Evaluation;Implementation;Case Presentation;Case Report;Search Terms;Case Description;Case Series;Background;Limitations;Additional Points;Case;Case 1;Case 2 etc.;Concern Details;Retraction Details;Copyright;Related Articles
摘要：
Diabetes foot ulcer (DFU) is a serious complication of diabetes, characterized by impaired vascular function, limited angiogenesis, and chronic inflammation. Direct stem cell injection on treating DFU is far from satisfactory in clinical practice, as this therapy neither protects nor localizes the injected cell suspension at the chronic ulcer site. Meanwhile, most of injected cells gradually perished within several days due to senescence or apoptosis. Acellular dermal matrix (ADM) has the potential to act as excellent cell delivery vehicles, considering it is highly biomimetic to native dermal tissue, has low immunogenicity, and suitable for stem cell attachment and proliferation. Hypoxia culture has significantly enhanced effects on the survival ability of in vitro cultured stem cells, indicating this culture mode is a suitable way for inhibiting the senescence or apoptosis of transplanted cells. In the current study, we, respectively, culture adipose-derived stem cells (ADSCs) on an ADM membrane under a hypoxia or normoxia condition to construct two kinds of tissue-engineered dressing membranes (H-ADSCs/ADM and N-ADSCs/ADM) and then comparatively evaluated their efficacy on DFU healing using a diabetic rat model. In vitro results showed that hypoxia precondition could stimulate the ADSCs secreting VEGF-A, and the culture medium from hypoxia-preconditioned ADSCs could enhance the proliferation, migration, and angiogenesis of HUVECs. In vivo results indicated that compared to the N-ADSCs/ADM membrane, the transplanted cells in the H-ADSCs/ADM membrane can survive longer at the chronic ulcer site, consequently improve angiogenesis, inhibit inflammation, and increase extracellular matrix remodeling, eventually accelerating DFU closure. This study provides an innovative covering graft for the treatment of DFU in the clinic.
作者机构：
[Zhao, Yong; Luo, Caiwu] Univ South China, Sch Resource Environm & Safety Engn, Hengyang 421001, Peoples R China.;[Zhao, Yong] China Inst Atom Energy, Dept Nucl Safety, Beijing 100000, Peoples R China.;[Gao, Yong] Xian Univ Sci & Technol, Coll Humanities & Foreign Languages, Xian 710054, Peoples R China.;[Liu, Jun] Chongqing Res Inst, China Coal Technol Engn Grp, Chongqing 400039, Peoples R China.
通讯机构：
[Yong Zhao] S;School of Resource Environment and Safety Engineering, University of South China, Hengyang, 421001, China<&wdkj&>Department of Nuclear Safety, China Institute of Atomic Energy, Beijing, 100000, China
关键词：
Uranium leaching;Low-frequency vibration;Chemical erosion;Low permeability;Permeability model
摘要：
Extraction of uranium from low-permeability sandstone is a long-standing challenge in mining. The improvement of sandstone permeability has therefore become a key research focus to improve the uranium leaching effect. To address the low-permeability problem and corresponding leaching limits, leaching experiments are performed using newly developed equipment that could apply low-frequency vibration to the sandstone samples. The test results indicate that low-frequency vibration significantly improves the uranium leaching performance and permeability of the sandstone samples. The leaching effect of low-frequency vibration treatment is approximately nine times more effective than ultrasonic vibration treatment, whereas the concentration of uranium ions generated without vibration treatment is not detectable. Mathematical model that considers the combined action of physico-mechanical vibration and chemical erosion is established to describe the effect of low-frequency vibration on the permeability. The calculated results are in good agreement with the tested permeability values. This study thus offers a new method to effectively leach more uranium from low-permeability sandstone using CO2+O-2 and provides an insight into the impact of low-frequency vibration on the uranium leaching process. (C) 2022 Institute of Rock and Soil Mechanics, Chinese Academy of Sciences. Production and hosting by Elsevier B.V. All rights reserved.
期刊：
Annals of Translational Medicine,2022年10(9) ISSN：2305-5839
作者机构：
[Yuan, Wei-Zhuang; Xu, Wei-Hai; Liu, Qing] Chinese Acad Med Sci CAMS & Peking Union Med Coll, Peking Union Med Coll Hosp, State Key Lab Complex Severe & Rare Dis, Dept Neurol, Shuaifuyuan1, Beijing 100730, Peoples R China.;[Shang, Liang] Chinese Acad Med Sci CAMS & Peking Union Med Coll, Inst Basic Med Sci, Beijing, Peoples R China.;[Tian, Dai-Shi] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Neurol, Wuhan, Peoples R China.;[Wu, Shi-Wen] Chinese Peoples Armed Police Force, Gen Hosp, Med Ctr 3, Dept Neurol, Beijing, Peoples R China.;[You, Yong] Univ South China, Affiliated Hosp 1, Dept Neurol, Hengyang, Peoples R China.
关键词：
Stroke in young adults;ischemic stroke;genetic
摘要：
Background: The prevalence of stroke in young adults is increasing. We investigated the monogenic basis of young adult cryptogenic stroke patients. Methods: This multicenter study enrolled cryptogenic stroke patients under 55 years old, and individuals with nonstroke diseases were included as controls. Targeted next-generation sequencing (NGS) was applied with a custom-designed gene panel that included 551 genes. Rare variants were classified into 2 groups: pathogenic variants and variants of unknown significance. Results: A total of 153 individuals, including 30 (21 males, 70%; mean age 36.1 +/- 10.2 years) in the disease group and 123 (59 males, 48.0%; mean age 40.4 +/- 13.1 years) in the control group, were recruited. In the disease group, 32 rare variants were identified. Among these individuals, 18 pathogenic variants in 16 patients were detected, with a 53.3% (16/30) diagnostic yield of monogenic causes for cryptogenic stroke. None of these mutations were observed in the control group. Among the mutant genes, the most prevalent were Notch receptor 3 (NOTCH3), protein kinase AMP-activated noncatalytic subunit gamma 2 (PRKAG2), and ryanodine receptor 2 (RYR2). Genes associated with cardiogenic diseases showed the highest mutation frequency (10/18, 55.6%) followed by genes associated with small-vessel diseases (SVI)s) and coagulation disorders. None of the patients with mutations had evident abnormalities in the heart or other systems checked by routine tests. For the imaging phenotype-genotype association analysis, infarctions in both the anterior and posterior cerebral circulation were only observed in patients with genes related to cardiogenic disease. Conclusions: In this study, pathogenic variants were identified in nearly half of the young-onset cryptogenic stroke patients, with genes related to cardiogenic diseases being the most frequently mutated. This may have implications for future clinical decision-making, including the development of finer and more sensitive examinations.
作者机构：
[Pang, Min; Chen, Xue-Kun; Liu, Jun; Tan, Jia-Ling] Univ South China, Sch Math & Phys, Hengyang 421001, Peoples R China.;[Xie, Zhong-Xiang] Hunan Inst Technol, Dept Math & Phys, Hengyang 421002, Peoples R China.;[Zhou, Wu-Xing] Hunan Univ Sci & Technol, Sch Mat Sci & Engn, Xiangtan 411201, Peoples R China.;[Zhou, Wu-Xing] Hunan Univ Sci & Technol, Hunan Prov Key Lab Adv Mat New Energy Storage & Co, Xiangtan 411201, Peoples R China.
通讯机构：
[Zhong-Xiang Xie] D;[Wu-Xing Zhou; Jun Liu] S;School of Materials Science and Engineering & Hunan Provincial Key Laboratory of Advanced Materials for New Energy Storage and Conversion, Hunan University of Science and Technology , Xiangtan 411201, China<&wdkj&>School of Mathematics and Physics, University of South China , Hengyang 421001, China<&wdkj&>Department of Mathematics and Physics, Hunan Institute of Technology , Hengyang 421002, China
通讯机构：
[Wang, Yu-Zhong] D;Department of Urology, Affiliated Hospital of Hebei University of Engineering, No.81, Congtai Road, Congtai District, Hebei Province, Handan, China
作者机构：
[Yang, Haiyan; Zeng, Liang; Li, Yizhi; Zhang, Yongchang; Yang, Nong; Huang, Zhe; Zhang, Xiangyu] Cent South Univ, Hunan Canc Hosp, Dept Med Oncol,Xiangya Sch Med, Lung Canc & Gastrointestinal Unit,Affiliated Canc, Changsha 410013, Peoples R China.;[Zhang, Yongchang; Yang, Nong; Huang, Zhe] Univ South China, Grad Collaborat Training Base, Hengyang Med Sch, Hunan Canc Hosp, Hengyang 421001, Hunan, Peoples R China.;[Xu, Qinqin] Qinghai Prov Peoples Hosp, Dept Med Oncol, Xining 810000, Peoples R China.;[Lizaso, Analyn] Burning Rock Biotech, Guangzhou 510300, Peoples R China.;[Xu, Chunwei] Nanjing Univ, Jinling Hosp, Dept Resp Med, Sch Med, Nanjing, Peoples R China.
通讯机构：
[Zhang, YC; Yang, N ] C;Cent South Univ, Hunan Canc Hosp, Dept Med Oncol,Xiangya Sch Med, Lung Canc & Gastrointestinal Unit,Affiliated Canc, Changsha 410013, Peoples R China.;Univ South China, Grad Collaborat Training Base, Hengyang Med Sch, Hunan Canc Hosp, Hengyang 421001, Hunan, Peoples R China.
摘要：
This retrospective study investigated the association between the pattern of disease progression and molecular mechanism of acquired resistance in a large cohort of 49 patients with ROS1-rearranged advanced non-small-cell lung cancer treated with first-line crizotinib. We found that treatment-emergent ROS1 point mutations were the major molecular mechanism of crizotinib resistance, particularly for patients who developed extracranial-only disease progression. Our findings highlight the importance of rebiopsy and gene testing for subsequent-line therapeutic management.
期刊：
Frontiers in Neuroscience,2022年0:1463 ISSN：1662-4548
作者机构：
Central South University, Changsha, China;University of South China, Hengyang, 421001, Hunan Province, China;Second Xiangya Hospital, Central South University, Changsha, Hunan Province, China;Zhejiang University, Hangzhou, 310058, Zhejiang Province, China
关键词：
Parkinson' disease;Depression;functional connectivity;Independent Component Analysis;resting-state functional magnetic resonance imaging
摘要：
Objective: To explore the neural network mechanism of Parkinson's disease (PD) with different degrees of depression using independent component analysis (ICA) of the functional connectivity changes in the forehead, limbic system, and basal ganglia regions. Methods: 106 PD patients were divided into three groups: PD with moderate-severe depression (PDMSD, n=42), PD with mild depression (PDMD, n=29), and PD without depression (PDND, n=35). Fifty gender- and age-matched health objects were recruited as a control group (HC). Three-dimensional T1-weighted image and resting-state functional magnetic resonance imaging (RS-fMRI) data were collected. Results: Different functional connectivity was observed in the left precentral gyrus, right precuneus, right inferior frontal gyrus, right medial and paracingulate gyrus, left supplementary motor area, right brain insula, and the inferior frontal gyrus of the left orbit among 4 groups (ANOVA, P<0.05, Voxel size>5). Both PDMD and PDMSD exhibited an increased functional connectivity in the superior-posterior default-mode network (spDMN) and left frontoparietal network (LFPN); they also exhibited a decreased functional connectivity in the interior Salience Network (inSN) when compared with the PDND group. The functional connectivity within the inSN network was decreased in the PDMSD group when compared with the PDMD group (Alphasim correction, P<0.05, voxel zise>5). Conclusion: PD with different degrees of depression has abnormal functional connectivity in multiple networks, which is an important neurobiological basis for the occurrence and development of depression in PD. The degree of decreased functional connectivity in the inSN network is related to the degree of depression in PD-D patients, which can be an imaging marker for PD to judge the severity of depression.
作者机构：
[梁瑜; 刘彦; 邹冬雪; 彭莉; 高勇强; 胡丽; 刘俊] Institute of Pathogenic Biology, Hengyang Medical School, University of South China, Hengyang 421001, China;[肖建华] Institute of Pathogenic Biology, Hengyang Medical School, University of South China, Hengyang 421001, China. *Corresponding author, E-mail: jhxiao223@163.com
摘要：
This study intends to explore miR-34a's effect on BMSCs osteogenic differentiation of hyperlipidemia. 20 SD rats were equally assigned into control group (normal diet) and high-fat group (research diet). Cells were transfected with miR-34a mimic or negative control followed by meausring miR-34a, Dvl2, PPAR-gamma, ALP, Runx2, and sp7, and ALP activity. The number of mineralized nodules, adipocytes, miR-34a and PPAR-gamma expression in high-fat group were significantly increased and Dvl2, ALP, Runx2, and sp7 mRNA showed opposite profiles. Meanwhile, Runx2, ALP protein, cytoplasm and nuclear blue-black particles, Dvl2 protein and mRNA in miR-34a mimic group were significantly downregulated (P < 0.05). Additionally, the luciferase activity of wild-type plasmid+ miR-34a mimic group was significantly lower than mutant group, indicating that miR-34a targets Dvl2. In conclusion, miR-34a inhibits the osteogenic differentiation of hyperlipidemia BMSCs by inhibiting the expression of Dvl2, Runx2 and ALP activity, indicating that it might be target in the hyperlipidemia treatment.
