作者机构：
[Li, Yu-kun; Zou, Juan; Ye, Dong-mei; Zeng, Xi] Univ South China, Hunan Prov Key Lab Tumor Cellular & Mol Pathol, Canc Res Inst, Hengyang 421001, Hunan, Peoples R China.;[Zeng, Ying] Univ South China, Sch Nursing, Hengyang 421001, Hunan, Peoples R China.;[Zeng, Xi] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Hunan, Peoples R China.;[Luo, Gui-fang; Chen, Chang-ye] Univ South China, Affiliated Hosp 1, Dept Gynecol, Hengyang 410011, Hunan, Peoples R China.
通讯机构：
[Zeng, Xi; Luo, Gui-fang] U;Univ South China, Hunan Prov Key Lab Tumor Cellular & Mol Pathol, Canc Res Inst, Hengyang 421001, Hunan, Peoples R China.;Univ South China, Affiliated Hosp 1, Dept Gynecol, Hengyang 410011, Hunan, Peoples R China.
关键词：
Apoptosis;Cancer;EMT;PAK5;Proliferation
摘要：
An oncogenic role, p21-activated kinase 5 (PAK5), has proven as a significant mediator for many cellular progression, which is expressed highly in human organs such as lung, liver, kidney, blood vessels endothelial cells and inflammatory cells. PAK5 was primitively detected in the cerebrum and accelerated the filopodia formation in neurocytes. It can reverse the effect of Rho and adjust its activity to mediate maintenance and development of nerve axon by binding with Cdc42-GTP. Moreover, PAK5 has been suggested to mediate protean, multitudinous and inscrutable functions in cancer. Currently, many researches indicated that PAK5 was dysregulated in ovarian cancer, cervical cancer, melanoma, osteosarcoma, renal carcinoma, breast cancer, gastric cancer and so on, which was involved in cell proliferation, apoptosis, migration and invasion. This review focuses the latest knowledge on the structure, expression, signalling pathway of PAK5, emphasizing its function in cancer.
期刊：
JOURNAL OF CELLULAR PHYSIOLOGY,2019年234(3):2095-2103 ISSN：0021-9541
通讯作者：
Zhao, Hong
作者机构：
[Yao, Pingbo; Zeng, Dehui] Univ South China, Affiliated Nanhua Hosp, Dept Orthoped, Hengyang, Peoples R China.;[Zhao, Hong] Univ South China, Inst Pharm & Pharmacol, Coll Nursing, Hengyang, Peoples R China.;[Zhao, Hong] Univ South China, Coll Nursing, Hengyang 421001, Peoples R China.
通讯机构：
[Zhao, Hong] U;Univ South China, Coll Nursing, Hengyang 421001, Peoples R China.
关键词：
bone cancer;osteoporosis;P2X7 receptor;rheumatoid arthritis;the stress fracture injury
摘要：
Abundant evidence indicted that P2X7 receptor show a essential role in human health and some human diseases including hypertension, atherosclerosis, pulmonary inflammation, tuberculosis infection, psychiatric disorders, and cancer. P2X7 receptor also has an important role in some central nervous system diseases such as neurodegenerative disorders. Recently, more research suggested that P2X7 receptor also plays a crucial role in bone and joint diseases. But the effect of P2X7 receptor on skeletal and joint diseases has not been systematically reviewed. In this article, the role of P2X7 receptor in skeletal and joint diseases is elaborated. The activation of P2X7 receptor can ameliorate osteoporosis by inducing a fine balance between osteoclastic resorption and osteoblastic bone formation. The activation of P2X7 receptor can relieve the stress fracture injury by increasing the response to mechanical loading and inducing osteogenesis. But the activation of P2X7 receptor mediates the cell growth and cell proliferation in bone cancer. In addition, the activation of P2X7 receptor can aggravate the process of some joint diseases such as osteoarthritis, rheumatoid arthritis, and acute gouty arthritis. The inhibition of P2X7 receptor can alleviate the pathological process of joint disease to some extent. In conclusion, P2X7 receptor may be a critical regulator and therapeutic target for bone and joint diseases.
摘要：
Heterogeneous nuclear ribonucleoprotein K (hnRNP K) is an RNA/DNA special binding protein that participates in regulating the expression of related genes, transcription, RNA alternative splicing, translation, posttranslational modification, cell signal transduction, cell movement, interacts with ncRNAs, and induces angiogenesis. Moreover, several cellular functions forcefully indicated that hnRNP K participates in tumorigenesis. Numerous studies indicated hnRNP K is aberrantly elevated in multiple tumors. In addition, hnRNP K abnormal accumulation in cytoplasmic is also associated with poor prognosis. This suggests that hnRNP K may play a role in the development and progression of tumors. However, related studies demonstrated that hnRNP K acts as a tumor suppressor to suppress tumor formation. Therefore, this paper aims to explore the role of hnRNPK in tumors.
摘要：
AIM: A randomised controlled trial (RCT) was implemented to verify the feasibility and acceptability of cognitive education in the format of mind maps for increasing perceived control and decreasing the symptom distress of lung cancer patients who were receiving chemotherapy. METHODS: A total of 136 lung cancer patients who were receiving chemotherapy were randomised using stratified blocks (1:1 ratio, from March 2016 to April 2017). The intervention group was given cognitive education in the format of mind maps. The control group was provided conventional education. The primary outcomes were perceived control, including cancer experience and cancer efficacy; the secondary outcomes included symptom distress (arising from fatigue, distress, sleep disturbance, poor appetite, drowsiness, shortness of breath, etc.). The Mann-Whitney U test, chi-squared test, two-sample t test and repeated measurement analysis of variance were used. RESULTS: Ninety-four patients completed the final study. The results of the repeated measurement analysis of variance indicated that at the 8th or 12th week following cognitive education intervention in the format of mind maps, the cancer experience, cancer efficacy (except personal efficacy) and symptom distress (arising from fatigue, distress, sleep disturbance, and sadness and its total scores) of the patients in the intervention group were considerably improved compared with those of the control group (p < 0.05). The longer the intervention was, the higher the level of the patients' perceived control was and the lower the degree of patient symptom distress was (p < 0.05). CONCLUSIONS: Our findings suggest that cognitive education in the format of mind maps could improve perceived control and decrease the symptom distress of lung cancer patients who were receiving chemotherapy and that it was feasible and acceptable. Cognitive education in the format of mind maps was found to be an effective teaching tool for lung cancer patients who were receiving chemotherapy.
摘要：
To investigate how uterine size and volume are associated with live birth rate in patients undergoing assisted reproduction technology. This prospective cohort study was conducted at the Reproductive Medicine Centre from January 2010 to May 2017. Multivariate binary logistic regression was used to evaluate the relations between uterine size, total volume, and live birth outcomes, after they were adjusted for the main influencing factors. A total of 7320 women of clinical pregnancy were enrolled. Compared with uterine lengths of 50 to 59 mm (referent), women with uterine lengths >= 60 mm had a lower live birth rate (RR = 1.541). Compared with uterine widths of >= 50 mm (referent), women with uterine widths <30 mm had a lower live birth rate (RR = 1.430). Compared with uterine anteroposterior diameters of <30 mm (referent), women with uterine anteroposterior diameters >= 50 mm had a lower live birth rate (RR = 1.636). Compared with uterine volumes of 30 to 49 mL (referent), women with volumes <30 mL and >= 70 mL had lower live birth rates (RR = 1.368 and 1.742, respectively). Our findings indicate that uterine sizes and volumes that were too large or too small reduced the live birth rate.
摘要：
The aim of this study was to investigate the relationships between uterine size and volume and clinical pregnancy rate.This longitudinal study was conducted among patients undergoing assisted reproduction technology (ART) treatment at the Reproductive Medicine Center from January 2010 to May 2017, all of whom provided informed consent to participate in the study. The uterine size, for all patients, was measured by transvaginal ultrasonography before ovarian stimulation. Clinical pregnancy was diagnosed by ultrasound confirmation of at least an intrauterine gestational sac and fetal cardiac activity 4 weeks after embryo transfer.A total of 11,924 patients were enrolled in this study. Compared to patients with uterine lengths of 50 to 59 mm (referent), patients with uterine lengths >/=60 mm had a lower clinical pregnancy rate. Compared to patients with uterine widths of 30 to 39 mm (referent), patients with uterine widths of 40 to 49 mm and those with uterine widths of >/=50 mm had a lower clinical pregnancy rate. Compared with those with a uterine anteroposterior diameter of <30 mm (referent), patients with uterine anteroposterior diameters of >/=50 mm had a lower clinical pregnancy rate. Compared with those with a uterine volume of 30 to 49 mL (referent), patients with a uterine volume >/=70 mL had a lower clinical pregnancy rate.The patients with an optimal uterine length, width, anteroposterior diameter, and volume had a higher clinical pregnancy rate than those with suboptimal uterine measurements. Uterine sizes and volumes that were too large reduced the clinical pregnancy rate.
摘要：
Atherosclerosis has been recognized as an inflammatory disease involving the vascular wall. MicroRNAs are a group of small noncoding RNAs to regulate gene expression at the transcriptional level through mRNA degradation or translation repression. Recent studies suggest that miR-296 may play crucial roles in the regulation of angiogenesis, inflammatory response, cholesterol metabolism, hypertension, cellular proliferation and apoptosis. In this review, we primarily discussed the molecular targets of miR-296 involved in the development of atherosclerosis, which may provide a basis for future investigation and a better understanding of the biological functions of miR-296 in atherosclerosis.
摘要：
The aim of this study was to describe the size and the shape of gravida-0 uteri in infertile Chinese Han women according to age, height, and body mass index (BMI).Registered data obtained from the Department of Reproductive Medicine, Xiangya Hospital of Central South University, were collected and analyzed. The length, width, and anteroposterior diameter of the uteri of nonpregnant women aged 20 to 45 years were measured by transvaginal ultrasonography. Statistical analyses among different populations were conducted using a 1-way analysis of variance analysis or a Kruskal-Wallis H test.A total of 5726 primary infertile women were enrolled. The mean age of the sample group was 29.18 +/- 4.22 years, and the mean BMI and the mean height of them were 21.51 +/- 2.91 kg/m and 158.13 +/- 4.71 cm, respectively. The mean uterine length, width, anteroposterior diameter, and L/W ratio were 49.33 +/- 7.00 mm, 39.94 +/- 7.23 mm, 44.95 +/- 8.11 mm, and 1.2662 +/- 0.2465, respectively. There were a statistically significant positive correlations between uterine length, width, anteroposterior diameter, and age in infertile women (all P < .001). Uterine L/W ratio gradually decreased with age, which was statistically significant (P < .001). The correlations between uterine length, width, anteroposterior diameter, and height were also considered statistically significant (all P < .001), while there was no correlation between L/W ratio and height. The results showed that uterine size and BMI had no statistical significance.The uterine length, width, and anteroposterior diameter gradually increased with increased age and height, but the increasing extents was different, and the uterine shape became rounder with age and had not changed with height in primary infertile women.
作者机构：
[Zhao, L.] Cent S Univ, Xiangya Nursing Sch, Changsha, Hunan, Peoples R China.;[Zhao, L.] Univ South China, Sch Nursing, Heangyang, Peoples R China.;[Yan, J.] Xiangya Hosp 3, Dept Nursing, Changsha, Hunan, Peoples R China.;[Yang, G. -L.; Liu, Y.] Xiangya Hosp 3, Organ Transplantat Ctr, Tongzipo Rd 138, Changsha 410013, Hunan, Peoples R China.
通讯机构：
[Liu, Y.] X;Xiangya Hosp 3, Organ Transplantat Ctr, Tongzipo Rd 138, Changsha 410013, Hunan, Peoples R China.
摘要：
BACKGROUND: Adherence to follow-up is vital for the medical surveillance of the postoperative blood concentration, but relatively little research has examined it, and there is less study on relationships between adherence to follow-up and quality of life (QoL). We investigated the status of adherence to follow-up and QoL and associated factors among kidney transplantation recipients in China. METHODS: A cross-sectional study with the use of a Kidney Transplantation Recipient's Adherence to Follow-Up Questionnaire and a Quality of Life of Kidney Transplantation Recipients Questionnaire was conducted among 250 kidney transplantation recipients in Changsha, China, from January to March in 2015. RESULTS: The mean score for adherence to follow-up was 54.71 +/- 6.46. Time after transplantation was the only factor affecting adherence to follow-up scores (beta = -0.210; P < .05). The mean total score for QoL was 140.39 +/- 13.56; physical functioning, 23.72 +/- 3.33; psychologic functioning, 24.46 +/- 4.23; social functioning, 44.43 +/- 6.80; treatment, 24.81 +/- 2.97; and subjective satisfaction, 21.28 +/- 3.15. Multiple linear regression analysis showed that adherence to follow-up, economic level, job status, donor source, and original disease affected with QoL. CONCLUSIONS: Adherence to follow-up decreases with time after transplantation, and better compliance is associated with better QoL in all areas. Improvements in adherence to follow-up, income and reimbursement, psychologic guidance, and social support may increase QoL of kidney transplantat recipients.
作者：
Wang, Bo;He, Ping-Ping;Zeng, Gao-Feng;Zhang, Tao;Yang, Xin-Ping Ou
期刊：
Biochimie,2017年132:38-44 ISSN：0300-9084
通讯作者：
Tao Zhang<&wdkj&>Xin-Ping Ou Yang
作者机构：
[Wang, Bo; Zeng, Gao-Feng] Univ South China, Affiliated Hosp 2, Dept Cardiovasc Med, Hengyang 421001, Hunan, Peoples R China.;[He, Ping-Ping; Yang, Xin-Ping Ou] Univ South China, Inst Cardiovasc Res, Key Lab Atherosclerol Hunan Prov, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Hunan, Peoples R China.;[He, Ping-Ping; Yang, Xin-Ping Ou] Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, 28 West Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.;[He, Ping-Ping] Univ South China, Sch Nursing, Hengyang 421001, Hunan, Peoples R China.;[Zhang, Tao] Univ South China, Dept Urol, Affiliated Hosp 2, Hengyang 421001, Hunan, Peoples R China.
通讯机构：
[Tao Zhang] D;[Xin-Ping Ou Yang] I;Institute of Cardiovascular Research, Key Laboratory for Atherosclerology of Hunan Province, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang, Hunan 421001, China<&wdkj&>Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, 28 West Changsheng Road, Hengyang 421001, Hunan, China<&wdkj&>Department of Physiology, The Neuroscience Institute, Medical College, University of South China, Hengyang, Hunan 421001, China<&wdkj&>Departments of Urology, The Second Affiliated Hospital, University of South China, Hengyang, Hunan 421001, China
期刊：
Asian Nursing Research,2017年11(3):187-193 ISSN：1976-1317
通讯作者：
He, Guo-Ping
作者机构：
[Huang, Yan-Jin; He, Guo-Ping] Cent South Univ, Dept Community Nursing, Xiangya Nursing Sch, Changsha, Hunan, Peoples R China.;[Parry, Monica] Univ Toronto, Dept Nurse Practitioner Field Study, Lawrence S Bloomberg Fac Nursing, Toronto, ON, Canada.;[Zeng, Ying] Univ South China, Dept Int & Humanist Nursing, Sch Nursing, Hengyang, Peoples R China.;[Luo, Yan] Xi An Jiao Tong Univ, Dept Surg Nursing, Sch Nursing, Xian, Shaanxi, Peoples R China.;[Yang, Jing] Univ South China, Affiliated Hosp 2, Dept Nursing, Hengyang, Peoples R China.
通讯机构：
[He, Guo-Ping] C;Cent South Univ, Xiangya Nursing Sch, 172 Tongzipo Rd, Changsha 410013, Hunan, Peoples R China.
