Engineering a highly selective leucine aminopeptidase near-infrared fluorescence probe for early diagnosis of diabetic nephropathy

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成果类型：

期刊论文

作者：

Liu, Yin;Liu, Xinru;Liu, Qian;Li, Donghong;Cheng, Dan;...

通讯作者：

He, LW;Cheng, D

作者机构：

[He, LW; Liu, Yin; He, Longwei; Li, Donghong; Liu, Xinru] Univ South China, Sch Pharmaceut Sci, Hengyang Med Sch, Postdoctoral Res Stn Basic Med, Hengyang 421001, Hunan, Peoples R China.

[Cheng, Dan; Liu, Qian] Univ South China, Affiliated Nanhua Hosp, Clin Res Inst, Hunan Prov Clin Res Ctr Metab Associated Fatty Liv, Hengyang 421002, Hunan, Peoples R China.

通讯机构：

[He, LW ; Cheng, D ] U

Univ South China, Sch Pharmaceut Sci, Hengyang Med Sch, Postdoctoral Res Stn Basic Med, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Affiliated Nanhua Hosp, Clin Res Inst, Hunan Prov Clin Res Ctr Metab Associated Fatty Liv, Hengyang 421002, Hunan, Peoples R China.

语种：

英文

关键词：

Diabetic nephropathy;Leucine aminopeptidase;Fluorescent probe;Near -infrared;High selectivity

期刊：

Sensors and Actuators B-Chemical

ISSN：

0925-4005

年：

2024

卷：

402

页码：

135127

DOI：

10.1016/j.snb.2023.135127

基金类别：

CRediT authorship contribution statement Li Donghong: Data curation, Formal analysis, Investigation. Liu Qian: Data curation, Formal analysis, Investigation. Cheng Dan: Conceptualization, Data curation, Formal analysis, acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing. He Longwei: Conceptualization, Data curation, Formal analysis, acquisition, Investigation, Methodology, Project administration, Resources,

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Diabetic nephropathy (DN) is one of the most serious and general complications of diabetes, while schedules for prevention and treatment are unsatisfactory. Leucine aminopeptidase (LAP) as one of the biomarkers of DN is associated with glomerular and/or tubular injury. Imaging of LAP activity in DN disease model in vivo is thus beneficial for early diagnosis and prevention of DN, but such a strategy is still lacking. Herein, an enzyme-activated probe HD-LAP with a NIR fluorescence emission for specific detection of LAP activity in the DN model is designed and synthesized. HD-LAP has a signific...

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Engineering a highly selective leucine aminopeptidase near-infrared fluorescence probe for early diagnosis of diabetic nephropathy

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