AN ANTI-SWELLABLE HYDROGEL STRAIN SENSOR FOR UNDERWATER MOTION DETECTION
作者：
Ren, Jiayuan;Liu, Yanhui;Wang, Zengqiang;Chen, Siqi;Ma, Yifan;...
期刊：
Advanced Functional Materials ,2022年32(13):2107404- ISSN：1616-301X
通讯作者：
Lu, Shaoyu;Wei, Hua
作者机构：
[Liu, Yanhui; Lu, Shaoyu; Ma, Yifan; Chen, Siqi; Wang, Zengqiang; Ren, Jiayuan] Lanzhou Univ, State Key Lab Appl Organ Chem, Key Lab Nonferrous Met Chem & Resources Utilizat, Dept Chem & Chem Engn, Lanzhou 730000, Peoples R China.;[Wei, Hua] Univ South China, Hengyang Med Coll & Hunan Prov Cooperat Innovat, Ctr Mol Target New Drug Study, Hengyang 421001, Peoples R China.;[Wei, Hua] Univ South China, Dept Pharm & Pharmacol, Hengyang 421001, Peoples R China.
通讯机构：
[Lu, Shaoyu] L;[Wei, Hua] U;Lanzhou Univ, State Key Lab Appl Organ Chem, Key Lab Nonferrous Met Chem & Resources Utilizat, Dept Chem & Chem Engn, Lanzhou 730000, Peoples R China.;Univ South China, Hengyang Med Coll & Hunan Prov Cooperat Innovat, Ctr Mol Target New Drug Study, Hengyang 421001, Peoples R China.;Univ South China, Dept Pharm & Pharmacol, Hengyang 421001, Peoples R China.
关键词：
anti-swelling;hydrogels;sensors;underwater
摘要：
Hydrogel-based wearable electronic devices have received increasing attention. However, the construction of underwater strain sensors remains a significant challenge because of the swelling of hydrogels in an aquatic environment. This work presents the fabrication of an anti-swellable hydrogel composed of polyvinyl alcohol (PVA), a copolymer of [2-(methacryloyloxy) ethyl]dimethyl-(3-sulfopropyl) ammonium hydroxide (SBMA) and 2-hydroxyethyl methacrylate. Interestingly, facile switch of the SBMA moiety from neutral to positively charged status at a low pH value leads to reduced osmotic pressure of the hydrogel for electrostatic repulsion-driven elimination of water molecules and anti-swelling. The resulting anti-swellable hydrogel exhibits high toughness (518kJ m−3) and compressive modulus (8.12 Mpa), ionic conductivity (up to 4.58 S m−1), and anti-swelling behavior (equilibrium swelling ratio of 9% in water for 30 days). An underwater strain sensor based on this anti-swellable hydrogel is further developed to monitor the movements of underwater sports. High sensitivity is achieved to identify multidirectional motions, including raising the head, swinging the arm, bending the elbow, knee and finger. Therefore, this study offers a facile strategy to generate hydrogel-based sensors that can be adopted in an underwater environment as well as expands the potential applications of wearable electronic devices. © 2021 Wiley-VCH GmbH
语种：
英文
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Facile synthesis and self-assembly behaviors of biodegradable amphiphilic hyperbranched copolymers with reducible poly(caprolactone) grafts
作者：
Zhang, Xianshuo;Wang, Peipei;Xu, Yaoyu;Wang, Jun;Shi, Yunfeng;...
期刊：
Polymer Chemistry ,2022年13(43):6162-6170 ISSN：1759-9954
通讯作者：
Shi, Yunfeng(shiyunfeng2009@gmail.com);Wei, Hua(weih@usc.edu.cn)
作者机构：
[Xu, Yaoyu; Zhang, Xianshuo; Liu, Ruru; Wang, Peipei; Shi, Yunfeng; Song, Wenjing; Niu, Wenxu] Anyang Normal Univ, Sch Chem & Chem Engn, Anyang 455000, Henan, Peoples R China.;[Wei, Hua; Wang, Jun; Yu, Cui-Yun] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Dept Pharm & Pharmacol, Hengyang 421001, Peoples R China.
通讯机构：
[Yunfeng Shi] S;[Hua Wei] H;School of Chemistry and Chemical Engineering, Anyang Normal University, Anyang, Henan 455000, China<&wdkj&>Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Department of Pharmacy and Pharmacology, University of South China, Hengyang, China
摘要：
The facile synthesis of amphiphilic hyperbranched copolymers with biodegradability generally suffers from sophisticated specific design and multistep preparation procedures integrating different synthetic approaches, leading to difficulty and complexity in scalable manufacture and potential biomedical applications. To develop a robust yet facile strategy toward biodegradable hyperbranched amphiphilic copolymers, we reported in this study the design and synthesis of a reducible macromonomer, 2-((2-hydroxyethyl)disulfanyl)ethyl methacrylate-graft-polycaprolactone (HSEMA-g-PCL). This macromonomer integrates polymerizable vinyl and hydrophobic poly(ϵ-caprolactone) (PCL) units via a disulfide link, which enables the successful preparation of two types of biodegradable amphiphilic hyperbranched copolymers, i.e., a hyperbranched statistical copolymer h-P(OEGMA-st-(HSEMA-g-PCL)) and a hyperbranched block-statistical copolymer h-P(HSEMA-g-PCL)-b-POEGMA, with an identical polymer composition but different polymer architectures via a reversible addition-fragmentation chain transfer self-condensing vinyl polymerization (RAFT-SCVP) process. The controlled synthesis of biodegradable hyperbranched copolymer panels was supported by the modulated degrees of branching (DBs) (0.05-0.14), narrow polydispersity indexes (Đ) (1.36-1.74) and CTA functionalities (fCTA) (2.4-4.3). Interestingly, the type and size of the resulting self-assembled aggregates depended on the relative content of the P(HSEMA-g-PCL) segment in the hyperbranched copolymers. A comparison study on the colloidal stability revealed greater stability of micelles formed by h-P(HSEMA-g-PCL)-b-POEGMA than that of micelle analogues self-assembled from h-P(OEGMA-st-(HSEMA-g-PCL)) because of the stronger steric hindrance of an individual POEGMA block in a block architecture. Therefore, the former micelle formulation with greater stability was chosen as a better nanocarrier for prolonged blood circulation. Doxorubicin (DOX)-loaded h-P(HSEMA-g-PCL)-b-POEGMA copolymer micelles showed an intracellular reduction-promoted drug release and efficient inhibition of MCF-7 cell proliferation. Taken together, the reducible hydrophobic macromonomer developed herein provides a facile yet robust strategy for biodegradable amphiphilic hyperbranched copolymers, and the block-statistical structure is identified as a better polymer architecture for controlled release applications. © 2022 The Royal Society of Chemistry.
语种：
英文
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Ugi Reaction Mediated Detergent Assembly for Membrane Protein Studies
作者：
Yang, Meifang;Luo, Weiling;Zhang, Wei;Wang, Huixia;Xue, Dongxiang;...
期刊：
CHEMISTRY-AN ASIAN JOURNAL ,2022年17(15):e202200372- ISSN：1861-4728
通讯作者：
Zheng, Xing(zhengxing9166@sohu.com);Tao, Houchao(houchao@shutcm.edu.cn);Zhao, Fei(zhaofei@shanghaitech.edu.cn)
作者机构：
[Yang, Meifang; Zheng, Xing] Univ South China, Dept Pharm, Grp Lead Compound, Hengyang 421001, Hunan, Peoples R China.;[Yang, Meifang; Tao, Houchao] Shanghai Univ Tradit Chinese Med, Innovat Res Inst Tradit Chinese Med, Shanghai Frontiers Sci Ctr TCM Chem Biol, Shanghai 201203, Peoples R China.;[Zhao, Fei; Luo, Weiling; Wang, Huixia; Zhang, Wei; Xue, Dongxiang; Wu, Yiran; Zhao, Suwen] ShanghaiTech Univ, iHuman Inst, Shanghai 201210, Peoples R China.;[Luo, Weiling] ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China.;[Luo, Weiling] Univ Chinese Acad Sci, Beijing 100049, Peoples R China.
通讯机构：
[Prof. Fei Zhao] i;[Prof. Xing Zheng] G;[Prof. Houchao Tao] S;Group of Lead Compound, Department of Pharmacy, University of South China, Hengyang, Hunan, 421001 P. R. China<&wdkj&>iHuman Institute, ShanghaiTech University, Shanghai, 201210 P. R. China<&wdkj&>Shanghai Frontiers Science Center of TCM Chemical Biology, Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203 P. R. China
关键词：
detergent;membrane proteins;micelle;NMR study;Ugi reaction
摘要：
Despite the continuous efforts, the current repertoire of detergents is still far from sufficient for the biophysics studies of membrane proteins (MPs). Toward the rapid expansion of detergent diversity, we herein report a new strategy based on Ugi reaction mediated modular assembly. Structural varieties, including hydrophobic tails and hydrophilic heads, could be conveniently introduced from the multiple reaction components. New detergents then were comprehensively evaluated in the physical properties and preliminarily screened by the thermal stabilization for a transporter MsbA and a spectrum of G protein-coupled receptors (GPCRs). For the glucagon-like peptide-1 receptor (GLP-1R), a class B GPCR, detergent M-23-M finally stood out in a second evaluation for the maintenance of homogeneity and was further illustrated its application in the improvement of NMR study. Besides the promising utility in the MP study, the current results exhibit intriguing structural-physical relationship that would allow the guidance in the tuning of detergent properties in the future. © 2022 Wiley-VCH GmbH.
语种：
英文
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A tumor pH-responsive autocatalytic nanoreactor as a H2O2 and O2 self-supplying depot for enhanced ROS-based chemo/photodynamic therapy
作者：
Liu, Furong;He, Tao;Gong, Songlin;Shen, Meiling;Ma, Shuang;...
期刊：
Acta Biomaterialia ,2022年154:510-522 ISSN：1742-7061
通讯作者：
Wu, Qinjie(cellwqj@163.com)
作者机构：
[Ma, Shuang; Gong, Changyang; Gong, Songlin; Huang, Xianzhou; Wang, Li; He, Tao; Li, Lu; Wu, Qinjie; Liu, Furong; Shen, Meiling] Sichuan Univ, West China Hosp, Canc Ctr, State Key Lab Biotherapy, Chengdu 610041, Peoples R China.;[Liu, Furong] Univ South China, Affiliated Nanhua Hosp, Inst Clin Pharm, Hengyang Med Sch, Hengyang 421001, Peoples R China.
通讯机构：
[Qinjie Wu] S;State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China
关键词：
Chemodynamic/photodynamic therapy;H2O2/O2 self-supplying;pH-responsive;Reactive oxygen species;Tumor hypoxia
摘要：
Combining the internal force-driven chemodynamic therapy (CDT) and the external energy-triggered photodynamic therapy (PDT) holds great promise to achieve an advanced anticancer effect based on reactive oxygen species (ROS). However, the insufficient oxy-substrates supply in tumor microenvironment, like hydrogen peroxide (H2O2) and oxygen (O2), is the Achilles heel that greatly restricts the efficacy of this ROS-based treatment. Herein, the construction of a copper peroxide-based tumor pH-responsive autocatalytic nanoreactor (CESAR), via an albumin-mediated biomimetic mineralization strategy is described. The decoration of human serum albumin endows the nanoreactor good hydrophilicity and biocompatibility, which is highly desired for the metal-based materials. Upon exposure to acidic tumor microenvironment, CESAR presents a pH-triggered disintegration with Cu2+, H2O2 and O2 generated instantly. The generated H2O2 complements the hyperoxide deficiency and initiates a localized Fenton-like reaction with the assistance of Cu2+ for highly toxic hydroxyl radicals (•OH) production for improving CDT. The evolved O2 gas enables hypoxia relief for enhanced Ce6-mediated PDT. This H2O2/O2 self-supplying strategy significantly amplifies the tumor oxidative damage and gains an optimal treatment outcome, which offers a new paradigm for optimizing the tumor therapeutic options limited by oxide or hyperoxide deficiency, not only for CDT/PDT, but also other oxy-substrates involved strategies. Statement of significance: The shortage of oxy-substrates in the tumor microenvironment remains a great challenge for ROS-based cancer therapy. Herein, we introduce human serum albumin as a scaffold to stabilize copper peroxide nanomaterials for constant production of H2O2 and O2 to enhance chemodynamic/photodynamic therapy. The tumor pH-triggered H2O2/O2 production and Cu2+ release are confirmed, assuring the strategy of a highly precise, effective way to destroy tumor without any side effects. This work lends new and exciting insights into the engineering design of autocatalytic oxy-substrates self-supply nanoreactor for overcoming the bottlenecks, like the oxy-substrates deficiency of CDT/PDT and the poor stability of metal peroxides, to achieve highly effective chemodynamic/photodynamic therapy. © 2022
语种：
英文
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Facile Synthesis of Hyperbranched Copolymers via an [A2+ B3] Click Polymerization Synthesized Reducible Hyperbranched Template
作者：
Liu, Yuping;Ma, Wei;Dong, Zhen;Qiu, Nanting;Ma, Liwei;...
期刊：
ACS APPLIED POLYMER MATERIALS ,2021年3(12):6375-6382 ISSN：2637-6105
通讯作者：
Chen, Zhong-Ren(chenzr@sustech.edu.cn);Wei, Hua(weih@usc.edu.cn);Ma, Liwei(malw@lzu.edu.cn)
作者机构：
[Liu, Yuping; Dong, Zhen; Qiu, Nanting; Chen, Zhong-Ren] Shenzhen Grubbs Institute and Department of Chemistry, Southern University of Science and Technology, Shenzhen;518005, China;[Ma, Wei; Wei, Hua] Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Department of Pharmacy and Pharmacology, University of South China, Hengyang;421001, China;[Ma, Liwei] College of Chemistry and Chemical Engineering, Lanzhou University, Gansu, Lanzhou
通讯机构：
[Liwei Ma] C;[Zhong-Ren Chen] S;[Hua Wei] H;Shenzhen Grubbs Institute and Department of Chemistry, Southern University of Science and Technology, Shenzhen 518005, China<&wdkj&>College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, Gansu 730000, China<&wdkj&>Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study & Department of Pharmacy and Pharmacology, University of South China, Hengyang, 421001, China<&wdkj&>College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, Gansu 730000, China
关键词：
acidic pH sensitivity;click polymerization;controlled drug release;degree of branch;hyperbranched polymer;reduction sensitivity
摘要：
Synthesis of multifunctional hyperbranched polymers (HPs) with simultaneously precisely modulated degrees of branch (DBs) and multibiorelevant signal-triggered sensitivities generally suffers from multistep preparation and purification procedures and uncontrolled DB. To develop a facile yet robust approach toward multifunctional HPs with a precisely modulated DB, we reported herein the synthesis of a reducible hyperbranched polymer template (HPT) with a fixed DB via an [A 2 + B 3 ]-based click polymerization and its further mediation of reversible addition–fragmentation chain transfer (RAFT) polymerization for the facile preparation of well-defined multifunctional HPs with a uniform DB, predetermined polymer compositions, and well-modulated molecular weights (MWs) and low dispersity ( Đ ) indexes. The breakthrough of this study is the design of a bioreducible HPT-based multimacro chain transfer agent (multimacro-CTA) with a fixed DB of 0.45 via click polymerization between an A 2 unit containing a central trithiocarbonate group for further conduction of RAFT polymerization of any vinyl-based monomers, two disulfide links for reduction sensitivity, and two azide groups and a branched B 3 unit with three highly reactive alkynyl functions. The resulting HPT was further adopted as a multimacro-CTA to mediate RAFT polymerization of a previously reported acidic pH cleavable oligo(ethylene glycol) monomethyl ether methacrylate (OEGMA) monomer, α-OEGMA, affording reduction and acidic pH dual sensitive HPT-P(α-OEGMA). Notably, the resulting polymer panel of HPT-P(α-OEGMA)s could self-assemble into stabilized unimolecular micelles with MW-dependent mean hydrodynamic size in a range from 18.9 to 27.0 nm. The drug-loaded HPT-P(α-OEGMA) micelles incubated in a reducing or an acidic pH condition showed accelerated drug release due to the reduction-triggered cleavage of the disulfide links or an acidic pH induced breakage of the acetal links for polymer degradation. Therefore, the universal HPT platform provides a facile yet robust approach toward well-defined multifunctional HPs with a uniform DB, well-controlled MWs, and low Đ indexes for biomedical applications.
语种：
英文
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DNA水凝胶的设计与构建
作者：
简雪婷;冯晓祎;熊菀伶;谢灵兮;谭俊艳;...
期刊：
高分子材料科学与工程 ,2021年37(5):102-108 ISSN：1000-7555
通讯作者：
Liu, Yang(liuyanghxl@126.com)
作者机构：
[简雪婷; 冯晓祎; 熊菀伶; 谢灵兮; 谭俊艳; 王萍; 刘阳] Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, College of Pharmacy, University of South China, Hengyang;421001, China;[简雪婷; 冯晓祎; 熊菀伶; 谢灵兮; 谭俊艳; 王萍; 刘阳] 421001, China
通讯机构：
[Liu, Y.] H;Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, China
关键词：
DNA水凝胶;物理交联;化学交联
摘要：
DNA水凝胶同时兼有DNA的生物功能和水凝胶的骨架功能,具有良好的生物相容性、生物可降解性、选择特异性、结构可设计性以及精确的分子识别能力等优点,在生物医学领域中应用前景广阔。随着研究的持续深入进行,研究人员巧妙地设计了各种各样的DNA水凝胶的交联制备方法,并通过向其中引入其它功能分子或基元,或与其它类型的功能材料进行结合,构建了具有优异性能的DNA水凝胶。文中从物理水凝胶和化学水凝胶两方面,介绍了DNA水凝胶的研究动态,重点分析和阐述了DNA水凝胶的设计和构建方法以及内部交联机制,并对所存在的问题及未来研究发展趋势进行了总结和展望,为DNA水凝胶的进一步发展提供参考。
语种：
中文
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Gold nanostar as an ultrasensitive colorimetric probe for picomolar detection of lead ion
作者：
Wang, Suyan;Huang, Xiaohui;An, Qingxiao;Zhou, Rongju;Xu, Weizhen;...
期刊：
Analytica Chimica Acta ,2021年1160:338380 ISSN：0003-2670
通讯作者：
Xu, Dong(philip198349@gmail.com);Lin, Qinlu(LinQL0403@163.com)
作者机构：
[An, Qingxiao; Zhou, Rongju; Xu, Dong; Wang, Suyan; Xu, Weizhen; Lin, Qinlu] Cent South Univ Forestry & Technol, Coll Food Sci & Engn, Natl Engn Lab Rice & Byprod Further Proc, Changsha 410004, Peoples R China.;[Xu, Dong; Wang, Suyan] Hunan Prov Key Lab Food Safety Monitoring & Early, Changsha 410004, Peoples R China.;[Huang, Xiaohui] Hunan Edible Fungi Inst, Changsha 410004, Peoples R China.;[Cao, Xuan] Univ South China, Dept Pharm, Henyang 421001, Peoples R China.
通讯机构：
[Lin, Qinlu] N;[Xu, Dong; Huang, Xiaohui] H;National Engineering Laboratory for Rice and By-products Further Processing, College of Food Science and Engineering, Central South University of Forestry & Technology, Changsha, 410004, China<&wdkj&>Hunan Provincial Key Laboratory of Food Safety Monitoring and Early Warning, Changsha, 410004, China<&wdkj&>National Engineering Laboratory for Rice and By-products Further Processing, College of Food Science and Engineering, Central South University of Forestry & Technology, Changsha, 410004, China
关键词：
Colorimetric;Etching;Gold nanostar;Lead ion
摘要：
The sensitivity for analytes of interest is vital for environment protection and food safety. Here, we propose an extremely sensitive assay toward Pb2+ by using gold nanostars (GNSs) as probes based on the catalytic activity of Pb on etching gold atoms after being reduced in the presence of 2-mercaptoethanol (2-ME) and sodium thiosulfate. GNSs were prepared by using 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid as both the reducing and capping agents, enabling high stability and sensitivity for quantitation of Pb2+. Upon increasing Pb2+ concentration over the range of 0–10 μM, GNS solution color changed from greenish-blue to blue to purple to red, and eventually to colorless. The color change can be distinguished by naked eye at the Pb2+ concentration as low as 200 pM. Through monitoring longitudinal localized surface plasmon of GNSs, Pb2+ could be detected with a limit of detection of 1.5 pM, and the working range is 2 pM-1 μM. The ultra-high sensitivity of our assay stems from the high catalysis of Pb on etching gold on tips and branches in the presence of 2-ME and sodium thiosulfate, leading to the shape deformation to spherical gold nanoparticle and the corresponding significant changes in their optical properties. The assay provides high selectivity of Pb2+ over the tested interfering metal ions like Cu2+. With high sensitivity and selectivity, the assay was efficiently validated by analyzing water samples and monitoring the migration of Pb2+ from the tested container to water. © 2021 Elsevier B.V.
语种：
英文
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Spider Toxin Peptide-Induced NIR Gold Nanocluster Fabrication for GSH-Responsive Cancer Cell Imaging and Nuclei Translocation
作者：
Tan, Huaxin;Liu, Sisi;He, Yaolin;Cheng, Guofeng;Zhang, Yu;...
期刊：
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY ,2021年9:780223 ISSN：2296-4185
通讯作者：
Hu, Lidan
作者机构：
[Tan, Huaxin; Hu, Lidan; Zhang, Yu; Cheng, Guofeng] Univ South China, Key Lab Ecol Environm & Crit Human Dis Prevent Hu, Dept Biochem & Mol Biol, Dept Educ,Sch Basic Med,Hengyang Med Sch, Hengyang, Peoples R China.;[Liu, Sisi] Univ South China, Sch Publ Hlth, Hengyang Med Sch, Hengyang, Peoples R China.;[He, Yaolin] Univ South China, Affiliated Hosp 2, Hengyang Med Sch, Dept Radiotherapy, Hengyang, Peoples R China.;[Wei, Xiaojie] Univ South China, Sch Pharm, Hengyang Med Sch, Hengyang, Peoples R China.
通讯机构：
[Hu, Lidan] U;Univ South China, Key Lab Ecol Environm & Crit Human Dis Prevent Hu, Dept Biochem & Mol Biol, Dept Educ,Sch Basic Med,Hengyang Med Sch, Hengyang, Peoples R China.
关键词：
NIR gold nanoclusters;spider toxin peptide;Cancer cell imaging;nuclei translocation;GSH-responsive
摘要：
Goldnanoclusters (GNCs) have become a promising nanomaterial for bioimaging because of their unique optical properties and biocompatibility. In this study, lycosin-I peptide, which possesses a highly selective anticancer activity by affecting the permeability of cancer cell membrane, was firstly modified for constructing fluorescent GNCs (LGNCs) for bioimaging of tumor cells. The obtained LGNCs exhibited strong near-infrared (NIR) fluorescence, which can be further enhanced by the peptide-induced aggregation and selectively stained three cancerous cell lines over normal cell lines with low intrinsic toxicity. After uptake by tumor cells, LGNC aggregates can be depolymerized into ultrasmall nanoclusters by high-level glutathione (GSH) and realize the nuclear targeting translocation. Collectively, our work suggests the potential of natural active biomolecules in designing NIR fluorescent GNCs for bioimaging. Copyright © 2021 Tan, Liu, He, Cheng, Zhang, Wei and Hu.
语种：
英文
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Development, Preparation, and Biomedical Applications of DNA-Based Hydrogels
作者：
Jian, Xueting;Feng, Xiaoyi;Luo, Yuning;Li, Fangjie;Tan, Junyan;...
期刊：
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY ,2021年9:661409 ISSN：2296-4185
通讯作者：
Liu, Yang(liuyanghxl@126.com)
作者机构：
[Li, Fangjie; Tan, Junyan; Jian, Xueting; Luo, Yuning; Liu, Yang; Feng, Xiaoyi; Yin, Yuli] Univ South China, Coll Pharm, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hunan Prov Key Lab Tumor Microenvironm Respons Dr, Hengyang, Peoples R China.
通讯机构：
[Liu, Y.] H;Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, China
关键词：
DNA;Pure DNA-based hydrogel;DNA-based hybrid hydrogel;Crosslinking;biomedical application
摘要：
Hydrogels have outstanding research and application prospects in the biomedical field. Among them, the design and preparation of biomedical hydrogels with deoxyribonucleic acid (DNA) as building blocks have attracted increasing research interest. DNA-based hydrogel not only has the skeleton function of hydrogel, but also retains its biological functions, including its excellent selection specificity, structural designability, precise molecular recognition ability, outstanding biocompatibility, and so on. It has shown important application prospects in the biomedical field, such as drug delivery, biosensing, and tissue engineering. In recent years, researchers have made full use of the characteristics of DNA molecules and constructed various pure DNA-based hydrogels with excellent properties through various crosslinking methods. Moreover, via introducing functional molecules or elements, or combining with other functional materials, a variety of multifunctional DNA-based hybrid hydrogels have also been constructed, which expand the breadth and depth of their applications. Here, we described the recent development trend in the area of DNA-based hydrogels and highlighted various preparation methods of DNA-based hydrogels. Representative biomedical applications are also exemplified to show the high performance of DNA-based hydrogels. Meanwhile, the existing problems and prospects are also summarized. This review provided references for the further development of DNA-based hydrogels. © Copyright © 2021 Jian, Feng, Luo, Li, Tan, Yin and Liu.
语种：
英文
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Molecular recognition and photoprotection of riboflavin in water by a biomimetic host
作者：
Zhang, Hong;Wang, Li-Li* ;Pang, Xin-Yu;Yang, Liu-Pan* ;Jiang, Wei*
期刊：
Chemical Communications ,2021年57(100):13724-13727 ISSN：1359-7345
通讯作者：
Wang, Li-Li;Yang, Liu-Pan;Jiang, Wei
作者机构：
[Yang, Liu-Pan; Jiang, Wei; Zhang, Hong; Pang, Xin-Yu; Wang, Li-Li; Yang, LP] Southern Univ Sci & Technol, Shenzhen Grubbs Inst, Guangdong Prov Key Lab Catalysis, Xueyuan Blvd 1088, Shenzhen 518055, Peoples R China.;[Yang, Liu-Pan; Jiang, Wei; Zhang, Hong; Pang, Xin-Yu; Wang, Li-Li; Yang, LP] Southern Univ Sci & Technol, Dept Chem, Xueyuan Blvd 1088, Shenzhen 518055, Peoples R China.;[Wang, Li-Li] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Peoples R China.;[Wang, Li-Li] Univ South China, Dept Pharm & Pharmacol, Hengyang 421001, Peoples R China.
通讯机构：
[Wang, LL; Yang, LP; Jiang, W] S;[Wang, Li-Li] U;Southern Univ Sci & Technol, Shenzhen Grubbs Inst, Guangdong Prov Key Lab Catalysis, Xueyuan Blvd 1088, Shenzhen 518055, Peoples R China.;Southern Univ Sci & Technol, Dept Chem, Xueyuan Blvd 1088, Shenzhen 518055, Peoples R China.;Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Peoples R China.
摘要：
A water-soluble tetralactam macrocycle with 2,6-diethoxynaphthalene groups as side walls is able to strongly bind riboflavin (Ka>107M−1) in water through hydrogen bonding and the hydrophobic effect. The encapsulated riboflavin can be stabilized by the host against photo-degradation under UV-vis irradiation, which may be harnessed to extend the shelf life of riboflavin. © The Royal Society of Chemistry 2021.
语种：
英文
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Virus-like mesoporous silica-coated plasmonic Ag nanocube with strong bacteria adhesion for diabetic wound ulcer healing
作者：
Wang, Peiyuan;Jiang, Suhua;Li, Yang;Luo, Qiang;Lin, Jinyan;...
期刊：
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE ,2021年34:102381 ISSN：1549-9634
通讯作者：
Liu, Xiaolong(xiaoloong.liu@gmail.com);Xue, Fangqin(xuefangqingsl@sina.com)
作者机构：
[Jiang, Suhua; Luo, Qiang; Lin, Jinyan; Liu, Xiaolong; Wang, Peiyuan; Li, Yang] Chinese Acad Sci, Fujian Inst Res Struct Matter, Key Lab Design & Assembly Funct Nanostruct, Fuzhou, Peoples R China.;[Xue, Fangqin] Fujian Med Univ, Shengli Clin Med Coll, Fuzhou, Peoples R China.;[Jiang, Suhua; Luo, Qiang; Lin, Jinyan; Liu, Xiaolong; Wang, Peiyuan; Li, Yang] Chinese Acad Sci, Xiamen Inst Rare Earth Mat, Dept Translat Med, Xiamen, Peoples R China.;[Jiang, Suhua; Luo, Qiang; Lin, Jinyan; Liu, Xiaolong; Wang, Peiyuan; Li, Yang] Fujian Med Univ, United Innovat Mengchao Hepatobiliary Technol Key, Mengchao Hepatobiliary Hosp, Fuzhou, Peoples R China.;[Hu, Lidan] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Dept Biochem & Mol Biol, Hengyang, Peoples R China.
通讯机构：
[Xiaolong Liu] K;Key Laboratory of Design and Assembly of Functional Nanostructures, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, PR China<&wdkj&>Department of Translational Medicine, Xiamen Institute of Rare Earth Materials, Chinese Academy of Sciences, Xiamen, PR China.<&wdkj&>The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, PR China
关键词：
Adhesion;Bacteriology;Cell adhesion;Diseases;Drug delivery;Escherichia coli;Hydrogen sulfide;Mesoporous materials;Nanostructures;Plasmonics;Shells (structures);Silica;Tissue regeneration;Viruses;Bacteria adhesions;Clinical application;Core shell nano structures;Diabetic foot ulcer;Escherichia coli (E. coli);Gram-positive bacterium;Mesoporous Silica;Pathogenic bacterium;Silver nanoparticles;gentamicin;mesoporous silica nanoparticle;nanocube;silver nanoparticle;virus like nanoparticle;antiinfective agent;metal nanoparticle;silicon dioxide;silver;animal experiment;animal model;Article;bacterial cell wall;bacterial clearance;bacterial viability;bacterium adherence;controlled study;diabetic wound;drug delivery system;Escherichia coli;high performance liquid chromatography;in vivo study;inductively coupled plasma mass spectrometry;M1 macrophage;methicillin resistant Staphylococcus aureus;mouse;nonhuman;pathogenesis;quantitative analysis;scanning electron microscopy;transmission electron microscopy;ulcer healing;chemistry;diabetic foot;drug effect;Escherichia coli;Escherichia coli infection;human;isolation and purification;microbiology;physiology;Staphylococcus aureus;Staphylococcus infection;wound healing;Anti-Bacterial Agents;Bacterial Adhesion;Diabetic Foot;Escherichia coli;Escherichia coli Infections;Humans;Metal Nanoparticles;Silicon Dioxide;Silver;Staphylococcal Infections;Staphylococcus aureus;Wound Healing
摘要：
The Gram-positive bacterium Staphylococcus aureus (MRSA) and the Gram-negative bacillus Escherichia coli (E. coli) can be commonly found in diabetic foot ulcers. However, the multi-drug resistant pathogenic bacteria infection is often difficult to eradicate by the conventional antibiotics and easy to spread which can lead to complications such as gangrene or sepsis. In this work, in order to pull through the low cell wall adhesion capability of typical antibacterial Ag nanoparticles, we fabricated biomimic virus-like mesoporous silica coated Ag nanocubes with gentamicin loading, and then the core-shell nanostructure was entrapped in the FDA approved hydrogel dressing. Interestingly, the Ag nanocubes with virus-like mesoporous silica coating are capable of effectively adsorbing on the rigid cell wall of both E. coli and MRSA. The intracellular H2S in natural bacterial environment can induce generation of small Ag nanospheres, which are the ideal antibacterial nanoagents. Combined with the gentamicin delivery, the pathogenic bacteria in diabetic wound can be completely eradicated by our dressing to improve the wound healing procedure. This virus-like core-shell nanostructure sheds light for the future wound healing dressing design to promote the clinical applications on antibacterial eradication. © 2021 Elsevier Inc.
语种：
英文
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Perfluoro-tert-butanol: a cornerstone for high performance fluorine-19 magnetic resonance imaging
作者：
Wu, Tingjuan;Li, Anfeng;Chen, Kexin;Peng, Xingxing;Zhang, Jing;...
期刊：
Chemical Communications ,2021年57(63):7743-7757 ISSN：1359-7345
通讯作者：
Zheng, Xing(zhengxing9166@sohu.com);Jiang, Zhong-Xing(zxjiang@whu.edu.cn);Zhou, Xin(xinzhou@wipm.ac.cn)
作者机构：
[Peng, Xingxing; Li, Anfeng; Jiang, Zhong-Xing; Wu, Tingjuan; Chen, Kexin; Zheng, Xing] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol New Drug Stud, Hunan Prov Key Lab Tumor Microenvironm Respons Dr, Grp Lead Cpd,Dept Pharm, Hengyang 421001, Hunan, Peoples R China.;[Zhang, Jing; Jiang, Zhong-Xing] Wuhan Univ, Sch Pharmaceut Sci, Hubei Prov Engn & Technol Res Ctr Fluorinated Pha, Wuhan 430071, Peoples R China.;[Zhou, Xin; Chen, Shizhen; Jiang, Mou] Chinese Acad Sci, Innovat Acad Precis Measurement Sci & Technol, Wuhan Inst Phys & Math, Natl Ctr Magnet Resonance Wuhan,State Key Lab Mag, Wuhan 430071, Peoples R China.
通讯机构：
[Jiang, Zhong-Xing; Wu, Tingjuan] G;[Jiang, Mou] S;[Zhang, Jing] H;Group of Lead Compound, Department of Pharmacy, Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang 421001, Hunan, China.;Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China.
摘要：
As a versatile quantification and tracking technology, 19F magnetic resonance imaging (19F MRI) provides quantitative 'hot-spot'images without ionizing radiation, tissue depth limit, and background interference. However, the lack of suitable imaging agents severely hampers its clinical application. First, because the 19F signals are solely originated from imaging agents, the relatively low sensitivity of MRI technology requires high local 19F concentrations to generate images, which are often beyond the reach of many 19F MRI agents. Second, the peculiar physicochemical properties of many fluorinated compounds usually lead to low 19F signal intensity, tedious formulation, severe organ retention, etc. Therefore, the development of 19F MRI agents with high sensitivity and with suitable physicochemical and biological properties is of great importance. To this end, perfluoro-tert-butanol (PFTB), containing nine equivalent 19F and a modifiable hydroxyl group, has outperformed most perfluorocarbons as a valuable building block for high performance 19F MRI agents. Herein, we summarize the development and application of PFTB-based 19F MRI agents and analyze the strategies to improve their sensitivity and physicochemical and biological properties. In the context of PFC-based 19F MRI agents, we also discuss the challenges and prospects of PFTB-based 19F MRI agents. © 2021 The Royal Society of Chemistry.
语种：
英文
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A tumor microenvironment (TME)-responsive nanoplatform for systemic saporin delivery and effective breast cancer therapy
作者：
Shen, Qian;Xu, Lei;Li, Rong;Wu, Guang;Li, Senlin;...
期刊：
Chemical Communications ,2021年57(20):2563-2566 ISSN：1359-7345
通讯作者：
Li, Rong(l7979r@163.com)
作者机构：
[Zhou, Yusheng; Li, Rong; Xu, Xiaoding; Shen, Qian; Wu, Guang] Univ South China, Inst Pharm & Pharmacol, Hengyang 421001, Peoples R China.;[Zhou, Yusheng; Li, Rong; Xu, Xiaoding; Shen, Qian; Wu, Guang] Univ South China, Affiliated Hosp 2, Hengyang 421001, Peoples R China.;[Saw, Phei Er; Xu, Xiaoding; Xu, Lei; Li, Senlin] Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Med Res Ctr, Guangdong Prov Key Lab Malignant Tumor Epigenet &, Guangzhou 510120, Peoples R China.;[Zhou, Yusheng] Univ South China, Affiliated Nanhua Hosp, Hengyang 421001, Peoples R China.
通讯机构：
[Shen, Qian; Zhou, Yusheng; Xu, Xiaoding] I;Institute of Pharmacy & Pharmacology and the Second Affiliated Hospital, University of South China, Hengyang 421001, P. R. China. yszhou08@126.com;Institute of Pharmacy & Pharmacology and the Second Affiliated Hospital, University of South China, Hengyang 421001, P. R. China. yszhou08@126.com and The Affiliated Nanhua Hospital, University of South China, Hengyang 421001, P. R. China. xuxiaod5@mail.sysu.edu.cn;Institute of Pharmacy & Pharmacology and the Second Affiliated Hospital, University of South China, Hengyang 421001, P. R. China. yszhou08@126.com and Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, P. R. China
摘要：
Intracellular delivery of therapeutic proteins remains a challenge for the success of protein-mediated disease treatment. We herein develop a robust nanoplatform made with a TME-pH responsive Meo-PEG-b-PPMEMA polymer and a cationic lipid-like compoundG0-C14forin vivodelivery of cytotoxic saporin and breast cancer therapy. This nanoplatform could respond to a TME pH to rapidly release saporin/G0-C14complexes, which could significantly improve the uptake of cytosolic saporin by tumor cells and subsequent endosomal escape, thereby leading to an effective inhibition of tumor growth. © The Royal Society of Chemistry 2021.
语种：
英文
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Highly Sensitive and Specific Mass Spectrometric Platform for miRNA Detection Based on the Multiple-Metal-Nanoparticle Tagging Strategy
作者：
Zhu, Yan-Li;Lian, Yan-Mei;Wang, Ji-Kai;Chen, Zeng-Ping;Yu, Ru-Qin
期刊：
Analytical Chemistry ,2021年93(14):5839-5848 ISSN：0003-2700
通讯作者：
Chen, Zeng-Ping(zpchen@hnu.edu.cn)
作者机构：
[Yu, Ru-Qin; Zhu, Yan-Li; Chen, Zeng-Ping; Lian, Yan-Mei] Hunan Univ, Coll Chem & Chem Engn, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Hunan, Peoples R China.;[Wang, Ji-Kai] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Inst Pharm & Pharmacol, Hengyang 421001, Peoples R China.
通讯机构：
[Zeng-Ping Chen] S;State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, Hunan 410082, P. R. China
摘要：
The multiple-metal-nanoparticle tagging strategy has generally been applied to the multiplexed detection of multiple analytes of interest such as microRNAs (miRNAs). Herein, it was used for the first time to improve both the specificity and sensitivity of a novel mass spectroscopic platform for miRNA detection. The mass spectroscopic platform was developed through the integration of the ligation reaction, hybridization chain reaction amplification, multiple-metal-nanoparticle tagging, and inductively coupled plasma mass spectrometry. The high specificity resulted from the adoption of the ligation reaction is further enhanced by the multiple-metal-nanoparticle tagging strategy. The combination of hybridization chain reaction amplification and metal nanoparticle tagging endows the proposed platform with the feature of high sensitivity. The proposed mass spectrometric platform achieved quite satisfactory quantitative results for Let-7a in real-world cell line samples with accuracy comparable to that of the real-time quantitative reverse-transcriptase polymerase chain reaction method. Its limit of detection and limit of quantification for Let-7a were experimentally determined to be about 0.5 and 10 fM, respectively. Furthermore, due to the unique way of utilizing the multiple-metal-nanoparticle tagging strategy, the proposed platform can unambiguously discriminate between the target miRNA and nontarget ones with single-nucleotide polymorphisms based on their response patterns defined by the relative mass spectral intensities among the multiple tagged metal elements and can also provide location information of the mismatched bases. Its unique advantages over conventional miRNA detection methods make the proposed platform a promising and alternative tool in the fields of clinical diagnosis and biomedical research. ©
语种：
英文
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Recent Progresses in NIR-I/II Fluorescence Imaging for Surgical Navigation
作者：
Li, Songjiao;Cheng, Dan;He, Longwei* ;Yuan, Lin
期刊：
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY ,2021年9:768698 ISSN：2296-4185
通讯作者：
He, Longwei
作者机构：
[He, Longwei; Li, Songjiao] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Dept Pharm & Pharmacol, Canc Res Inst,Hengyang Med Sch,Affiliated Hosp 1, Hengyang, Peoples R China.;[Cheng, Dan] Univ South China, Hengyang Med Sch, Affiliated Nanhua Hosp, Hengyang, Peoples R China.;[Yuan, Lin; Cheng, Dan] Hunan Univ, Coll Chem & Chem Engn, State Key Lab Chemo Biosensing & Chemometr, Changsha, Peoples R China.
通讯机构：
[He, Longwei] U;Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Dept Pharm & Pharmacol, Canc Res Inst,Hengyang Med Sch,Affiliated Hosp 1, Hengyang, Peoples R China.
关键词：
surgical navigation;NIR-I;NIR-II;tumor;Fluorescence Imaging;Image-guided cancer surgeries
摘要：
Cancer is still one of the main causes of morbidity and death rate around the world, although diagnostic and therapeutic technologies are used to advance human disease treatment. Currently, surgical resection of solid tumors is the most effective and a prior remedial measure to treat cancer. Although medical treatment, technology, and science have advanced significantly, it is challenging to completely treat this lethal disease. Near-infrared (NIR) fluorescence, including the first near-infrared region (NIR-I, 650–900nm) and the second near-infrared region (NIR-II, 1,000–1,700nm), plays an important role in image-guided cancer surgeries due to its inherent advantages, such as great tissue penetration, minimal tissue absorption and emission light scattering, and low autofluorescence. By virtue of its high precision in identifying tumor tissue margins, there are growing number of NIR fluorescence-guided surgeries for various living animal models as well as patients in clinical therapy. Herein, this review introduces the basic construction and operation principles of fluorescence molecular imaging technology, and the representative application of NIR-I/II image-guided surgery in biomedical research studies are summarized. Ultimately, we discuss the present challenges and future perspectives in the field of fluorescence imaging for surgical navigation and also put forward our opinions on how to improve the efficiency of the surgical treatment. Copyright © 2021 Li, Cheng, He and Yuan.
语种：
英文
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多价环状模板法合成交联胶束和类环胶体
作者：
Zhang Miao;Peng Jinlei;Liu Ying;Liu Fangjun;Ma Wei;...
期刊：
高等学校化学学报 ,2021年42(11):3526-3536 ISSN：0251-0790
通讯作者：
Wei Hua
作者机构：
[Wei Hua; Zhang Miao; Liu Ying] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Dept Pharm & Pharmacol, Hengyang 421001, Peoples R China.;[Wei Hua; Ma Wei; Zhang Miao; Peng Jinlei; Liu Fangjun] Lanzhou Univ, Key Lab Nonferrous Met Chem & Resources Utilizat, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China.
通讯机构：
[Wei Hua] U;[Wei Hua] L;Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Dept Pharm & Pharmacol, Hengyang 421001, Peoples R China.;Lanzhou Univ, Key Lab Nonferrous Met Chem & Resources Utilizat, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China.
关键词：
交联胶束;类环胶体;多价环状模板
摘要：
通过点击偶联法,用二茂铁(Fc)修饰环状聚甲基丙烯酸羟乙酯[c-P(HEMA)_(50)]的侧链羟基,得到多价环状聚合物模板c-P(HEMA-Fc)_(50),该模板可通过β-CD/Fc的主客体识别作用,在Fc位点有序偶联以亲水聚乙二醇(PEG)和硫辛酸(LA)功能化的β-环糊精(β-CD),形成具有明显核壳结构的超分子胶束[c-P(HEMA-Fc)_(50)/β-CDPEG-LA].该超分子胶束可通过二硫苏糖醇(DTT)催化的分子内自交联(CL)形成交联的超分子胶束,作为交联β-CD-PEG-LA的环状胶体前驱体.与三臂星状聚合物模板相比,环状聚合物模板的优势在于环状多价结构具有更高的稳定性和空间位阻效应,以环状聚合物为模板制备的交联胶束和类环胶体的胶束前驱溶液的浓度可显著提高至1.0 mg/mL.
语种：
中文
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Folate-Targeted Anticancer Drug Delivery via a Combination Strategy of a Micelle Complex and Reducible Conjugation
作者：
Wang, Mingqi;Long, Jinrong;Zhang, Simin;Liu, Fangjun;Zhang, Xiaolong;...
期刊：
ACS BIOMATERIALS SCIENCE & ENGINEERING ,2020年6(3):1565-1572 ISSN：2373-9878
通讯作者：
Yu, Cuiyun;Wei, Hua
作者机构：
[Long, Jinrong; Wei, Hua; Yu, Cuiyun; Wang, Mingqi; Wei, H] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Peoples R China.;[Long, Jinrong; Wei, Hua; Yu, Cuiyun; Wang, Mingqi; Wei, H] Univ South China, Dept Pharm & Pharmacol, Hengyang 421001, Peoples R China.;[Wei, Hua; Ma, Liwei; Zhang, Xianshuo; Sun, Lu; Zhang, Xiaolong; Zhang, Simin; Liu, Fangjun] Lanzhou Univ, Key Lab Nonferrous Met Chem & Resources Utilizat, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China.;[Wei, Hua; Ma, Liwei; Zhang, Xianshuo; Sun, Lu; Zhang, Xiaolong; Zhang, Simin; Liu, Fangjun] Lanzhou Univ, Coll Chem & Chem Engn, Lanzhou 730000, Gansu, Peoples R China.
通讯机构：
[Yu, CY; Wei, H] U;[Wei, Hua] L;Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Peoples R China.;Univ South China, Dept Pharm & Pharmacol, Hengyang 421001, Peoples R China.;Lanzhou Univ, Key Lab Nonferrous Met Chem & Resources Utilizat, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China.
关键词：
folic acid-targeted;mixed micelles;reducible conjugation;miktoarm star-shaped polymers;anticancer drug delivery
摘要：
Conjugation of various active targeting ligands to the surface of nanocarriers to realize specific recognition by the corresponding receptors localized on the membrane of the cancer cells has provided a powerful means toward enhanced cancer therapy. Folic acid (FA) is one of the most used targeting ligands due to the overexpressed FA receptors in many cancer cell lines. However, conjugation of hydrophobic FA to the surface of nanocarriers usually alters the hydrophilic/hydrophobic balance of the stabilized nanoparticles, leading to their thermodynamic instability and subsequent formation of aggregates, which apparently compromises the in vivo long circulation and minimized side effects of nanocarriers. The currently leading strategy to overcome this issue is to incorporate a protecting hydrophilic stealth that can be deshielded to expose the targeting ligand at the desired tumor site, which generally involves multistep chemical modifications, conjugations, and purifications. To develop a simple alternative toward FA-mediated enhanced anticancer drug delivery, a combination strategy of micelle complex and reducible conjugation was reported in this study. FA was first conjugated to the terminus of the hydrophilic block of a reduction-sensitive miktoarm star-shaped amphiphilic copolymer, PCL3-SS-POEGMA1, with the previously optimized star structure by click coupling via a reducible disulfide link. The resulting PCL3-SS-POEGMA1-SS-FA was further mixed with the parent PCL3-SS-POEGMA1 to afford a micelle complex with both reducibly conjugated and relatively low amount of FA-targeting ligands toward excellent FA-mediated targeted drug delivery without compromised salt stability in vitro and in vivo. Therefore, the combined strategy developed herein provides a simple and powerful means to promote FA-mediated anticancer drug delivery. Copyright © 2020 American Chemical Society.
语种：
英文
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Quantitatively Fine-Tuning the Physicochemical and Biological Properties of Peptidic Polymers through Monodisperse PEGylation
作者：
Wang, Xuemeng;Li, Yu;Wu, Tingjuan;Yang, Zhigang;Zheng, Xing;...
期刊：
Biomacromolecules ,2020年21(2):725-731 ISSN：1525-7797
通讯作者：
Zhou, Xin;Jiang, Zhong-Xing
作者机构：
[Jiang, Zhong-Xing; Wang, Xuemeng; Yang, Zhigang] Wuhan Univ, Wuhan, Peoples R China.;[Li, Yu; Zhou, Xin; Chen, Shizhen] Chinese Acad Sci, Wuhan, Peoples R China.;[Wu, Tingjuan; Zheng, Xing] Univ South China, Hengyang, Peoples R China.
通讯机构：
[Zhou, Xin] C;[Jiang, Zhong-Xing] W;Chinese Acad Sci, Wuhan, Peoples R China.;Wuhan Univ, Wuhan, Peoples R China.
摘要：
In biomedicine, PEGylation is one of the most successful strategies to modify the physicochemical and biological properties of peptides, proteins, and other biomacromolecules. Because of the polydisperse nature of regular PEGs and limited PEGylation strategies, it is challenging to quantitatively fine-tune and accurately predict the properties of biomacromolecules after PEGylation. However, such fine-tuning and prediction may be crucial for their biomedical applications. Herein, some monodisperse PEGylation strategies, including backbone PEGylation, side-chain PEGylation, and highly branched PEGylation, have been developed. In a comparative fashion, the impact of PEGylation strategies and monodisperse PEG sizes on the physicochemical and biological properties, including lipophilicity, thermosensitivity, biocompatibility, plasma stability, and drug delivery capability, of peptidic polymers has been quantitatively studied. It was found that the physicochemical and biological properties of PEGylated peptidic polymers can be quantitatively fine-tuned and accurately predicted through these monodisperse PEGylation strategies. After the comparative study, a side-chain monodisperse PEGylated peptidic polymer was chosen as fluorine-19 magnetic resonance and fluorescence dual-imaging traceable drug delivery vehicle. Our study may not only promote the transformation of PEGylation from an empirical technology to a quantitative science but also shed light on the rational design of PEGylated biomaterials and pharmaceutics.
语种：
英文
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Synthesis and application in asymmetric catalysis of P-stereogenic pincer-metal complexes
作者：
Xiang, Yijun;Ge, Qianyi;Wu, Shulei;Zheng, Xing* ;Yang, Zehua*
期刊：
RSC Advances ,2020年10(16):9563-9578 ISSN：2046-2069
通讯作者：
Zheng, Xing;Yang, Zehua
作者机构：
[Ge, Qianyi; Xiang, Yijun; Yang, Zehua; Zheng, Xing; Yang, ZH; Wu, Shulei] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hunan Prov Key Lab Tumor Microenvironm Respons Dr, 28 Western Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.
通讯机构：
[Zheng, X; Yang, ZH] U;Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hunan Prov Key Lab Tumor Microenvironm Respons Dr, 28 Western Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.
摘要：
P-stereogenic pincer-metal complexes are one of the most interesting pincer type organometallic compounds. Many kinds of this type of complexes were synthesized and used as catalysts in asymmetric catalysis. On the basis of our work in this field, this paper reports the recent progress in P-stereogenic pincer chemistry, including the synthesis of P-stereogenic pincer ligands, the synthesis of P-stereogenic pincer-metal complexes, and the achievements in P-stereogenic pincer-metal complex catalyzed asymmetric synthesis. This journal is © The Royal Society of Chemistry.
语种：
英文
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Fabrication of hypoxia-responsive and uperconversion nanoparticles-modified RBC micro-vehicles for oxygen delivery and chemotherapy enhancement
作者：
Wang, Peiyuan;Jiang, Suhua;Li, Yang;Luo, Qiang;Lin, Jinyan;...
期刊：
BIOMATERIALS SCIENCE ,2020年8(16):4595-4602 ISSN：2047-4830
通讯作者：
Fan, Lingling;Zhu, Jun
作者机构：
[Jiang, Suhua; Luo, Qiang; Lin, Jinyan; Wang, Peiyuan; Li, Yang] Chinese Acad Sci, Fujian Inst Res Struct Matter, Key Lab Design & Assembly Funct Nanostruct, Fuzhou 350002, Peoples R China.;[Luo, Qiang; Fan, Lingling; Xu, Congjian; Wang, Peiyuan] Fudan Univ, Obstet & Gynecol Hosp, Shanghai 200011, Peoples R China.;[Jiang, Suhua; Luo, Qiang; Lin, Jinyan; Wang, Peiyuan; Li, Yang] Fujian Med Univ, Mengchao Hepatobiliary Hosp, United Innovat Mengchao Hepatobiliary Technol Key, Fuzhou 350025, Peoples R China.;[Jiang, Suhua; Lin, Jinyan; Wang, Peiyuan; Li, Yang] Chinese Acad Sci, Xiamen Inst Rare Earth Mat, Dept Translat Med, Xiamen 361024, Peoples R China.;[Hu, Lidan] Univ South China, Dept Biochem & Mol Biol, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Peoples R China.
通讯机构：
[Fan, Lingling] F;[Zhu, Jun] T;Fudan Univ, Obstet & Gynecol Hosp, Shanghai 200011, Peoples R China.;Tongji Univ, Sch Med, Shanghai Pulm Hosp, Dept Oncol, Shanghai, Peoples R China.
摘要：
Solid tumor cells in hypoxic regions resist chemotherapy treatment with conventional antitumor drugs (such as paclitaxel, PTX) because the inadequate O2 attenuates the intracellular generation of reactive oxygen species (ROS) and upregulates multidrug resistance protein expression. Hyperbaric O2 therapy concentrates on improving O2 delivery to the hypoxic tumor area, thereby enhancing the sensitivity of cancer cells to chemotherapy drugs. However, the implementation of this therapy often elicits immune response or potentiates toxicity of the drugs toward normal cells. In this work, we successfully fabricated RBC-based micro-vehicles for precise hypoxia-activated O2 delivery under the 980 nm laser irradiation. Interestingly, the subsequent chemotherapy of PTX for ovarian tumors was significantly enhanced owing to the alleviation of hypoxia tumor microenvironment. Meanwhile, the RBC-based micro-vehicles have low side tissue effects, superior biocompatibility, and ultra-low immune response. Overall, the RBC-based drug delivery system holds a fascinating perspective towards O2 delivery for chemotherapy enhancement in other clinical solid malignancies. This journal is © The Royal Society of Chemistry.
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英文
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