期刊论文

Synthesis of Crosslinked Micelles and Ring-like Colloids via a Cyclic Template with Multivalency

Wei Hua

中文

高等学校化学学报

0251-0790

2021

42

11

3526-3536

10.7503/cjcu20210370

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [51473072,21504035]; Thousand Young Talent Program of China; General Project of Human Provincial Education Department,China [19C1597]

本校为第一且通讯机构

通过点击偶联法,用二茂铁（Fc）修饰环状聚甲基丙烯酸羟乙酯[c-P（HEMA）50]的侧链羟基,得到多价环状聚合物模板c-P（HEMA-Fc）50,该模板可通过β-CD/Fc的主客体识别作用,在Fc位点有序偶联以亲水聚乙二醇（PEG）和硫辛酸（LA）功能化的β-环糊精（β-CD）,形成具有明显核壳结构的超分子胶束[c-P（HEMA-Fc）50/β-CDPEG-LA].该超分子胶束可通过二硫苏糖醇（DTT）催化的分子内自交联（CL）形成交联的超分子胶束,作为交联β-CD-PEG-LA的环状胶体前驱体.与三臂星状聚合物模板相比,环状聚合物模板的优势在于环状多价结构具有更高的稳定性和空间位阻效应,以环状聚合物为模板制备的交联胶束和类环胶体的...

The pendant hydroxyl groups of c-P(HEMA)50 were first decorated with ferrocene(Fc) by click coupling to afford c-P(HEMA-Fc)50, which was then used as a core template to direct the supramolecular comple-xation with β-cyclodextrin(β-CD) functionalized with both hydrophilic poly(ethylene glycol)(PEG) and lipoic acid(LA)(β-CD-PEG-LA) viaβ-CD/Fc host-guest inclusion complexation. The resulting supramolecular micelle formed by c-P(HEMA-Fc)50/β-CD-PEG-LA could be crosslinked via dithiothreitol(DTT)-catalyzed intramolecular self-crosslinking of th...