Long non-coding RNA GAS5 in human cancer (Review)

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成果类型：

期刊论文

作者：

Yang, Xiaoyan;Xie, Zhizhong;Lei, Xiaoyong*;Gan, Runliang*

通讯作者：

Gan, Runliang;Lei, Xiaoyong

作者机构：

[Gan, Runliang; Yang, Xiaoyan] Univ South China, Hengyang Med Coll, Canc Res Inst, 28 Western Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

[Yang, Xiaoyan; Xie, Zhizhong; Lei, Xiaoyong] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Hunan, Peoples R China.

[Yang, Xiaoyan; Xie, Zhizhong; Lei, Xiaoyong] Univ South China, Inst Pharm & Pharmacol, 28 Western Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Gan, Runliang; Lei, Xiaoyong] U

Univ South China, Hengyang Med Coll, Canc Res Inst, 28 Western Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Inst Pharm & Pharmacol, 28 Western Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

growth arrest specific transcript 5;long untranslated RNA;protein p53;unclassified drug;angiogenesis;antineoplastic activity;Article;breast carcinoma;cancer prognosis;cancer staging;carcinogenesis;cell invasion;cell proliferation;cell viability;colorectal cancer;DNA damage;down regulation;endometrium cancer;esophageal squamous cell carcinoma;GAS5 gene;gene;gene expression level;gene overexpression;glioblastoma;human;liver cell carcinoma;lung cancer;lymph node metastasis;malignant neoplasm;MAPK signaling;melanoma;neuroblastoma;osteosarcoma;ovary cancer;Pi3K/Akt signaling;prostate carcinoma;quality of life;squamous cell carcinoma;stomach cancer;tumor growth;tumor suppressor gene;tumor volume;uterine cervix cancer

期刊：

ONCOLOGY LETTERS

ISSN：

1792-1074

年：

2020

卷：

期：

页码：

2587-2594

DOI：

10.3892/ol.2020.11809

基金类别：

The present study was funded by The Provincial Natural Science Foundation of Hunan (grant nos. 2019JJ50500 and 2017JJ2226), The Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research [Hunan Provincial Science and Technology Department Document (grant number 2019-56)], The Scientific Research Fund of Hunan Provincial Education Department (grant no. 17C1402), The Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study (grant no. 2014-405) and The Undergraduate Research-based Learning and Innovative Experimental Program of University of South China (grant nos. 2017XJYZ040 and 2018XJXZ348).

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

Long non-coding RNAs (lncRNAs) constitute a group of >200-nucleotide ncRNA molecules. lncRNAs regulate several cell functions, such as proliferation, apoptosis, invasion and metastasis. Meanwhile, lncRNAs are abnormally expressed in human malignancies, where they suppress or promote tumor growth. The present study focused on growth arrest-specific transcript 5 (GAS5), a well-known lncRNA that acts as a tumor suppressor but is suppressed in multiple types of cancer, including mammary carcinoma, prostate cancer, colorectal cancer, gastric cancer,...

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