期刊：
Food and Function,2018年9(5):2809-2819 ISSN：2042-6496
通讯作者：
Zhang, P.-F.
作者机构：
[Bi, Wu] Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China. zhangpf690421@csu.edu.cn
通讯机构：
[Zhang, Peng-fei] Cent S Univ, Xiangya Hosp, Chinese Minist Hlth, Key Lab Canc Prote, Changsha 410008, Hunan, Peoples R China.
关键词：
Colon cancer cells - Colorectal cancer - Flow cytometry analysis - Human colon cancer cells - MRNA expression level - Nuclear translocations - Phenolic compounds - Signaling pathways
作者机构：
[Xiao, Ji-Chang; Wei, Yun; Zheng, Qu-Tong; Zheng, Xing; Wang, Zong-Bao] Institute of Pharmacy and Pharmacology, University of South China, 28 Western Changsheng Road, Hengyang Hunan, 421001, China;[Xiao, Ji-Chang; Lin, Jin-Hong; Zhao, Gang; Zheng, Jian; Wei, Yun; Zheng, Qu-Tong; Duan, Ya-ya] Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Road, Shanghai, 200032, China;[Xiao, Ji-Chang; Wei, Yun; Zheng, Qu-Tong; Zheng, Xing; Wang, Zong-Bao] Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, 28 Western Changsheng Road, Hengyang Hunan, 421001, China
通讯机构：
[Zheng, X; Xiao, JC] Univ South China, Inst Pharm & Pharmacol, 28 Western Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.;[Zheng, X; Xiao, JC] Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, 28 Western Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.;[Lin, JH; Xiao, JC] Univ Chinese Acad Sci, Chinese Acad Sci, Key Lab Organofluorine Chem, Shanghai Inst Organ Chem, 345 Lingling Rd, Shanghai 200032, Peoples R China.
作者：
Zhang, Jia;Xiao, Li;Yin, Yufang;Sirois, Pierre;Gao, Hanlin;Li, Kai
期刊：
Applied Biochemistry and Biotechnology,2010年162(2):321-328 ISSN：0273-2289
通讯作者：
Li, K.
作者机构：
the Second Affiliated Hospital of Soochow University<&wdkj&>University of South China<&wdkj&>University of Sherbrooke<&wdkj&>City of Hope;[Zhang, Jia; Xiao, Li] the Second Affiliated Hospital of Soochow University;[Yin, Yufang] University of South China;[Sirois, Pierre] University of Sherbrooke;[Gao, Hanlin] City of Hope
摘要：
Indels in evolutionary studies are rapidly decayed obeying a power law. The present study analyzed the length distribution of small insertions and deletions associated with human diseases and confirmed that the decay pattern of these small mutations is similar to that of indels when the mutation datasets are large enough. The describable decay pattern of somatic mutations may have application in the evaluation of varied penetrance of different mutations and in association study of gene mutation with carcinogenesis.
作者机构：
State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology, Hunan University, Changsha, Hunan 410082, P. R. China<&wdkj&>Department of Chemistry, Tsinghua University, Beijing 100084, P. R. China<&wdkj&>Institute of Pharmacy and Pharmacology, University of South China, Hengyang, Hunan 421001, P. R. China;[Wen, Xiaodong; Pan, Qi; He, Yan; Lei, Gang; Feng, Jingjing] Department of Chemistry, Tsinghua University , Beijing 100084, P. R. China;[He, Yan; Cao, Xuan] State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology, Hunan University , Changsha, Hunan 410082, P. R. China;[Cao, Xuan] Institute of Pharmacy and Pharmacology, University of South China , Hengyang, Hunan 421001, P. R. China
期刊：
Research on Chemical Intermediates,2017年43(8):4833-4850 ISSN：0922-6168
通讯作者：
Hu, A.
作者机构：
College of Chemistry and Chemical Engineering, Hunan University, Changsha, China<&wdkj&>School of Chemistry and Chemical Engineering, University of South China, Hengyang, China;[Wu, Zhilin; Tang, Yuting; Ye, Jiao; Peng, Junmei; Hu, Aixi] College of Chemistry and Chemical Engineering, Hunan University, Changsha, China;[Ding, Na] School of Chemistry and Chemical Engineering, University of South China, Hengyang, China
作者：
Song Xiudao;He Jun;Ma Jin;Liu Yunmei;Zheng Xing;Lei Xiaoyong;Guo Yu
期刊：
高等学校化学学报,2014年35(7):1465-1470 ISSN：0251-0790
通讯作者：
Liu, Y.
作者机构：
南华大学药物药理研究所，湖南省药物蛋白质组学重点实验室;化学化工学院,衡阳,421001;[Song Xiudao; Ma Jin; Liu Yunmei; Zheng Xing; Lei Xiaoyong; Guo Yu] 南华大学;[He Jun] 化学化工学院
通讯机构：
[Liu Yunmei] Univ South China, Inst Pharm & Pharmacol, Key Lab Hunan Prov Pharmacoprote, Hengyang 421001, Peoples R China.;Key Laboratory of Hunan Province Pharmacoproteomics, Institute of Pharmacy and Pharmacology, University of South China, China
期刊：
Organic and Biomolecular Chemistry,2018年16(44):8537-8545 ISSN：1477-0520
通讯作者：
Lv, Xiaoyan
作者机构：
[Lv, Xiaoyan] Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China. zxjiang@whu.edu.cn
通讯机构：
[Lv, Xiaoyan] Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China.
作者机构：
Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China<&wdkj&>Institute of Pharmacy and Pharmacology, University of South China, Hengyang 421001, China<&wdkj&>Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China<&wdkj&>Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China<&wdkj&>State Key Laboratory for Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan 430071, China<&wdkj&>Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China<&wdkj&>State Key Laboratory for Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan 430071, China<&wdkj&>Institute of Pharmacy and Pharmacology, University of South China, Hengyang 421001, China<&wdkj&>State Key Laboratory for Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan 430071, China<&wdkj&>Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China;[Xiao, Yan; Zheng, Xing] Institute of Pharmacy and Pharmacology , University of South China , Hengyang 421001 , China;[Li, Yu; Jiang, Zhong-Xing; Zhu, Junfei; Zhang, Huaibin; Yang, Zhigang] Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals, School of Pharmaceutical Sciences , Wuhan University , Wuhan 430071 , China;[Zhou, Xin; Chen, Shizhen; Yuan, Yaping] State Key Laboratory for Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics , Chinese Academy of Sciences , Wuhan 430071 , China
通讯机构：
[Jiang, Zhong-Xing] Wuhan Univ, Sch Pharmaceut Sci, Hubei Prov Engn & Technol Res Ctr Fluorinated Pha, Wuhan 430071, Peoples R China.;Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals, School of Pharmaceutical Sciences, Wuhan University, Wuhan, China
关键词：
Body temperature - Fluorescent imaging - Imaging modality - Lower critical solution temperature - Multiple imaging modality - Solid phase peptide synthesis - Thermo sensitive - Thermo-responsive
摘要：
Thermosensitive and imaging-traceable materials with fine-tunable lower critical solution temperature (LCST) around body temperature are highly valuable in biomedicine. However, such materials are rare because it is challenging to fine-tune the LCST and incorporate suitable imaging modalities. Herein, peptidic monodisperse polyethylene glycol (M-PEG) "combs" with fine-tunable LCST, "hot spot" fluorine-19 magnetic resonance imaging ((19)F MRI), thermoresponsive fluorescent imaging, and drug loading ability were developed through accurately programming their structures during solid phase peptide synthesis (SPPS). The easy availability, structural accuracy, biocompatibility, and versatility provide the M-PEG "combs" with promising prospects as thermoresponsive and imaging-traceable biomaterials for controlled drug delivery.
期刊：
Journal of Physical Chemistry B,2009年113(45):14839-14843 ISSN：1520-6106
通讯作者：
Si-Xue Cheng
作者机构：
Department of Pharmacy, School of Life Sciences and Technology, University of South China, Hengyang, 421001, People’s Republic of China, and Key Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry, Wuhan University, Wuhan 430072, People’s Republic of China;[Zhang, Xian-Zheng; Wei, Hua; Yu, Cui-Yun; Cheng, Si-Xue; Zhuo, Ren-Xi; Zhang, Qiao] Department of Chemistry, Wuhan UniVersity, Ministry of Education, Wuhan 430072, China;[Yu, Cui-Yun] Department of Pharmacy, School of Life Sciences and Technology, UniVersity of South China, Hengyang, 421001, China
通讯机构：
[Cheng, SX ] Wuhan Univ, Key Lab Biomed Polymers, Minist Educ, Dept Chem, Wuhan 430072, Peoples R China.;Department of Chemistry, Wuhan UniVersity, Ministry of Education, China
关键词：
Aggregation behavior - Aqueous media - Aqueous solutions - Effect of ions - Ion concentrations - Nano-sized - Organic/inorganic - Simple approach
期刊：
Trends in Biotechnology,2005年23(2):92-96 ISSN：0167-7799
通讯作者：
Zhang, J.
作者机构：
[Zhang, J] SNP Institute, North District of the School, Nanhua University, Hengyang, Hunan, 421001, China
通讯机构：
[Li, K] Nanhua Univ, N Dist Sch, SNP Inst, Hengyang 421001, Hunan, Peoples R China.;SNP Institute, North District of the School, Nanhua University, China
关键词：
DNA polymerases - Genetic analysis - Genotyping assays - Single nucleotide polymorphism (SNP)
摘要：
DNA polymerases with 3'-5' proofreading function mediate high fidelity DNA replication but their application for mutation detection was almost completely neglected before 1998. The obstacle facing the use of exo(+) polymerases for mutation detection could be overcome by primer-3'-termini modification, which has been tested using allele-specific primers with 3' labeling, 3' exonuclease-resistance and 3' dehydroxylation modifications. Accordingly, three new types of single nucleotide polymorphism (SNP) assays have been developed to carry out genome-wide genotyping making use of the fidelity advantage of exo(+) polymerases. Such SNP assays might also provide a novel approach for re-sequencing and de novo sequencing. These new mutation detection assays are widely adaptable to a variety of platforms, including real-time PCR, multi-well plate and microarray technologies. Application of exo(+) polymerases to genetic analysis could accelerate the pace of personalized medicine.
作者机构：
The Second Affiliated Hospital of Suzhou University<&wdkj&>Biotecan Center of Molecular Medicine<&wdkj&>Nanhua University<&wdkj&>City of Hope National Medical Center<&wdkj&>Genomics Institute of the Novartis Research Foundation;[Xiao, Li] The Second Affiliated Hospital of Suzhou University;[Saldivar, Juan-Sebastian; Sirois, Pierre] Biotecan Center of Molecular Medicine;[Zhou, Cuilan; Zhang, Jia] Nanhua University;[Chen, Chengli] City of Hope National Medical Center
通讯机构：
[Li, Kai] Suzhou Univ, Affiliated Hosp 2, Mol Med Ctr, Suzhou 215004, Jiangsu, Peoples R China.;Molecular Medicine Center, Second Affiliated Hospital, Suzhou University, China
摘要：
We propose a short definition of GENOME: The full complement of genetic materials possessed by an intracellular parasite, a cell, or an organism. Accordingly, the human genome is the entire complement of inherited genetic materials possessed by an individual person, or possessed by a cell in an individual person. For higher species, the genomic makeup includes DNA in the nucleus and in the organelles regardless of the number of chromosomes and the homoplasmic or heteroplasmic status of the mitochondrial or chloroplastic DNA. Practically, GENOME can be referred to at the molecular, cellular, individual, and species levels, which has various implications in biotechnological research and molecular diagnostics.
作者机构：
[Li ZiShan; Wu, Duan-Sheng; Yang, Hui-Ling; Peng, Hui-Bing; Xu, Yang-Yan; Quan, Zhi-Hua] Institute of Clinical Medicine, University of South China, Hengyang, 421001, Hunan Province, China;[Chen, Wei-Qiong; Wu, Duan-Sheng; Yang, Hui-Ling; Xu, Yang-Yan] Institute of Pharmacology and Pharmacy, University of South China, Western Changsheng Road 28, Hengyang 421001, Hunan Province, China
会议名称：
2009 2nd International Conference on Biomedical Engineering and Informatics, BMEI 2009
会议时间：
October 17, 2009 - October 19, 2009
会议地点：
Tianjin, China
会议主办单位：
(1) Institute of Clinical Medicine, University of South China, Hengyang, 421001, Hunan Province, China; (2) Institute of Pharmacology and Pharmacy, University of South China, Western Changsheng Road 28, Hengyang 421001, Hunan Province, China
会议论文集名称：
International Conference on Biomedical Engineering and Informatics
关键词：
Caveolin-1 - Control groups - Down-regulation - HepG2 cell line - Immunofluorescence staining - In-vitro - Indirect immunofluorescence - Lentiviral expression - Lipid droplets - Phosphatidylserine - Potent inhibition - Red oil - Reverse transcription-polymerase chain reaction - Scavenger receptor - Short hairpin RNA (shRNA) - Smooth muscle cells - Therapeutic targets - Western blots - Western blotting
期刊：
Journal of Physical Chemistry C,2008年112(43):16774-16778 ISSN：1932-7447
通讯作者：
Cheng, S.-X.
作者机构：
[Yin, Bo-Cheng; Zhang, Xian-Zheng; Jia, Li-Hui; Yu, Cui-Yun; Cheng, Si-Xue; Zhuo, Ren-Xi] Key Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry, Wuhan University, Wuhan 430072, China;[Yu, Cui-Yun] Department of Pharmacy, School of Life Sciences and Technology, University of South China, Hengyang, 421001, China
作者机构：
[Tian, Li; Fu, Mingde; Jia, Lianqun; Tian, Haoming] Laboratory of Endocrinology and Metabolism,West China Hospital,Sichuan University,Chengdu 610041,Sichuan,People's Republic of China;[Xu, Yanhua] Chengdu Hoist Biotechnology Co.,LTD,Sichuan,PR China;[Long, Shiyin; Tian, Ying] Department of Biochemistry and Molecular Biology,Nanhua University,Hengyang,Hunan,Chengdu 610041,PR China
通讯机构：
[Fu, Mingde] Sichuan Univ, W China Hosp, Lab Endocrinol & Metab, New Bldg 6,Room 902,16 Sect 3,People S Rd, Chengdu 610041, Sichuan, Peoples R China.
作者机构：
[Feng, Shaolong] The School of Public Health, Nanhua University, Hengyang 421001, China
通讯机构：
[Wang, Xinming] Chinese Acad Sci, State Key Lab Organ Geochem, Guangzhou Inst Geochem, Guangzhou 510640, Peoples R China.;The State Key Laboratory of Organic Geochemistry, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, China
期刊：
BioTechnology: An Indian Journal,2013年8(4):543-550 ISSN：0974-7435
通讯作者：
Liao, D.-F.(dfliao66@aliyun.com)
作者机构：
[Tuo, Qin-Hui; Liao, Duan-Fang; Gong, Yong-Zhen; Sun, Shao-Wei] Hunan University of Chinese Medicine, Hanpu Science and Education District, 1# Xiangzui Road, Changsha 410208, Hunan, China;[Ke-Tang, Chao] Institute of Cardiovascular Disease, Life Science Research Center, University of South China, 28# Changsheng Western Road, Hengyang 421001, Hunan, China;[Tuo, Qin-Hui; Ke-Tang, Chao; Liao, Duan-Fang; Gong, Yong-Zhen; Zhang, Xiao-Ying; Sun, Shao-Wei] Division of biochemistry, School of pharmacy and Life Science, University of South China, 28# Changsheng West Road, Hengyang 421001, Hunan, China;[Zhang, Xiao-Ying] Division of Pharmacoproteomics, School of pharmacy and Life Science, University of South China, 28# Changsheng Western Road, Hengyang 421001, Hunan, China
