Nanoarchitectonics with Two-Dimensional Black Phosphorus and MnO2 for Synergistic Photodynamic-/Radiotherapy Against Cancer through Enhanced Reactive Oxygen Species Activity

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Liu, Renyu;Sheng, Jiangping;Zeng, Ke;Deng, Yuanyuan;Deng, Liu*;...

通讯作者：

Shen, Lin;Deng, Liu;Liu, You-Nian

作者机构：

[Deng, Yuanyuan; Liu, Renyu; Shen, Lin] Cent South Univ, Xiangya Hosp, Changsha 410008, Hunan, Peoples R China.

[Sheng, Jiangping; Zeng, Ke; Deng, Liu; Liu, You-Nian] Cent South Univ, Coll Chem & Chem Engn, Hunan Prov Key Lab Micro & Nano Mat Interface Sci, Changsha 410083, Hunan, Peoples R China.

[Sheng, Jiangping] Univ Elect Sci & Technol China, Sch Resources & Environm, Chengdu 611731, Sichuan, Peoples R China.

[Zeng, Ke] Univ South China, Coll Chem & Chem Engn, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Shen, Lin; Deng, L; Liu, YN] C

Cent South Univ, Xiangya Hosp, Changsha 410008, Hunan, Peoples R China.

Cent South Univ, Coll Chem & Chem Engn, Hunan Prov Key Lab Micro & Nano Mat Interface Sci, Changsha 410083, Hunan, Peoples R China.

语种：

英文

关键词：

black phosphorus nanosheets;lysozyme modification;MnO2 nanosheets;photodynamic therapy;radiotherapy

期刊：

Advanced Therapeutics

ISSN：

2366-3987

年：

2022

卷：

期：

页码：

2100210-

DOI：

10.1002/adtp.202100210

基金类别：

This work was supported by the National Natural Science Foundation of China (Nos. 21878342 and 21807117), the Hunan Provincial Science and Technology Plan Project, China (Nos. 2019TP1001 and 2020JJ3044).

机构署名：

本校为其他机构

院系归属：

化学化工学院

摘要：

Reactive oxygen species (ROS) can kill cancer cells in tumor therapy. However, the anticancer efficacy of ROS is generally suppressed by the reductive press in tumor microenvironment (TME). Herein, lysozyme (LZM) modified black phosphorous (BP) /manganese dioxide nanosheets (LZM@BP/MnO2 NSs, LBM) as an effective and biocompatible nanodrug platform for synergistic photodynamic-/radio- therapy are prepared. The controllable preparation of negatively charged MnO2 NSs is achieved through biomimetic mineralization strategy using bovine serum albumin (BSA) as a template. To facilitate the loading of...

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Nanoarchitectonics with Two-Dimensional Black Phosphorus and MnO2 for Synergistic Photodynamic-/Radiotherapy Against Cancer through Enhanced Reactive Oxygen Species Activity

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