摘要：
European Journal of Inflammation, Volume 20, Issue , January-December 2022. <br/>BackgroundAbdominal aortic aneurysm (AAA) is a potentially life-threatening vascular abnormality, that, if ruptured, is almost universally fatal without repair, and is associated with up to 50% mortality even if repaired in hospital. To date, there is no drug therapy that has clinically proven benefit to reduce or prevent expansion of AAA. The aim of this study was to investigate whether Daxx could affect AAA through inhibiting the PI3K/AKT/ID2 signaling pathway mediated by transforming growth factor β-1 (TGFβ1).MethodsThe AAA model was constructed by injecting angiotensin Ⅱ (Ang-Ⅱ) into rats, and the Daxx lentivirus vector was constructed. Hematoxylin and eosin (HE) staining was used to detect the wall thickness of the abdominal aorta in rats. The gene and protein expressions in abdominal aortic tissues were detected utilizing western blot, immunohistochemistry (IHC) and fluorescence quantitative real-time polymerase chain reaction (qRT-PCR). Finally, the concentration of TGF-β1 in abdominal aortic tissue was determined by ELISA.ResultsThe abdominal aortic wall thickness was decreased in the Daxx expression group (by HE staining), and Daxx overexpression markedly reduced the protein expression levels of MMP2 and MMP9. Proteins related to the PI3K/AKT/ID2 signaling pathway were highly enhanced in the aneurysm wall of rats, but were reduced following Daxx addition. Moreover, Daxx reduced the damage to elastin (by IHC), and the expression levels of α-SMA and SM22α were up-regulated by Daxx (by qRT-PCR). The concentration of TGF-β1 was correlated with the activation of the PI3K/AKT/ID2 signaling pathway (by ELISA), whereas AKT overexpression weakened the inhibitory effect of Daxx.ConclusionDaxx ameliorated several mechanisms that contributed to expansion of AAA suppressing the tissue concentration of TGF-β1, thereby inhibiting the activation of the PI3K/AKT/ID2 signaling pathway. This evidence might form the basis to develop a therapeutic target for AAA.
摘要：
Radiation-induced pulmonary fibrosis (RIPF) is a chronic and progressive respiratory tract disease characterized by collagen deposition. The pathogenesis of RIPF is still unclear. Type 2 alveolar epithelial cells (AT2), the essential cells that maintain the structure and function of lung tissue, are crucial for developing pulmonary fibrosis. Recent studies indicate the critical role of AT2 cell senescence during the onset and progression of RIPF. In addition, clearance of senescent AT2 cells and treatment with senolytic drugs efficiently improve lung function and radiation-induced pulmonary fibrosis symptoms. These findings indicate that AT2 cell senescence has the potential to contribute significantly to the innovative treatment of fibrotic lung disorders. This review summarizes the current knowledge from basic and clinical research about the mechanism and functions of AT2 cell senescence in RIPF and points to the prospects for clinical treatment by targeting senescent AT2 cells.
作者机构：
[Chen, Yang; Wang, Qian] Fujian Normal Univ, Sch Econ, Fuzhou 350117, Fujian, Peoples R China.;[Wang, Qian; Guan, Heshan] Univ South China, Sch Econ & Management & Law, Hengyang 421001, Peoples R China.;[Lyulyov, Oleksii; Pimonenko, Tetyana] Sumy State Univ, Dept Mkt, UA-40007 Sumy, Ukraine.
通讯机构：
[Tetyana Pimonenko] D;Department of Marketing, Sumy State University, 40007 Sumy, Ukraine<&wdkj&>Author to whom correspondence should be addressed.
关键词：
technological innovation efficiency;SBM-Tobit model;kernel density estimation
作者机构：
[Luo, Zeyu; Wen, Feng; Li, Junjun; Long, Xingxing; Cao, Yixiong; Luo, Cong] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Hematol, Hengyang, Peoples R China.
通讯机构：
[Cong Luo] D;Department of Hematology, The 1st Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, People’s Republic of China
通讯机构：
[Qian Li] K;Key Discipline Laboratory for National Defence of Biotechnology in Uranium Mining and Hydrometallurgy, Hengyang, China<&wdkj&>School of Resources and Environment and Safety Engineering, University of South China, Hengyang, China
通讯机构：
[Min Liu] C;College of Nuclear Science and Technology, University of South China, Hengyang, 421001 China
关键词：
cluster state;molecular field theory;Mossbauer spectroscopy;REBpB'O-1-p(3)
摘要：
This work determines the first calculation of the cluster state of the perovskite REFe1−xCrxO3 system based on magnetic calculations using molecular field theory, using GdFe0.5Cr0.5O3 as an example, and the calculations show that the system has some Fe‐ and Cr‐rich cluster behavior. The calculated results are verified by the Mossbauer spectra. This work has focused on the cluster state of B‐site ions in the rare‐earth perovskite REFepCr1−pO3, and GdFe0.5Cr0.5O3 is taken for instance. This analysis indicates a paramagnetic behavior of the system, which originates from the paramagnetic contribution of the Gd3+. An internal‐field model is used to simplify the superexchange interaction between the A/B‐sites. Furthermore, the cluster state of B‐site ions is computed using the average number of nearest‐neighborhoods. Using Marine Predator Algorithm to fit the experiment data, it is found that Fe–Cr interaction does not conform to the case of ferromagnetic superexchange; therefore, there is no spin glass behavior in this system. Via fitting the Mossbauer spectrum at low temperatures (120 and 12 K), the calculations described above are verified. The calculation gives the hyperfine‐field intervals ΔH of 2.47 and 0.92 T at 120 and 12 K. It is found that B‐site ions tend to form clusters. The arrangement of the ions is random and without the tendency of orderly interval occupation of ions (like double perovskite). The study sheds light on the mechanism of single‐ion clustering and introduces new methods for calculating single‐ion clustering states. It can also be applied to the case of other A‐site ions in perovskite system and is not just limited to p = 0.5 in REBpB’1−pO3.
期刊：
World Neurosurgery,2022年157:E301-E307 ISSN：1878-8750
通讯作者：
Peng, Jun
作者机构：
[Liu, Shucheng] Univ South China, Affiliated Hosp, Dept Urol, Hengyang City, Peoples R China.;[Peng, Jun] Univ South China, Affiliated Hosp, Dept Neurol, Hengyang City, Peoples R China.;[Wang, Yilin] Univ South China, Affiliated Nanhua Hosp, Dept Crit Care Med, Hengyang City, Peoples R China.;[Gao, Bin] Univ South China, Affiliated Nanhua Hosp, Dept Endocrinol, Hengyang City, Peoples R China.
通讯机构：
[Peng, Jun] U;Univ South China, Affiliated Hosp, Dept Neurol, Hengyang City, Peoples R China.
摘要：
BACKGROUND: The aim of this study was to develop and validate a nomogram for predicting the risk of venous thromboembolism among critically ill patients with primary intracerebral hemorrhage. METHODS: Patients aged ≥ 18 years with primary intracerebral hemorrhage within 24 hours of onset were screened from January 2019 to April 2021. Univariate and multivariate logistic regression analysis were performed to screen out the independent predictors that were significantly associated with venous thromboembolism. A nomogram was constructed based on the results of a multivariate regression analysis. Discrimination and calibration were used to evaluate its performance. A decision curve analysis was used to assess its clinical utility. RESULTS: A total of 369 patients were enrolled in this study. The nomogram included three predictors from the regression analysis: D-Dimer value, National Institute of Health Stroke Scale score and Glasgow Coma Scale score on admission. The area under the receiver operating characteristic curves was 0.794, indicating good discrimination of the nomogram. The nomogram demonstrated calibration curves with slight deviation from the ideal predictions. Decision curve analysis showed that the prediction nomogram was clinically useful. CONCLUSIONS: The nomogram composed of D-Dimer value, National Institute of Health Stroke Scale score and Glasgow Coma Scale score on admission can predict the risk of venous thromboembolism in critically ill patients with intracerebral hemorrhage accurately.
期刊：
Oxidative Medicine and Cellular Longevity,2022年2022:2281870 ISSN：1942-0900
通讯作者：
Luo, L.
作者机构：
[Yang, Zhen; Zeng, Lijin; Cai, Guoyi] Sun Yat Sen Univ, Affiliated Hosp 1, Div Emergency Med, Guangzhou, Peoples R China.;[Yang, Zhen; Zhang, Cong; Zeng, Lijin; Zhu, Yuanting] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Cardiol, Guangzhou, Peoples R China.;[Yang, Zhen; Zhang, Cong; Zeng, Lijin; Zhu, Yuanting] Sun Yat Sen Univ, NHC Key Lab Assisted Circulat, Guangzhou, Peoples R China.;[Zhang, Bin] Sun Yat Sen Univ, Jiangmen Cent Hosp, Dept Cardiovasc Dis, Affiliated Jiangmen Hosp, Jiangmen, Peoples R China.;[Zhang, Bin] Sun Yat Sen Univ, Jiangmen Cent Hosp, Clin Expt Ctr, Affiliated Jiangmen Hosp, Jiangmen, Peoples R China.
通讯机构：
Department of Critical Care Medicine, Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, China
摘要：
<i>Background</i>. Aging is an independent risk factor for heart failure (HF), and endothelial progenitor cell (EPC) function decreases with aging. Here, we further investigated whether age has a detrimental effect on circulating EPC function in HF with mildly reduced ejection fraction (HFmrEF) and its relationship with systemic inflammation. <i>Methods</i>. 58 HFmrEF patients were recruited. The adhesive, migrative, and proliferative activities of circulating EPCs, MAGGIC scores, and plasma interleukin (IL)-17 and IL-23 levels of these patients were assessed. <i>Results</i>. Older patients with HFmrEF had higher MAGGIC scores and lower circulating EPC adhesion, migration, and proliferation than younger patients. The similar tendency was observed in plasma IL-17 and IL-23 levels. The EPC functions were negatively associated with MAGGIC scores and plasma IL-17 or IL-23 levels. <i>Conclusions</i>. In patients with HFmrEF, aging leads to attenuated circulating EPC function, which is correlated with disease severity and systemic inflammation. The present investigation provides some novel insights into the mechanism and intervention targets of HFmrEF.
通讯机构：
[Li, Weiqin; Tong, Zhihui] D;Department of Critical Care Medicine, Jinling Hospital, Medical School of Nanjing University, No. 305 Zhongshan East Road, Nanjing, 210000, Jiangsu, China.;Department of Critical Care Medicine, Jinling Hospital, Nanjing Medical University, Nanjing, 210010, Jiangsu, China.;National Institute of Healthcare Data Science, Nanjing University, Nanjing, 210010, Jiangsu, China. . CN - Chinese Acute Pancreatitis Clinical Trials Group (CAPCTG)
作者机构：
[Li, Jun; Niu, Ting; Wang, Zhongwang; Liao, Dan; Wang, Fujue] Sichuan Univ, West China Hosp, Dept Hematol, Chengdu, Peoples R China.;[Liao, Dan] Third Hosp Mianyang, Dept Hematol, Mianyang, Sichuan, Peoples R China.;[Wang, Fujue] Univ South China, Affiliated Hosp 1, Dept Hematol, Hengyang, Peoples R China.;[Li, Yueshan; Xiong, Yu] Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu, Peoples R China.;[Li, Yueshan; Xiong, Yu] Sichuan Univ, West China Hosp, Canc Ctr, Chengdu, Peoples R China.
通讯机构：
[Niu, Ting] S;Sichuan Univ, West China Hosp, Dept Hematol, Chengdu, Peoples R China.
关键词：
Receptor-interacting protein kinase-1;acute myeloid leukemia;FLT3-ITD;chidamide;necroptosis
摘要：
Acute myeloid leukemia (AML) with FLT3-ITD mutation accounts for a large proportion of relapsed/refractory AML with poor prognosis. RIPK1 is a known key regulator of necroptosis and RIPK1 inhibition shows anti-AML effects in vitro. Chidamide is a histone deacetylase inhibitor (HDACi) with proven ability to induce apoptosis in FLT3-ITD positive AML cells. In the present study, we evaluated the effects of the combination of 22b, a novel RIPK1 inhibitor, and chidamide on proliferation and apoptosis in FLT3-ITD positive AML cell lines and primary cells. The results showed that 22b could significantly enhance the anti-leukemia effect of low-dose chidamide both on cell lines and primary cells. In a subcutaneous xenograft AML model, the combination of 22b and chidamide exhibited obviously elevated anti-tumor activity. In conclusion, our results support that the combination of RIPK1 inhibitor 22b and chidamide may be a novel therapeutic avenue for FLT3-ITD positive AML patients.
作者机构：
[Liu, Shengyun; Zhang, Yuqi; Li, Wei; Li, Tianfang] Zhengzhou Univ, Affiliated Hosp 1, Dept Rheumatol, 1 Jianshe East Rd, Zhengzhou 450052, Henan, Peoples R China.;[Wang, Yan] Zhengzhou Univ, Affiliated Hosp 1, Dept Resp & Crit Care Med, 1 Jianshe East Rd, Zhengzhou 450052, Henan, Peoples R China.;[He, Feng; Liu, Zhuo] Capital Inst Pediat, Dept Biochem & Immunol, 2 Yabao Rd, Beijing 100020, Peoples R China.;[Dong, Jie] Hunan Childrens Hosp, Pediat Res Inst Hunan Prov, Changsha, Peoples R China.;[Chen, En] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Lab Med, Hengyang 421001, Hunan, Peoples R China.
通讯机构：
[Shengyun Liu; En Chen] D;Department of Rheumatology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China<&wdkj&>Department of Laboratory Medicine, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, China
期刊：
JOURNAL OF NURSING ADMINISTRATION,2022年52(3):160-166 ISSN：0002-0443
通讯作者：
Liu, H.-P.
作者机构：
[Zhang, Xin; Feng, Ting-ting; Liu, Di; Liu, Hua-ping] Chinese Acad Med Sci & Peking Union Med Coll, Sch Nursing, Beijing, Peoples R China.;[Tan, Ling-ling] Univ South China, Affiliated Hosp 2, Nursing Dept, Hengyang, Hunan, Peoples R China.;[Dai, Li-cao] Univ South China, Inst Human Factors & Ergon, Hengyang, Hunan, Peoples R China.
通讯机构：
33 Ba Da Chu Rd, Shijingshan District, Beijing, China
摘要：
OBJECTIVES The aim of this study was to depict a comprehensive description of near miss research and clarify research gaps. BACKGROUND Learning from near miss can provide early warnings and is critical for proactive and prospective risk management. Because of the lack of structured reviews, there is little knowledge about how near miss management has been managed in the past. METHODS This review was conducted following the Arksey and O'Malley's methodology and reported by the PRISMA Extension for Scoping Reviews. RESULTS Sixty-seven research articles were included. The results revealed that the most investigated fields include near miss reporting, near miss characteristics, and good catch project. Poor theoretical investigation, underreporting, and inconsistent outcome indicators are major problems. CONCLUSIONS Solely understanding causes of near misses cannot guarantee effective learning; we also need to apply appropriate learning theories. Advanced technologies should be applied to solve long-standing underreporting issues. Accurate and consistent indicators should be applied in near miss research and management.
摘要：
Visual inspection techniques for rail surface defects have become prevalent approaches to obtain information on rail surface damage. However, uneven illumination leads to illegibility of local information, and the change of the wheel-rail area results in the changeful background of the rail surface, both of which pose challenges to the visual inspection. This paper proposes a novel algorithm that detects rail surface defects via partitioned edge features (PEF). PEF eliminates the effect of uneven illumination by effectively extracting edge features and building homogeneous background on the rail surface. In the process of edge feature extraction, the thresholding based on adaptive partition of rail surface (APRS) plays an indispensable role. In APRS, the rail surface is adaptively partitioned into three types of regions according to the wheel-rail contact degree. After that, the dynamic threshold is set adaptively for each region type on the basis of the prior information of defect proportion. Subsequently, based on neighborhood information and fuzzy decision, the spatial information of adjacent pixels and the direction information of fracture edges are utilized to realize the effective recovery of incomplete defect contours. In addition, defect contours are precisely filled via a flexible combination of morphological hole filling operation and defect region extraction based on improved background difference. The accuracy of this PEF algorithm was confirmed by experiments and comparisons with related algorithms. The experiment results show that PEF detects defects with 92.03% recall and 88.49% precision, which achieves higher accuracy than the established detection algorithms for rail surface defects.
