A tumor microenvironment (TME)-responsive nanoplatform for systemic saporin delivery and effective breast cancer therapy

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成果类型：

期刊论文

作者：

Shen, Qian;Xu, Lei;Li, Rong;Wu, Guang;Li, Senlin;...

通讯作者：

Li, Rong(l7979r@163.com)

作者机构：

[Zhou, Yusheng; Li, Rong; Xu, Xiaoding; Shen, Qian; Wu, Guang] Univ South China, Inst Pharm & Pharmacol, Hengyang 421001, Peoples R China.

[Zhou, Yusheng; Li, Rong; Xu, Xiaoding; Shen, Qian; Wu, Guang] Univ South China, Affiliated Hosp 2, Hengyang 421001, Peoples R China.

[Saw, Phei Er; Xu, Xiaoding; Xu, Lei; Li, Senlin] Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Med Res Ctr, Guangdong Prov Key Lab Malignant Tumor Epigenet &, Guangzhou 510120, Peoples R China.

[Zhou, Yusheng] Univ South China, Affiliated Nanhua Hosp, Hengyang 421001, Peoples R China.

通讯机构：

[Shen, Qian; Zhou, Yusheng; Xu, Xiaoding] I

Institute of Pharmacy & Pharmacology and the Second Affiliated Hospital, University of South China, Hengyang 421001, P. R. China. yszhou08@126.com

Institute of Pharmacy & Pharmacology and the Second Affiliated Hospital, University of South China, Hengyang 421001, P. R. China. yszhou08@126.com and The Affiliated Nanhua Hospital, University of South China, Hengyang 421001, P. R. China. xuxiaod5@mail.sysu.edu.cn

Institute of Pharmacy & Pharmacology and the Second Affiliated Hospital, University of South China, Hengyang 421001, P. R. China. yszhou08@126.com and Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, P. R. China

语种：

英文

期刊：

Chemical Communications

ISSN：

1359-7345

年：

2021

卷：

期：

页码：

2563-2566

DOI：

10.1039/d0cc07808e

基金类别：

International Scientific and Technological Cooperation Program from Guangdong Science and Technology Department [2018A050506033]; Guangzhou Science and Technology Bureau [201902020015]

机构署名：

本校为第一机构

院系归属：

药学与生物科学学院

摘要：

Intracellular delivery of therapeutic proteins remains a challenge for the success of protein-mediated disease treatment. We herein develop a robust nanoplatform made with a TME-pH responsive Meo-PEG-b-PPMEMA polymer and a cationic lipid-like compoundG0-C14forin vivodelivery of cytotoxic saporin and breast cancer therapy. This nanoplatform could respond to a TME pH to rapidly release saporin/G0-C14complexes, which could significantly improve the uptake of cytosolic saporin by tumor cells and subsequent endosomal escape, thereby leading to an effecti...

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A tumor microenvironment (TME)-responsive nanoplatform for systemic saporin delivery and effective breast cancer therapy

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