The facile synthesis of amphiphilic hyperbranched copolymers with biodegradability generally suffers from sophisticated specific design and multistep preparation procedures integrating different synthetic approaches, leading to difficulty and complexity in scalable manufacture and potential biomedical applications. To develop a robust yet facile strategy toward biodegradable hyperbranched amphiphilic copolymers, we reported in this study the design and synthesis of a reducible macromonomer, 2-((2-hydroxyethyl)disulfanyl)ethyl methacrylate-graft...