Small Nucleolar RNA, C/D Box 16 (SNORD16) Acts as a Potential Prognostic Biomarker in Colon Cancer

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

He, Jun-yan;Liu, Xin;Qi, Zhen-hua;Wang, Qi;Lu, Wen-qing;...

通讯作者：

Wang, Zhi-dong;Zhang, Qing-tong;He, Shu-ya

作者机构：

[He, Shu-ya; He, Jun-yan] Univ South China, Hengyang Med Coll, Inst Biochem & Mol Biol, Hengyang, Peoples R China.

[Lu, Wen-qing; Qi, Zhen-hua; He, Jun-yan; Wang, Qi; Liu, Xin; Wang, Zhi-dong] Beijing Inst Radiat Med, Beijing Key Lab Radiobiol, Dept Radiobiol, Beijing 100850, Peoples R China.

[Zhang, Qing-tong] China Med Univ, Liaoning Canc Hosp & Inst, Canc Hosp, Dept Colorectal Surg, Shenyang, Peoples R China.

[Wang, Zhi-dong] Univ South China, Sch Publ Hlth, Hengyang, Peoples R China.

[He, Shu-ya] Univ South China, Hengyang Key Lab Biol Effects Nucl Radiat, Hengyang 421001, Peoples R China.

通讯机构：

[Wang, Zhi-dong] B

[Zhang, Qing-tong] C

[Wang, Zhi-dong; He, Shu-ya] U

Beijing Inst Radiat Med, Beijing Key Lab Radiobiol, Dept Radiobiol, Beijing 100850, Peoples R China.

China Med Univ, Liaoning Canc Hosp & Inst, Canc Hosp, Dept Colorectal Surg, Shenyang, Peoples R China.

语种：

英文

关键词：

small nucleolar RNA;SNORD16;colon cancer;oncogene;prognostic biomarker

期刊：

Dose-Response

ISSN：

1559-3258

年：

2020

卷：

期：

页码：

155932582091782

DOI：

10.1177/1559325820917829

基金类别：

The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the National Natural Science Foundation of China [31770913 to Z.W.].

机构署名：

本校为第一且通讯机构

院系归属：

药学与生物科学学院

公共卫生学院

摘要：

Colon cancer (CC) is considered one of the most common and lethal malignancies occurring both in male and female. Its widespread prevalence demonstrates the need for novel diagnostic and prognostic biomarkers for CC. Emerging evidence has shown that small nucleolar RNAs play critical roles in tumor development. In this study, we investigated the expression profile and functions of SNORD16 in CC. Our data showed that SNORD16, rather than its host gene (RPL4), was upregulated in CC cell lines. Compared to matched adjacent normal tissues, CC tissues showed higher SNORD16 expression levels, and no...

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Small Nucleolar RNA, C/D Box 16 (SNORD16) Acts as a Potential Prognostic Biomarker in Colon Cancer

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