期刊论文

Zheng, Xing(zhengxing9166@sohu.com);Tao, Houchao(houchao@shutcm.edu.cn);Zhao, Fei(zhaofei@shanghaitech.edu.cn)

英文

CHEMISTRY-AN ASIAN JOURNAL

1861-4728

2022

17

15

e202200372-

10.1002/asia.202200372

This research was financially supported by Hunan Provincial Hengyang Joint Fund (2020JJ6052 to X.Z.), Laboratory of Tea and Health of Hengyang (202150083704 to X.Z.), and the National Natural Science Foundation of China (No. 21672147 to H.T.) for financial support. We thank J. Liu, Q. Shi, Q. Tan and L. Yang for assistance in the membrane preparation and NMR processing at the Core Facility of iHuman Institute.

本校为第一机构

Despite the continuous efforts, the current repertoire of detergents is still far from sufficient for the biophysics studies of membrane proteins (MPs). Toward the rapid expansion of detergent diversity, we herein report a new strategy based on Ugi reaction mediated modular assembly. Structural varieties, including hydrophobic tails and hydrophilic heads, could be conveniently introduced from the multiple reaction components. New detergents then were comprehensively evaluated in the physical properties and preliminarily screened by the thermal ...