摘要：
Theoretical investigations are conducted to examine the impact of toroidal rotation and ion collisional viscosity on low-frequency zonal flow (LFZF) in a tokamak plasma with the fluid model. The results indicate that while the frequency of LFZF remains unchanged during an isothermal process with gamma=1, its damping rate is influenced by both toroidal rotation and ion collisional viscosity. Specifically, as the ion collisional viscosity increases, so does the damping rate of LFZF; conversely, as the toroidal rotation As its Mach number rises, its damping rate decreases. For a non-isothermal process with gamma > 1 (such as gamma = 5/3), the damping rate and frequency of LFZF are influenced by both toroidal rotation and ion collisional viscosity. It has been demonstrated that when the toroidal rotation Mach number surpasses a certain threshold, the frequency transitions from zero to a finite value, while the damping rate decreases as the toroidal rotation Mach number increases for LFZF. Furthermore, it has been observed that the damping rate of LFZF increases while the frequency decreases with an increase in ion collisional viscosity. Moreover, when the ion collisional viscosity surpasses a certain threshold, the frequency of LFZF drops to zero.
摘要：
One of the key features of cancer is energy metabolic reprogramming which is tightly related to cancer proliferation, invasion, metastasis, and chemotherapy resistance. NcRNAs are a class of RNAs having no protein-coding potential and mainly include microRNAs, lncRNAs and circRNAs. Accumulated evidence has suggested that ncRNAs play an essential role in regulating cancer metabolic reprogramming, and the altered metabolic networks mediated by ncRNAs primarily drive carcinogenesis by regulating the expression of metabolic enzymes and transporter proteins. Importantly, accumulated research has revealed that dysregulated ncRNAs mediate metabolic reprogramming contributing to the generation of therapeutic tolerance. Elucidating the molecular mechanism of ncRNAs in cancer metabolic reprogramming can provide promising metabolism-related therapeutic targets for treatment as well as overcome therapeutic tolerance. In conclusion, this review updates the latest molecular mechanisms of ncRNAs related to cancer metabolic reprogramming.
作者机构：
[Wang, YB; Wang, Youbin; Li, Yongkun; Zhou, Jiashun; Zhou, Bingtao] Guangxi Univ, Sch Resources Environm & Mat, State Key Lab Featured Met Mat & Life Cycle Safety, Nanning 530004, Peoples R China.;[Wang, YB; Wang, Youbin; He, Kezhun] Guangxi Alnan Inst Aerosp Transit Aluminum Alloy &, Nanning 530031, Peoples R China.;[Wei, Yuezhou] Univ South China, Sch Nucl Sci & Technol, Hengyang 421001, Peoples R China.
通讯机构：
[Wang, YB ] G;Guangxi Univ, Sch Resources Environm & Mat, State Key Lab Featured Met Mat & Life Cycle Safety, Nanning 530004, Peoples R China.;Guangxi Alnan Inst Aerosp Transit Aluminum Alloy &, Nanning 530031, Peoples R China.
摘要：
In order to enhance the corrosion resistance of 6061 Al, a simple and efficient electrodeposition method for one-step preparation of ZnAlCe layered double hydroxides (LDH) protective film was proposed. The microstructure and corrosion resistance of LDH film were characterized. The results indicated that the presence of Ce promoted the growth of LDH, resulting in denser, thicker ZnAlCe-LDH film, which effectively slowed down the corrosion rate of 6061Al. Particularly, the electrodeposition behavior was investigated in situ using electrochemical quartz crystal microbalance. The electrodeposition of LDH films was divided into rapid deposition of hydroxide and nucleation growth of LDH, and these two processes were described in detail. This work provided novel ideas for the preparation of LDH films on Al alloys.
作者机构：
[Xu, Changjin; Xu, CJ] Guizhou Univ Finance & Econ, Guizhou Key Lab Econ Syst Simulat, Guiyang 550004, Peoples R China.;[Liu, Zixin; Pang, Yicheng] Guizhou Univ Finance & Econ, Sch Math & Stat, Guiyang 550025, Peoples R China.;[Shen, Jianwei] North China Univ Water Resources & Elect Power, Sch Math & Stat, Zhengzhou 450046, Peoples R China.;[Liao, Maoxin] Univ South China, Sch Math & Phys, Hengyang 421001, Peoples R China.;[Li, Peiluan] Henan Univ Sci & Technol, Sch Math & Stat, Luoyang 471023, Peoples R China.
通讯机构：
[Xu, CJ ] G;Guizhou Univ Finance & Econ, Guizhou Key Lab Econ Syst Simulat, Guiyang 550004, Peoples R China.
关键词：
ergodic theory;markov Process;hessian matrix;Ito formula
摘要：
In the literature [16], the COVID-19 model has been constructed using deterministic approach. The present manuscript examines a stochastic model designed to capture the interplay between COVID-19 and varying infection rates on disease dynamics. We present the necessary criteria for a global solution to the considered model to exist and be unique. To illustrate several outcomes pertaining to the ergodic properties of the given system, the we utilize nonlinear analysis. Furthermore, the model undergoes simulation and is compared with deterministic dynamics. To verify the efficacy of the considered model and demonstrate its utility, we compare the dynamics of the infected population to real statistical data from multiple countries, such as the United Kingdom, Australia, Spain, and India. The proposed model has proven to be a reliable and effective tool for understanding the intricate nature of COVID-19 dynamics. Moreover, we provide a visually striking depiction of the impact of different infection rates on the propagation of the model under investigation. This visualization provides valuable insight into the multifaceted nature of the pandemic and significantly contributes to the comprehension of COVID-19 dynamics.
作者机构：
[Yu, Miao; Guo, Xin; Zhang, Kai] Sichuan Univ, Sch Mech Engn, Chengdu 610065, Peoples R China.;[Yu, Miao; Guo, Xin; Zhang, Kai] Sichuan Univ, Yibin Ind Technol Res Inst, Yibin 644000, Peoples R China.;[Kang, Xiaomin] Univ South China, Sch Mech Engn, Hengyang 421001, Peoples R China.;[Zhang, Song] Moutai Inst, Dept Food Sci & Engn, Renhuai 564502, Guizhou, Peoples R China.;[Qian, Lu; Qian, L] South China Univ Technol, Sch Mat Sci & Engn, Guangzhou 510641, Peoples R China.
通讯机构：
[Zhang, S ] M;[Qian, L ] S;Moutai Inst, Dept Food Sci & Engn, Renhuai 564502, Guizhou, Peoples R China.;South China Univ Technol, Sch Mat Sci & Engn, Guangzhou 510641, Peoples R China.
摘要：
Hyaluronic acid (HA), a vital glycosaminoglycan in living organisms, possesses remarkable mechanical and viscoelastic properties that have garnered significant attention in therapeutic, biomedical, and cosmetic applications. However, a comprehensive picture of the physicochemical and biocharacterization of HA at the single-molecule level remains elusive. In this work, atomic force microscopy (AFM)-based single-molecule force spectroscopy (SMFS) and molecular dynamics (MD) simulation were used to investigate the nanomechanics and water retention properties of HA at the single-molecule level. The present study aims to unravel the intricate details of the influence of molecular structure on HA behavior and shed light on its unique attributes. According to the force measurements, the energy used to stretch a HA chain in water is 8.45 kJ/mol, significantly surpassing that of Curdlan (3.45 kJ/mol) and chitin (2.23 kJ/mol), both of which possess molecular structures partially similar to that of HA. Intriguingly, the strength of the intrachain interaction of HA (5.54 kJ/mol) was considerably weaker compared to Curdlan (11.06 kJ/mol) and chitin (or cellulose, 10.76 kJ/mol). This result indicates that HA exhibits a preference for interacting with water rather than with itself, thereby showing enhanced water affinity. Moreover, the force measurements demonstrated that changing the glycosidic bond from β-(1-3) (Curdlan) or β-(1-4) (chitin or cellulose) to β-(1-3) + β-(1-4) (HA) resulted in polysaccharides displaying improved water affinity and more extended conformation. These conclusions were further verified by molecular dynamics (MD) simulations. Overall, our work sheds new light on the nanomechanics and water retention properties of HA at the single-molecule level, offering valuable insights for future research in this field.
作者机构：
[Wei, Rui; Liu, Qingqing; Luo, Jun-Li; Wei, R; Sun, Yangqing; Luo, JL] Cent South Univ, Xiangya Hosp, Dept Oncol, Changsha 410008, Peoples R China.;[Zhong, Shangwei; Luo, Jun-Li; Luo, JL] Univ South China, Affiliated Hosp 2, Canc Res Inst, Hengyang Med Sch, Hengyang 421001, Peoples R China.;[Luo, Jun-Li; Luo, JL] Hunan Prov Maternal & Child Hlth Care Hosp, Natl Hlth Commiss, Key Lab Birth Defect Res & Prevent, Changsha 410008, Peoples R China.
通讯机构：
[Wei, R; Luo, JL ] C;Cent South Univ, Xiangya Hosp, Dept Oncol, Changsha 410008, Peoples R China.;Univ South China, Affiliated Hosp 2, Canc Res Inst, Hengyang Med Sch, Hengyang 421001, Peoples R China.;Hunan Prov Maternal & Child Hlth Care Hosp, Natl Hlth Commiss, Key Lab Birth Defect Res & Prevent, Changsha 410008, Peoples R China.
关键词：
FTSJ1;tumor promotor;CD8+T cell infiltration;triple-negative breast cancer
摘要：
Simple Summary In this study, we found that high FTSJ1 expression in triple-negative breast cancer patients was associated with poor prognosis and was associated with reduced infiltration of CD8+T cells in the tumor microenvironment. By knocking down FTSJ1, we observed an inhibitory effect on the proliferation and migration of triple-negative breast cancer, while inducing apoptosis and increasing the sensitivity of TNBC cells to T-cell-mediated cytotoxicity. This finding highlights the importance of FTSJ1 as a potential immunotherapy target in triple-negative breast cancer.Abstract FtsJ RNA 2 '-O-methyltransferase 1 (FTSJ1) is a member of the methyltransferase superfamily and is involved in the processing and modification of ribosomal RNA. We herein demonstrate that FTSJ1 favors TNBC progression. The knockdown of FTSJ1 inhibits TNBC cell proliferation and development, induces apoptosis of cancer cells, and increases the sensitivity of TNBC cells to T-cell-mediated cytotoxicity. Furthermore, the high expression of FTSJ1 in TNBC attenuates CD8+T cell infiltration in the tumor microenvironment (TME) correlated with poorer prognosis for clinical TNBC patients. In this study, we establish that FTSJ1 acts as a tumor promotor, is involved in cancer immune evasion, and may serve as a potential immunotherapy target in TNBC.
摘要：
OBJECTIVE: How different surgical procedures, including the robotic-assisted liver resection (RLR) and laparoscopic liver resection (LLR), can affect the prognosis of patients with liver malignancies is unclear. Thus, in this study, we compared the effects of RLR and LLR on the surgical and oncological outcomes in patients with liver malignancies through propensity score-matched cohort studies. METHODS: The PubMed, Embase, and Cochrane databases were searched using Medical Subject Headings terms and keywords from inception until May 31, 2023. The quality of the included studies was assessed using the Newcastle-Ottawa quality assessment scale. The mean difference with 95% confidence interval (95% CI) was used for analysis of continuous variables; the risk ratio with 95% CI was used for dichotomous variables; and the hazard ratio with 95% CI was used for survival-related variables. Meta-analysis was performed using a random-effects model. RESULTS: Five high-quality cohort studies with 986 patients were included (370 and 616 cases for RLR and LLR, respectively). In terms of surgical outcomes, there were no significant differences in the operation time, conversion rate to open surgery, overall complication rate, major complication rate, and length of hospital stay between the RLR and LLR groups. In terms of oncological outcomes, there were no significant differences in the 5-year overall survival and disease-free survival between the two groups. CONCLUSION: Surgical and oncological outcomes are comparable between RLR and LLR on patients with liver malignancies. Therefore, the benefits of applying RLR in patients with liver malignancies need to be further explored.
作者机构：
[Min, Junxia; Yu, Yingying; Wang, Fudi; Liu, Yutong; Zhou, Jiahui; Yue, Wuyang; Su, Yunxing; Yang, Sisi; Li, Xiaopeng; Min, JX; Sun, Shumin] Zhejiang Univ, Affiliated Hosp 1, Affiliated Hosp 2, Inst Translat Med,Sch Med, Hangzhou 310058, Peoples R China.;[Yu, Yingying; Wang, Fudi; Lin, Zhiting] Univ South China, Affiliated Hosp 1, Sch Publ Hlth, Hengyang Med Sch, Hengyang 421001, Peoples R China.;[Shah, YM; Shah, Yatrik M.; Das, Nupur K.] Univ Michigan, Div Gastroenterol, Internal Med, Ann Arbor, MI 48109 USA.;[Shah, YM; Shah, Yatrik M.; Das, Nupur K.] Univ Michigan, Dept Mol & Integrat Physiol, Ann Arbor, MI 48109 USA.;[Wu, Qian] Zhejiang Univ, Int Inst Med, Sch Med, Yiwu, Zhejiang, Peoples R China.
通讯机构：
[Wang, FD ; Min, JX] Z;[Shah, YM ] U;Zhejiang Univ, Affiliated Hosp 1, Affiliated Hosp 2, Inst Translat Med,Sch Med, Hangzhou 310058, Peoples R China.;Univ South China, Affiliated Hosp 1, Sch Publ Hlth, Hengyang Med Sch, Hengyang 421001, Peoples R China.;Univ Michigan, Div Gastroenterol, Internal Med, Ann Arbor, MI 48109 USA.
关键词：
FG-4592;HIF;anemia of inflammation;chemotherapy-induced anemia;hypoxia;iron-refractory iron deficiency anemia
摘要：
In clinics, hepcidin levels are elevated in various anemia-related conditions, particularly in iron-refractory anemia and in high inflammatory states that suppress iron absorption, which remains an urgent unmet medical need. To identify effective treatment options for various types of iron-refractory anemia, the potential effect of hypoxia and pharmacologically-mimetic drug FG-4592 (Roxadustat) are evaluated, a hypoxia-inducible factor (HIF)-prolyl hydroxylase (PHD) inhibitor, on mouse models of iron-refractory iron-deficiency anemia (IRIDA), anemia of inflammation and 5-fluorouracil-induced chemotherapy-related anemia. The potent protective effects of both hypoxia and FG-4592 on IRIDA as well as other 2 tested mouse cohorts are found. Mechanistically, it is demonstrated that hypoxia or FG-4592 could stabilize duodenal Hif2 alpha, leading to the activation of Fpn transcription regardless of hepcidin levels, which in turn results in increased intestinal iron absorption and the amelioration of hepcidin-activated anemias. Moreover, duodenal Hif2 alpha overexpression fully rescues phenotypes of Tmprss6 knockout mice, and Hif2 alpha knockout in the gut significantly delays the recovery from 5-fluorouracil-induced anemia, which can not be rescued by FG-4592 treatment. Taken together, the findings of this study provide compelling evidence that targeting intestinal hypoxia-related pathways can serve as a potential therapeutic strategy for treating a broad spectrum of anemia, especially iron refractory anemia. In this article, it is demonstrated that targeting the duodenal Hif2 alpha-Fpn axis as a novel strategy to improve refractory hepcidin-activated anemias, including iron-refractory iron-deficiency anemia (IRIDA), inflammatory anemia and chemotherapy-induced anemia, in mice, which provides compelling evidence for further clinical translation.image
摘要：
We present an atomistic simulation of thermoelectric properties in cove-edged graphene nanoribbons (CGNRs) via the nonequilibrium Green's function. Different from gapless zigzag graphene nanoribbons (ZGNRs), CGNRs exhibit a noticeable bandgap. Such a bandgap can be modulated by varying three structural parameters (namely, the width N, the distance between adjacent coves m, as well as the shortest offset n) of CGNRs, which can give rise to the transition from semiconducting to semi-metallic. Due to the less dispersive phonon bands and the decrease in the number of phonon channels of CGNRs, they are found to have the lower phonon thermal conductance than ZGNRs. Modulation of CGNRs can produce over tenfold improvement of the maximum of ZT compared to ZGNRs. This improvement is due to the promotion of the Seebeck coefficient together with the degradation of the phonon thermal conductance of CGNRs compared to ZGNRs.
摘要：
The accurate monitors of the electron beams and g -ray fluxes are very important for laser -driven photonuclear studies. The flux -weighted average cross sections and average cross sections per equivalent quantum of 27Al(g, x; x = 2p, p, 3)24Na reactions were measured above the giant dipole resonance region through activation methods. Laser -driven ultra -intense bremsstrahlung grays, generated by laser wakefield accelerated quasi-monoenergetic electrons, were used in the experiment at the 200 TW laser facility of the Compact Laser Plasma Accelerator Laboratory, Peking University. The results demonstrated good agreement with previous works and were compared with theoretical values given by TALYS 1.9 calculations. The experimental cross sections were confirmed to be 2.4 times higher than TALYS 1.9 with default options. This work proved the feasibility of using the 27Al(g, x)24Na reactions as monitors for laser wakefield accelerated electrons and their bremsstrahlung g -ray fluxes.
期刊：
POLISH JOURNAL OF ENVIRONMENTAL STUDIES,2024年33(1):253-269 ISSN：1230-1485
通讯作者：
Jia, XF
作者机构：
[Li, Xiangtao; Xie, Baojian] Jinan Univ, Sch Econ, Guangzhou, Peoples R China.;[Jia, Xiaofang; Jia, XF] Univ South China, Sch Econ Management & Law, Hengyang, Peoples R China.
通讯机构：
[Jia, XF ] U;Univ South China, Sch Econ Management & Law, Hengyang, Peoples R China.
关键词：
public resources trading center;market-oriented allocation of public resources;environmental supervision;enterprise green innovation;time-varying DID
摘要：
Green innovation is not only a significant source of sustainable enterprise development, but it is also critical to China's aim of carbon peak and carbon neutrality. Under the current context of informatization and resource-based development, whether the public resource trading center, as a highly standardized and unified public resource trading platform, can assist firms in improving their green innovation level merits further investigation. The policy of public resource trading centers is used as a quasi-natural experiment in this article, and empirical research is conducted using data from China's A-share listed companies from 2008 to 2021. The study found that the establishment of public resource trading centers can considerably enhance enterprise green innovation, and this conclusion holds up after a series of robustness tests. It is worth noting that green invention patents typically have a stronger promotion effect than green utility model patents. Meanwhile, the establishment of public resource trading centers has a stronger influence on green innovation incentives for state-owned enterprises, small and mediumsized enterprises, and enterprises in high-polluting industries, according to the heterogeneity study. Furthermore, the establishment of public resource trading centers promotes green enterprise innovation through improving normalization and standardization of public resource trading and strengthening the responsibility of regional environmental supervision and management.
期刊：
Finite Fields and Their Applications,2024年94:102354 ISSN：1071-5797
通讯作者：
Kan, HB
作者机构：
[Zheng, Lijing] Univ South China, Sch Math & Phys, Hengyang 421001, Hunan, Peoples R China.;[Kan, Haibin] Fudan Univ, Sch Comp Sci, Shanghai Key Lab Intelligent Informat Proc, Shanghai 200433, Peoples R China.;[Kan, Haibin] Shanghai Engn Res Ctr Blockchain, Shanghai 200433, Peoples R China.;[Kan, Haibin] Fudan Univ, Yiwu Res Inst, Yiwu City 322000, Peoples R China.;[Zhang, Tongliang] North China Univ Sci & Technol, Coll Sci, Tangshan 063000, Hebei, Peoples R China.
通讯机构：
[Kan, HB ] F;Fudan Univ, Sch Comp Sci, Shanghai Key Lab Intelligent Informat Proc, Shanghai 200433, Peoples R China.;Shanghai Engn Res Ctr Blockchain, Shanghai 200433, Peoples R China.;Fudan Univ, Yiwu Res Inst, Yiwu City 322000, Peoples R China.
关键词：
Finite field;Permutation trinomial
摘要：
Let q = 2m and Fq3 be the finite field with q3 elements. In this paper, based on the multivariate method, resultant elimination, and transforming into dealing with some equations over finite fields, we propose two classes of permutation trinomials of Fq3. We illustrate that these two classes of permutation trinomials are QM-inequivalent to all known permutation polynomials over Fq3. Some well-known results can be covered by our theorems.(c) 2023 Elsevier Inc. All rights reserved.
摘要：
A new Cp*Rh(III)-catalyzed regioselective cyclization reaction of aromatic amides with allenes is reported. The use of allenyl derivatives bearing a directing-group assistant as a reaction promoter was the key to the success of this protocol. In this catalytic system, N-(pivaloyloxy)benzamide substrates react with allenes via Rh-σ-alkenyl intermediates, while N-(pivaloyloxy) indol substrates react via Rh-π-allyl intermediates. These reactions were characterized by mild reaction conditions, a broad substrate scope, and high functional-group compatibility to yield several high-value isoquinolinone and pyrimido[1,6-a]indol-1(2H)-one skeleton-containing compounds. The synthetic applications and primary mechanisms were also investigated.
摘要：
An essential industrial application is the examination of surface flaws in hot-rolled steel strips. While automatic visual inspection tools must meet strict real-time performance criteria for inspecting hot-rolled steel strips, their capabilities are constrained by the accuracy and processing speed of the algorithm used to identify defects. To solve the problems of poor detection accuracy, low detection efficiency, and unsuitability of low computing power platforms of the hot-rolled strip surface defect detection algorithm The Swin-Transformer-YOLOv5 model based on the improved one-stage detector is proposed. By employing GhostNet, the model's lightweight design, and guaranteed detection accuracy are both achieved. The C3 module introduces Swin-Transformer to address the issues of cluttered backdrops of defect photos and easily confused defect categories. With the addition of the CoordAttention module, the model's capacity to extract defective features is improved, and its performance keeps getting better. The issue of huge differences in different scales and poor detection of small flaws is resolved by employing BiFPN for feature fusion, and the detector's capacity to adapt to targets of different scales is improved. The experimental results demonstrate that the improved Swin-Transformer-Yolov5 model significantly outperforms the industry-standard target detection algorithms, and the model's mAP value still improves by 8.39% over the original model while reducing the number of parameters, GFLOPs, and weight by 36.6%, 40.0%, and 34.7%, respectively. The model is better suited for use on low-arithmetic platforms as a result.
期刊：
Journal of Hazardous Materials,2024年461:132664 ISSN：0304-3894
通讯作者：
Yin, XB;Wang, XP
作者机构：
[Fujita, Toyohisa; Wang, Xinpeng; Lin, Zheyang; Chen, Yuliang] Guangxi Univ, Sch Resources Environm & Mat, State Key Lab Featured Met Mat & Life Cycle Safety, 100 Daxue East Rd, Nanning 530004, Peoples R China.;[Yin, Xiangbiao; Ning, Shunyan; Zheng, Ningchao] Univ South China, Sch Nucl Sci & Technol, 28 Changsheng West Rd, Hengyang 421001, Peoples R China.;[Chen, Yanliang] East China Inst Technol, Minist Educ, Engn Res Ctr Nucl Technol Applicat, Nanchang 330013, Peoples R China.;[Wang, Xinpeng; Wang, XP] Guangxi Univ, Sch Resources Environm & Mat, 100 Daxue East Rd, Nanning 530004, Peoples R China.
通讯机构：
[Wang, XP ] G;[Yin, XB ] U;Univ South China, Sch Nucl Sci & Technol, 28 Changsheng West Rd, Hengyang 421001, Peoples R China.;Guangxi Univ, Sch Resources Environm & Mat, 100 Daxue East Rd, Nanning 530004, Peoples R China.
关键词：
Electro adsorption;NASICON;Seawater;Uranium
摘要：
As an eco-friendly technique with the superior adsorption performance, electroadsorption has shown great potential for application in uranium (U(VI)) recovery in recent years. However, the electrodes used in the electrosorption generally suffer the adsorbent to be loaded on the conductors, which greatly limited the adsorption performance of the electrodes for uranyl ions. In present study, a flexible self-supporting Na(3)MnTi(PO(4))(3)@C fibers (NMTP@C fibers) electrode material was rationally designed and prepared by electrostatic spinning method and annealing technique, and its ability to capture U(VI) efficiently was preliminarily demonstrated by batch adsorption and electro sorption. The plentiful phosphate groups provide sufficient active sites for adsorption, while the axially continuous electron conduction and radially short-range ion transport give NMTP@C fibers fast charge/ion transport capability. The NMTP@C fiber can remove 99% of 5ppmU(VI) in seawater by electro absorption within 1h. After several cycles of adsorption under seawater conditions, the adsorbent can still maintain a stable adsorption capacity. The adsorption mechanism of NMTP@C nanofibers for U(VI) was investigated by XPS, FT-IR, Raman, SEM-EDS, and XRD, which was electrostatic interactions and surface complexation. These results suggest that NMTP@C fibers are promising high-capacity adsorbents for efficient and selective capture of U(VI) from seawater.
摘要：
The cardioprotective effect of microRNAs (miRNAs) on myocardial ischemic-reperfusion (I/R) injury has been documented. Here, we aim to decipher the mechanism of miR-24 delivered by human umbilical cord mesenchymal stem cell-derived extracellular vesicles (hUC-MSC-EVs) in myocardial I/R injury after dexmedetomidine (DEX) preconditioning. We collected and identified hUC-MSCs and extracted EVs, which were co-cultured with DEX-preconditioned hypoxia/reoxygenation (H/R) cardiomyocyte models or injected into I/R mouse models. The cardiomyocytes and myocardial injury were evaluated by molecular biology experiments. miR-24 was highly expressed in hUC-MSC-EVs. hUC-MSC-EVs could transfer miR-24 into cardiomyocytes where miR-24 augmented cell viability and inhibited cell apoptosis after DEX preconditioning. In the co-culture system of RAW264.7 macrophages with hUC-MSC-EVs, miR-24 promoted M2-type polarization of macrophages and reduced M1-type macrophage polarization. Mechanistically, miR-24 targeted KEAP1 and inhibited its expression, resulting in disruption of the Nrf2/HO-1 signaling. In vivo data confirmed that miR-24 delivered by hUC-MSC-EVs enhanced the suppressing effect of DEX preconditioning on inflammation and apoptosis in rats following myocardial I/R injury. Overall, miR-24 delivered by hUC-MSC-EVs can promote M2 polarization of macrophages and enhance the protective effect of DEX preconditioning on myocardial I/R injury by down-regulating the KEAP1/Nrf2/HO-1 signaling axis.
作者：
Luo, Yan-Hua;Xie, Li;Li, Jiao-Yang;Xie, Yuan;Li, Man -Qin;...
期刊：
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy,2024年16:1013-1020 ISSN：1178-7007
通讯作者：
Li Zhou
作者机构：
[Luo, Yan-Hua; Zhou, Li; Li, Man -Qin] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Metab & Endocrinol, Hengyang 421001, Hunan, Peoples R China.;[Xie, Li] Univ South China, Affiliated Hosp 1, Pediat Med Ctr, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.;[Li, Jiao-Yang] Wuhan Univ, Sch Publ Hlth, Dept Prevent Med, Wuhan 430071, Hubei, Peoples R China.;[Xie, Yuan] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Radiol, Hengyang 421001, Hunan, Peoples R China.
通讯机构：
[Li Zhou] D;Department of Metabolism and Endocrinology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, People’s Republic of China
关键词：
children;mitochondrial-derived peptides;MOTS-C;obese;vascular endothelial function
摘要：
Mitochondria are not only the power plant for intracellular oxidative phosphorylation and ATP synthesis, but also involved in cell proliferation, differentiation, signaling and apoptosis. Recent studies have shown that mitochondria play an important role in other pathophysiological functions in addition to cellular energy metabolism. Mitochondria release mitochondrial DNA (mtDNA) as a damage-associated molecular pattern (DAMP) to activate Toll-like receptor 9 (TLR9), NOD-, LRR-, and pyrin domain-containing 3 (NLRP3) inflammasome and cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) innate immune signaling pathways against foreign pathogenic microorganisms. The innate immune response not only promotes antimicrobial immune defense and regulates antiviral signaling, but their overactivation also induces the onset and progression of inflammatory diseases. In this paper, we review the role of mtDNA in the activation of innate immune signaling pathways and the crosstalk among innate immune signaling pathways activated by mtDNA, providing clues for the study of inflammatory diseases caused by mtDNA cytoplasmic translocation.
摘要：
INTRODUCTION: Colorectal cancer (CRC) is the third most common cause of cancer and the second leading cause of cancer-related deaths worldwide. Microsatellite instability-high (MSI-H) is a distinct molecular subtype of CRC that occurs in approximately 15% of all cases. Recently, immune checkpoint inhibitors (ICIs) have emerged as a promising therapeutic approach for patients with MSI-H colorectal cancer, exhibiting higher response rates than standard chemotherapies. To assess the effectiveness and safety of ICIs for the treatment of patients with MSI-H CRC, we propose a comprehensive pooled analysis of clinical trial data. METHODS AND ANALYSIS: A systematic search of multiple electronic databases, including PubMed, EMBASE, Cochrane Library, and Clinicaltrials.gov, will be conducted from their inception until September, 2023 to identify eligible randomized controlled trials (RCTs) and non-randomized studies. Inclusion criteria comprise studies of adult patients with histologically confirmed MSI-H CRC treated with immune checkpoint inhibitors, with a comparison to a control group receiving conventional therapies. Outcomes of interest will be overall survival (OS), progression-free survival (PFS), objective response rate (ORR), disease control rate (DCR), and incidence of treatment-related adverse events (AEs). The Cochrane Risk of Bias tool and the Risk of Bias in Non-randomized Studies of Interventions (ROBINS-I) tool will be employed to evaluate the methodological quality of included studies. A random-effects model using the DerSimonian and Laird method will be applied for pooling the effect estimates, calculating hazard ratios (HRs) or risk ratios (RRs) with their corresponding 95% confidence intervals (CIs). Heterogeneity will be assessed using I² statistics, and subgroup analysis and meta-regression will be performed to explore potential effect modifiers in case of substantial heterogeneity. Publication bias will be evaluated with funnel plots and Egger's test. Sensitivity analysis will be conducted to assess the robustness of the results. DISCUSSION: This meta-analysis will synthesize available evidence from clinical trials on immune checkpoint inhibitors in treating MSI-H colorectal cancer. The findings will offer valuable information about the effectiveness and safety of ICIs in this patient population, contributing to the refinement of clinical guidelines and enhancing the decision-making process for healthcare providers, policy-makers, and patients. The comprehensive analysis of subgroups and sensitivity allows for an in-depth understanding of potential effect modification, providing essential directions for future research. ETHICS AND DISSEMINATION: This study will involve the use of published data; hence, ethical approval is not required. The results of the study will be disseminated through publications in peer-reviewed journals and presentations at relevant conferences. The findings will potentially impact clinical decision-making and contribute to the development of evidence-based treatment recommendations for patients with MSI-H colorectal cancer. CLINICAL TRIAL REGISTRATION: Open Science Framework identifier, 10.17605/OSF.IO/ZHJ85.
摘要：
AKG protects against CTX‐induced POI by inhibiting NLRP3‐mediated pyroptosis of granulosa cells, restoring the glycolysis and improving ovarian reserve function.(Created with BioRender.com). Scope Premature ovarian insufficiency (POI) is a common female infertility problem, with its pathogenesis remains unknown. The NOD‐like receptor family pyrin domain‐containing 3 (NLRP3)‐mediated pyroptosis has been proposed as a possible mechanism in POI. This study investigates the therapeutic effect of α‐ketoglutarate (AKG) on ovarian reserve function in POI rats and further explores the potential molecular mechanisms. Methods and results POI rats are caused by administration of cyclophosphamide (CTX) to determine whether AKG has a protective effect. AKG treatment increases the ovarian index, maintains both serum hormone levels and follicle number, and improves the ovarian reserve function in POI rats, as evidence by increased the level of lactate and the expression of rate‐limiting enzymes of glycolysis in the ovaries, additionally reduced the expression of NLRP3, Gasdermin D (GSDMD), Caspase‐1, Interleukin‐18 (IL‐18), and Interleukin‐1 beta (IL‐1β). In vitro, KGN cells are treated with LPS and nigericin to mimic pyroptosis, then treated with AKG and MCC950. AKG inhibits inflammatory and pyroptosis factors such as NLRP3, restores the glycolysis process in vitro, meanwhile inhibition of NLRP3 has the same effect. Conclusion AKG ameliorates CTX‐induced POI by inhibiting NLRP3‐mediated pyroptosis, which provides a new therapeutic strategy and drug target for clinical POI patients.
