作者机构：
[Gan, Runliang; Yu, Siwei; Han, Ruyue] Univ South China, Hengyang Med Sch, Canc Res Inst, Key Lab Canc Cellular & Mol Pathol Hunan Prov, Hengyang 421001, Hunan, Peoples R China.
通讯机构：
[Gan, Runliang] C;Cancer Research Institute, Key Laboratory of Cancer Cellular and Molecular Pathology in Hunan Province, Hengyang Medical School, University of South China, 421001, Hengyang, Hunan, P. R. China.
摘要：
Leukaemia and lymphoma are common malignancies. The Wnt pathway is a complex network of proteins regulating cell proliferation and differentiation, as well as cancer development, and is divided into the Wnt/β-catenin signalling pathway (the canonical Wnt signalling pathway) and the noncanonical Wnt signalling pathway. The Wnt/β-catenin signalling pathway is highly conserved evolutionarily, and activation or inhibition of either of the pathways may lead to cancer development and progression. The aim of this review is to analyse the mechanisms of action of related molecules in the Wnt/β-catenin pathway in haematologic malignancies and their feasibility as therapeutic targets.
期刊：
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING,2022年25(11):1897-1906 ISSN：1386-2073
通讯作者：
Lei, X.;Gan, R.
作者机构：
[Yang, Xiaoyan; Xie, Zhizhong; Lei, Xiaoyong] Hunan Prov Key Lab Tumor Microenvironm Respons Dr, Hengyan, Peoples R China.;[Yang, Xiaoyan; Xie, Zhizhong; Lei, Xiaoyong] Inst Pharm & Pharmacol, 28 West Changsheng Rd, Hengyang City, Hunan, Peoples R China.;[Gan, Runliang; Zhang, Yang; Tang, Yunlian; Yang, Jing] Univ South China, Hengyang Med Coll, Canc Res Inst, 28 Western Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.
通讯机构：
[Lei, X.] I;[Gan, R.] C;Institute of Pharmacy and Pharmacology, No. 28, West Changsheng Road, Hunan Province, China;Cancer Research Institute, No. 28, West Chang-sheng Road, Hunan Province, China
摘要：
Globally, there were over 1 million new gastric cancer (GC) patients in 2018 and GC has become the sixth most common cancer worldwide. GC caused 783,000deaths worldwide in 2018, making it the third most deadly cancer type. miRNAs are short (~22nucleotides in length) non‑coding RNA molecules, which can regulate gene expression passively at a post‑transcriptional level. There are more and more in‑depth studies on miRNAs. There are numerous conclusive evidences that there is an inseparable link between miRNAs and GC. miRNAs can affect the entire process of GC, including the oncogenesis, development, diagnosis, treatment and prognosis of GC. Although many miRNAs have been linked to GC, few can be applied to clinical practice. This review takes the clinical changes of GC as a clue and summarizes the miRNAs related to GC that have confirmed the mechanism of action in the past three years. Through in‑depth study and understanding of the mechanism of those miRNAs, we predict their possible clinical uses, and suggest some new insights to overcome GC.
摘要：
Epstein-Barr virus (EBV) is closely associated with multiple human cancers. EBV-associated cancers are mainly lymphomas derived from B cells and T cells (Hodgkin lymphoma, Burkitt lymphoma, NK/T-cell lymphoma, and posttransplant lymphoproliferative disorder (PTLD)) and carcinomas derived from epithelial cells (nasopharyngeal carcinoma and gastric carcinoma). EBV can induce oncogenesis in its host cell by activating various signaling pathways, such as nuclear factor-κB (NF-κB), phosphoinositide-3-kinase/protein kinase B (PI3K/AKT), Janus kinase/signal transducer and transcription activator (JAK/STAT), mitogen-activated protein kinase (MAPK), transforming growth factor-β (TGF-β), and Wnt/β-catenin, which are regulated by EBV-encoded proteins and noncoding RNA. In this review, we focus on the oncogenic roles of EBV that are mediated through the aforementioned signaling pathways.
作者机构：
[Gan, Runliang; Yang, Xiaoyan] Univ South China, Hengyang Med Coll, Canc Res Inst, 28 Western Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.;[Yang, Xiaoyan; Xie, Zhizhong; Lei, Xiaoyong] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Hunan, Peoples R China.;[Yang, Xiaoyan; Xie, Zhizhong; Lei, Xiaoyong] Univ South China, Inst Pharm & Pharmacol, 28 Western Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.
通讯机构：
[Gan, Runliang; Lei, Xiaoyong] U;Univ South China, Hengyang Med Coll, Canc Res Inst, 28 Western Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.;Univ South China, Inst Pharm & Pharmacol, 28 Western Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.
期刊：
Cancer Letters,2020年495:191-199 ISSN：0304-3835
通讯作者：
Gan, Runliang
作者机构：
[Hu, Guangsheng; Yang, Jing; Zeng, Bin] Univ South China, Dept Gastroenterol, Affiliated Hosp 1, Hengyang 421001, Hunan, Peoples R China.;[Gan, Runliang; Yang, Jing] Univ South China, Canc Res Inst, Hunan Prov Key Lab Tumor Cellular & Mol Pathol, Hengyang 421001, Hunan, Peoples R China.;[Liu, Zhifeng] Univ South China, Dept Otorhinolaryngol, Affiliated Hosp 1, Hengyang 421001, Hunan, Peoples R China.
通讯机构：
[Gan, Runliang] U;Univ South China, Canc Res Inst, Hunan Prov Key Lab Tumor Cellular & Mol Pathol, Hengyang 421001, Hunan, Peoples R China.
关键词：
Gastric cancer;Epstein-barr virus (EBV);Molecular features;Clinicopathological features
摘要：
Epstein-Barr virus (EBV)-associated gastric cancer (EBVaGC) is a common malignant tumor associated with EBV infection. The molecular classification of gastric carcinoma indicates that EBVaGC is a distinct subtype in terms of oncogenesis and molecular features. Viral proteins, Bam-HI-A rightward transcripts (BART) miRNAs, and Bam-HI A rightward frame 1 (BARF1) promote oncogenesis after EBV infection via the induction of methylation, regulation of host gene expression, and malignant transformation. Together with abnormal mutations and amplification of the host genome as driving factors, interactions between the EBV genome and host genome accelerate carcinogenesis. The molecular profile of EBVaGC is that of EBV driving DNA hypermethylation, frequent phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (PIK3CA) mutations, and the overexpression of Janus kinase 2 (JAK2), programmed death ligand-1 (PD-L1), and PD-L2. Clinically, the frequency of lymph node metastasis is lower, and the prognosis is better for EBVaGC than EBV-negative gastric cancer (EBVnGC). Pathologically, EBVaGC is a gastric adenocarcinoma with lymphoid stroma. This review interprets how the EBV genome is involved in the oncogenesis of gastric cancer and describes the molecular and clinicopathological features of EBVaGC.
摘要：
The early stage of oncogenesis is linked to the disorder of the cell cycle. Abnormal gene expression often leads to cell cycle disorders, resulting in malignant transformation of human cells. Epstein–Barr virus (EBV) is associated with a diverse range of human neoplasms, such as malignant lymphoma, nasopharyngeal carcinoma and gastric cancer. EBV mainly infects human lymphocytes and oropharyngeal epithelial cells. EBV is latent in lymphocytes for a long period of time, is detached from the cytoplasm by circular DNA, and can integrate into the chromosome of cells. EBV expresses a variety of latent genes during latent infection. The interaction between EBV latent genes and oncogenes leads to host cell cycle disturbances, including the promotion of G1/S phase transition and inhibition of cell apoptosis, thereby promoting the development of EBV-associated neoplasms. Molecular mechanisms of EBV-driven cell cycle progression and oncogenesis involve diverse genes and signal pathways. Here, we review the molecular mechanisms of EBV-driven cell cycle progression and promoting oncogenesis.
作者机构：
[Peng Qiu; Gan Run-Liang] Univ South China, Canc Res Inst, Hengyang 421001, Peoples R China.;[Liu Liang-Zhuan] Univ South China, Expt Ctr Med Res, Hengyang 421001, Peoples R China.
通讯机构：
[Gan Run-Liang] U;Univ South China, Canc Res Inst, Hengyang 421001, Peoples R China.
摘要：
Hepatocellular carcinoma (HCC), a disease that is a major health care issue across the globe, includes the deviant expression of miRNAs in its development, progression, and resistance to treatment. We focused our study on miR-503 expression and its role in HCC. miR-503 was found in HCC tissues and cell lines using quantitative real-time PCR (RT-qPCR). Western blot analyses and the luciferase reporter assay were used to determine the miR-503 potential target in the HCC cells. We used MTT to analyze cell proliferation activity and noted that there was a considerable decrease of miR-503 in HCC tissues and cell lines when measured against the controls. miR-503 upregulation decreased expression of eukaryotic translation initiation factor 4E (EIF4E), and reduced HCC cell proliferation and sensitized HCC cells to anticancer drugs. miR-503 overexpression hindered luciferase activity of EIF4E 3' untranslated region-based reporter construct among HepG2, BEL-7402, and SMMC-7721 cells, revealing that miR-503 may increase sensitivity to therapies at least partially through targeting EIF4E suppression of HCC proliferation.
作者机构：
[杨晓燕] Institute of Biologic Research;[杨晓燕] Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang Hunan 421001, China;[殷杰; 谢红艳] Institute of Biologic Research, University of South China, Hengyang Hunan 421001, China;[向琼; 雷小勇; 虞佳] Institute of Pharmacy and Pharmacology, University of South China, Hengyang Hunan 421001, China;[甘润良; 雷小勇] Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study
通讯机构：
Cancer Research Institute, University of South China, Hengyang Hunan, China
