Progesterone/Org inhibits lung adenocarcinoma cell growth via membrane progesterone receptor alpha

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Xiao, Jian;Chen, Xi;Lu, Xiaoxiao;Xie, Mingxuan;He, Bixiu;...

通讯作者：

Chen, Qiong

作者机构：

[Xie, Mingxuan; He, Bixiu; Lu, Xiaoxiao; Chen, Qiong; Xiao, Jian] Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha 410008, Hunan, Peoples R China.

[Xie, Mingxuan; He, Bixiu; Chen, Qiong; Xiao, Jian] Cent South Univ, Xiangya Hosp, Resp Med, Dept Geriatr, Changsha 410008, Hunan, Peoples R China.

[Chen, Xi] Cent South Univ, Xiangya Hosp, Dept Resp & Crit Care Med, Changsha, Hunan, Peoples R China.

[He, Shuya] Univ South China, Dept Biochem & Mol Biol, Hengyang, Peoples R China.

[You, Shaojin] Emory Univ, Lab Canc Expt Therapy, Histopathol Core, Atlanta Res & Educ Fdn 151F,Atlanta VA Med Ctr, Decatur, GA USA.

通讯机构：

[Chen, Qiong] C

Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha 410008, Hunan, Peoples R China.

Cent South Univ, Xiangya Hosp, Resp Med, Dept Geriatr, Changsha 410008, Hunan, Peoples R China.

语种：

英文

关键词：

Adenocarcinoma;lung cancer;mPR alpha;progesterone

期刊：

Thoracic Cancer

ISSN：

1759-7706

年：

2020

卷：

期：

页码：

2209-2223

DOI：

10.1111/1759-7714.13528

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81572284, 81770045, 81602028]; Hunan Provincial Clinical Medical Technology Innovation Guidance Project [2018SK52608]; Clinical Research Fund of Xiangya Hospital [2016L02]

机构署名：

本校为其他机构

院系归属：

化学化工学院

药学与生物科学学院

摘要：

Background The aim of this study was to determine whether progesterone could inhibit the growth of lung adenocarcinoma cells via membrane progesterone receptor alpha (mPR alpha) and elucidate its potential mechanism. The relationship between mPR alpha expression and the survival prognosis of lung adenocarcinoma patients was studied. Methods A mPR alpha knockdown lung adenocarcinoma cell line was constructed and treated with P4 and Org (a derivative of P4 and specific agonist of mPR alpha). Cell proliferation was assessed using CCK-8 and plate colony formation assays. Protein expression was det...

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Progesterone/Org inhibits lung adenocarcinoma cell growth via membrane progesterone receptor alpha

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