Hydrogen sulfide attenuates depression-like behaviours in Parkinson\'s disease model rats by improving synaptic plasticity in a hippocampal Warburg effect-dependent manner - 成果

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Hydrogen sulfide attenuates depression-like behaviours in Parkinson's disease model rats by improving synaptic plasticity in a hippocampal Warburg effect-dependent manner

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成果类型：

期刊论文

作者：

Liu, Fen;Tian, Qing;Tang, Hui-Ling;Cheng, Xiang;Zou, Wei*;...

通讯作者：

Zou, Wei;Zhang, P

作者机构：

[Zou, Wei; Liu, Fen; Tang, Hui-Ling; Zhang, Ping] Univ South China, Affiliated Nanhua Hosp, Hengyang Med Sch, Dept Neurol, Hengyang, Peoples R China.

[Tian, Qing] Univ South China, Inst Neurosci, Hengyang Med Sch, Key Lab Cognit Disorders & Neurodegenerat Dis, Hengyang, Peoples R China.

[Cheng, Xiang] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Clin Lab, Hengyang, Peoples R China.

[Zou, Wei; Zhang, Ping] Univ South China, Affiliated Nanhua Hosp, Dept Neurosurg, 336 Dongfeng South Rd, Hengyang 421002, Hunan, Peoples R China.

通讯机构：

[Zou, W; Zhang, P ] U

Univ South China, Affiliated Nanhua Hosp, Dept Neurosurg, 336 Dongfeng South Rd, Hengyang 421002, Hunan, Peoples R China.

语种：

英文

关键词：

Depression-like behaviour;Hippocampal synaptic plasticity;Hydrogen sulfide;Parkinson's disease;Warburg effect

期刊：

Pharmacology Biochemistry and Behavior

ISSN：

0091-3057

年：

2024

卷：

234

页码：

173677

DOI：

10.1016/j.pbb.2023.173677

基金类别：

This study was supported by the National Natural Science Foundation of China (82271229), the Clinical Medical Technology Innovation Guidance Project of Hunan Province (2021SK51901), and the Major Research Topics of the Health Commission of Hunan Province (20201911).

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

BACKGROUND: Depression is a highly prevalent comorbidity arising in patients with Parkinson's disease (PD). However, depression in patients with PD is poorly treated. Hydrogen sulfide (H(2)S), a neuromodulator, has the potential to relieve depression. OBJECTIVE: To investigate whether H(2)S attenuates depression-like behaviours in a rat model of PD and examine the underlying mechanisms. METHODS: We utilised rotenone to develop a PD model with subcutaneous injections in the dorsal cervical region of Sprague-Dawley rats. The depression-like behaviours in the rotenone-induced PD model rats were a...

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Hydrogen sulfide attenuates depression-like behaviours in Parkinson's disease model rats by improving synaptic plasticity in a hippocampal Warburg effect-dependent manner

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