Folate-Targeted Anticancer Drug Delivery via a Combination Strategy of a Micelle Complex and Reducible Conjugation

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Wang, Mingqi;Long, Jinrong;Zhang, Simin;Liu, Fangjun;Zhang, Xiaolong;...

通讯作者：

Yu, Cuiyun;Wei, Hua

作者机构：

[Long, Jinrong; Wei, Hua; Yu, Cuiyun; Wang, Mingqi; Wei, H] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Peoples R China.

[Long, Jinrong; Wei, Hua; Yu, Cuiyun; Wang, Mingqi; Wei, H] Univ South China, Dept Pharm & Pharmacol, Hengyang 421001, Peoples R China.

[Wei, Hua; Ma, Liwei; Zhang, Xianshuo; Sun, Lu; Zhang, Xiaolong; Zhang, Simin; Liu, Fangjun] Lanzhou Univ, Key Lab Nonferrous Met Chem & Resources Utilizat, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China.

[Wei, Hua; Ma, Liwei; Zhang, Xianshuo; Sun, Lu; Zhang, Xiaolong; Zhang, Simin; Liu, Fangjun] Lanzhou Univ, Coll Chem & Chem Engn, Lanzhou 730000, Gansu, Peoples R China.

通讯机构：

[Yu, CY; Wei, H] U

[Wei, Hua] L

Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Peoples R China.

Univ South China, Dept Pharm & Pharmacol, Hengyang 421001, Peoples R China.

Lanzhou Univ, Key Lab Nonferrous Met Chem & Resources Utilizat, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China.

语种：

英文

关键词：

folic acid-targeted;mixed micelles;reducible conjugation;miktoarm star-shaped polymers;anticancer drug delivery

期刊：

ACS BIOMATERIALS SCIENCE & ENGINEERING

ISSN：

2373-9878

年：

2020

卷：

期：

页码：

1565-1572

DOI：

10.1021/acsbiomaterials.9b01920

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China [51473072, 21504035, 81471777]; Thousand Young Talent Program; Outstanding Youth Fund of Natural Science Foundation of Hunan ProvinceNatural Science Foundation of Hunan Province [2017E1024]; National Key R&D Program of China [2018YFB1900201]; Open Research Fund of State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences

机构署名：

本校为第一且通讯机构

院系归属：

药学与生物科学学院

摘要：

Conjugation of various active targeting ligands to the surface of nanocarriers to realize specific recognition by the corresponding receptors localized on the membrane of the cancer cells has provided a powerful means toward enhanced cancer therapy. Folic acid (FA) is one of the most used targeting ligands due to the overexpressed FA receptors in many cancer cell lines. However, conjugation of hydrophobic FA to the surface of nanocarriers usually alters the hydrophilic/hydrophobic balance of the stabilized nanoparticles, leading to their thermo...

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Folate-Targeted Anticancer Drug Delivery via a Combination Strategy of a Micelle Complex and Reducible Conjugation

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