Epstein–Barr virus-associated gastric cancer: A distinct subtype

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成果类型：

期刊论文

作者：

Yang, Jing;Liu, Zhifeng;Zeng, Bin;Hu, Guangsheng;Gan, Runliang*

通讯作者：

Gan, Runliang

作者机构：

[Hu, Guangsheng; Yang, Jing; Zeng, Bin] Univ South China, Dept Gastroenterol, Affiliated Hosp 1, Hengyang 421001, Hunan, Peoples R China.

[Gan, Runliang; Yang, Jing] Univ South China, Canc Res Inst, Hunan Prov Key Lab Tumor Cellular & Mol Pathol, Hengyang 421001, Hunan, Peoples R China.

[Liu, Zhifeng] Univ South China, Dept Otorhinolaryngol, Affiliated Hosp 1, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Gan, Runliang] U

Univ South China, Canc Res Inst, Hunan Prov Key Lab Tumor Cellular & Mol Pathol, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

Gastric cancer;Epstein-barr virus (EBV);Molecular features;Clinicopathological features

期刊：

Cancer Letters

ISSN：

0304-3835

年：

2020

卷：

495

页码：

191-199

DOI：

10.1016/j.canlet.2020.09.019

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81372134]; Hunan Province Key Laboratory of Tumor Cellular & Molecular Pathology [2016TP1015]; Key Project of Hunan Provincial Health Commission [20201921]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Epstein-Barr virus (EBV)-associated gastric cancer (EBVaGC) is a common malignant tumor associated with EBV infection. The molecular classification of gastric carcinoma indicates that EBVaGC is a distinct subtype in terms of oncogenesis and molecular features. Viral proteins, Bam-HI-A rightward transcripts (BART) miRNAs, and Bam-HI A rightward frame 1 (BARF1) promote oncogenesis after EBV infection via the induction of methylation, regulation of host gene expression, and malignant transformation. Together with abnormal mutations and amplification of the host genome as driving factors, interact...

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Epstein–Barr virus-associated gastric cancer: A distinct subtype

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