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Betaine attenuate chronic restraint stress-induced changes in testicular damage and oxidative stress in male mice

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成果类型:
期刊论文
作者:
Meng, Xingqi;Peng, Lixuan;Xu, Jie;Guo, Dongming;Cao, Wenyu;...
通讯作者:
Yang Xu<&wdkj&>Suyun Li
作者机构:
[Xu, Jie; Meng, Xingqi; Cao, Wenyu; Peng, Lixuan; Guo, Dongming; Li, Suyun] Univ South China, Hengyang Med Sch, Clin Anat & Reprod Med Applicat Inst, Hengyang 421001, Hunan, Peoples R China.
[Xu, Yang] Univ South China, Hengyang Med Sch, Dept Physiol, Hengyang 421001, Hunan, Peoples R China.
通讯机构:
[Yang Xu] D
[Suyun Li] C
Department of Physiology, Hengyang Medical School, University of South China, Hengyang, China<&wdkj&>Clinical Anatomy & Reproductive Medicine Application Institute, Hengyang Medical School, University of South China, Hengyang, China
语种:
英文
关键词:
Betaine;Chronic restraint stress;Spermatogenic dysfunction;Oxidative stress
期刊:
Reproductive Biology and Endocrinology
ISSN:
1477-7827
年:
2022
卷:
20
期:
1
页码:
1-13
基金类别:
The present study was supported by the Natural Sciences Foundation of Hunan Province (No.2021JJ30593), the Scientific Research Key Funding Project (No. 19A428) of the Ministry of Education of China Hunan Foundation.
机构署名:
本校为第一机构
院系归属:
医学院
摘要:
Scope: Male fertility and sperm quality are negatively affected by psychological stress. Chronic restraint stress (CRS) is a common psychological stress that has a negative effect on sperm. Betaine (BET), an active ingredient isolated from Lycium barbarum, has anti-oxidant, anti-inflammatory and other pharmacological activities. This study aims to explore whether betaine has a therapeutic effect on sperm deformity and vitality under CRS and its mechanism. Methods and results: Chronic restraint stress was induced in 8-week-old male C57BL/6 J mic...

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