期刊论文

Min, Junxia;Wang, Fudi

英文

CELL DEATH AND DIFFERENTIATION

1350-9047

2022

29

3

467-480

10.1038/s41418-022-00941-0

We thank Drs. Yilong Zou, Boyi Gan, Li Jiang, and Yingying Yu for helpful discussion, and we apologize to our colleagues whose valuable contributions were not cited in this manuscript due entirely to space limitations. This study was supported by research grants from the National Natural Science Foundation of China (31970689 to J.M. and 31930057 to F.W.), the National Key R&D Program of China (2018YFA0507801 to J.M. and 2018YFA0507802 to F.W.).

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Ferroptosis is an iron-dependent form of non-apoptotic cell death characterized by excessive lipid peroxidation and associated with a plethora of pathological conditions in the liver. Emerging evidence supports the notion that dysregulated metabolic pathways and impaired iron homeostasis play a role in the progression of liver disease via ferroptosis. Although the molecular mechanisms by which ferroptosis causes disease are poorly understood, several ferroptosis-associated genes and pathways have been implicated in liver disease. Here, we revie...