Targets and mechanisms of Alpinia oxyphylla Miquel fruits in treating neurodegenerative dementia

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成果类型：

期刊论文

作者：

Zeng, Peng;Liu, Yuan-Cheng;Wang, Xiao-Ming;Ye, Chao-Yuan;Sun, Yi-Wen;...

通讯作者：

Tian, Q.;Li, M.

作者机构：

[Wang, Xiao-Ming; Li, Man; Ye, Chao-Yuan; Tian, Qing; Zeng, Peng; Liu, Yuan-Cheng; Qiu, Shuo-Wen; Sun, Yi-Wen; Su, Hong-Fei] Huazhong Univ Sci & Technol, Sch Basic Med Tongji Med Coll, Key Lab Neurol Dis Natl Educ Minist, Wuhan, Peoples R China.

[Zeng, Peng] Univ South China, Hengyang Med Coll, Sch Basic Med, Dept Histol & Embryol, Hengyang, Peoples R China.

[Li, Ya-Nan; Wang, Yan-Chun; Wang, Yao; Ma, Jun] Hubei Univ Chinese Med, Coll Acupuncture & Orthoped, Wuhan, Peoples R China.

通讯机构：

[Li, M.; Tian, Q.] K

Key Laboratory of Neurological Disease of National Education Ministry, China

语种：

英文

关键词：

acetylcholinesterase;Alpinia oxyphylla Miquel;amyloid-β;neurodegenerative dementia;tau

期刊：

FRONTIERS IN AGING NEUROSCIENCE

ISSN：

1663-4365

年：

2022

卷：

页码：

1013891

DOI：

10.3389/fnagi.2022.1013891

基金类别：

This work was supported by grants from the National Natural Science Foundation of China (82041478) and the Health Committee of Hubei Province (ZY2021M041). The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results.

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

The dried and ripe fruits of Alpinia oxyphylla and ripe fruits of Alpinia oxyphylla Miquel (AO) have the effects of tonifying kidney-essence and nourishing intelligence and thus have been widely used in treating dementia. Alzheimer’s disease (AD) is a typical form of neurodegenerative dementia with kidney-essence deficiency in Traditional Chinese Medicine (TCM). So far, there is a lack of systematic studies on the biological basis of tonifying kidney-essence and nourishing intelligence and the corresponding phytochemicals. In this study, we in...

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Targets and mechanisms of Alpinia oxyphylla Miquel fruits in treating neurodegenerative dementia

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