期刊：
Journal of Healthcare Engineering,2022年2022:1-13 ISSN：2040-2295
通讯作者：
Huayan Xie<&wdkj&>Jian Xiao<&wdkj&>Yong Zou<&wdkj&>Ke Shi<&wdkj&>Baishuang Yang<&wdkj&>Anqi Guan<&wdkj&>Ziyu Dai<&wdkj&>Shuya He et al.<&wdkj&>Xi Chen<&wdkj&>Qi Deng<&wdkj&>Bin Xie<&wdkj&>Shasha Yang
作者机构：
[Yang, Baishuang; Xie, Huayan; Chen, Qiong; Xiao, Jian; Guan, Anqi; Yang, Shasha; Xie, Bin; Shi, Ke; Dai, Ziyu] Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha 410008, Peoples R China.;[Yang, Baishuang; Xie, Huayan; Chen, Qiong; Xiao, Jian; Guan, Anqi; Yang, Shasha; Xie, Bin; Dai, Ziyu] Cent South Univ, Xiangya Hosp, Dept Geriatr, Resp Med, Changsha 410008, Peoples R China.;[Chen, Xi] Cent South Univ, Xiangya Hosp, Dept Resp Med, Changsha 410008, Peoples R China.;[Deng, Qi] Cent South Univ, Xiangya Hosp, Dept Neurol, Changsha 410008, Peoples R China.;[Shi, Ke] Cent South Univ, Xiangya Hosp, Dept Geriatr, Changsha 410008, Peoples R China.
通讯机构：
[Huayan Xie; Jian Xiao; Ke Shi; Baishuang Yang; Anqi Guan; Ziyu Dai; Bin Xie; Shasha Yang] N;[Yong Zou; Xi Chen; Qi Deng] D;[Shuya He et al.] I;Institute of Biochemistry and Molecular Biology,Hengyang Medical College,University of South China,China<&wdkj&>Department of Emergency Medicine,Xiangya Hospital,Central South University,China<&wdkj&>Department of Neurology,Xiangya Hospital,Central South University,China<&wdkj&>Department of Respiratory Medicine,Xiangya Hospital,Central South University,China<&wdkj&>National Clinical Research Center for Geriatric Disorders,Xiangya Hospital,Central South University,China<&wdkj&>Department of Geriatrics,Respiratory Medicine,Xiangya Hospital,Central South University,China<&wdkj&>National Clinical Research Center for Geriatric Disorders,Xiangya Hospital,Central South University,China<&wdkj&>Department of Geriatrics,Xiangya Hospital,Central South University,China
期刊：
Indian Journal of Microbiology,2021年61(4):417-426 ISSN：0046-8991
通讯作者：
Xiao, F.;He, S.
作者机构：
[He, Shuya; Xiao, Fangzhu; Zhu, Qiqi; Guo, Kexin; Li, Shanshan] Univ South China, Sch Publ Hlth, Hengyang 421001, Hunan, Peoples R China.;[Luo, Jiaqi; Xie, Jingxi] Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Hunan, Peoples R China.;[Shu, Yangzhen] Univ South China, Sch Resources Environm & Safety Engn, Hengyang 421001, Hunan, Peoples R China.
通讯机构：
[Fangzhu Xiao; Shuya He] S;School of Public Health, University of South China, Hengyang, China<&wdkj&>School of Public Health, University of South China, Hengyang, China
关键词：
Deinococcus radiodurans;Biological treatment of environmental pollution;Genetic engineering bacteria;Uranium wastewater
摘要：
Radioactive uranium wastewater contains a large amount of radionuclide uranium and other heavy metal ions. The radioactive uranium wastewater discharged into the environment will not only pollute the natural environment, but also threat human health. Therefore, the treatment of radioactive uranium wastewater is a current research focus for many researchers. The treatment in radioactive uranium wastewater mainly includes physical, chemical and biological methods. At present, the using of biological treatment to treat uranium in radioactive uranium wastewater has been gradually shown its superiority and advantages. Deinococcus radiodurans is a famous microorganism with the most radiation resistant to ionizing radiation in the world, and can also resist various other extreme pressures. D. radiodurans can be directly used for the adsorption of uranium in radioactive waste water, and it can also transform other functional genes into D. radiodurans to construct genetically engineered bacteria, and then applied to the treatment of radioactive uranium containing wastewater. Radionuclides uranium in radioactive uranium-containing wastewater treated by D. radiodurans involves a lot of mechanisms. This article reviews currently the application of D. radiodurans that directly or construct genetically engineered bacteria in the treatment of radioactive uranium wastewater and discusses the mechanism of D. radiodurans in bioremediation of uranium. The application of constructing an engineered bacteria of D. radiodurans with powerful functions in uranium-containing wastewater is prospected.
关键词：
small nucleolar RNA;SNORD16;colon cancer;oncogene;prognostic biomarker
摘要：
Colon cancer (CC) is considered one of the most common and lethal malignancies occurring both in male and female. Its widespread prevalence demonstrates the need for novel diagnostic and prognostic biomarkers for CC. Emerging evidence has shown that small nucleolar RNAs play critical roles in tumor development. In this study, we investigated the expression profile and functions of SNORD16 in CC. Our data showed that SNORD16, rather than its host gene (RPL4), was upregulated in CC cell lines. Compared to matched adjacent normal tissues, CC tissues showed higher SNORD16 expression levels, and no correlation was found between SNORD16 and RPL4. Patients with high SNORD16 expression levels had a worse prognosis, and multivariate analysis showed the high SNORD16 expression was an independent prognostic factor for CC. In vitro gain- and loss-of-function studies revealed that SNORD16 can promote cell growth, proliferation, migration, and invasion of CC cells by inhibiting apoptosis. These results suggested that SNORD16 has an oncogenic role in CC and might be a novel diagnostic and prognostic biomarker for CC.
期刊：
Research in Microbiology,2020年171(2):45-54 ISSN：0923-2508
通讯作者：
He, Shu-ya
作者机构：
[He, Shu-ya; Wang, Wu-zhou; He, Jun-yan; Ma, Yun; Qi, Hui-zhou] Univ South China, Hengyang Med Coll, Inst Biochem & Mol Biol, Hengyang 421001, Peoples R China.;[Qi, Hui-zhou] Univ South China, Hengyang Med Coll, Funct Lab Ctr, Hengyang 421001, Peoples R China.;[He, Shu-ya; Wang, Wu-zhou; He, Jun-yan; Xiao, Fang-zhu; Qi, Hui-zhou] Univ South China, Hengyang Key Lab Biol Effects Nucl Radiat, Hengyang 421001, Peoples R China.
通讯机构：
[He, Shu-ya] U;Univ South China, Hengyang Key Lab Biol Effects Nucl Radiat, Hengyang 421001, Peoples R China.
关键词：
Antioxidative system;Deinococcus radiodurans;Manganese;PprI;PprM;Reactive oxygen species
摘要：
Deinococcus radiodurans is famous for its extreme resistance to various stresses such as ionizing radiation (IR), desiccation and oxidative stress. The underlying mechanism of exceptional resistance of this robust bacterium still remained unclear. However, the antioxidative system of D. radiodurans has been considered to be the determinant factor for its unparalleled resistance and protects the proteome during stress, then the DNA repair system and metabolic system exert their functions to restore the cell to normal physiological state. The antioxidative system not only equipped with the common reactive oxygen species (ROS) scavenging enzymes (e.g. catalase and superoxide dismutase) but also armed with a variety of non-enzyme antioxidants (e.g. carotenoids and manganese species). And the small manganese complexes play an important role in the antioxidative system of D. radiodurans. Recent studies have characterized several regulators (e.g., PprI and PprM) in D. radiodurans, which play critical roles in the protection of the bacteria from various stresses. In this review, we offer a panorama of the progress regarding the characteristics of the antioxidative system in D. radiodurans and its application in the future.
作者机构：
[刘政海; 李彩; 王五洲; 曹文宇; 罗诗诗] Clinical Anatomy & Reproductive Medicine Application Institute, Medical College, University of South China, Hengyang, 421001, China;[徐杨] Department of Physiology, Medical College, University of South China, Hengyang, 421001, China;[何洁] Department of Pathology, Medical College, University of South China, Hengyang, 421001, China;[Wang W.; 何淑雅] School of Public Health, University of South China, Hengyang, 421001, China;[艾小红] Department of Radiation Oncology, The First Affiliated Hospital of University of South China, Hengyang, 421001, China
通讯机构：
[Cao, W.] C;Clinical Anatomy & Reproductive Medicine Application Institute, China
摘要：
<jats:sec><jats:title>Background</jats:title><jats:p>The aim of this study was to determine whether progesterone could inhibit the growth of lung adenocarcinoma cells via membrane progesterone receptor alpha (mPRα) and elucidate its potential mechanism. The relationship between mPRα expression and the survival prognosis of lung adenocarcinoma patients was studied.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>A mPRα knockdown lung adenocarcinoma cell line was constructed and treated with P4 and Org (a derivative of P4 and specific agonist of mPRα). Cell proliferation was assessed using CCK‐8 and plate colony formation assays. Protein expression was detected by western blotting. A nude mouse model of lung adenocarcinoma was established to assess the antitumor effect of P4/Org in vivo.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>We initially determined that mPRα could promote the development of lung adenocarcinoma through the following lines of evidence. High expression of mPRα both at the mRNA and protein level was significantly associated with the poor prognosis of lung adenocarcinoma patients. The downregulation of mPRα inhibited the proliferation of lung adenocarcinoma cells. We further showed that mPRα mediates the ability of P4 to inhibit the growth of lung adenocarcinoma cells through the following lines of evidence: P4/Org inhibited the proliferation of lung adenocarcinoma cells; mPRα mediated the ability of P4/Org to inhibit lung adenocarcinoma cell proliferation; mPRα mediated the ability of P4/Org to inhibit the PKA (cAMP‐dependent protein kinase)/CREB (cAMP responsive element binding protein) and PKA/β‐catenin signaling pathways; and P4/Org inhibited the growth of a lung adenocarcinoma tumor model in vivo.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>In summary, the results of our study show that progesterone can inhibit lung adenocarcinoma cell growth via mPRα.</jats:p></jats:sec>
通讯机构：
[He, Shu-Ya; Peng, Guo-Wen] U;Univ South China, Sch Publ Hlth, Hengyang 421001, Peoples R China.;Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.;Univ South China, Sch Resource Environm & Safety Engn, Hengyang 421001, Peoples R China.;Univ South China, Hunan Prov Engn Technol Res Ctr Uranium Tailings, Hengyang 421001, Peoples R China.
关键词：
calixarene, Fe3O4, magnetic materials, separation.
摘要：
<jats:p>
Environmental contextUranium-containing wastewaters have high potential to harm the environment and human health. We found that the combination of calix[4]arene with magnetic Fe3O4 particles produced good adsorption of uranium from wastewater. In addition, this material can be recycled and reused, so it has good prospects in practical applications for uranium remediation.
AbstractA magnetic functionalised calix[4]arene composite consisting of Fe3O4 and calix[4]arene phosphonate derivative (CPD) was prepared through a facile self-assembly method. The composite was characterised by scanning electron microscopy (SEM), powder X-ray diffraction (PXRD) and Fourier transform infrared spectroscopy (FTIR). The as-synthesised Fe3O4/CPD composite was used to remove UVI from aqueous solutions under different conditions. Meanwhile, the adsorption isotherm, kinetics and thermodynamics were fitted and analysed. The results show that the Fe3O4/CPD composite may be a promising adsorption material for the separation and enrichment of UVI from aqueous solutions in the cleanup of environmental pollution.
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