Chronic Sleep Deprivation Impairs Visual Functions via Oxidative Damage in Mice

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成果类型：

期刊论文

作者：

Tang, Liying;Zhang, Houjian;Liao, Yi;Zhou, Shengmei;Yang, Yaqiong;...

通讯作者：

Hu, Jiaoyue;Liu, ZG

作者机构：

[Zhang, Minjie; Yang, Yaqiong; Huang, Caihong; Zhang, Mouxin; Zhuang, Jingbin; Zhang, Houjian; Liao, Yi; Lin, Xiang; Tang, Liying; Guo, Yuli; Wang, Shaopan; Ouyang, Weijie; Zhou, Shengmei; Zhao, Jiankai; Zhang, Rongrong] Xiamen Univ, Fujian Engn & Res Ctr Eye Regenerat Med, Fujian Prov Key Lab Ophthalmol & Visual Sci, Eye Inst, Xiamen, Peoples R China.

[Chen, Shikun; Tang, Liying; Xie, Tingyu] Xiamen Univ, Zhongshan Hosp, Sch Med, Xiamen, Peoples R China.

[Zhang, Houjian; Guo, Yuli] Univ South China, Dept Ophthalmol, Affiliated Hosp 1, Hengyang, Peoples R China.

[Hu, Jiaoyue; Lin, Xiang] Xiamen Univ, Dept Ophthalmol, Xiangan Hosp, Xiamen, Peoples R China.

[Hu, Jiaoyue; Zhang, Houjian] Xiamen Univ, Dept Ophthalmol, Xiangan Hosp, Xiamen 361102, Peoples R China.

通讯机构：

[Hu, JY; Liu, ZG ] X

Xiamen Univ, Inst Xiamen Univ, Xiangan Hosp, Med Coll, 401,hengyi Bldg,S Xiangan Rd, Xiamen 361102, Fujian, Peoples R China.

语种：

英文

期刊：

AMERICAN JOURNAL OF PATHOLOGY

ISSN：

0002-9440

年：

2024

卷：

194

期：

页码：

307-320

DOI：

10.1016/j.ajpath.2023.11.004

基金类别：

Natural Science Foundation of Fujian Province [2022J05297]; National Natural Science Foundation of China [82271054, U20A20363]; National Key R&D Program of China [2019YFA0111200]; Natural Science Foundation of Xiamen [3502Z20227099]

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

Sleep deprivation (SD) is a global public health burden, and has a detrimental role in the nervous system. Retina is an important part of the central nervous system; however, whether SD affects retinal structures and functions remains largely unknown. Herein, chronic SD mouse model indicated that loss of sleep for 4 months could result in reductions in the visual functions, but without obvious morphologic changes of the retina. Ultrastructural analysis by transmission electron microscope revealed the deterioration of mitochondria, which was acc...

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Chronic Sleep Deprivation Impairs Visual Functions via Oxidative Damage in Mice

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