MiR-33b-5p sensitizes gastric cancer cells to chemotherapy drugs via inhibiting HMGA2 expression

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成果类型：

期刊论文

作者：

Yang, Xiaoyan;Zhao, Qian;Yin, Huali;Lei, Xiaoyong*;Gan, Runliang*

通讯作者：

Lei, Xiaoyong;Gan, Runliang

作者机构：

[Gan, Runliang; Yang, Xiaoyan; Lei, Xiaoyong; Lei, XY; Gan, RL] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang, Hunan, Peoples R China.

[Yang, Xiaoyan] Univ South China, Inst Biol Res, Hengyang, Hunan, Peoples R China.

[Gan, Runliang; Zhao, Qian; Yin, Huali] Univ South China, Canc Res Inst, Hengyang, Hunan, Peoples R China.

[Lei, Xiaoyong] Univ South China, Inst Pharm & Pharmacol, Hengyang, Hunan, Peoples R China.

通讯机构：

[Lei, XY; Gan, RL] U

Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang, Hunan, Peoples R China.

语种：

英文

关键词：

HMGA2;MiR-33b-5p;chemo-sensitivity;gastric cancer

期刊：

Journal of Drug Targeting

ISSN：

1061-186X

年：

2017

卷：

期：

页码：

653-660

DOI：

10.1080/1061186X.2017.1323220

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81372579]; Scientific Research Fund of Hunan Provincial Education DepartmentHunan Provincial Education Department [17C1402]; Provincial Natural Science Foundation of HunanNatural Science Foundation of Hunan Province [2017JJ2226]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

MicroRNAs (miRNAs) are internal, non-coding, and ∼22 nt small RNAs that display cell- and tissue-specific expression. They play important regulatory roles in cell proliferation and chemo-sensitivity. This study focused on tumor-suppressive miR-33b-5p expression as well as its role in gastric cancer. MiR-33b-5p was found low expression in gastric cancer cell lines. Functionally, western blots and the luciferase reporter assay were used to confirm that HMGA2 was the potential target of miR-33b-5p. Next, we used CCK-8 kits to analyze the effect o...

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MiR-33b-5p sensitizes gastric cancer cells to chemotherapy drugs via inhibiting HMGA2 expression

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