摘要：
Capsaicin is the main active ingredient of chili peppers and the most pungent alkaloid. It is reported that capsaicin has many pharmacological effects such as analgesia, anticancer, anti-inflammatory, antibacterial, and anti-obesity. However, the application of capsaicin is limited by its adverse side effects, such as stomach irritation, stomach cramps, and burning sensation. In recent years, many capsaicin derivatives have been synthesized and their biological activities have been evaluated. Some capsaicin derivatives have shown promising activities in cells and animal models. Herein, we described the synthesis and biological activity of capsaicin and its derivatives. It is hoped that the insights obtained in this perspective will facilitate the synthesis of a second generation of capsaicin analogs with improved biological activities.
作者机构：
[Fang, Hongyi; Ke, Weijun; Pu, Dexin; Guan, Hongling; Zhou, Shun; Chen, Guoyi; Fang, Guojia; Fu, Shiqiang; Ke, WJ; Jia, Peng; Wang, Chen] Wuhan Univ, Sch Phys & Technol, Key Lab Artificial Micro & Nanostruct, Minist Educ, Wuhan 430072, Peoples R China.;[Jumabaev, Abduvakhid; Hushvaktov, Hakim] Samarkand State Univ, 15 Univ Blvd, Samarkand 140104, Uzbekistan.;[Meng, Weiwei] South China Normal Univ, South China Acad Adv Optoelect, Guangzhou 510006, Peoples R China.;[Wang, Xingzhu; Wang, XZ] Southern Univ Sci & Technol, Dept Mat Sci & Engn, Shenzhen 518055, Peoples R China.;[Wang, Xingzhu; Wang, XZ] Univ South China, Sch Elect Engn, Hengyang 421001, Peoples R China.
通讯机构：
[Meng, WW ; Wang, XZ ; Jumabaev, A ] S;[Ke, WJ ] W;Wuhan Univ, Sch Phys & Technol, Key Lab Artificial Micro & Nanostruct, Minist Educ, Wuhan 430072, Peoples R China.;Samarkand State Univ, 15 Univ Blvd, Samarkand 140104, Uzbekistan.;South China Normal Univ, South China Acad Adv Optoelect, Guangzhou 510006, Peoples R China.
关键词：
blade coating;large area;strain;tandem solar cells;wide-bandgap perovskites
摘要：
Blade‐coated wide‐bandgap perovskites encounter top–down inhomogeneity strains. Utilizing mixed‐cation post‐treatment for strain relief, large‐area wide‐bandgap solar cells demonstrate enhanced efficiency and stability. Specifically, 1 cm2‐area 1.77 eV‐bandgap cells achieve an 18.71% efficiency (stabilized at 18.50%), while 4‐terminal all‐perovskite tandems reach an exceptional 27.64% efficiency, coupled with enhanced stability. Abstract The realization of efficient large‐area perovskite solar cells stands as a pivotal milestone for propelling their future commercial viability. However, the upscaling fabrication of perovskite solar cells is hampered by efficiency losses, and the underlying growth mechanism remains enigmatic. Here, it is unveiled that a prevalent upscaling technology, namely blade‐coating, inherently triggers top‐down inhomogeneity strains, predominantly concentrated on the surface of wide‐bandgap perovskite films. Through strain mitigation strategies, the perovskite films exhibit reduced halide vacancies, leading to enhanced stability and improved optoelectronic characteristics. Consequently, the blade‐coated perovskite solar cells achieve minimal efficiency loss when transitioning from small‐area to large‐area devices, enabling the realization of 1 cm2‐area 1.77 eV‐bandgap cells with a remarkable efficiency of 18.71%. Additionally, the strain‐relieved device exhibits an exceptional 109% retention of its initial efficiency even after 400 h of continuous operation, in stark contrast to the control device which experiences a decline to 91%. Furthermore, the resulting 4‐terminal all‐perovskite tandem solar cells crafted utilizing blade‐coated 1.77 eV‐bandgap subcells achieve a maximum efficiency of 27.64% (stabilized at 27.28%). This study not only sheds light on the intricacies of upscaling preparation techniques but also overcomes potential obstacles that can impede the trajectory toward achieving large‐scale perovskite solar cells.
摘要：
In order to improve the utilization of spent fuel, molten salt electrolysis is used to separate lanthanides from spent fuel. The electrochemical reduction mechanism of Ce(III) ions and dynamic properties of Ce(III)/Ce(0) were provided in the LiCl-KCl molten salt by diversified electrochemical techniques. The diffusion coefficient of Ce(III) and the exchange current densities of Ce(III)/Ce(0) on the W electrode were calculated by cyclic vol-tammetry and linear polarization, and the reaction activation energy was calculated to be 30.8 kJ center dot mol-1. The electrochemical behaviors were measured in the LiCl-KCl-CeCl3-K2ZrF6 molten salt on the W electrode and LiCl-KCl-CeCl3 molten salt on the Zr electrode at 753 K. The redox mechanism of Ce(III) ions was studied on the Zr electrode. Compared the reaction at different electrodes, the reduction potential of cerium on the Zr electrode is more correct than that on the W electrode, the underpotential displacement of cerium and zirconium due to the formation of alloy is 0.26 V, which was detecteted using cyclic voltammetry, square wave voltammetry and chronopotentiometry. In addition, the feasibility of extracting Ce on the Zr electrode by potentiostatic elec-trolysis at-1.9 V and-2.2 V in the LiCl-KCl molten salt. The cathodic deposition output was characterized by XRD and SEM-EDS, Ce-Zr solid solution was derived under the different conditions. Simultaneously, the Ce metal was discovered when the deposition potential at-2.2 V. The ICP-OES results showed that the extraction ratio of was about 94.02 % for Ce(III) after potentiostatic electrolysis at-2.2 V for 5 h.
摘要：
Diabetic nephropathy (DN) is one of the most serious and general complications of diabetes, while schedules for prevention and treatment are unsatisfactory. Leucine aminopeptidase (LAP) as one of the biomarkers of DN is associated with glomerular and/or tubular injury. Imaging of LAP activity in DN disease model in vivo is thus beneficial for early diagnosis and prevention of DN, but such a strategy is still lacking. Herein, an enzyme-activated probe HD-LAP with a NIR fluorescence emission for specific detection of LAP activity in the DN model is designed and synthesized. HD-LAP has a significant fluorescence enhancement after reacted with LAP and shows a NIR fluorescence emission at 704 nm based on intramolecular charge transfer mechanism. Moreover, HD-LAP can be employed to image LAP activity in HK-2 and HepG2 cells. More importantly, HD-LAP is the first example to real-time image LAP in DN mice and clinical serum samples. These results demonstrated that HD-LAP is promising as a powerful tool for the research on LAP associated diabetic diseases in future.
摘要：
Neutralizing antibodies are a key component in protective humoral immunity against SARS-CoV-2. Currently, available technologies cannot track epitope-specific antibodies in global antibody repertoires. Thus, the comprehensive repertoire of spike-specific neutralizing antibodies elicited by SARS-CoV-2 infection is not fully understood. We therefore combined high-throughput immunoglobulin heavy chain (IgH) repertoire sequencing, and structural and bioinformatics analysis to establish an antibodyomics pipeline, which enables tracking spike-specific antibody lineages that target certain neutralizing epitopes. We mapped the neutralizing epitopes on the spike and determined the epitope-preferential antibody lineages. This analysis also revealed numerous overlaps between immunodominant neutralizing antibody-binding sites and mutation hotspots on spikes as observed so far in SARS-CoV-2 variants. By clustering 2677 spike-specific antibodies with 360 million IgH sequences that we sequenced, a total of 329 shared spike-specific antibody clonotypes were identified from 33 COVID-19 convalescents and 24 SARS-CoV-2-naïve individuals. Epitope mapping showed that the shared antibody responses target not only neutralizing epitopes on RBD and NTD but also non-neutralizing epitopes on S2. The immunodominance of neutralizing antibody response is determined by the occurrence of specific precursors in human naïve B-cell repertoires. We identified that only 28 out of the 329 shared spike-specific antibody clonotypes persisted for at least 12 months. Among them, long-lived IGHV3-53 antibodies are likely to evolve cross-reactivity to Omicron variants through accumulating somatic hypermutations. Altogether, we created a comprehensive atlas of spike-targeting antibody lineages in COVID-19 convalescents and antibody precursors in human naïve B cell repertoires, providing a valuable reference for future vaccine design and evaluation.
期刊：
NEW JOURNAL OF CHEMISTRY,2024年48(6):2855-2865 ISSN：1144-0546
通讯作者：
Sun, YK;Sun, Yunkai;Yang, PF
作者机构：
[Ding, Yi; Sun, Yunkai] Changzhou Inst Technol, Sch Chem Engn & Mat, Changzhou 213032, Peoples R China.;[Yang, Pengfei; Liu, Cheng; Sun, Yunkai; Yin, Na] Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.;[Ding, Yi; Sun, Yunkai] Changzhou Inst Technol, Ind Coll Carbon Fiber & New Mat, Changzhou 213032, Peoples R China.
通讯机构：
[Sun, YK ] C;[Sun, YK; Yang, PF ] U;Changzhou Inst Technol, Sch Chem Engn & Mat, Changzhou 213032, Peoples R China.;Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.;Changzhou Inst Technol, Ind Coll Carbon Fiber & New Mat, Changzhou 213032, Peoples R China.
摘要：
Nanoscale zero-valent iron (nZVI) was cured by vulcanization and biochar functionalization to overcome the tendency of oxidation and aggregation, and the sulfurized nano-zero-valent iron functional material supported by amino biochar (SnZVI-BC-NH2) was obtained, which was used to remove U(VI) from wastewater in this study. A variety of measurements (SEM, TEM, XRD, BET, VSM, FT-IR, and XPS) were used to characterize the morphology, structure, magnetic properties, characteristic functional groups and chemical bonds of SnZVI-BC-NH2. Analysis results confirm that the aminated biochar can support sulfurized nZVI well. The good kinetics, thermodynamics, and large removal capacity data (at pH 6, T = 298 K, Q(m) = 158.1 mg g(-1)) indicate that SnZVI-BC-NH2 has excellent removal performance for U(VI), and the experimental data are in good agreement with the pseudo-second-order kinetic model. Cycling and anti-oxidation tests demonstrate that the FeSx shell plays a crucial role in enhancing the removal of SnZVI-BC-NH2 on U(VI). XPS and FT-IR analysis results show that SnZVI-BC-NH2 removes U(VI) through the synergistic effect of adsorption and reduction.
期刊：
FRONTIERS IN NEUROLOGY,2024年15:1322228 ISSN：1664-2295
通讯作者：
Zhu, Shuzhen;Wang, Q
作者机构：
[Zhu, Shuzhen; Li, Fangyi; Zhang, Wenjie; Deng, Bin; Zhu, SZ; Wang, Qing; Zhou, Hang; Wang, Q; Weng, Guomei; Luo, Yuqi] Southern Med Univ, Dept Neurol, Zhujiang Hosp, Guangzhou, Peoples R China.;[Li, Fangyi] Univ South China, Affiliated Changsha Cent Hosp, Hengyang Med Sch, Dept Neurol, Changsha, Peoples R China.;[Weng, Guomei] First Peoples Hosp Zhaoqing, Dept Neurol, Zhaoqing, Peoples R China.;[Tao, Xi] Hunan Normal Univ, Hunan Prov Peoples Hosp, Dept Neurol Rehabil, Affiliated Hosp 1, Changsha, Peoples R China.;[Deng, Mingzhu] Brain Hosp Hunan Prov, Peoples Hosp Hunan Prov 2, Dept Neurol, Changsha, Peoples R China.
通讯机构：
[Wang, Q ; Zhu, SZ] S;Southern Med Univ, Dept Neurol, Zhujiang Hosp, Guangzhou, Peoples R China.
关键词：
Parkinson’s disease;inflammation;lymphocyte-to-monocyte ratio;neutrophil-to-high-density lipoprotein ratio;neutrophil-to-lymphocyte ratio
摘要：
BACKGROUND: Inflammation plays a pivotal role in the pathogenesis of Parkinson's disease (PD). However, the correlation between peripheral inflammatory markers and the severity of PD remains unclear. METHODS: The following items in plasma were collected for assessment among patients with PD (n = 303) and healthy controls (HCs; n = 303) were assessed for the neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR) and neutrophil-to-high-density-lipoprotein ratio (NHR) in plasma, and neuropsychological assessments were performed for all patients with PD. Spearman rank or Pearson correlation was used to evaluate the correlation between the NLR, the LMR and the NHR and the severity of PD. Receiver operating characteristic (ROC) curves were used to evaluate the diagnostic performance of the NLR, LMR and NHR for PD. RESULTS: The plasma NLR and NHR were substantially higher in patients with PD than in HCs, while the plasma LMR was substantially lower. The plasma NLR was positively correlated with Hoehn and Yahr staging scale (H&Y), Unified Parkinson's Disease Rating Scale (UPDRS), UPDRS-I, UPDRS-II, and UPDRS-III scores. Conversely, it exhibited a negative relationship with Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) scores. Furthermore, the plasma NHR was positively correlated with H&Y, UPDRS, UPDRS-I, UPDRS-II and UPDRS-III scores. Moreover, negative associations were established between the plasma LMR and H&Y, UPDRS, UPDRS-I, UPDRS-II, and UPDRS-III scores. Finally, based on the ROC curve analysis, the NLR, LMR and NHR exhibited respectable PD discriminating power. CONCLUSION: Our research indicates that a higher NLR and NHR and a lower LMR may be relevant for assessing the severity of PD and appear to be promising disease-state biomarker candidates.
摘要：
BACKGROUND: Depression is a highly prevalent comorbidity arising in patients with Parkinson's disease (PD). However, depression in patients with PD is poorly treated. Hydrogen sulfide (H(2)S), a neuromodulator, has the potential to relieve depression. OBJECTIVE: To investigate whether H(2)S attenuates depression-like behaviours in a rat model of PD and examine the underlying mechanisms. METHODS: We utilised rotenone to develop a PD model with subcutaneous injections in the dorsal cervical region of Sprague-Dawley rats. The depression-like behaviours in the rotenone-induced PD model rats were assessed through forced swimming, tail suspension, open field, novelty-suppressed feeding, and elevated plus-maze tests. The expression of postsynaptic density protein-95 and synapsin-1, related to synaptic plasticity, was detected using Western blot in the hippocampus. The hippocampal ultrastructure, including the synaptic density, length of the synaptic active zone, postsynaptic density thickness, and synaptic gap width, was detected using transmission electron microscopy. RESULTS: We proved that sodium hydrosulfide (NaHS; a donor of H(2)S) significantly attenuated the depression-like behaviours and disorders of hippocampal synaptic plasticity in rotenone-induced PD rats. Furthermore, inhibition of the hippocampal Warburg effect by 2-deoxyglucose abolished NaHS-enhanced hippocampal synaptic plasticity and reversed NaHS-attenuated depression-like behaviours in the rotenone-induced PD rats. CONCLUSION: H(2)S attenuates PD-associated depression by improving the hippocampal synaptic plasticity in a hippocampal Warburg effect-dependent manner.
摘要：
Electrochemical conversion of nitrate offers an efficient solution to nitrate pollution and a sustainable strategy for ammonia generation. Cu and Fe bimetallic electrocatalysts exhibit excellent electrochemical reduction of nitrate (NO3RR) reactivity but the conventional preparation strategy is complex and time-consuming and this reaction is still suffers from unsatisfied kinetic and unidentified mechanisms. Herein, in situ electrodeposition strategy is employed to induce Cu to modify the Fe active sites of iron-based N-doping carbon nanofiber electrode (Fe/Fe3C@NCNFs) during NO3RR in Cu-contained nitrate solution. Benefiting from the synergistic effect between Cu and Fe sites of CuFe/Fe3C@NCNFs electrode, superior activity of rate-determining reaction (*NO(3 )to *NO2) and reduced energy barriers of the following deoxidation and hydrogenation steps are achieved. Compared with Fe/Fe3C@NCNFs-500, the pseudo-first-order (PFO) rate constant for NO3RR by CuFe/Fe3C@NCNFs demonstrates nearly two-fold improvement with high current efficiencies over wide pH and voltage range. Furthermore, the maximum NO3N removal capacity and N-2 selectivity of CuFe/Fe3C@NCNFs reach 15593.8 mg N g(-1) Fe and ca. 92% after twenty cycles. This work offers an avenue for highly active bimetallic electrode design, paving more insights into the interactions between active site construction and NO3RR performance.
关键词：
Germanium;Tartaric acid;Selective separation;Column separation;D201 x 7 resin
摘要：
Germanium (Ge) exhibits excellent optical and electrical properties. Due to the low reserves of Ge and lack of independent mineral resources, zinc refinery residues have become an important source of Ge. In this work, a D201 x 7 resin has been employed in the selective separation of Ge from a sulfuric solution using tartaric acid as a complexing agent. In the sulfuric acid system, Ge(OH)4 was converted to an anionic complex [GeO2(OH)2C4H4O4]2- at a 1:1 tartaric acid to Ge molar ratio. The anion exchange D201 x 7 resin adsorbed the Ge tartrate anionic complex. The adsorption process exhibited pseudo-second-order kinetic behavior and adhered to the Langmuir isothermal adsorption model. The maximum adsorption capacity of D201 x 7 resin for Ge was 214 mg g-1. Selective Ge uptake and purification could proceed by column separation The results showed that enrichment factor was 74.7, and the desorption concentration of Ge was increased from 500 mg L-1 to 36.6 g L-1. The D201 x 7 resin exhibited high selectivity, excellent adsorption performance and good stability, making it a viable candidate in industrial applications.
摘要：
This paper presents a theoretical solution for bond-slip behavior of SRC interface based on experiment, numerical simulation, and theoretical derivation. Push-out tests of five specimens were firstly carried out, based on which, the simplified bond-slip model was proposed. The specimen was fabricated using the Q345H-shape steel (400 mm x 200 mmx13 mm x 8 mm) and C50 concrete (350 mm x 600 mm) with a bonding length of 500 mm. A FE model was established based on the bond-slip model to analyze the nonlinear bonding stress that are difficult to obtain from the experiment. The research shows that although the bonding stress in the elastic stage is not uniformly distributed, it is basically uniformly distributed when the ultimate bearing capacity is reached. It proves that assuming the average interfacial bonding stress under ultimate load to replace the maximum bonding stress is reasonable, which is crucial for designer to estimate interface bearing capacity and maximum bonding stress. Moreover, five different stages were obtained by the FE model analysis and the theoretical equations of bonding stress nonlinear distribution were obtained based on the boundary condition of each stage. The theoretical solution clearly showed the relationship between interface nonlinear stress distribution and influencing parameters including the bond area, elasticity modulus of material, section area of specimen, bond-slip constitutive model, and the external load. Based on the theoretical model, the influences of different parameters can be directly obtained without conducting further experiments and establishing different FE models.
摘要：
Sleep deprivation (SD) is a global public health burden, and has a detrimental role in the nervous system. Retina is an important part of the central nervous system; however, whether SD affects retinal structures and functions remains largely unknown. Herein, chronic SD mouse model indicated that loss of sleep for 4 months could result in reductions in the visual functions, but without obvious morphologic changes of the retina. Ultrastructural analysis by transmission electron microscope revealed the deterioration of mitochondria, which was accompanied with the decrease of multiple mitochondrial proteins in the retina. Mechanistically, oxidative stress was provoked by chronic SD, which could be ameliorated after rest, and thus restore retinal homeostasis. Moreover, the supplementation of two antioxidants, α-lipoic acid and N-acetyl-l-cysteine, could reduce retinal reactive oxygen species, repair damaged mitochondria, and, as a result, improve the retinal functions. Overall, this work demonstrated the essential roles of sleep in maintaining the integrity and health of the retina. More importantly, it points towards supplementation of antioxidants as an effective intervention strategy for people experiencing sleep shortages.
摘要：
ATP-binding cassette protein A1 (ABCA1) is a key protein in the transport of intracellular cholesterol to the extracellular and plays an important role in reduc-ing cholesterol accumulation in surrounding tissues. Bibliometric analysis refers to the cross-science of quan-titative analysis of a variety of documents by mathemati-cal and statistical methods. It combines an analysis of structural and temporal patterns in scholarly publica-tions with a description of topic concentration and types of uncertainty. This paper analyzes the history, hotspot, and development trend of ABCA1 through bibliometrics. It will provide readers with the research status and development trend of ABCA1 and help the hot research in this field explore new research directions. After screening, the research on ABCA1 is still in a hot phase in the past 20 years. ABCA1 is emerging in previously unrelated disciplines such as cancer. There were 551 key-words and 6888 breakout citations counted by CiteSpace. The relationship between cancer and cardiovascular dis-ease has been linked by ABCA1. This review will guide readers who are not familiar with ABCA1 research to quickly understand the development process of ABCA1 and provide researchers with a possible future research focus on ABCA1. (Curr Probl Cardiol 2024;49:102036.)
作者机构：
[Dai, Hailu; He, Shoucheng] Yancheng Inst Technol, Sch Mat Sci & Engn, Yancheng 224051, Peoples R China.;[Bi, Lei] Univ South China, Sch Resource Environm & Safety Engn, Hengyang 421001, Peoples R China.
通讯机构：
[Bi, L ] U;Univ South China, Sch Resource Environm & Safety Engn, Hengyang 421001, Peoples R China.
关键词：
Sb doping;Cathode;LaFeO3;PCFCs;SOFCs
摘要：
The La0.5Sr0.5FeO3-delta (LSF) material is modified with Sb doping to improve the performance of conventional LSF cathode for protonic ceramic fuel cells (PCFCs). The Sb cations can be inserted into the LSF lattice to develop a new composition La0.5Sr0.5Fe0.9Sb0.1O3-delta (LSFSb), which reduces the formation energy of oxygen vacancies and lowers the proton migration energy of the Sb-doped material when compared to the Sb-free LSF. Additional experimental findings reveal that Sb doping enhances the proton/oxygen transport and surface exchange kinetics. The fuel cell with the LSFSb cathode has a substantially higher peak power density of 933 mW cm-2 at 700 degrees C than the LSF cell, which only reaches 606 mW cm-2 under the same testing conditions. Using the LSFSb composite cathode further improved the fuel-cell performance, resulting in a promising fuel cell performance of 1388 mW cm-2, which is high for LSF-based PCFCs, thus demonstrating that LSFSb is a suitable cathode for PCFCs.
作者机构：
[Zeng, Huilan] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Ophthalmol, Hengyang 421001, Hunan, Peoples R China.;[Wadkins, David; Mayberry, Jordan E.; Kuehn, Markus H.; Chen, Nathan] Univ Iowa, Dept Ophthalmol & Visual Sci, Iowa City, IA 52242 USA.;[Wadkins, David; Mayberry, Jordan E.; Kuehn, Markus H.; Chen, Nathan] Iowa City VA Ctr Prevent & Treatment Visual Loss, Iowa City, IA 52246 USA.;[Summers, Daniel W.] Univ Iowa, Dept Biol, Iowa City, IA 52242 USA.
通讯机构：
[Kuehn, MH ] U;Univ Iowa, Dept Ophthalmol & Visual Sci, Iowa City, IA 52242 USA.;Iowa City VA Ctr Prevent & Treatment Visual Loss, Iowa City, IA 52246 USA.
摘要：
Glaucoma is one of the leading causes of irreversible blindness worldwide and vision loss in the disease results from the deterioration of retinal ganglion cells (RGC) and their axons. Metabolic dysfunction of RGC plays a significant role in the onset and progression of the disease in both human patients and rodent models, highlighting the need to better define the mechanisms regulating cellular energy metabolism in glaucoma. This study sought to determine if Sarm1, a gene involved in axonal degeneration and NAD+ metabolism, contributes to glaucomatous RGC loss in a mouse model with chronic elevated intraocular pressure (IOP). Our data demonstrate that after 16weeks of elevated IOP, Sarm1 knockout (KO) mice retain significantly more RGC than control animals. Sarm1 KO mice also performed significantly better when compared to control mice during optomotor testing, indicating that visual function is preserved in this group. Our findings also indicate that Sarm1 KO mice display mild ocular developmental abnormalities, including reduced optic nerve axon diameter and lower visual acuity than controls. Finally, we present data to indicate that SARM1 expression in the optic nerve is most prominently associated with oligodendrocytes. Taken together, these data suggest that attenuating Sarm1 activity through gene therapy, pharmacologic inhibition, or NAD+ supplementation, may be a novel therapeutic approach for patients with glaucoma.
期刊：
Scandinavian Journal of Immunology,2024年99(3):e13357- ISSN：0300-9475
通讯作者：
Lei, AH;Zhang, HJ
作者机构：
[Long, WeiXiang; Lei, AH; Lei, Aihua; Dai, Zhongling; Liu, Duo; Gong, Zhande; Wang, Cui] Univ South China, Inst Pathogen Biol, Sch Basic Med Sci, Hengyang Med Sch, 28 Changsheng Western Rd, Hengyang 421001, Hunan, Peoples R China.;[Long, WeiXiang; Lei, Aihua; Dai, Zhongling; Liu, Duo; Gong, Zhande; Wang, Cui] Univ South China, Hunan Prov Key Lab Special Pathogens Prevent & Con, Hengyang, Peoples R China.;[Long, WeiXiang; Lei, Aihua; Dai, Zhongling; Liu, Duo; Gong, Zhande; Wang, Cui] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dru, Hengyang, Peoples R China.;[Zhang, Haijun] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Cardiol, 69 Chuanshan Ave, Hengyang 421000, Hunan, Peoples R China.
通讯机构：
[Lei, AH ; Zhang, HJ ] U;Univ South China, Inst Pathogen Biol, Sch Basic Med Sci, Hengyang Med Sch, 28 Changsheng Western Rd, Hengyang 421001, Hunan, Peoples R China.;Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Cardiol, 69 Chuanshan Ave, Hengyang 421000, Hunan, Peoples R China.
关键词：
allergic airway inflammation;hormones;ILC2s
摘要：
Group 2 innate lymphoid cells (ILC2s) are a type of innate immune cells that produce a large amount of IL-5 and IL-13 and two cytokines that are crucial for various processes such as allergic airway inflammation, tissue repair and tissue homeostasis. It is known that damaged epithelial-derived alarmins, such as IL-33, IL-25 and thymic stromal lymphopoietin (TSLP), are the predominant ILC2 activators that mediate the production of type 2 cytokines. In recent years, abundant studies have found that many factors can regulate ILC2 development and function. Hormones synthesized by the body's endocrine glands or cells play an important role in immune response. Notably, ILC2s express hormone receptors and their proliferation and function can be modulated by multiple hormones during allergic airway inflammation. Here, we summarize the effects of multiple hormones on ILC2-driven allergic airway inflammation and discuss the underlying mechanisms and potential therapeutic significance.
摘要：
BACKGROUND: Neuronal ferroptosis plays a critical role in the pathogenesis of cognitive deficits. The present study explored whether artemisinin protected type 2 diabetes mellitus (T2DM) mice from cognitive impairments by attenuating neuronal ferroptosis in the hippocampal CA1 region. METHODS: STZ-induced T2DM mice were treated with artemisinin (40 mg/kg, i.p.), or cotreated with artemisinin and Nrf2 inhibitor MEL385 or ferroptosis inducer erastin for 4 weeks. Cognitive performance was determined by the Morris water maze and Y maze tests. Hippocampal ROS, MDA, GSH, and Fe(2+) contents were detected by assay kits. Nrf2, p-Nrf2, HO-1, and GPX4 proteins in hippocampal CA1 were assessed by Western blotting. Hippocampal neuron injury and mitochondrial morphology were observed using H&E staining and a transmission electron microscope, respectively. RESULTS: Artemisinin reversed diabetic cognitive impairments, decreased the concentrations of ROS, MDA and Fe(2+), and increased the levels of p-Nr2, HO-1, GPX4 and GSH. Moreover, artemisinin alleviated neuronal loss and ferroptosis in the hippocampal CA1 region. However, these neuroprotective effects of artemisinin were abolished by Nrf2 inhibitor ML385 and ferroptosis inducer erastin. CONCLUSION: Artemisinin effectively ameliorates neuropathological changes and learning and memory decline in T2DM mice; the underlying mechanism involves the activation of Nrf2 to inhibit neuronal ferroptosis in the hippocampus.
摘要：
Uranium mining operations produce large volumes of acidic uranium mining wastewater, necessitating the development of environmentally friendly and recyclable materials for efficient uranium removal and recovery. The current study successfully produced hydroxyapatite (HAP-L) and magnetic phosphate composites (CaFeP-1, CaFeP-2, and FePO4) through a combination of mixing, ultrasonication, hydrothermal precipitation, and calcination methods. The research explores the influence of various parameters such as pH, solid-liquid ratio, contact time, initial uranium concentration, co-existing ions, and recyclability on the uranium removal efficiency of these materials. The findings indicate exceptional uranium adsorption capacities, with CaFeP-1 exhibiting the highest capacity among the materials, especially in acidic environments. Moreover, CaFeP-1 displays strong resistance to interference from other ions and can be recycled multiple times while maintaining high removal rates. Treatment of acidic uranium mining wastewater by CaFeP-1 results in pH adjustment and the reduction of uranium and other ion concentrations, making it a promising solution for comprehensive remediation of acidic uranium mining wastewater. The U(VI) removal mechanism by CaFeP-1 was validated through XRD, FT-IR, and XPS results. The U(VI) removal was attributed to processes such as dissolution-precipitation, surface complexation, and ion exchange. The formation of sodium uranyl phosphate hydrate was identified as a new product following U(VI) abatement by CaFeP-1. In summary, CaFeP-1 shows great potential for the effective treatment of acidic uranium mining wastewater.
作者机构：
[Fu, Lichun; Zhen, Deshuai; Yang, Jing; Xiong, Lihao; Luo, Chunhua] Hengyang Market Supervis Inspect & Testing Ctr, Hengyang 421001, Peoples R China.;[Zhen, Deshuai; Xiong, Lihao; Yang, Fei] Univ South China, Sch Publ Hlth, Hengyang 421001, Peoples R China.;[Gao, Linxiao; Zhen, Deshuai; Luo, Xiaohu] Qiannan Normal Univ Nationalities, Engn Res Ctr Loss Efficacy & Anticorros Mat Guizho, Sch Chem & Chem Engn, Duyun 558000, Peoples R China.;[Zhou, Huang] Huaihua Univ, Coll Chem & Mat Engn, Huaihua 418000, Peoples R China.;[Yang, Lixia] Nanchang Hangkong Univ, Key Lab Jiangxi Prov Persistent Pollutants Control, Nanchang 330063, Peoples R China.
通讯机构：
[Gao, LX] Q;[Zhen, DS ] H;Hengyang Market Supervis Inspect & Testing Ctr, Hengyang 421001, Peoples R China.;Univ South China, Sch Publ Hlth, Hengyang 421001, Peoples R China.;Qiannan Normal Univ Nationalities, Engn Res Ctr Loss Efficacy & Anticorros Mat Guizho, Sch Chem & Chem Engn, Duyun 558000, Peoples R China.
关键词：
Yb@TiO2;Perfluorooctane Sulfonate;Tetrabromobisphenol A;Contaminants;SELDI-TOF MS
摘要：
Ytterbium modified TiO2 nanoparticles (Yb@TiO2), synthesized by a sol-gel process, were employed as an efficient adsorbent and matrix for the analysis of Perfluorooctane sulfonate (PFOS) and Tetrabromobisphenol A (TBBPA) via surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS). The detection limits for PFOS and TBBPA are achievement with 0.01 pg center dot mL-1. The results of the analysis of camellia oil samples show good recovery (80.3%-86.8%) with a low detection limit for TBBPA.
通讯机构：
[Chen, GD; Wu, DC ] U;Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Hepatopancreatobiliary Surg,Lab Struct Immuno, Hengyang 421001, Hunan, Peoples R China.
关键词：
Combination therapy;Therapeutic cancer vaccine;Tumor antigen
摘要：
Therapeutic cancer vaccines have shown promising efficacy in helping immunotherapy for cancer patients, but the systematic characterization of the clinical application and the method for improving efficacy is lacking. Here, we mainly summarize the classification of therapeutic cancer vaccines, including protein vaccines, nucleic acid vaccines, cellular vaccines and anti-idiotypic antibody vaccines, and subdivide the above vaccines according to different types and delivery forms. Additionally, we outline the clinical efficacy and safety of vaccines, as well as the combination strategies of therapeutic cancer vaccines with other therapies. This review will provide a detailed overview and rationale for the future clinical application and development of therapeutic cancer vaccines.
