Oxygen-carrying biomimetic nanoplatform for sonodynamic killing of bacteria and treatment of infection diseases

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成果类型：

期刊论文

作者：

Geng, Xiaorui;Chen, Yuhao;Chen, Zhiyi;Wei, Xianyuan;Dai, Yunlu;...

通讯作者：

Yuan, Z

作者机构：

[Chen, Yuhao; Yuan, Zhen; Yuan, Z; Wei, Xianyuan; Dai, Yunlu; Geng, Xiaorui] Univ Macau, Fac Hlth Sci, Canc Ctr, Taipa, Macau, Peoples R China.

[Chen, Zhiyi] Univ South China, Affiliated Hosp 1, Med Imaging Ctr, Hengyang Med Sch, Hengyang, Hunan, Peoples R China.

[Chen, Zhiyi] Univ South China, Hengyang Med Sch, Inst Med Imaging, Hengyang, Peoples R China.

[Yuan, Zhen; Yuan, Z] Univ Macau, Ctr Cognit & Brain Sci, Taipa, Macau, Peoples R China.

通讯机构：

[Yuan, Z ] U

Univ Macau, Fac Hlth Sci, Canc Ctr, Taipa, Macau, Peoples R China.

Univ Macau, Ctr Cognit & Brain Sci, Taipa, Macau, Peoples R China.

语种：

英文

关键词：

Sonodynamic therapy;Metal organic frameworks (MOFs);Infection diseases;Nanomedicine;Hemoglobin;Multidrug-resistant (MDR) bacteria

期刊：

Ultrasonics Sonochemistry

ISSN：

1350-4177

年：

2022

卷：

页码：

105972

DOI：

10.1016/j.ultsonch.2022.105972

基金类别：

University of Macau [MYRG 2020-00067-FHS, MYRG2019-00082-FHS, MYRG2018-00081-FHS]; Macao Science and Technology Development Fund [FDCT 0011/2018/A1, FDCT 0020/2019/AMJ]; Guangdong Natural Science FoundationNational Natural Science Foundation of Guangdong Province [EF017/FHS-YZ/2021/GDSTCRSKTO]; Shenzhen Basic Research Project [JCYJ20180305125425815]; Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Sci-ence and Brain-Inspired Intelligence Fund [2019011]; [0020/2019/AMJ]

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摘要：

Among various novel antimicrobial therapies, sonodynamic therapy (SDT) exhibits its advantages for the treatment of bacterial infections due to its high penetration depth and low side effects. In this study, a new nanosonosensitizer (HFH@ZIF-8) that loads sonosensitizer hematoporphyrin monomethyl ether (HMME) into zeolitic imidazolate framework-8 (ZIF-8), was constructed for killing multidrug-resistant (MDR) bacteria and treatment of in vivo infection diseases by SDT. In particular, the developed HFH@ZIF-8 exhibited enhanced water-solubility, good biocompatibility, and improved disease-targeti...

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Oxygen-carrying biomimetic nanoplatform for sonodynamic killing of bacteria and treatment of infection diseases

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