miR-503 inhibits proliferation making human hepatocellular carcinoma cells susceptible to 5-fluorouracil by targeting EIF4E

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成果类型：

期刊论文

作者：

Yang, Xiaoyan;Zang, Jinglei;Pan, Xia;Yin, Jie;Xiang, Qiong;...

通讯作者：

Lei, Xiaoyong;Gan, Runliang

作者机构：

[Yang, Xiaoyan; Yin, Jie; Pan, Xia; Xiang, Qiong; Lei, Xiaoyong; Yu, Jia] Univ South China, Inst Pharm & Pharmacol, Hengyang 421001, Hunan, Peoples R China.

[Gan, Runliang; Yang, Xiaoyan; Lei, Xiaoyong] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, 28 Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

[Gan, Runliang] Univ South China, Inst Tumor Res, 28 Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

[Zang, Jinglei] Changsha Hlth Vocat Coll, Changsha 410100, Hunan, Peoples R China.

通讯机构：

[Lei, Xiaoyong; Gan, Runliang] U

Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, 28 Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Inst Tumor Res, 28 Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

miR-503;eukaryotic translation initiation factor 4E;5-fluorouracil;drug sensitivity;hepatocellular carcinoma cells

期刊：

ONCOLOGY REPORTS

ISSN：

1021-335X

年：

2017

卷：

期：

页码：

563-570

DOI：

10.3892/or.2016.5220

基金类别：

National Natural Sciences Foundation of China [81372579]; Health Department Medical Scientific Research Projects of Hunan Province [B2014-048]; Hunan Provincial Education Department [13C832]

机构署名：

本校为第一且通讯机构

院系归属：

药学与生物科学学院

摘要：

Hepatocellular carcinoma (HCC), a disease that is a major health care issue across the globe, includes the deviant expression of miRNAs in its development, progression, and resistance to treatment. We focused our study on miR-503 expression and its role in HCC. miR-503 was found in HCC tissues and cell lines using quantitative real-time PCR (RT-qPCR). Western blot analyses and the luciferase reporter assay were used to determine the miR-503 potential target in the HCC cells. We used MTT to analyze cell proliferation activity and noted that there was a considerable decrease of miR-503 in HCC ti...

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miR-503 inhibits proliferation making human hepatocellular carcinoma cells susceptible to 5-fluorouracil by targeting EIF4E

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