Artemisinin ameliorates cognitive decline by inhibiting hippocampal neuronal ferroptosis via Nrf2 activation in T2DM mice

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成果类型：

期刊论文

作者：

Wang, Bo;Zhu, Sheng;Guo, Miao;Ma, Run-Dong;Tang, Ya-Ling;...

通讯作者：

Gu, HF

作者机构：

[Wang, Bo; Ma, Run-Dong; Nie, Ya-Xiong] Univ South China, Affiliated Hosp 1, Inst Anesthesiol, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.

[Zhu, Sheng] Xiangnan Univ, Affiliated Hosp, Dept Nucl Med, 25 Renmin West Rd, Chenzhou 423001, Hunan, Peoples R China.

[Gu, Hong-Feng; Tang, Ya-Ling; Guo, Miao; Gu, HF] Univ South China, Hengyang Med Sch, Dept Physiol, Hengyang 421001, Hunan, Peoples R China.

[Gu, Hong-Feng; Tang, Ya-Ling; Guo, Miao; Gu, HF] Univ South China, Inst Neurosci, Hengyang Med Sch, Key Lab Hunan Prov Major Brain Dis, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Gu, HF ] U

Univ South China, Hengyang Med Sch, Dept Physiol, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Inst Neurosci, Hengyang Med Sch, Key Lab Hunan Prov Major Brain Dis, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

Diabetic cognitive deficit;Ferroptosis;Hippocampus;Artemisinin;Nrf2

期刊：

MOLECULAR MEDICINE

ISSN：

1076-1551

年：

2024

卷：

期：

页码：

1-14

DOI：

10.1186/s10020-024-00797-9

基金类别：

This work was supported by grants from the National Natural Science Foundation of China (Grants No. 81500349), the Natural Science Foundation of Hunan Province, China (Grant No. 2022JJ30534; Grant No. 2022JJ30509), the key program of Educational Commission of Hunan Province, China (Grant No. 21A0273), Clinical Medical Technology Innovation Guidance Project of Hunan Province (2021SK51813).

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Background: Neuronal ferroptosis plays a critical role in the pathogenesis of cognitive deficits. The present study explored whether artemisinin protected type 2 diabetes mellitus (T2DM) mice from cognitive impairments by attenuating neuronal ferroptosis in the hippocampal CA1 region. Methods: STZ-induced T2DM mice were treated with artemisinin (40 mg/kg, i.p.), or cotreated with artemisinin and Nrf2 inhibitor MEL385 or ferroptosis inducer erastin for 4 weeks. Cognitive performance was determined by the Morris water maze and Y maze tests. Hippo...

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Artemisinin ameliorates cognitive decline by inhibiting hippocampal neuronal ferroptosis via Nrf2 activation in T2DM mice

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