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Advances in investigating microcystin-induced liver toxicity and underlying mechanisms

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成果类型:
期刊论文
作者:
Li, Tong;Fan, Xinting;Cai, Meihan;Jiang, Yuanyuan;Wang, Yaqi;...
通讯作者:
Liu, J
作者机构:
Univ South China, Sch Basic Med Sci, Hengyang Med Sch, Inst Cytol & Genet,Dept Cell Biol & Genet,Key Lab, Hengyang 421001, Hunan, Peoples R China.
Univ South China, Sch Publ Hlth, Hengyang Med Sch, Hunan Key Lab Typ Environm Pollut & Hlth Hazards, Hengyang 421001, Hunan, Peoples R China.
[Liu, Jun] 28 Changsheng West Rd, Hengyang 421001, Hunan, Peoples R China.
通讯机构:
[Liu, J ] 2
28 Changsheng West Rd, Hengyang 421001, Hunan, Peoples R China.
语种:
英文
关键词:
Liver;MCs;Mechanisms;Toxicity
期刊:
Science of The Total Environment
ISSN:
0048-9697
年:
2023
卷:
905
页码:
167167
基金类别:
Project of Hengyang Science and Technology Bureau [2018KJ111, 2016KF14]; Hunan Key Laboratory of Typical Environmental Pollution and Health Hazards, School of Public Health, Hengyang Medical School, University of South China [2019TP1027]; Key Laboratory of Ecological Environment and Critical Human Diseases Prevention of Hunan Province Department of Education, School of Basic Medical Sciences, Hengyang Medical School, University of South China [2019-379]; Project of College Students' Innovative Entrepreneurial Training of Hunan Province [S202310555206]
机构署名:
本校为第一机构
院系归属:
公共卫生学院
摘要:
Microcystins (MCs) are a class of biologically active cyclic heptapeptide pollutants produced by the freshwater alga Microcystis aeruginosa. With increased environmental pollution, MCs have become a popular research topic. In recent years, the hepatotoxicity of MCs and associated effects and mechanisms have been studied extensively. Current epidemiological data indicate that long-term human exposure to MCs can lead to severe liver toxicity, acute toxicity, and death. In addition, current toxicological studies on the liver, a vital target organ of MCs, indicate that MC contamination is associat...

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