Loss of Sarm1 reduces retinal ganglion cell loss in chronic glaucoma

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成果类型：

期刊论文

作者：

Zeng, Huilan;Mayberry, Jordan E.;Wadkins, David;Chen, Nathan;Summers, Daniel W.;...

通讯作者：

Kuehn, MH

作者机构：

[Zeng, Huilan] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Ophthalmol, Hengyang 421001, Hunan, Peoples R China.

[Wadkins, David; Mayberry, Jordan E.; Kuehn, Markus H.; Chen, Nathan] Univ Iowa, Dept Ophthalmol & Visual Sci, Iowa City, IA 52242 USA.

[Wadkins, David; Mayberry, Jordan E.; Kuehn, Markus H.; Chen, Nathan] Iowa City VA Ctr Prevent & Treatment Visual Loss, Iowa City, IA 52246 USA.

[Summers, Daniel W.] Univ Iowa, Dept Biol, Iowa City, IA 52242 USA.

通讯机构：

[Kuehn, MH ] U

Univ Iowa, Dept Ophthalmol & Visual Sci, Iowa City, IA 52242 USA.

Iowa City VA Ctr Prevent & Treatment Visual Loss, Iowa City, IA 52246 USA.

语种：

英文

关键词：

Axonal degeneration;Glaucoma;NAD+ metabolism;Neuroprotection;RGC loss;SARM1;Sarm1

期刊：

Acta Neuropathologica Communications

ISSN：

2051-5960

年：

2024

卷：

期：

页码：

DOI：

10.1186/s40478-024-01736-9

基金类别：

U.S. Department of Veterans Affairs

机构署名：

本校为第一机构

摘要：

Glaucoma is one of the leading causes of irreversible blindness worldwide and vision loss in the disease results from the deterioration of retinal ganglion cells (RGC) and their axons. Metabolic dysfunction of RGC plays a significant role in the onset and progression of the disease in both human patients and rodent models, highlighting the need to better define the mechanisms regulating cellular energy metabolism in glaucoma. This study sought to determine if Sarm1, a gene involved in axonal degeneration and NAD+ metabolism, contributes to glaucomatous RGC loss in a mouse model with chronic el...

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Loss of Sarm1 reduces retinal ganglion cell loss in chronic glaucoma

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