Fabrication of hypoxia-responsive and uperconversion nanoparticles-modified RBC micro-vehicles for oxygen delivery and chemotherapy enhancement

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Wang, Peiyuan;Jiang, Suhua;Li, Yang;Luo, Qiang;Lin, Jinyan;...

通讯作者：

Fan, Lingling;Zhu, Jun

作者机构：

[Jiang, Suhua; Luo, Qiang; Lin, Jinyan; Wang, Peiyuan; Li, Yang] Chinese Acad Sci, Fujian Inst Res Struct Matter, Key Lab Design & Assembly Funct Nanostruct, Fuzhou 350002, Peoples R China.

[Luo, Qiang; Fan, Lingling; Xu, Congjian; Wang, Peiyuan] Fudan Univ, Obstet & Gynecol Hosp, Shanghai 200011, Peoples R China.

[Jiang, Suhua; Luo, Qiang; Lin, Jinyan; Wang, Peiyuan; Li, Yang] Fujian Med Univ, Mengchao Hepatobiliary Hosp, United Innovat Mengchao Hepatobiliary Technol Key, Fuzhou 350025, Peoples R China.

[Jiang, Suhua; Lin, Jinyan; Wang, Peiyuan; Li, Yang] Chinese Acad Sci, Xiamen Inst Rare Earth Mat, Dept Translat Med, Xiamen 361024, Peoples R China.

[Hu, Lidan] Univ South China, Dept Biochem & Mol Biol, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Peoples R China.

通讯机构：

[Fan, Lingling] F

[Zhu, Jun] T

Fudan Univ, Obstet & Gynecol Hosp, Shanghai 200011, Peoples R China.

Tongji Univ, Sch Med, Shanghai Pulm Hosp, Dept Oncol, Shanghai, Peoples R China.

语种：

英文

期刊：

BIOMATERIALS SCIENCE

ISSN：

2047-4830

年：

2020

卷：

期：

页码：

4595-4602

DOI：

10.1039/d0bm00678e

基金类别：

National Key Research and Development Project Nanotechnology [2017YFA0205100]; Western Medicine Guide Project of Shanghai Municipal Commission of Science and Technology [17411960800]; National Natural Science Foundation of China (NSFC)National Natural Science Foundation of China (NSFC) [61905248]

机构署名：

本校为其他机构

院系归属：

化学化工学院

药学与生物科学学院

摘要：

Solid tumor cells in hypoxic regions resist chemotherapy treatment with conventional antitumor drugs (such as paclitaxel, PTX) because the inadequate O2 attenuates the intracellular generation of reactive oxygen species (ROS) and upregulates multidrug resistance protein expression. Hyperbaric O2 therapy concentrates on improving O2 delivery to the hypoxic tumor area, thereby enhancing the sensitivity of cancer cells to chemotherapy drugs. However, the implementation of this therapy often elicits immune response or potentiates toxicity of the dr...

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Fabrication of hypoxia-responsive and uperconversion nanoparticles-modified RBC micro-vehicles for oxygen delivery and chemotherapy enhancement

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