mPRα mediates P4/Org OD02-0 to improve the sensitivity of lung adenocarcinoma to EGFR-TKIs via the EGFR-SRC-ERK1/2 pathway

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成果类型：

期刊论文

作者：

Lu, Xiaoxiao;Guan, Anqi;Chen, Xi;Xiao, Jian;Xie, Mingxuan;...

通讯作者：

Chen, Qiong

作者机构：

[Xie, Mingxuan; Yang, Baishuang; Lu, Xiaoxiao; Chen, Qiong; Xiao, Jian; Guan, Anqi] Cent S Univ, Xiangya Hosp, Dept Geriatr, Resp Med, Changsha 410008, Hunan, Peoples R China.

[Lu, Xiaoxiao] NCI, Lab Genome Integr, Ctr Canc Res, NIH, Bethesda, MD 20892 USA.

[Chen, Xi] Cent S Univ, Xiangya Hosp, Dept Resp, Changsha, Hunan, Peoples R China.

[He, Shuya] Univ South China, Dept Biochem & Biol, Hengyang, Peoples R China.

[You, Shaojin] Emory Univ, Atlanta VA Med Ctr, Atlanta Res & Educ Fdn 151F, Lab Canc Expt Therapy,Histopathol Core, Decatur, GA USA.

通讯机构：

[Chen, Qiong] C

Cent S Univ, Xiangya Hosp, Dept Geriatr, Resp Med, Changsha 410008, Hunan, Peoples R China.

语种：

英文

关键词：

bosutinib;epidermal growth factor receptor;epidermal growth factor receptor kinase inhibitor;gefitinib;membrane progesterone receptor alpha;mifepristone;mitogen activated protein kinase 1;mitogen activated protein kinase 3;org od 02 0;progesterone;progesterone derivative;progesterone receptor;progesterone receptor membrane component 1;protein tyrosine kinase;unclassified drug;epidermal growth factor receptor;gefitinib;progesterone;progesterone receptor;progesterone receptor A;protein kinase inhibitor;protein tyrosine kinase;A-549 cell line;adult;animal experiment;animal model;animal tissue;antitumorigenic activity;apoptosis;Article;cancer growth;cancer resistance;cell invasion;cell migration;cell proliferation;controlled study;DNA sequence;drug efficacy;female;genotype;human;human cell;human tissue;immunofluorescence;immunoprecipitation;in vitro study;in vivo study;lung adenocarcinoma;major clinical study;male;mouse;nonhuman;overall survival;phenotype;point mutation;priority journal;progression free survival;signal transduction;adenocarcinoma;animal;Bagg albino mouse;drug effect;drug resistance;drug screening;genetics;lung tumor;MAPK signaling;metabolism;middle aged;mutation;nude mouse;procedures;survival analysis;tumor cell line;A549 Cells;Adenocarcinoma;Animals;Cell Line, Tumor;Drug Resistance, Neoplasm;ErbB Receptors;Female;Gefitinib;Humans;Lung Neoplasms;Male;MAP Kinase Signaling System;Mice, Inbred BALB C;Mice, Nude;Middle Aged;Mutation;Progesterone;Protein Kinase Inhibitors;Receptors, Progesterone;src-Family Kinases;Survival Analysis;Xenograft Model Antitumor Assays

期刊：

Molecular Carcinogenesis

ISSN：

0899-1987

年：

2020

卷：

期：

页码：

179-192

DOI：

10.1002/mc.23139

基金类别：

This work was supported by National Natural Science Foundation of China (No. 81572284, 81770045 to Q. Chen, No. 81602028 to M. Xie), Clinical Medical Technology Innovation Project of Hunan Province (No. 2018SK52608) and China Scholarship Council Foundation (CSC No. 201706370122 to X. Lu). This work was supported by National Natural Science Foundation of China (No. 81572284, 81770045 to Q. Chen, No. 81602028 to M. Xie), Clinical Medical Technology Innovation Project of Hunan Province (No. 2018SK52608) and China Scholarship Council Foundation (CSC No. 201706370122 to X. Lu).

机构署名：

本校为其他机构

院系归属：

药学与生物科学学院

摘要：

The discovery of epidermal growth factor receptor (EGFR) mutations has made EGFR tyrosine kinase inhibitors (EGFR-TKIs) a milestone in the treatment for advanced non–small cell lung cancer (NSCLC). However, patients lacking EGFR mutations are not sensitive to EGFR-TKI treatment and the emergence of secondary resistance poses new challenges for the targeted therapy of lung cancer. In this study, we identified that the expression of membrane progesterone receptor α (mPRα) was associated with EGFR mutations in lung adenocarcinoma patients and s...

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mPRα mediates P4/Org OD02-0 to improve the sensitivity of lung adenocarcinoma to EGFR-TKIs via the EGFR-SRC-ERK1/2 pathway

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