通讯机构:
[Wen Luo; Weimin Zhou] S;School of Nuclear Science and Technology, University of South China, 421001 Hengyang, People's Republic of China<&wdkj&>Science and Technology on Plasma Physics Laboratory, Laser Fusion Research Center, China Academy of Engineering Physics, 621900 Mianyang, People's Republic of China
关键词:
laser plasma;high-energy electron beam;photonuclear reaction;medical isotopes
摘要:
Radioisotopes are indispensable agents in medical diagnosis and treatment, among which copper-62, 64 (Cu-62,Cu-64) and gallium-68 (Ga-68) are medical isotopes widely used in positron emission tomography (PET) imaging. Experiments that generate these radioisotopes via laser-induced photonuclear reactions were performed on the XingGuangIII laser facility of the Laser Fusion Research Center in Mianyang. High-charge (Q(e) similar to 40 nC) MeV electron (e(-)) beams were generated with 100 terawatts, picosecond laser pulses. The e(-) beams were then impinged on a metal stack composed of Ta foil and activation plates (natural Cu and Ga2O3), producing high-energy bremsstrahlung x-rays and medical isotopes Cu-62,Cu-64 and Ga-68, respectively. The characteristic emissions of the produced Cu-62,Cu-64 and Ga-68 were detected off-line , and the production yields of Cu-62,Cu-64 and Ga-68 were obtained to be of the order of 10(6) per laser shot. For electrons with energy higher than 8 MeV, the dependence of isotope production efficiency (per e(-)) on electron temperature (T-e) is investigated through Geant4 simulations. It is found that the production efficiency increases with the T-e. At T-e similar to 10 MeV, the values are 10(-4) for Cu-62 and 2 x 10(-5) for Ga-68, respectively. The prospect of producing the medical isotopes Cu-62,Cu-64 and Ga-68 are further evaluated using a table-top femtosecond laser system of high repetition. With a repetition rate of 100 Hz, their activity is expected to reach 0.2 GBq for Cu-62, 0.1 GBq for Cu-64 and 0.05 GBq for Ga-68, respectively. Such activity would meet the required dose for clinical PET imaging, indicating the great potential to produce medical isotopes with an all-optical, high-repetition laser system.
作者机构:
[Contreras, Miguel Angel Martin] Univ South China, Sch Nucl Sci & Technol, Hengyang, Peoples R China.;[Vega, Alfredo] 28 Changsheng West Rd, Hengyang, Hunan, Peoples R China.;[Vega, Alfredo] Univ Valparaiso, Inst Fis & Astron, A Gran Bretana 1111, Valparaiso, Chile.
通讯机构:
[Contreras, MAM ] U;Univ South China, Sch Nucl Sci & Technol, Hengyang, Peoples R China.
摘要:
In the context of bottom-up AdS/QCD models, we discuss how the configurational entropy can describe heavy non-qq over bar states. Using the nonquadratic softwall model, introduced to describe nonlinear Regge trajectories, we parametrize different multiquark and exotic meson structures to describe Z,, psi, and Zb states as non-qq over bar hadrons in terms of stability. We found that Z, is better described as a hybrid meson with one gluon tube, psi as hadrocharmonium, and Zb as hadronic molecule.
摘要:
Background:Unintended pregnancy is a problem that women encounter throughout their reproductive age. Excessive and prolonged uterine bleeding is one of the most common and critical adverse reactions of induced abortion, for it increases the risk of anemia and intrauterine infection. To provide reliable clinical evidence, we performed a protocol for systematic review and meta-analysis to evaluate the hemostatic effect of motherwort in postabortion. Methods:This review protocol has been registered in the international prospective register of systematic reviews. The statement of Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols will be used as guidelines for reporting present review protocol. Original clinical randomized controlled trials assessing the beneficial effects and safety of motherwort on induced abortion will be included. Databases searched include China National Knowledge Infrastructure, Chinese Scientific Journals Database, Wanfang Database, China Biological Medicine Database, PubMed, and EMBASE Database and Cochrane Central Register of Controlled Trials. Cochrane collaboration tool is used to assess the risk of bias of included randomized controlled trials. All calculations are carried out with Stata 11.0 (The Cochrane Collaboration, Oxford, United Kingdom). Results:This systematic review and meta-analysis will provide a detailed summary of the current evidence related to the efficacy of motherwort injection preventing postabortion hemorrhage after induced abortion. Conclusion:This evidence will be useful to practitioners, patients, and health policy-makers regarding the use of motherwort injection in induced abortion.
作者:
Ablikim, M.;Achasov, M. N.;Adlarson, P.;Ai, X. C.;Aliberti, R.;...
期刊:
PHYSICAL REVIEW D,2023年108(9) ISSN:2470-0010
通讯作者:
Ablikim, M
作者机构:
[Yu, B. X.; Yu, G.; Li, Xiaoyu; Hu, T.; Ning, Z.; Zhang, P.; Wen, S. P.; Shi, X.; Sun, G. X.; Ma, M. M.; Zhao, Ling; Chen, T.; Hou, X. T.; Zhu, Z. A.; Xu, G. F.; Wang, K.; Zhou, L. P.; Heng, Y. K.; Ji, Q.; Zhang, J. W.; Rong, G.; Guan, C. Y.; Qi, F. Z.; Wang, Y. F.; Wang, L. L.; Ouyang, Q.; Liao, Y. P.; Zhang, A. Q.; Ji, X. B.; Qian, S.; Dong, M. Y.; Zhang, Jiawei; Fang, S. S.; Chang, J. F.; Liu, Z. A.; Yan, X. Q.; Wu, J. F.; Wang, Yaqian; Rivetti, A.; Sun, S. S.; Ding, B.; Fu, C. D.; Lou, X. C.; Lin, T.; Zhang, B. X.; Xing, T. Y.; Cao, G. F.; Wu, L. H.; Zhao, Y. B.; Fu, Y. W.; Zheng, J. P.; Jiang, X. S.; Kiuchi, R.; Gu, M. H.; Lu, Y. P.; Dong, L. Y.; Zhang, H. Q.; Zhao, G.; Wu, L. J.; Li, L. J.; Yang, Yifan; Yuan, Y.; Lu, X. L.; Wu, Z.; Fang, Y.; Luo, X. L.; Ji, X. L.; Zhang, X. M.; Li, L. K.; Li, H. B.; Liang, H.; Huang, Y. P.; Zhang, J. Y.; Yin, J. H.; Batozskaya, V.; Liu, Huanhuan; Song, W. M.; Chen, X. T.; Zhang, J. Z.; He, K. L.; Chen, G.; Ablikim, M.; Liu, C. X.; Chang, W. L.; Zhu, K.; Zhao, J. Z.; Yang, Tao; Mao, Z. P.; Xiao, S. Y.; Lu, J. G.; Liu, P. L.; Jing, M. Q.; Sun, H. K.; Chen, Y. B.; Zhang, Shuihan; Du, M. C.; Wang, Z.; Ablikim, M; Liu, Fang; Zhao, J. Y.; Dong, J.; Liu, K.; Shi, J. Y.; Wang, H. P.; Yuan, C. Z.; Tang, G. Y.; Yuan, S. C.; Zhang, H. Y.; Chen, M. L.; Zhang, Z. H.; Hou, G. Y.; Shen, H. F.; Shao, L. G.; Hou, Z. L.; Sun, Y. Z.; Liu, B. J.; Li, Ke; Zhu, K. J.; Liu, H. M.; Xu, C. F.; Ma, H. L.; Sun, T.; Ye, M.; Xie, Y. G.; Chen, H. S.; Cao, N.; Deng, Z. Y.; Ma, Q. M.; Wang, Z. Y.; Cai, X.; Yuan, X. Q.; Zhang, Y. H.; Ma, R. Q.; Shi, R. S.; Zheng, W. J.; Zou, J. H.; Zhang, Yao; Liu, J. Y.; Li, W. G.; Wang, Y. Q.; Mo, X. H.; Fang, J.; Shen, X. Y.; Ma, X. Y.; Hu, H. M.; Gong, W. X.; Xu, W.; Hu, Y.; Wang, B.; Zhang, B. L.; Ma, J. L.; Wang, Meng; Yang, Y. X.; Miao, H.; Li, F.; Lu, Z. H.; Yang, H. X.; Qin, Z. H.; Li, G.; Ping, R. G.; Sarantsev, A.; Qiu, J. F.; Dai, H. L.; Li, W. D.; Fang, W. X.; Zeng, Y. J.] Inst High Energy Phys, Beijing 100049, Peoples R China.;[Yuan, L.] Beihang Univ, Beijing 100191, Peoples R China.;[Li, Lei] Beijing Inst Petrochem Technol, Beijing 102617, Peoples R China.;[Jaeger, S.; Fritsch, M.; Kuessner, M.; Pelizaeus, M.; Kopf, B.; Wollenberg, L.; Holtmann, T.; de Boer, R. E.; Feldbauer, F.; Wiedner, U.; Heinsius, F. H. H.; Coen, S. C.; Wenzel, C. W.] Bochum Ruhr Univ, D-44780 Bochum, Germany.;[Achasov, M. N.; Nikolaev, I. B.; Muchnoi, N. Yu.] Budker Inst Nucl Phys SB RAS BINP, Novosibirsk 630090, Russia.
通讯机构:
[Ablikim, M ] I;Inst High Energy Phys, Beijing 100049, Peoples R China.
摘要:
Based on a dataset of (27.12 +/- 0.10) x 10(8) psi(3686) events collected at the BESIII experiment, the absolute branching fractions of the three dominant Omega(-) decays are measured to be B Omega-->Xi 0 pi- = (25.03 +/- 0.44 +/- 0.53) %, B Omega-->Xi-pi 0 = (8.43 +/- 0.52 +/- 0.28) %, and B Omega-->Lambda K- = (66.3 +/- 0.8 +/- 2.0) %, where the first and second uncertainties are statistical and systematic, respectively. The ratio between B Omega-->Xi 0 pi- and B Omega-->Xi-pi 0 is determined to be 2.97 +/- 0.19 +/- 0.11, which is in good agreement with the PDG value of 2.74 +/- 0.15, but greater by more than four standard deviations than the theoretical prediction of 2 obtained from the Delta I = 1/2 rule.
作者机构:
[Yan, Mengshi; Yan, MS] Peking Univ, Dept Phys, Beijing 100871, Peoples R China.;[Yan, Mengshi; Yan, MS] Peking Univ, State Key Lab Nucl Phys & Technol, Beijing 100871, Peoples R China.;[Hou, Tie-Jiun] Univ South China, Sch Nucl Sci & Technol, Hengyang 421001, Hunan, Peoples R China.;[Nadolsky, Pavel] Southern Methodist Univ, Dept Phys, Dallas, TX 75275 USA.;[Nadolsky, Pavel] Fermilab Natl Accelerator Lab, POB 500, Batavia, IL 60510 USA.
通讯机构:
[Yan, MS ] P;Peking Univ, Dept Phys, Beijing 100871, Peoples R China.;Peking Univ, State Key Lab Nucl Phys & Technol, Beijing 100871, Peoples R China.
摘要:
In this paper, we present a CT18 PDF global QCD analysis at leading order in QCD perturbation theory. The CT18 LO PDFs is obtained within the general CT18 framework, along with two additional procedures imposed to improve the quality of the fit. We take the W -boson charge asymmetry and inclusive single-top production at LHC as examples to illustrate implications of the CT18 LO PDFs.
期刊:
Hormone and Metabolic Research,2023年55(09):634-641 ISSN:0018-5043
通讯作者:
Xiao, XH
作者机构:
[Hong, Tao; Mei, Lang; Xiao, Xin-Hua; Li, Jiaoyang; Wen, Jie; Li, Ruixiang] Univ South China, Affiliated Hosp 2, Med Coll, Dept Endocrinol & Metab, Hengyang, Peoples R China.;[Zhou, Junlin] Univ South China, Affiliated Hosp 1, Med Coll, Hlth Management Ctr, Hengyang, Peoples R China.;[Xiao, Xin-Hua; Xiao, XH] Univ South China, Med Coll, Dept Metab & Endocrinol, Hengyang 421001, Hunan, Peoples R China.
通讯机构:
[Xiao, XH ] U;Univ South China, Med Coll, Dept Metab & Endocrinol, Hengyang 421001, Hunan, Peoples R China.
关键词:
autophagy;insulin, diabetes;forkhead box protein O1;gamma-aminobutyric acid A receptor-associated protein-like 1;hepatocellular carcinoma;type 2 diabetes
摘要:
Hyperinsulinemia and insulin resistance in T2D have a potent suppressive effect
on hepatic autophagy, however, the underlying mechanisms remain unclear. To
explore the effect of insulin on hepatic autophagy and its possible signaling
pathways, HL-7702 cells were treated with insulin with or without insulin
signaling inhibitors. The interaction between insulin and the promoter region of
GABARAPL1 was assessed through luciferase assay and EMSA. There were significant
dose-dependent decreases in the number of intracellular autophagosomes and the
protein levels of GABARAPL1 and beclin1 in insulin-treated HL-7702 cells.
Insulin signaling inhibitors reversed the inhibitory effect of insulin on
rapamycin-induced autophagy and autophagy-related gene upregulation. Insulin
blocks the binding of FoxO1 to putative insulin response elements in GABARAPL1
gene promoter, leading to the repressed transcription of GABARAPL1 gene and the
suppression of hepatic autophagy. Our study identified GABARAPL1 as a novel
target of insulin in suppressing hepatic autophagy.
作者:
Hamza, Mohammed F.;Guibal, Eric;Wei, Yuezhou;Fouda, Amr;Althumayri, Khalid;...
期刊:
Journal of Water Process Engineering,2023年54:103928 ISSN:2214-7144
通讯作者:
Wei, YZ;Guibal, E
作者机构:
[Wei, Yuezhou; Hamza, Mohammed F.] Univ South China, Sch Nucl Sci & Technol, Heng Yang 421001, Peoples R China.;[Abu Khoziem, Hanaa A.; Hamza, Mohammed F.] Nucl Mat Author, POB 530, Cairo, Egypt.;[Guibal, Eric; Guibal, E] IMT Mines Ales, Polymers Compos & Hybrids PCH, Ales, France.;[Wei, Yuezhou] Shanghai Jiao Tong Univ, Sch Nucl Sci & Engn, Shanghai, Peoples R China.;[Fouda, Amr] Al Azhar Univ, Fac Sci, Bot & Microbiol Dept, Cairo 11884, Egypt.
通讯机构:
[Wei, YZ ] U;[Guibal, E ] I;Univ South China, Sch Nucl Sci & Technol, Heng Yang 421001, Peoples R China.;IMT Mines Ales, Polymers Compos & Hybrids PCH, Ales, France.;Shanghai Jiao Tong Univ, Sch Nucl Sci & Engn, Shanghai, Peoples R China.
关键词:
Cadmium(II) sorption;Uptake kinetics;Sorbent recycling;Sulfur derivative of gellan gum;TBP-functionalization;Selective separation
摘要:
Two sorbents are successfully synthesized based on the chemical modification of gellan gum (GG). First, thiosemicarbazide is grafted onto GG to produce GEG-C. In a second step, GEG-C is functionalized with a derivative of tributyl phosphate (dTBP, giving GEG-P sorbent). The sorption properties are compared for recovery of Cd(II) from aqueous solutions. GEG-C is expected to bind Cd(II) through carboxylic, amine, and thiocarbonyl groups, while phosphate groups in GEG-P contribute to increase metal sorption. The chemical modification improves not only the uptake kinetics (equilibrium time & AP;30 min, vs. 45 min) but also the sorption capacities (& AP;2.79 vs. 1.60 mmol Cd g-1), at optimum pH (i.e., pH 5). The functionalization also improves (a) the sorbent stability (weaker reduction of the loss in sorption efficiency after five cycles of reuse compared with GEG-C) and (b) the sorption selectivity in the presence of competitor ions (from equimolar multicomponent solutions), especially at pH 4. Different sorption mechanisms may be involved depending on the pH (deprotonation of reactive groups) including chelation (onto deprotonated amine and phosphonate groups) and ion exchange (protonated groups with metal cations). Cadmium sorption is reversed by contact with 0.3 M HCl solution. The functionalization (GEG-P) strongly increases the selectivity coefficient for Cd(II) against major elements in mining effluent, especially at pH higher than 5. These results confirm the interest of multifunctionality in the development of new sorbents based on renewable resources (such as gellan gum).
摘要:
It is crucial to detect high-severity defects, such as memory leaks that can result in system crashes or severe resource depletion, in order to reduce software development costs and ensure software quality and reliability. The primary cause of high-severity defects is usually resource scheduling errors, and in the program source code, these defects have contextual features that require defect context to confirm their existence. In the context of utilizing machine learning methods for defect automatic confirmation, the single-feature label method cannot achieve high-precision defect confirmation results for high-severity defects. Therefore, a multi-feature fusion defect automatic confirmation method is proposed. The label generation method solves the dimensionality disaster problem caused by multi-feature fusion by fusing features with strong correlations, improving the classifier's performance. This method extracts node features and basic path features from the program dependency graph and designs high-severity contextual defect confirmation labels combined with contextual features. Finally, an optimized Support Vector Machine is used to train the automatic detection model for high-severity defects. This study uses open-source programs to manually implant defects for high-severity defect confirmation verification. The experimental results show that compared with existing methods, this model significantly improves the efficiency of confirming high-severity defects.
期刊:
Clinical and Experimental Medicine,2023年 ISSN:1591-8890
通讯作者:
Zhang, TL
作者机构:
[Zhang, Taolan; Hu, Haihong; Zhan, Wendi; Zhang, TL; Zhu, Hongxia; Zhang, Jingdi; Wang, Siyu] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Pharm, 69 Chuanshan Rd, Hengyang 421001, Hunan, Peoples R China.;[Zhang, Taolan; Hu, Haihong; Zhan, Wendi; Zhang, TL; Zhu, Hongxia; Zhang, Jingdi; Wang, Siyu] Univ South China, Hengyang Med Coll, Sch Pharm, 28 Western Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.;[Zhang, Taolan; Zhang, TL] Univ South China, Hengyang Med Sch, Affiliated Hosp 1, Phase Clin Trial Ctr 1, Hengyang 421001, Hunan, Peoples R China.;[Yan, Ting] Univ South China, Hengyang Med Sch, Affiliated Hosp 1, Dept Breast & Thyroid Surg, Hengyang 421001, Hunan, Peoples R China.;[Jiang, Lingxiang] Indiana Univ Sch Med, Melvin & Bren Simon Comprehens Canc Ctr, Dept Radiat Oncol, Indianapolis, IN 46202 USA.
通讯机构:
[Zhang, TL ] U;Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Pharm, 69 Chuanshan Rd, Hengyang 421001, Hunan, Peoples R China.;Univ South China, Hengyang Med Coll, Sch Pharm, 28 Western Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.;Univ South China, Hengyang Med Sch, Affiliated Hosp 1, Phase Clin Trial Ctr 1, Hengyang 421001, Hunan, Peoples R China.
关键词:
Breast cancer;Immune checkpoint-related genes;Immune infiltration;Immunotherapy
摘要:
Breast cancer is one of the most prevailing forms of cancer globally. Immunotherapy has demonstrated efficacy in improving the overall survival of breast cancer. The aim of us was to formulate a novel signature predicated on immune checkpoint-related genes (ICGs) that could anticipate the prognosis and further analyze the immune status of patients with breast cancer. After acquiring data, we pinpointed the definitive ICGs for constructing the prognostic model of breast cancer. We constructed a novel prognostic model and created a fresh risk score called Immune Checkpoint-related Risk Score in breast cancer (ICRSBC). The nomogram was constructed to evaluate the accuracy of the model, and the new web-based tool was created to be more intuitive for predicting prognosis. We also investigated immunotherapy responsiveness and analyzed the tumor mutational burden (TMB) in ICRSBC subgroups. The ICRSBC was found to have significant correlations with the immune environment, immunotherapy responsiveness, and TMB. The expression levels of the 9 ICGs that construct the prognostic model and their promoter methylation levels are significantly different between breast cancer and normal tissues. Furthermore, the mutation profiles, the copy number alterations, and the levels of protein expression also exhibit marked disparities among the 9 ICGs. We have identified and validated a novel signature related to ICGs that is strongly associated with breast cancer progression. This signature enables us to create a risk score for prognosticating the survival and assessing the immune status of individuals affected by breast cancer.
摘要:
Research on porphyrin-based photosensitizing drugs is becoming increasingly popular. They possess unique diagnostic capabilities and therapeutic effects that have gained wide recognition in oncology drug development. In recent years, the rapid growth of nanotechnology has brought great hope for nanopharmaceutical formula-tions. By combining porphyrins with various nanomaterials, people have improved the properties of porphyrin compounds, making drug delivery easier. Porphyrin-based nanoparticles can enhance the effect of photodynamic therapy for cancer treatment, providing opportunities for achieving complex targeting strategies and versatility with promising applications in drug carriers, tumor imaging, and treatment. This paper reviews recent porphyrin nanodrugs, including inorganic-organic hybrid nanoparticles, nanomicelles, self-assembled nanoparticles, and combination therapeutic nanodrugs, and their actions and effects on cancer cells when performing photodynamic therapy. It also discusses the drawbacks as well as the prospects for development.
期刊:
Science of The Total Environment,2023年905:167167 ISSN:0048-9697
通讯作者:
Liu, J
作者机构:
Univ South China, Sch Basic Med Sci, Hengyang Med Sch, Inst Cytol & Genet,Dept Cell Biol & Genet,Key Lab, Hengyang 421001, Hunan, Peoples R China.;Univ South China, Sch Publ Hlth, Hengyang Med Sch, Hunan Key Lab Typ Environm Pollut & Hlth Hazards, Hengyang 421001, Hunan, Peoples R China.;[Liu, Jun] 28 Changsheng West Rd, Hengyang 421001, Hunan, Peoples R China.
通讯机构:
[Liu, J ] 2;28 Changsheng West Rd, Hengyang 421001, Hunan, Peoples R China.
关键词:
MCs;Liver;Toxicity;Mechanisms
摘要:
Microcystins (MCs) are a class of biologically active cyclic heptapeptide pollutants produced by the freshwater alga Microcystis aeruginosa. With increased environmental pollution, MCs have become a popular research topic. In recent years, the hepatotoxicity of MCs and associated effects and mechanisms have been studied extensively. Current epidemiological data indicate that long-term human exposure to MCs can lead to severe liver toxicity, acute toxicity, and death. In addition, current toxicological studies on the liver, a vital target organ of MCs, indicate that MC contamination is associated with the development of liver cancer, nonalcoholic fatty liver, and liver fibrosis. MCs produce hepatotoxicity that affects the metabolic homeostasis of the liver, induces apoptosis, and acts as a pro-cancer factor, leading to liver lesions. MCs mainly mediate the activation of signaling pathways, such as the ERK/JNK/p38 MAPK and IL-6-STAT3 pathways, which leads to oxidative damage and even carcinogenesis. Moreover, MCs can act synergistically with other pollutants to produce combined toxicity. However, few systematic reviews have been performed on these new findings. This review systematically summarizes the toxic effects and mechanisms of MCs on the liver and discusses the combined liver toxicity effects of MCs and other pollutants to provide reference for subsequent research. The toxicity of different MC isomers deserves further study. The detection methods and limit standards of MCs in agricultural and aquatic products will represent important research directions in the future. Standard protocols for fish sampling during harmful algal blooms or to evaluate the degree of MC toxicity in nature are lacking. In future, bioinformatics can be applied to offer insights into MC toxicology research and potential drug development for MC poisoning. Further research is essential to understand the molecular mechanisms of liver function damage in combined-exposure toxicology studies to establish treatment for MC-induced liver damage.
摘要:
Patulin (PAT), a fungal metabolite, which mainly exists in various moldy fruits, is greatly harmful to human. However, there are still many unsolved problems in the current detection of PAT. In the work, an ultra-highly sensitive and effective monitoring strategy for PAT was explored based on a novel electrochemiluminescence (ECL) aptasensor. Here, 3, 4, 9, 10-perylenetetracarboxylic acid (PTCA) was chosen as luminophore and terbium (Tb) metal organic gel (MOG) was prepared as a co-reaction accelerator. The MOG displayed a large surface area for immobilization of sufficient PTCA to catalyze co-reactant K2S2O8 to generate more sulfate radical anions (SO4 & BULL; -), thus accelerating the electron-transfer (ET) rate to facilitate ECL efficiency. In the presence of PAT, the ECL signal was greatly quenched, which could be attributed to the specific binding effect between PAT aptamer and PAT. Based on this process, a wide range of PAT concentrations from 0.1 fg & BULL;mL-1 to 0.1 & mu;g & BULL;mL-1 and a low detection limit of 0.02 fg & BULL;mL-1 (S/N = 3) were analyzed. The aptasensor showed excellent detection properties for trace patulin in terms of selectivity, sensitivity, stability, reproducibility and practicability. The designing ideas could serve as a model for the application of metal organic gels to design ultra-highly sensitive ECL platforms for food safety.
作者机构:
[Xu, Shoulong; Liu, Na; Huang, Yan; Zhao, Fang] Univ South China, Sch Resource Environm & Safety Engn, Hengyang 421001, Peoples R China.;[Xu, Shoulong; Liu, Na; Huang, Yan; Zhao, Fang; Zou, Shuliang] Univ South China, Key Lab Hunan Prov Nucl Emergency Safety Technol &, Hengyang 421001, Peoples R China.;[Song, Xiaoming] Nucl Power Inst China, Chengdu 610213, Peoples R China.
关键词:
floating nuclear power plant;migration regularity;Lagrange model (CALPUFF);sensitivity analysis
摘要:
Studying the migration and diffusion of radionuclides plays an important role in emergency decision making and accident mitigation of floating nuclear power plants. Based on the CALPUFF model, this paper simulates the spatial distribution and concentration distribution of airborne radionuclides I-131 diffusion under the conditions of sailing and power supply under LOCA (Loss-of-Coolant Accident) of the floating nuclear power plant, and the influence of four meteorological parameters, namely wind speed, cloudiness, temperature and air pressure, on the migration was analyzed using sensitivity analysis. The results show that the wind direction affects the diffusion direction of I-131, and the concentration of I-131 decreases with the increase in the diffusion distance; under the same conditions, the radionuclides diffuses farther and the affected area is larger under the sailing condition. Wind speed is the dominant factor affecting the diffusion of radionuclides, followed by the cloud amount parameter, temperature parameter, and air pressure parameter. The research results can provide theoretical support for emergency responses to nuclear accidents in offshore floating nuclear power plants.
摘要:
Feedrate scheduling is one of the most critical technologies in CNC machining, requiring a reasonable balance between efficiency and quality. This paper proposes a jerk-continuous feedrate smoothing (JCFS) method to generate a low-vibration and smooth feedrate profile for non-uniform rational B-spline (NURBS) interpolation. Firstly, the segmentation concept is introduced to subdivide the entire trajectory into segments to accommodate curvature changes of the NURBS curve, accelerating the acceleration/deceleration process. Secondly, a length threshold-based curve segment classification method is proposed to overcome the complexity of the traditional acceleration and deceleration algorithms. The curve segments are divided into long, medium, and short types, and the length threshold calculation model is derived. Next, to avoid computational complexity for engineering applications, a model is established for the first time to calculate the actual maximum feedrate for different types of segments. Finally, the horizontal-8-shaped and butterfly-shaped NURBS curves are simulated and analyzed. The simulation results indicate that the machining quality is steadily improved while several key indicators remain within the given tolerances. Compared with the traditional method, the proposed method reduces the computational and interpolation time by 17.2% and 22.8%, respectively, demonstrating the feasibility and effectiveness of the method.
期刊:
Journal of Translational Medicine,2023年21(1):1-13 ISSN:1479-5876
通讯作者:
Xiao, ZJ
作者机构:
[He, Bing; Deng, Limin; Zhou, Guijuan; Xu, Yan; Xie, Juan; Chen, Shuangxi; Xiao, Zijian; Wen, Xuanwei; Li, Sijing; Zhu, Guanghua; Xiao, ZJ; Wu, Lin] Univ South China, Affiliated Hosp 1, Multi Res Ctr Brain Disorders, Hengyang Med Sch,Dept Neurol, Hengyang 421001, Hunan, Peoples R China.;[He, Bing; Deng, Limin; Zhou, Guijuan; Xu, Yan; Xie, Juan; Chen, Shuangxi; Xiao, Zijian; Wen, Xuanwei; Li, Sijing; Zhu, Guanghua; Xiao, ZJ; Wu, Lin] Univ South China, Affiliated Hosp 1, Clin Res Ctr Immune Related Encephalopathy Hunan P, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.;[Wu, Lin] Univ South China, Affiliated Hosp 2, Hengyang Med Sch, Dept Neurol, Hengyang 421000, Hunan, Peoples R China.
通讯机构:
[Xiao, ZJ ] U;Univ South China, Affiliated Hosp 1, Multi Res Ctr Brain Disorders, Hengyang Med Sch,Dept Neurol, Hengyang 421001, Hunan, Peoples R China.;Univ South China, Affiliated Hosp 1, Clin Res Ctr Immune Related Encephalopathy Hunan P, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.
摘要:
Brachial plexus root avulsion (BPRA), a disabling peripheral nerve injury, induces substantial motoneuron death, motor axon degeneration and denervation of biceps muscles, leading to the loss of upper limb motor function. Acetylglutamine (N-acetyl-L-glutamine, NAG) has been proven to exert neuroprotective and anti-inflammatory effects on various disorders of the nervous system. Thus, the present study mainly focused on the influence of NAG on motor and sensory recovery after BPRA in rats and the underlying mechanisms. Male adult Sprague Dawley (SD) rats were subjected to BPRA and reimplantation surgery and subsequently treated with NAG or saline. Behavioral tests were conducted to evaluate motor function recovery and the mechanical pain threshold of the affected forelimb. The morphological appearance of the spinal cord, musculocutaneous nerve, and biceps brachii was assessed by histological staining. Quantitative real-time PCR (qRT‒PCR) was used to measure the mRNA levels of remyelination and regeneration indicators in myocutaneous nerves. The protein levels of inflammatory and pyroptotic indicators in the spinal cord anterior horn were measured using Western blotting. NAG significantly accelerated the recovery of motor function in the injured forelimbs, enhanced motoneuronal survival in the anterior horn of the spinal cord, inhibited the expression of proinflammatory cytokines and pyroptosis pathway factors, facilitated axonal remyelination in the myocutaneous nerve and alleviated atrophy of the biceps brachii. Additionally, NAG attenuated neuropathic pain following BPRA. NAG promotes functional motor recovery and alleviates neuropathic pain by enhancing motoneuronal survival and axonal remyelination and inhibiting the pyroptosis pathway after BPRA in rats, laying the foundation for the use of NAG as a novel treatment for BPRA.
期刊:
Chemical Engineering Journal,2023年452:139434 ISSN:1385-8947
通讯作者:
Hong, Bo(bohong@cjlu.edu.cn)
作者机构:
[Wang, Xingqin; Zhan, Xingyu; Hong, Bo; Zeng, Yunxiong] China Jiliang Univ, Coll Mat & Chem, Zhejiang Prov Key Lab Magnet Mat, Hangzhou 310018, Peoples R China.;[Xia, Yingchun] Tsinghua Univ, Dept Chem Engn, State Key Lab Chem Engn, Beijing 100084, Peoples R China.;[Ding, Yangbin] Huzhou Univ, Dept Mat Chem, Huzhou 313000, Peoples R China.;[Cai, Tao] Univ South China, Sch Resource & Environm & Safety Engn, Hengyang 421001, Peoples R China.;[Yang, Liming; Yin, Kai; Luo, Shenglian] Nanchang Hangkong Univ, Key Lab Jiangxi Prov Persistent Pollutants Control, Nanchang 330063, Jiangxi, Peoples R China.
通讯机构:
[Bo Hong] C;[Yingchun Xia] T;[Shenglian Luo] K;College of Materials and Chemistry, Zhejiang Province Key Laboratory of Magnetic Materials, China Jiliang University, Hangzhou 310018, PR China<&wdkj&>The State Key Laboratory of Chemical Engineering, Department of Chemical Engineering, Tsinghua University, Beijing 100084, PR China<&wdkj&>Key Laboratory of Jiangxi Province for Persistent Pollutants Control and Resources Recycle, Nanchang Hangkong University, Nanchang, Jiangxi 330063, PR China<&wdkj&>College of Environmental Science and Engineering, Hunan University, Changsha 410018, PR China
关键词:
Surface Atom Rearrangement;Electronic Structures;Carbon Nitride;Antibiotics Degradation;Photocatalysis
期刊:
Journal of Pharmacy and Pharmacology,2023年75(3):363-369 ISSN:0022-3573
通讯作者:
Shu-zhi Wang
作者机构:
[Liu, Shu-ting; Wang, Shu-zhi; Wang, Zong-bao; Chen, Ming-xin; Deng, Bo-yan] Univ South China, Inst Pharm & Pharmacol, Hengyang, Peoples R China.;[Liu, Shu-ting; Wang, Shu-zhi; Wang, Zong-bao; Chen, Ming-xin; Deng, Bo-yan] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang, Peoples R China.
通讯机构:
[Shu-zhi Wang] I;Institute of Pharmacy and Pharmacology, University of South China , Hengyang , China<&wdkj&>Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China , Hengyang , China
摘要:
Salusins are discovered in 2003 and divided into salusin-α and salusin-β, which are bioactive peptides with hemodynamic and mitotic activity and mainly distributed in plasma, urine, endocrine glands and kidneys. A large number of studies have shown that salusins can regulate lipid metabolism, inflammatory response and vascular proliferation. Despite the profound and diverse physiological properties of salusins, the exact mechanism of their cardiovascular effects remains to be determined. The potential mechanisms of action of salusins in cardiovascular-related diseases such as atherosclerosis, hypertension, heart failure, myocardial infarction and myocarditis, and their use as biomarkers of cardiovascular disease are discussed. This review aims to provide a new strategy for the diagnosis and prevention of clinical cardiovascular diseases.
通讯机构:
[Zhu, GH; Yan, A ] H;Hunan Childrens Hosp, Dept Pediat Orthoped, Changsha, Peoples R China.;Univ South China, Sch Pediat, Hengyang Med Sch, Changsha, Peoples R China.;Hunan Childrens Hosp, Hunan Prov Key Lab Pediat Orthoped, Changsha, Hunan, Peoples R China.
关键词:
all-inside;arthroscopy;closed osteocavity;direct visualization;physeal bar
摘要:
BACKGROUND: Physeal bar resection has been used for partial growth arrest treatment for a decade while removing the bony bar minimally invasively and accurately is challenging. This research aims to illustrate a modified arthroscopically assisted surgery, by which all the procedure was under all-inside visualization, without the constant exchange between burring under fluoroscopy, followed by irrigation, suction, and arthroscopy of the canal. METHODS: We retrospectively reviewed the patients who sustained physeal bar resection under direct all-inside visualization of the arthroscope during 2016-2021. Patients who underwent physeal bar resection with the aid of an arthroscope for identifying the physeal cartilage but not resecting and visualizing the physeal bar simultaneously were excluded from this study. RESULTS: In total, nine patients with ten related joints were included in this study. All the patients were followed up for at least two years. The average following time was 28.5 ± 6.7 months. Eight patients with nine related joints had an improvement of angular deformity, averaging 8.3 ± 6.9 degrees, and one had a worsening of the angular deformity. All the patients had a leg length discrepancy improvement, while four patients still had LLD >1 cm. The surgery time was 3.1 ± 0.7 h. There were no postoperative fractures, infections, or intraoperative complications such as neurovascular injury. CONCLUSIONS: Using clamps to form a closed osteocavity could make physeal bar resection under all-inside arthroscopic visualization feasible, which is minimally invasive, accurate, and safe.