Spider Toxin Peptide-Induced NIR Gold Nanocluster Fabrication for GSH-Responsive Cancer Cell Imaging and Nuclei Translocation

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成果类型：

期刊论文

作者：

Tan, Huaxin;Liu, Sisi;He, Yaolin;Cheng, Guofeng;Zhang, Yu;...

通讯作者：

Hu, Lidan

作者机构：

[Tan, Huaxin; Hu, Lidan; Zhang, Yu; Cheng, Guofeng] Univ South China, Key Lab Ecol Environm & Crit Human Dis Prevent Hu, Dept Biochem & Mol Biol, Dept Educ,Sch Basic Med,Hengyang Med Sch, Hengyang, Peoples R China.

[Liu, Sisi] Univ South China, Sch Publ Hlth, Hengyang Med Sch, Hengyang, Peoples R China.

[He, Yaolin] Univ South China, Affiliated Hosp 2, Hengyang Med Sch, Dept Radiotherapy, Hengyang, Peoples R China.

[Wei, Xiaojie] Univ South China, Sch Pharm, Hengyang Med Sch, Hengyang, Peoples R China.

通讯机构：

[Hu, Lidan] U

Univ South China, Key Lab Ecol Environm & Crit Human Dis Prevent Hu, Dept Biochem & Mol Biol, Dept Educ,Sch Basic Med,Hengyang Med Sch, Hengyang, Peoples R China.

语种：

英文

关键词：

NIR gold nanoclusters;spider toxin peptide;Cancer cell imaging;nuclei translocation;GSH-responsive

期刊：

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY

ISSN：

2296-4185

年：

2021

卷：

页码：

780223

DOI：

10.3389/fbioe.2021.780223

基金类别：

This work was supported by the National Natural Science Foundation of China (Grant Nos. 31800846, 21904061), the Hunan Provincial Natural Science Foundation (Grant Nos. 2019JJ50527, 2019JJ50501), the University of South China (Grant No. X202010555393), and Hunan Students Innovation and Entrepreneurship Training Program (Grant No. 2751, 2020).

机构署名：

本校为第一且通讯机构

院系归属：

化学化工学院

药学与生物科学学院

公共卫生学院

摘要：

Goldnanoclusters (GNCs) have become a promising nanomaterial for bioimaging because of their unique optical properties and biocompatibility. In this study, lycosin-I peptide, which possesses a highly selective anticancer activity by affecting the permeability of cancer cell membrane, was firstly modified for constructing fluorescent GNCs (LGNCs) for bioimaging of tumor cells. The obtained LGNCs exhibited strong near-infrared (NIR) fluorescence, which can be further enhanced by the peptide-induced aggregation and selectively stained three cancer...

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Spider Toxin Peptide-Induced NIR Gold Nanocluster Fabrication for GSH-Responsive Cancer Cell Imaging and Nuclei Translocation

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