Deep immunoglobulin repertoire sequencing depicts a comprehensive atlas of spike-specific antibody lineages shared among COVID-19 convalescents

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成果类型：

期刊论文

作者：

Yan, Qihong;Zhang, Yudi;Hou, Ruitian;Pan, Wenjing;Liang, Huan;...

通讯作者：

Xiong, Xiaoli;Chen, L;Zhao, Jincun;Niu, XF;Li, S

作者机构：

[Chen, Ling; He, Ping; Zhang, Yudi; Lin, Zihan; Zhao, Xinwei; Yan, Qihong; Liu, Banghui; Qu, Linbing; Deng, Weiqi; Chen, Zhaoming; Li, Pingchao; Xiong, Xiaoli; Xiong, XL; Huang, Xiaohan] Chinese Acad Sci, Guangzhou Inst Biomed, State Key Lab Resp Dis, Guangdong Lab Computat Biomed, Guangzhou, Peoples R China.

[Zhao, Jincun; Niu, Xuefeng; Yan, Qihong; Niu, XF; Liang, Huan; Huang, Xiaohan] Guangzhou Med Univ, Affiliated Hosp 1, Guangzhou Inst Resp Hlth, State Key Lab Resp Dis, Guangzhou, Peoples R China.

[Chen, Ling; Hou, Ruitian] Guangzhou Med Univ, Guangzhou Peoples Hosp 8, Guangzhou Inst Infect Dis, Guangzhou, Peoples R China.

[Li, Song; Pan, Wenjing; Li, S] Univ South China, Hengyang Med Sch, Hengyang, Peoples R China.

通讯机构：

[Zhao, JC; Niu, XF ] G

[Li, S ] U

[Chen, L ; Xiong, XL] C

Chinese Acad Sci, Guangzhou Inst Biomed, State Key Lab Resp Dis, Guangdong Lab Computat Biomed, Guangzhou, Peoples R China.

Chinese Acad Sci, Guangzhou Inst Hlth, Guangzhou, Peoples R China.

语种：

英文

关键词：

SARS-CoV-2;spike;antibodyomics;antibody repertoire;epitope mapping;lineage tracking

期刊：

Emerging Microbes & Infections

ISSN：

2222-1751

年：

2024

卷：

期：

页码：

2290841

DOI：

10.1080/22221751.2023.2290841

基金类别：

National Natural Science Foundation of China [82201932, 92269201, 61971187, 32170941]; National Natural Science Foundation of China [2022M710891]; China Postdoctoral Science Foundation [SKLRD-Z-202324]; State Key Laboratory of Respiratory Disease [2060206-202201020428]; Guangzhou Science and Technology Bureau - Municipal Schools and Colleges

机构署名：

本校为通讯机构

摘要：

Neutralizing antibodies are a key component in protective humoral immunity against SARS-CoV-2. Currently, available technologies cannot track epitope-specific antibodies in global antibody repertoires. Thus, the comprehensive repertoire of spike-specific neutralizing antibodies elicited by SARS-CoV-2 infection is not fully understood. We therefore combined high-throughput immunoglobulin heavy chain (IgH) repertoire sequencing, and structural and bioinformatics analysis to establish an antibodyomics pipeline, which enables tracking spike-specifi...

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Deep immunoglobulin repertoire sequencing depicts a comprehensive atlas of spike-specific antibody lineages shared among COVID-19 convalescents

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