作者机构：
[CHEN, X; LIAO, DF] HUNAN MED UNIV,DEPT PHARMACOL,CHANGSHA 410078,PEOPLES R CHINA.;[LIAO, DF] HENGYANG MED COLL,DEPT PHARMACOL,HENGYANG 421001,PEOPLES R CHINA.
通讯机构：
[LIAO, DF] H;HENGYANG MED COLL,DEPT PHARMACOL,HENGYANG 421001,PEOPLES R CHINA.
摘要：
We report here the protective effect of the angiotensin converting enzyme inhibitors captopril and ramiprilat against damage due to oxygen free radicals on aortic endothelium in a superfusion cascade system. Oxygen free radicals were generated by electrolysis of Krebs solution. Acetylcholine was infused through the donor aortic segment and relaxation of the detector aortic ring was used to indicate the release of endothelium-derived relaxing factor (EDRF). The percentage of relaxation before and after electrolysis was compared to calculate the relaxation index. Electrolyzed Krebs solution impaired the release of EDRF, as shown by a reduction in the relaxation index with a concomitant decrease in the tissue levels of superoxide dismutase and 6-keto PGF1 alpha and increase in malondialdehyde in the donor vessel. Captopril (100 microM), 15 microM ramiprilat and 30 nM iloprost had a protective effect as shown by a significantly smaller reduction in the relaxation index and the level of 6-keto PGF1 alpha and by an attenuation of the production of malondialdehyde. In addition, 1 microM indomethacin almost eliminated the protection by captopril. We conclude that both the SH-containing angiotensin-converting enzyme inhibitor captopril and the non-SH-containing ramiprilat, as well as iloprost, a stable analog of prostacyclin, can protect rabbit aortic endothelium against damage due to oxygen free radicals. The mechanism of such protection may be partly associated with the facilitation of the release of prostacyclin and consequent reduction in lipid peroxidation.
作者机构：
[MA, W] South China Univ of China, Guangzhou, China
通讯机构：
[MA, W] S;S CHINA UNIV CHINA,DEPT RADIO ENGN,GUANGZHOU 510641,PEOPLES R CHINA.
关键词：
SIGNAL PROCESSING;TRANSFORMS
摘要：
The minimal number of real multiplications necessary to compute a length-2/sup m/ two-dimensional discrete cosine transform is determined. The method of derivation shows that the polynomial transform computation and the Chebyshev transform computation of a 2D DCT have the same multiplicative complexity.<
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期刊：
Electromagnetic Biology and Medicine,1988年7(1):97-102 ISSN：1536-8378
通讯作者：
LIU, YH
作者机构：
LIAN YUAN STEEL PLANT,STAFF & WORKERS HOSP,HUNAN,PEOPLES R CHINA.;HENGYANG MED COLL,TEACHING HOSP 2,HUNAN,PEOPLES R CHINA.;[LIU, YH] HUNAN TEACHERS UNIV,DEPT BIOL,HUNAN,PEOPLES R CHINA.
通讯机构：
[LIU, YH] H;HUNAN TEACHERS UNIV,DEPT BIOL,HUNAN,PEOPLES R CHINA.
