miR-4295 Promotes the Malignant Progression of Gastric Cancer via Targeting PTEN

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成果类型：

期刊论文

作者：

Yang, Xiaoyan;Yang, Jing;Tang, Yunlian;Xie, Zhizhong;Zhang, Yang;...

通讯作者：

Lei, X.;Gan, R.

作者机构：

[Yang, Xiaoyan; Xie, Zhizhong; Lei, Xiaoyong] Hunan Prov Key Lab Tumor Microenvironm Respons Dr, Hengyan, Peoples R China.

[Yang, Xiaoyan; Xie, Zhizhong; Lei, Xiaoyong] Inst Pharm & Pharmacol, 28 West Changsheng Rd, Hengyang City, Hunan, Peoples R China.

[Gan, Runliang; Zhang, Yang; Tang, Yunlian; Yang, Jing] Univ South China, Hengyang Med Coll, Canc Res Inst, 28 Western Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Lei, X.] I

[Gan, R.] C

Institute of Pharmacy and Pharmacology, No. 28, West Changsheng Road, Hunan Province, China

Cancer Research Institute, No. 28, West Chang-sheng Road, Hunan Province, China

语种：

英文

关键词：

MiR-4295;PTEN;gastric cancer;invasion;migration;proliferation

期刊：

COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

ISSN：

1386-2073

年：

2022

卷：

期：

页码：

1897-1906

DOI：

10.2174/1386207325666211110095307

基金类别：

This work was funded by the Natural Science Foundation of Hunan Province [grant number 2019JJ50500], China. The Scientific Research Fund Project of Hunan Provincial Health Commission [grant number 20201921].

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

Background: Gastric cancer (GC), one of the common clinical malignant tumors of the digestive system, is the fourth most commonly diagnosed cancer and the second lethal cancer worldwide and has the characteristics of high metastasis, fatality, and recurrence rate. This research was conducted to investigate the role and mechanism of miR-4295 in gastric cancer. Methods: The expression capacity of miR-4295 was determined in gastric cancer tissues and its normal tissues by qRT-PCR. PTEN expression level was detected by western blot. SGC-7901 and MG...

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miR-4295 Promotes the Malignant Progression of Gastric Cancer via Targeting PTEN

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