期刊论文

Gan, Runliang

英文

Biomedicine & Pharmacotherapy

0753-3322

2019

116

108984

10.1016/j.biopha.2019.108984

This work was supported by the National Natural Science Foundation of China (No. 81272182 , 81372134 and 81641012 ), the Key Project of Hunan Provincial Education Department ( 16K077 , 17K081 ), Hunan Province Key Laboratory of Tumor Cellular & Molecular Pathology ( 2016TP1015 ), Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study ( 2014-405 ). We thank Li Cao (Molecular Genetics Lab of Cancer Research Institute, Central South University) for kindly providing Raji cell line. We are grateful to Kangchen Bio-tech Inc (Shanghai, China) for providing whole genome microarray and hybridization experiment.

本校为第一且通讯机构

Although the Epstein-Barr virus (EBV) is a well-known human oncogenic virus, its molecular mechanisms involved in the transformation of healthy human cells remain poorly understood. In this study, human lymphocytes were isolated from the peripheral blood of healthy adults, and lymphocytes were transformed in vitro by EBV. Agilent human whole genome microarrays were used to detect the differential gene expression profiles of EBV-transformed lymphoblasts and healthy peripheral blood lymphocytes (PBLs). By constructing the gene functional network of EBV-induced lymphocyte transformation, we scree...