期刊论文

Wang, Chengkun;Gan, Runliang

英文

Cancer Cell International

1475-2867

2021

21

1

1-11

10.1186/s12935-021-01793-3

This work was supported by the National Natural Science Foundation of China (No. 81372134), Hunan Province Key Laboratory of Tumor Cellular & Molecular Pathology (2016TP1015), and The Key Project of Hunan Provincial Health Commission (20201921).

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Epstein-Barr virus (EBV) is closely associated with multiple human cancers. EBV-associated cancers are mainly lymphomas derived from B cells and T cells (Hodgkin lymphoma, Burkitt lymphoma, NK/T-cell lymphoma, and posttransplant lymphoproliferative disorder (PTLD)) and carcinomas derived from epithelial cells (nasopharyngeal carcinoma and gastric carcinoma). EBV can induce oncogenesis in its host cell by activating various signaling pathways, such as nuclear factor-κB (NF-κB), phosphoinositide-3-kinase/protein kinase B (PI3K/AKT), Janus kinas...