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Gene regulation for the extreme resistance to ionizing radiation of Deinococcus radiodurans

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成果类型:
期刊论文
作者:
Wang, Wuzhou;Ma, Yun;He, Junyan;Qi, Huizhou;Xiao, Fangzhu;...
通讯作者:
He, Shuya
作者机构:
[Wang, Wuzhou; He, Shuya; He, Junyan; Ma, Yun] Univ South China, Hengyang Med Coll, Inst Biochem & Mol Biol, Hengyang 421001, Peoples R China.
[Qi, Huizhou] Univ South China, Hengyang Med Coll, Funct Lab Ctr, Hengyang 421001, Peoples R China.
[He, Shuya; Qi, Huizhou; Xiao, Fangzhu; He, Junyan] Univ South China, Hengyang Key Lab Biol Effects Nucl Radiat, Hengyang 421001, Peoples R China.
通讯机构:
[He, Shuya] U
Univ South China, Hengyang Med Coll, Inst Biochem & Mol Biol, Hengyang 421001, Peoples R China.
Univ South China, Hengyang Key Lab Biol Effects Nucl Radiat, Hengyang 421001, Peoples R China.
语种:
英文
关键词:
Radioresistance;RDRM;Two-component systems;sRNA;Deinococcus radiodurans
期刊:
Gene
ISSN:
0378-1119
年:
2019
卷:
715
页码:
144008
基金类别:
Regulatory RNAs, also referred to as sRNAs because of their small sizes, are generally noncoding RNAs (ncRNAs) (Gottesman, 2004). sRNAs have been identified and reported to act major players in bacteria to handle a vast array of stresses, such as oxidative stress, temperature stress, iron deficiency stress, pH stress, and metabolite stress (Repoila and Gottesman, 2001; Opdyke et al., 2004; Jonas and Melefors, 2009; Holmqvist and Wagner, 2017). Hundreds of sRNAs have been predicted to be present
机构署名:
本校为第一且通讯机构
院系归属:
药学与生物科学学院
摘要:
Deinococcus radiodurans is a model microorganism used for studies on DNA repair and antioxidation due to its extraordinary tolerance to ionizing radiation and other DNA-damaging agents. Various transcriptome analyses have revealed that hundreds of genes are induced and that many other genes are repressed during recovery of D. radiodurans following irradiation, suggesting that gene regulation is of great importance for the extreme resistance of this microorganism to ionizing radiation. In this article, we focus on some reported strategies that a...

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