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Hydrogen sulfide attenuates depression-like behaviours in Parkinson's disease model rats by improving synaptic plasticity in a hippocampal Warburg effect-dependent manner

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成果类型:
期刊论文
作者:
Liu, Fen;Tian, Qing;Tang, Hui-Ling;Cheng, Xiang;Zou, Wei*;...
通讯作者:
Zou, Wei;Zhang, P
作者机构:
[Zou, Wei; Liu, Fen; Tang, Hui-Ling; Zhang, Ping] Univ South China, Affiliated Nanhua Hosp, Hengyang Med Sch, Dept Neurol, Hengyang, Peoples R China.
[Tian, Qing] Univ South China, Inst Neurosci, Hengyang Med Sch, Key Lab Cognit Disorders & Neurodegenerat Dis, Hengyang, Peoples R China.
[Cheng, Xiang] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Clin Lab, Hengyang, Peoples R China.
[Zou, Wei; Zhang, Ping] Univ South China, Affiliated Nanhua Hosp, Dept Neurosurg, 336 Dongfeng South Rd, Hengyang 421002, Hunan, Peoples R China.
通讯机构:
[Zou, W; Zhang, P ] U
Univ South China, Affiliated Nanhua Hosp, Dept Neurosurg, 336 Dongfeng South Rd, Hengyang 421002, Hunan, Peoples R China.
语种:
英文
关键词:
deoxyglucose;disks large homolog 4;hydrogen sulfide;rotenone;synapsin I;hydrogen sulfide;rotenone;sodium bisulfide;animal cell;animal experiment;animal model;animal tissue;antidepressant activity;Article;cell ultrastructure;controlled study;depression;elevated plus maze test;forced swim test;hippocampus;nerve cell plasticity;nonhuman;novelty suppressed feeding test;open field test;Parkinson disease;postsynaptic density;protein expression level;rat;rat model;synapse;tail suspension test;transmission electron microscopy;Warburg effect;Western blotting;animal;depression;hippocampus;human;metabolism;nerve cell plasticity;Sprague Dawley rat;Animals;Depression;Hippocampus;Humans;Hydrogen Sulfide;Neuronal Plasticity;Parkinson Disease;Rats;Rats, Sprague-Dawley;Rotenone
期刊:
Pharmacology Biochemistry and Behavior
ISSN:
0091-3057
年:
2024
卷:
234
页码:
173677
基金类别:
This study was supported by the National Natural Science Foundation of China ( 82271229 ), the Clinical Medical Technology Innovation Guidance Project of Hunan Province ( 2021SK51901 ), and the Major Research Topics of the Health Commission of Hunan Province ( 20201911 ).
机构署名:
本校为第一且通讯机构
院系归属:
医学院
摘要:
Background: Depression is a highly prevalent comorbidity arising in patients with Parkinson's disease (PD). However, depression in patients with PD is poorly treated. Hydrogen sulfide (H2S), a neuromodulator, has the potential to relieve depression. Objective: To investigate whether H2S attenuates depression-like behaviours in a rat model of PD and examine the underlying mechanisms. Methods: We utilised rotenone to develop a PD model with subcutaneous injections in the dorsal cervical region of Sprague-Dawley rats. The depression-like behaviour...

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