摘要：
Among various novel antimicrobial therapies, sonodynamic therapy (SDT) exhibits its advantages for the treatment of bacterial infections due to its high penetration depth and low side effects. In this study, a new nanosonosensitizer (HFH@ZIF-8) that loads sonosensitizer hematoporphyrin monomethyl ether (HMME) into zeolitic imidazolate framework-8 (ZIF-8), was constructed for killing multidrug-resistant (MDR) bacteria and treatment of in vivo infection diseases by SDT. In particular, the developed HFH@ZIF-8 exhibited enhanced water-solubility, good biocompatibility, and improved disease-targeting capability for delivering and releasing HMME and ablating the infected lesion. More importantly, the presence of oxygen-carrying hemoglobin for HFH@ZIF-8 can offer sufficient oxygen consumption by SDT, augmenting the efficacy of SDT by improving ROS generating efficiency against deep tissue multidrug-resistant bacterial infection. Therefore, this study paves a new avenue for treating infection disease, particularly for antibiotic resistant bacterial infection.
摘要：
Objective: The unicondylar knee arthroplasty (UKA) procedure is primarily indicated for osteoarthritis of the knee. Anterior cruciate ligament (ACL) defects have long been considered a contraindication to UKA. However, recent clinical studies have found that ACL defects do not affect postoperative outcomes in UKA. To elucidate whether ACL defects affect postoperative outcomes in UKA, we performed a systematic review and Meta-analysis of observational cohort studies comparing the effects of ACL defects and intactness on surgical outcomes in UKA. Methods: In this study, we used "Anterior Cruciate Ligament ", "Anterior Cruciate Ligament Injuries " and "Arthroplasty, Replacement, Knee " as the subject terms according to PICOS principles. These subject terms and the corresponding free texts were used to conduct a systematic search in the three major databases PubMed, Embase and Cochrane on December 9, 2021. The main study variables included age, gender, region, definition of ACL defect and diagnosed diseases. The study used a random effect model to pool the effect of 95% CIs. To explore the sources of heterogeneity and to test the stability of the results, a sensitivity analysis was performed. Results: The systematic review found no significant differences in postoperative clinical outcomes in the elderly population when unicondylar replacement was performed in the setting of multiple factors such as injury, defects, longitudinal tear, and synovial bursa injury defined as ACL deficiency. The primary clinical outcomes included postoperative revision, Tegner activity score, and Oxford Knee Score (OKS). After statistical meta-analysis, postoperative outcomes such as postoperative revision (OR, 1.174; 95% CIs, 0.758-1.817) and Tegner activity score (OR, -0.084; 95% CIs, -0.320-0.151) were not statistically different. Conclusion: There was no difference in postoperative revision rates and functional outcomes such as Tegner activity score between the ACL-deficient group compared with the ACL-intact group. For the present results, it is not advisable to consider ACL deficiency as a contraindication of UKA.
摘要：
Background: The efficacy of a traditional anticancer drug is challenged by adverse effects of the drug, including its nonspecific bio-distribution, short half-life, and side effects. Dendrimer-based targeted drug delivery system has been considered a promising strategy to increase targeting ability and reduce adverse effects of anti-cancer drugs.<&wdkj&>Objective: This study analyzed the feasibility of whether the anticancer drug 5-fluorouracil (5-FU) could be delivered by functionalized fifth-poly(amidoamine) (PAMAM) with the peptide WP05 and the acetic anhydride to the liver cancer cells, reducing the toxicity of the PAMAM and improving the targeting property of 5-FU during delivery.<&wdkj&>Methods: The functionalized PAMAM-based nanoformulation (WP05-G5.0NHAC-FUA) was fabricated through an amide condensation reaction to improve the therapeutic efficacy of 5-Fluorouracil (5-FU) in hepatocellular carcinoma (HCC). The physicochemical structure, particle size, zeta potential, stability, and in vitro release characteristics of WP05-G5.0NHAC-FUA were evaluated. In addition, the targeting, biocompatibility, anti-proliferation, and anti-migration of WP05-G5.0NHAC-FUA were investigated. The anti-tumor effect of WP05-G5.0NHAC-FUA in vivo was evaluated by constructing xenograft tumor models of human hepatoma cells (Bel-7402) implanted in nude mice.<&wdkj&>Results: The resultant WP05-G5.0NHAC-FUA displayed spherical-like nanoparticles with a size of 174.20 ± 3.59 nm. Zeta potential and the drug loading of WP05-G5.0NHAC-FUA were 5.62 ± 0.41mV and 28.67 ± 1.25%, respectively. Notably, the optimized 5-FU-loaded formulation showed greater cytotoxicity with an IC50 of 30.80 ± 4.04 μg/mL than free 5-FU (114.93 ± 1.43 μg/mL) in Bel-7402 cancer liver cells, but a significantly reduced side effect relative to free 5-FU in L02 normal liver cells. In vivo animal study further confirmed efficient tumor accumulation and enhanced therapeutic efficiency.<&wdkj&>Conclusion: The developed nanoformulation is a promising platform for the targeting delivery of 5-FU and provides a promising solution for improving the efficacy of hepatocellular carcinoma chemotherapy.
期刊：
Reproductive Biology and Endocrinology,2022年20(1):1-13 ISSN：1477-7827
通讯作者：
Yang Xu<&wdkj&>Suyun Li
作者机构：
[Xu, Jie; Meng, Xingqi; Cao, Wenyu; Peng, Lixuan; Guo, Dongming; Li, Suyun] Univ South China, Hengyang Med Sch, Clin Anat & Reprod Med Applicat Inst, Hengyang 421001, Hunan, Peoples R China.;[Xu, Yang] Univ South China, Hengyang Med Sch, Dept Physiol, Hengyang 421001, Hunan, Peoples R China.
通讯机构：
[Yang Xu] D;[Suyun Li] C;Department of Physiology, Hengyang Medical School, University of South China, Hengyang, China<&wdkj&>Clinical Anatomy & Reproductive Medicine Application Institute, Hengyang Medical School, University of South China, Hengyang, China
期刊：
Journal of Ultrasound in Medicine,2022年41(6):1343-1353 ISSN：0278-4297
通讯作者：
Zhiyi Chen
作者机构：
[Wang, Ziyao; Liu, Zhenyu; Chen, Zhiyi] Univ South China, Affiliated Hosp 1, Med Imaging Ctr, Hengyang Med Sch, 69 Chuanshan Rd, Hengyang 421001, Peoples R China.;[Du, Meng; Chen, Zhiyi] Univ South China, Inst Med Imaging, Hengyang, Peoples R China.
通讯机构：
[Zhiyi Chen ] T;The First Affiliated Hospital, Medical Imaging Center, Hengyang Medical School, University of South China, Hengyang, China<&wdkj&>Institute of Medical Imaging, University of South China, Hengyang, China
摘要：
The incidence of infertility is continuously increasing nearly all over the world in recent years, and novel methods for accurate assessment are of great need. Artificial Intelligence (AI) has gradually become an effective supplementary method for the assessment of female reproductive function. It has been used in clinical follicular monitoring, optimum timing for transplantation, and prediction of pregnancy outcome. Some literatures summarize the use of AI in this field, but few of them focus on the assessment of female reproductive function by AI-aided ultrasound. In this review, we mainly discussed the applicability, feasibility, and value of clinical application of AI in ultrasound to monitor follicles, assess endometrial receptivity, and predict the pregnancy outcome of in vitro fertilization and embryo transfer (IVF-ET). The limitations, challenges, and future trends of ultrasound combined with AI in providing efficient and individualized evaluation of female reproductive function had also been mentioned.
作者机构：
[Liu, Ying; Wang, Weiguo; Yang, Lin; He, Jian; He, Dongxiu; Tian, Jinming] Univ South China, Inst Pharm & Pharmacol, Hengyang 421000, Hunan, Peoples R China.;[Liu, Ying; Wang, Weiguo; Yang, Lin; He, Jian; He, Dongxiu; Tian, Jinming] Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang, Hunan, Peoples R China.;[Liu, Ying; Wang, Weiguo; Yang, Lin; He, Jian; He, Dongxiu; Tian, Jinming] Hunan Xinhexin Biol Med Co Ltd, Pharm Grad Educ Innovat Base, Hengyang, Hunan, Peoples R China.;[Wu, Gui-Long] Univ South China, Med Instrument & Equipment Technol Lab, Hengyang Med Coll, Hengyang 421000, Hunan, Peoples R China.
通讯机构：
[Wang, WG ] U;Univ South China, Inst Pharm & Pharmacol, Hengyang 421000, Hunan, Peoples R China.;Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang, Hunan, Peoples R China.;Hunan Xinhexin Biol Med Co Ltd, Pharm Grad Educ Innovat Base, Hengyang, Hunan, Peoples R China.
摘要：
The urchin-like trimetallic nanozyme Pd-Pt-Ir was firstly prepared through atomic replication. Due to the high affinity to H2O2, the activity of Pd-Pt-Ir is higher than that of Pd-Pt. Based on this concept, Pd-Pt-Ir was applied for the detection of ascorbic acid and hydrogen peroxide. The linear range of ascorbic acid and hydrogen peroxide were 25-800 mu M and 3.9-62.5 mM, respectively, and the LODs were11.7 mu M and 3.6 mM, respectively. Furthermore, the Pd-Pt-Ir nanozyme was applied for the rapid detection of ascorbic acid, and a test strip was built. Ascorbic acid concentrations ranging from 0 to 31.2 mM were observed. Based on this work, the simple and rapid method proposed offers excellent application prospects for the detection of ascorbic acid and hydrogen peroxide.
期刊：
Journal of Radioanalytical and Nuclear Chemistry,2022年331(10):4179-4188 ISSN：0236-5731
通讯作者：
Zhenghua Xu
作者机构：
[Chen, Yifan; Lin, Dongyin; Dai, Xingwang; Chen, Yan] Univ South China, Sch Resource Environm & Safety Engn, Hengyang 421001, Hunan, Peoples R China.;[Chen, Yifan; Lin, Dongyin; Dai, Xingwang; Xu, Zhenghua; Liu, Yong; Chen, Yan] Hunan Prov Engn Technol Res Ctr Uranium Tailings, Hengyang 421001, Hunan, Peoples R China.;[Liu, Yong] Shenzhen Univ, Coll Phys & Optoelect Engn, Shenzhen 518060, Guangdong, Peoples R China.;[Xu, Zhenghua] Univ South China, Sch Math & Phys, Hengyang 421001, Hunan, Peoples R China.
通讯机构：
[Zhenghua Xu] H;Hunan Province Engineering Technology Research Centre of Uranium Tailings Treatment Technology, Hengyang, China<&wdkj&>School of Mathematics and Physics, University of South China, Hengyang, China
摘要：
Acceleration, displacement, stress response, and other dynamic response topics are currently the key topics of research. Because uranium tailings reservoirs are radioactive, earthquakes can also cause radon to be released. In order to monitor the acceleration response, displacement (both surface and interior), and radon exhalation rate of the dam body of the uranium tailings reservoir under various seismic peak accelerations, the shaker model test is used. When the peak acceleration is 0.7 g, the displacement swings even more visibly, and when the peak acceleration is 1.0 g, the surface of the dam shows clear fissures. However, the radon response will be quicker and stronger, and as the acceleration of the seismic peak keeps rising, the response gets stronger and stronger. As a result, the dynamic reaction can also be determined from the radon response. The findings of the tests can be used as a guide for the safe and stable operation of uranium tailings reservoirs.
通讯机构：
[Lijun Hu; Hongqing Wang] A;Authors to whom correspondence should be addressed.<&wdkj&>Hunan Key Laboratory for the Design and Application of Actinide Complexes, University of South China, Hengyang 421001, China<&wdkj&>School of Chemistry and Chemical Engineering, University of South China, Hengyang 421001, China
摘要：
Oxygen vacancy manipulation and hierarchical morphology construction in oxygen-containing semiconductors have been demonstrated to be effective strategies for developing high efficiency photocatalysts. In most studies of bismuth-based photocatalysts, hierarchical morphology and crystal defects are achieved separately, so the catalysts are not able to benefit from both features. Herein, using boiling ethylene glycol as the treatment solution, we developed an etching-recrystallization method for the fabrication of 3D hierarchical defective BiOCl at ambient pressure. The target hierarchical 3D-BiOCl is composed of self-assembled BiOCl nanosheets, which exhibit a hexagonal prism-like morphology on a micron scale, while simultaneously containing numerous oxygen vacancies within the crystal structure. Consequently, the target catalyst was endowed with a higher specific surface area, greater light harvesting capability, as well as more efficient separation and transfer of photo-excited charges than pristine BiOCl. As a result, 3D-BiOCl presented an impressive photocatalytic activity for the degradation of tetracycline hydrochloride in both visible light and natural white light emitting diode (LED) irradiation. Moreover, an extraordinary recycling property was demonstrated for the target photocatalyst thanks to its hierarchical structure. This study outlines a simple and energy-efficient approach for producing high-performance hierarchically defective BiOCl, which may also open up new possibilities for the morphological and crystal structural defect regulation of other Bi-based photocatalysts.
通讯机构：
[Shen, Lin; Deng, L; Liu, YN] C;Cent South Univ, Xiangya Hosp, Changsha 410008, Hunan, Peoples R China.;Cent South Univ, Coll Chem & Chem Engn, Hunan Prov Key Lab Micro & Nano Mat Interface Sci, Changsha 410083, Hunan, Peoples R China.
关键词：
black phosphorus nanosheets;lysozyme modification;MnO2 nanosheets;photodynamic therapy;radiotherapy
摘要：
Reactive oxygen species (ROS) can kill cancer cells in tumor therapy. However, the anticancer efficacy of ROS is generally suppressed by the reductive press in tumor microenvironment (TME). Herein, lysozyme (LZM) modified black phosphorous (BP) /manganese dioxide nanosheets (LZM@BP/MnO2 NSs, LBM) as an effective and biocompatible nanodrug platform for synergistic photodynamic-/radio- therapy are prepared. The controllable preparation of negatively charged MnO2 NSs is achieved through biomimetic mineralization strategy using bovine serum albumin (BSA) as a template. To facilitate the loading of BP on MnO2, lysozyme is used to modify BP to obtain positively charged BP NSs. The as-obtained LBM possess higher biostability and exhibit superior ROS generation efficiency to BP, owing to the alleviation of reductive species (i.e., GSH) in TME by the oxidation of MnO2. Moreover, LBM can be easily decomposed in the tumor sites, leading to the good biocompatibility both in vitro and in vivo. The amplified intracellular ROS generation properties of LBM assisted combination of photodynamic therapy and radiotherapy ultimately boost the synergistic therapeutic efficacy against cancer.
摘要：
Non-alcoholic fatty liver disease (NAFLD), recently re-defined and re-classified as metabolic dysfunction-associated fatty liver disease (MAFLD), has become increasingly prevalent and emerged as a public health problem worldwide. To date, the precise pathogenic mechanisms underpinning MAFLD are not entirely understood, and there is no effective pharmacological therapy for NAFLD/MAFLD. As a newly discovered form of iron-dependent programmed cell death, ferroptosis can be involved in the development and progression of various chronic diseases, but the pathogenic connections and mechanisms that link MAFLD and ferroptosis have not been fully elucidated. The main characteristics of ferroptosis are the accumulation of lipid peroxides and reactive oxygen species. In this brief narrative review, the mechanisms of ferroptosis and its putative pathogenic role in MAFLD are discussed to highlight potential new research directions and ideas for the prevention and treatment of MAFLD.
关键词：
6G Internet of Things (IoT);6G mobile communication;Computational modeling;Confident Information Coverage Model (CIC);Coverage Hole (CHs);Energy consumption;Internet of Things;Maintenance engineering;Mobile Edge Computing (MEC);Q-learning;QLearning;Reliability
关键词：
Solid waste treatment;Resource recycling;Biogas power generation;Environmental impact;Materials flow;Energy balance
摘要：
Extensive research has been conducted on the life cycle assessment of anaerobic digestion of food waste. However, few studies have evaluated the environmental impact of anaerobic digestion from a technical perspective. This study focuses on the environmental impact of using ionization radiation pretreatment technology in the anaerobic digestion of food waste and compares it with that of traditional hydrothermal pretreatment. Model construction, environmental impact assessment, and Monte Carlo simulation calculations were performed using the OpenLCA software. Data for the analysis were obtained from an actual plant in China, experiments, literature, and databases. The results show that the introduction of the proposed ionizing radiation pretreatment causes the treatment of food waste via anaerobic digestion to have the lowest environmental impact in 14 of the 18 categories analyzed. Pretreatment was found to be the most energy-consuming unit in food waste treatment, accounting for 71-75% of the total energy consumption. This research has an important guiding role in the development and application of ionizing radiation pretreatment technology for food waste.
作者：
Du, Meng;Li, Yue;Zhang, Qing;Zhang, Jiaming;Ouyang, Shuming;...
期刊：
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY,2022年174:41-49 ISSN：0079-6107
通讯作者：
Zhiyi Chen
作者机构：
[Du, Meng; Li, Yue; Chen, Zhiyi] Univ South China, Affiliated Hosp 1, Med Imaging Ctr, Hengyang Med Sch, Hengyang, Hunan, Peoples R China.;[Du, Meng; Li, Yue; Chen, Zhiyi; Zhang, Qing] Univ South China, Inst Med Imaging, Hengyang Med Sch, Hengyang, Peoples R China.;[Li, Yue] Guangzhou Med Univ, Lab Ultrasound Mol Imaging, Affiliated Hosp 3, Guangzhou, Peoples R China.;[Chen, Zhiyi; Zhang, Qing] Univ South China, Affiliated Hosp 7, Hunan Vet Adm Hosp, Hengyang Med Sch, Changsha, Hunan, Peoples R China.;[Ouyang, Shuming; Zhang, Jiaming] Univ South China, Affiliated Hosp 1, Ctr Reprod Med, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.
通讯机构：
[Zhiyi Chen] T;The First Affiliated Hospital, Medical Imaging Centre, Hengyang Medical School, University of South China, Hengyang, Hunan, China<&wdkj&>Institute of Medical Imaging, Hengyang Medical School, University of South China, Hengyang, China<&wdkj&>The Seventh Affiliated Hospital, Hunan Veterans Administration Hospital, Hengyang Medical School, University of South China, Changsha, Hunan, China
摘要：
Low intensity ultrasound (LIUS) has been adopted for a variety of therapeutic purposes because of its bioeffects such as thermal, mechanical, and cavitation effects. The mechanism of impact and cellular responses of LIUS in cellular regulations have been revealed, which helps to understand the role of LIUS in tumor treatment, stem cell therapy, and nervous system regulation. The review summarizes the bioeffects of LIUS at the cellular level and its related mechanisms, detailing the corresponding theoretical basis and latest research in the study of LIUS in the regulation of cells. In the future, the design of specific LIUS-mediated treatment strategies may benefit from promising investigations which is hoped to provide encouraging therapeutic data.
摘要：
Network lifetime and coverage are the key evaluation metrics of Wireless Sensor Networks (WSNs). Aiming at network lifetime, Hierarchical Clustering-task Scheduling Policy (HCSP) breaks the traditional clustering framework, but it doesnt fully consider the network coverage problem. We propose a Hierarchical Clustering Node Collaborative Scheduling (HCNCS) protocol that optimizes HCSP to extend the network lifetime and improves the coverage performance of WSNs by nodes collaborative sensing. According to the deployment location, HCNCS classifies nodes into Node Collaborative Sensing Disks(NCSDs), which as units for data sensing and transmission. Nodes are rotated in WSNs to balance the energy consumption and through collaborative sensing to improve the coverage of NCSDs. In addition, HCNCS constrains the number of clusters by NCSDs classification based on K-means to reduce the communication energy consumption of clustering. Based on the HCNCS, this paper further proposes an Enhanced Hierarchical Clustering Node Collaborative Scheduling (EHCNCS) protocol. Compared with HCNCS, EHCNCS selects NCSDs according to Node Collaborative Scheduling (NCS) algorithm after clustering, which improves the coverage capability of NCSDs at the cost of increasing a small amount of the communication energy consumption. EHCNCS also rotates Cluster Heads (CHs) by the CH rotation candidate table to balance network energy consumption. The extensive simulations show that HCNCS has an obvious advantage over HCSP in terms of network lifetime and network coverage. Compared with HCNCS, EHCNCS significantly prolongs the network lifetime of WSNs at the expense of a bit of coverage performance.
