期刊论文

Function and Significance of EBV-encoded miRNAs in Viral Infection and Oncogenesis

Gan Run-Liang

中文

生物化学与生物物理进展

1000-3282

2019

46

8

787-795

10.16476/j.pibb.2019.0090

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81372134, 81641012]

本校为第一且通讯机构

EB病毒(Epstein-Barr virus,EBV)是一种172 kb大小的线性双链DNA病毒,与鼻咽癌、淋巴瘤、胃癌等恶性肿瘤的发生密切相关. EBV编码的微小RNAs (miRNAs)可以调节病毒和宿主细胞基因的表达,并且在癌症发生发展中起着多种作用.本文综述了EBV编码的miRNAs (EBV-encoded miRNA,EBV miRNAs)在病毒感染和肿瘤发生、侵袭转移、抗凋亡、信号通路等方面的生物学功能,以及对于EBV相关肿瘤诊断标志物的潜在意义. EB病毒编码的miRNAs也可能成为进一步研究EBV相关肿瘤治疗的一个候选靶点.

Epstein-Barr virus (EBV) has a relatively large double-stranded DNA genome. The EBV genome is approximately 172 kb in length. EBV has been associated with several cancer types, such as nasopharyngeal carcinoma, lymphoma and gastric cancer. EBV miRNAs can regulate gene expressions of virus and host cell, and play a variety of roles in the development of EBV-associated cancers. This article reviews the biological functions of EBV miRNAs in viral infection, oncogenesis, tumor invasion and metastasis, anti-apoptosis, signaling pathway, and potential significance as biomarkers for diagnosis of EBV-...