作者机构：
[Tang, Ke; Shao, Xiaodan; Zhang, Yan; Wang, Na; Zhang, Y] Univ South China, Sch Nursing, 28 Changsheng West Rd, Hengyang 421001, Hunan, Peoples R China.;[Jiang, Yuting; Zhang, Yan; Wang, Kunning; Zhang, Y; Shen, Zhiwei] Univ South China, Inst Pathogen Biol, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.;[Tan, Zhangyan; Xie, Jiangxiu] Univ South China, Affiliated Hosp 2, Dept Obstet, Hengyang 421001, Hunan, Peoples R China.
通讯机构：
[Zhang, Y ] U;Univ South China, Sch Nursing, 28 Changsheng West Rd, Hengyang 421001, Hunan, Peoples R China.;Univ South China, Inst Pathogen Biol, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.
摘要：
OBJECTIVE: To provide an overview of the symptom experience and interrelationships among symptoms during chemotherapy in cancer patients, as well as the state of symptom network research in this field. METHODS: This scoping review was conducted using the framework proposed by Arksey and O'Malley and the PRISMA guidelines. It included studies that focused on symptom network analysis of cancer patients currently undergoing chemotherapy treatment. A comprehensive search was conducted in both English and Chinese databases, including PubMed/MEDLINE, Cochrane, EMBASE, CINAHL (EBSCO), Web of Science, ProQuest, CNKI, VIPC, and CSPD, up to September 10, 2024.Studies were included if they involved cancer patients aged ≥ 18years undergoing chemotherapy and excluded those involving radiotherapy. Data were extracted based on study characteristics, cancer types, sample characteristics, treatment, study design, instruments, R packages used, core symptoms, and main findings. RESULTS: From 8948 initial articles, 12 studies were included. These studies varied in sample size, symptom survey instruments, and methods of symptom categorization. Six studies extracted symptom clusters, and core symptoms were identified in eight studies. Fatigue was commonly reported as a core symptom across different cancer types. The longitudinal study indicated that overall symptoms peaked after the initial chemotherapy session and gradually decreased with subsequent cycles, although some symptoms like skin changes and neuropathy worsened over time. CONCLUSIONS: Symptom network analysis offers insights into the complex interplay of symptoms during chemotherapy, highlighting fatigue as a central symptom. Future research should focus on longitudinal studies to better understand the dynamic changes in symptom networks and their implications for symptom management interventions.
摘要：
Aim To explore and explain the mechanisms that influence surface acting in nursing students with different characteristics.
To explore and explain the mechanisms that influence surface acting in nursing students with different characteristics.
Background Nurses are now expected to deliver patient-centered care which necessitates the emotional labor. Surface acting, a form of emotional labor, can lead to negative outcomes. Given that nursing students are the backbone of the future nursing profession, there is an urgent need to investigate their surface acting tendencies and identify potential factors for early intervention.
Nurses are now expected to deliver patient-centered care which necessitates the emotional labor. Surface acting, a form of emotional labor, can lead to negative outcomes. Given that nursing students are the backbone of the future nursing profession, there is an urgent need to investigate their surface acting tendencies and identify potential factors for early intervention.
Design A cross-sectional study.
A cross-sectional study.
Methods This study was surveyed in a vocational college in Gansu, China. Participants completed the general information questionnaire, Bem Sex Role Inventory, Professional Identity Questionnaire of Nursing Students and Surface Acting Scale. K-means cluster analysis was performed, followed by random forest algorithm and SHapley Additive exPlanations based on Python program.
This study was surveyed in a vocational college in Gansu, China. Participants completed the general information questionnaire, Bem Sex Role Inventory, Professional Identity Questionnaire of Nursing Students and Surface Acting Scale. K-means cluster analysis was performed, followed by random forest algorithm and SHapley Additive exPlanations based on Python program.
Results A total of 1241 nursing students from vocational college were investigated and were clustered into 4 groups. The five dimensions of professional identity had higher feature importance in all four groups, with professional self-image having the highest feature importance in Cluster 3. Professional self-image and understanding retention benefits and turnover risks were negative predictors of surface acting in all four groups. Social comparison and self-reflection, independence of career choice and social modeling regarding nursing profession were positively correlated with surface acting in specific groups. In Cluster 1, there exists a positive correlation between professional self-image and the constructs of social comparison and self-reflection; as well as a negative correlation between maternal education and understanding of retention benefits and turnover risks.
A total of 1241 nursing students from vocational college were investigated and were clustered into 4 groups. The five dimensions of professional identity had higher feature importance in all four groups, with professional self-image having the highest feature importance in Cluster 3. Professional self-image and understanding retention benefits and turnover risks were negative predictors of surface acting in all four groups. Social comparison and self-reflection, independence of career choice and social modeling regarding nursing profession were positively correlated with surface acting in specific groups. In Cluster 1, there exists a positive correlation between professional self-image and the constructs of social comparison and self-reflection; as well as a negative correlation between maternal education and understanding of retention benefits and turnover risks.
Conclusions Professional identity significantly influences surface acting behaviors among nursing students, with professional self-image serving as a key negative predictor. Positive family conditions, access to educational resources, parental literacy, masculine or feminine gender roles and first-year nursing students, these traits have implications when dimensions of professional identity are used to predict surface acting behaviors.
Professional identity significantly influences surface acting behaviors among nursing students, with professional self-image serving as a key negative predictor. Positive family conditions, access to educational resources, parental literacy, masculine or feminine gender roles and first-year nursing students, these traits have implications when dimensions of professional identity are used to predict surface acting behaviors.
摘要：
BACKGROUND: The importance of self-management behavior has been widely acknowledged in global studies, demonstrating its effectiveness in improving patients' emotional well-being, enhancing quality of life, preventing stroke recurrence, and reducing mortality and readmission rates. However, existing research indicates that self-management behavior among older adults hospitalized for stroke remains underdeveloped. Furthermore, limited studies have examined the correlations between self-management behavior, family care, and chronic disease resource utilization in this population. OBJECTIVE: This study aims to investigate self-management behavior, family care, and chronic disease resource utilization among Chinese older adults hospitalized for stroke and to explore the relationships among these variables. Specifically, it examines the mediating role of chronic disease resource utilization between self-management behavior and family care. METHODS: A cross-sectional correlational design followed the Strengthening the Reporting of Observational Studies in Epidemiology checklist for quality reporting. Between December 2023 and January 2025, a total of 627 Chinese older adults hospitalized for stroke were recruited from three tertiary grade-A hospitals in two cities in China. Data were collected using the Demographic Characteristics Questionnaire, the Stroke Patient Self-Management Behavior Assessment Scale, the Family APGAR Scale, and the Chronic Illness Resources Survey. Descriptive statistics, univariate analysis, correlation analysis, and process plug-in mediation effect analysis were applied to the data. RESULTS: The total scores for self-management behavior, family care, and chronic disease resource utilization were (M = 165.94, SD = 51.26), (M = 5.51, SD = 1.65), and (M = 72.15, SD = 16.73), respectively. These scores indicate moderate levels of self-management behavior, family care, and chronic disease resource utilization. Self-management behavior was positively correlated with family care (r = 0.615, p < 0.01) and chronic disease resource utilization (r = 0.536, p < 0.01). Furthermore, chronic disease resource utilization partially mediated the relationship between self-management behavior and family care, accounting for 41.6% of the total effect. CONCLUSION: The self-management behavior, family care, and chronic disease resource utilization among Chinese older adults hospitalized for stroke were found to be at moderate levels, indicating a need for improvement. Family care directly affects self-management behavior and indirectly affects it through chronic disease resource utilization. Healthcare professionals should focus on enhancing health education and providing psychological support for stroke patients to improve family care, alleviate fears regarding disease progression, and ultimately promote better self-management behavior.
期刊：
International Journal of General Medicine,2025年18:2823-2838 ISSN：1178-7074
通讯作者：
Hu, HJ
作者机构：
[Mi, Ziyi; Zhang, Bingxue] Univ South China, Sch Nursing, Hengyang 421000, Hunan, Peoples R China.;[Hu, Hongjuan] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Publ Hlth Serv, Hengyang 421001, Hunan, Peoples R China.;[Liu, Haidi] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Rehabil Med, Hengyang 421001, Hunan, Peoples R China.
通讯机构：
[Hu, HJ ] U;Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Publ Hlth Serv, Hengyang 421001, Hunan, Peoples R China.
关键词：
exercise;hypertension;older;population health management;systematic review
摘要：
PURPOSE: This study was based on the PICO framework to systematically evaluate the effects of aerobic exercise on key health management indicators such as blood pressure, heart rate and cardiorespiratory fitness in older hypertensive patients. PATIENTS AND METHODS: A systematic search of randomized controlled trials from four English language databases, Web of Science, PubMed, Cochrane, and Embase, and four Chinese language databases, CNKI, VIP, Wanfang, and Sinomed, was performed (April 2014 to April 2024). StataCorp Stata v.18.0 was used for data analysis. In a random-effects meta-analysis, continuous variables were represented by the mean difference, and each effect size was represented by a 95% confidence interval. RESULTS: Nine randomized controlled trials with 484 participants were included. The meta-analysis revealed that compared with the control group, participants engaging in aerobic exercise significantly reduced systolic blood pressure (SMD = -0.93, 95% CI = -1.48 to -0.39, P =0.001), diastolic blood pressure (SMD = -0.48, 95% CI = -0.75 to -0.21, P =0.001), and heart rate (SMD = -1.78, 95% CI = -3.31 to -0.24, P =0.024), and improved cardiorespiratory health (SMD =0.71, 95% CI =0.24 to 1.18, P =0.003). CONCLUSION: Older patients with hypertension aged 60 years should engage in 120-150minutes of low- to moderate-intensity aerobic exercise per week, maintaining 40-75% maximum HR or 40-60% VO(2)max (20-30minutes per day, 5 days per week, or 75-150minutes of exercise only once or twice a week. However, it is crucial that individuals assess their own health conditions, make appropriate time adjustments, and gradually increase the duration and intensity of exercise. And central randomization with blinded assessment should be used in future randomized controlled trials to reduce implementation bias and measurement bias.
作者：
Liang, Cong;Huang, Xinlin;Pu, Yucui;Zhang, Pei;Wang, Rong
期刊：
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES,2025年34(1):108104 ISSN：1052-3057
通讯作者：
Wang, R
作者机构：
[Wang, Rong; Zhang, Pei; Liang, Cong] Univ South China, Sch Nursing, Heng Yang 421001, Peoples R China.;[Liang, Cong] Yellow River Conservancy Commiss, Yellow River Ctr Hosp, Zhengzhou 450000, Peoples R China.;[Huang, Xinlin] Hong Kong Polytech Univ, Hong Kong, Peoples R China.;[Pu, Yucui] Chongqing Presch Educ Coll, Chongqing, Peoples R China.
通讯机构：
[Wang, R ] U;Univ South China, Sch Nursing, Heng Yang 421001, Peoples R China.
关键词：
Walking pace;Stroke;Mendelian randomization;Genome-wide association study
摘要：
Background Walking pace (WP), a simple physiological indicator, has been found to be strongly associated with a variety of health outcomes in recent years. Among them, the relationship between walking pace and stroke is of particular interest. Given the high morbidity, disability and mortality associated with stroke, identifying modifiable indicators of health, such as walking pace, could help in stroke prevention strategies. However, the causal relationship between WP and stroke risk remains unclear. This study aims to determine the causal relationship between walking pace and risk of stroke using a two-sample Mendelian randomization approach in a European-ancestry population.
Walking pace (WP), a simple physiological indicator, has been found to be strongly associated with a variety of health outcomes in recent years. Among them, the relationship between walking pace and stroke is of particular interest. Given the high morbidity, disability and mortality associated with stroke, identifying modifiable indicators of health, such as walking pace, could help in stroke prevention strategies. However, the causal relationship between WP and stroke risk remains unclear. This study aims to determine the causal relationship between walking pace and risk of stroke using a two-sample Mendelian randomization approach in a European-ancestry population.
Methods In order to evaluate the potential for a causal relationship between WP and stroke in people of European heritage, a two-sample Mendelian randomization (MR) study was carried out. Statistics about the association of single nucleotide polymorphisms (SNPs) with stroke were taken from FinnGen (R8) (n = 284,040), while the UK Biobank genome-wide association studies (GWAS) provided the summary data on the association of SNPs with WP (n = 459,915). The inverse-variance weighted (IVW) method was utilised as the primary strategy to examine the causal connection between WP and stroke. Additionally, complementary analyses were conducted using the MR-Egger and weighted median. In order to identify the potential directional pleiotropy and heterogeneity, the MR-Egger intercept test, the MR-PRESSO test, and Cochran's Q statistic were all carried out. This connection was evaluated using OR with 95% confidence intervals (CIs).
In order to evaluate the potential for a causal relationship between WP and stroke in people of European heritage, a two-sample Mendelian randomization (MR) study was carried out. Statistics about the association of single nucleotide polymorphisms (SNPs) with stroke were taken from FinnGen (R8) (n = 284,040), while the UK Biobank genome-wide association studies (GWAS) provided the summary data on the association of SNPs with WP (n = 459,915). The inverse-variance weighted (IVW) method was utilised as the primary strategy to examine the causal connection between WP and stroke. Additionally, complementary analyses were conducted using the MR-Egger and weighted median. In order to identify the potential directional pleiotropy and heterogeneity, the MR-Egger intercept test, the MR-PRESSO test, and Cochran's Q statistic were all carried out. This connection was evaluated using OR with 95% confidence intervals (CIs).
Results A total of 48 SNPs were identified as valid instrumental variables in our two-sample MR analysis. The result showed that a slower walking pace is associated with a higher risk of stroke (OR = 0.573; 95% CI, 0.383-0.858, P = 0.007). The “leave-one-out” analysis demonstrated that the absence of a single SNP did not affect the robustness of our results. The MR-Egger intercept test indicated that genetic pleiotropy did not introduce bias into the results [intercept = −2.9E−03, SE = 0.008, P = 0.719] and Cochran's Q test revealed no heterogeneity. Therefore, the sensitivity analyses yielded comparable results. Consequently, the results of the sensitivity analyses were consistent.
A total of 48 SNPs were identified as valid instrumental variables in our two-sample MR analysis. The result showed that a slower walking pace is associated with a higher risk of stroke (OR = 0.573; 95% CI, 0.383-0.858, P = 0.007). The “leave-one-out” analysis demonstrated that the absence of a single SNP did not affect the robustness of our results. The MR-Egger intercept test indicated that genetic pleiotropy did not introduce bias into the results [intercept = −2.9E−03, SE = 0.008, P = 0.719] and Cochran's Q test revealed no heterogeneity. Therefore, the sensitivity analyses yielded comparable results. Consequently, the results of the sensitivity analyses were consistent.
Conclusion Our MR study revealed that WP is inversely associated with risk of stroke. These results provided evidence that slower WP causally increased the risk of stroke, recommending that patients with lower WP should have a prompt physical examination and targeted interventions to reduce their risk of stroke and enhance their quality of life.
Our MR study revealed that WP is inversely associated with risk of stroke. These results provided evidence that slower WP causally increased the risk of stroke, recommending that patients with lower WP should have a prompt physical examination and targeted interventions to reduce their risk of stroke and enhance their quality of life.
作者机构：
[Huang, Yanjin] School of Nursing, Fudan University, 220 Fenglin Road Xuhui District, Shanghai, China. Electronic address: huangyanjin@fudan.edu.cn;[He, Zhiqing] School of Nursing, University of South China, 28 Changshengxi Road, Hengyang, Hunan, 421001 PR China. Electronic address: JIJIOKIN7@163.com;[Zhang, Weikun] The Department of Public Health, The Central Hospital of Shaoyang No.36, Qianyuan Alley, Shaoyang, 422000, P. R. China. Electronic address: 13187380015@163.com;[Liu, Yuqian] The Department of Public Health, The Central Hospital of Shaoyang No.36, Qianyuan Alley, Shaoyang, 422000, P. R. China. Electronic address: 15616638277@163.com;[Zeng, Wen] The Department of Public Health, The Central Hospital of Shaoyang No.36, Qianyuan Alley, Shaoyang, 422000, P. R. China. Electronic address: zengwen2030@163.com
通讯机构：
[Liu, Yuqian; Chen, Rong; Zeng, Wen; Zhang, Weikun] T;[He, Zhiqing; Yuan, Changrong; Huang, Yanjin] S;School of Nursing, Fudan University, 220 Fenglin Road Xuhui District, Shanghai, China. Electronic address:;School of Nursing, University of South China, 28 Changshengxi Road, Hengyang, Hunan, 421001 PR China. Electronic address:;The Department of Public Health, The Central Hospital of Shaoyang No.36, Qianyuan Alley, Shaoyang, 422000, P. R. China. Electronic address:
关键词：
depression;latent class analysis;sex characteristics;stroke;symptom assessment
摘要：
Purpose Patients with stroke often experience a series of symptoms during treatment and rehabilitation, which may present various characteristics in different subgroups. The aims of this study were to explore the characteristics of latent class groups of depression, fatigue, and pain in patients of different sexes with stroke and to determine the influence of demographic characteristics on different latent class groups by sex.
Patients with stroke often experience a series of symptoms during treatment and rehabilitation, which may present various characteristics in different subgroups. The aims of this study were to explore the characteristics of latent class groups of depression, fatigue, and pain in patients of different sexes with stroke and to determine the influence of demographic characteristics on different latent class groups by sex.
Methods The data of 501 patients with stroke were collected from two tertiary hospitals using convenience sampling between March 2022 and September 2022. The three-domain short forms of PROMIS were measured. Two homogenous classes were identified in the men and women groups using the latent class analysis (LCA) method. Multivariable logistic regression analyses were used to examine the relationships of latent classes with demographic data by sex.
The data of 501 patients with stroke were collected from two tertiary hospitals using convenience sampling between March 2022 and September 2022. The three-domain short forms of PROMIS were measured. Two homogenous classes were identified in the men and women groups using the latent class analysis (LCA) method. Multivariable logistic regression analyses were used to examine the relationships of latent classes with demographic data by sex.
Results For the 501 patients studied, the LCA model fit with the two latent classes was statistically significant for both men and women. In the men group, Class 1 comprised 38.8% of the men population, Class 2 made up the remaining 61.2%, and the probability of membership was 52.2% and 47.8% for Class 1 and Class 2 in the women, respectively. Women had more severe symptom characteristics and more demographically impacted parameters than men. The factors that influenced male and female patients differed, with household monthly income having the same influence in both groups.
For the 501 patients studied, the LCA model fit with the two latent classes was statistically significant for both men and women. In the men group, Class 1 comprised 38.8% of the men population, Class 2 made up the remaining 61.2%, and the probability of membership was 52.2% and 47.8% for Class 1 and Class 2 in the women, respectively. Women had more severe symptom characteristics and more demographically impacted parameters than men. The factors that influenced male and female patients differed, with household monthly income having the same influence in both groups.
Conclusion This study found that the latent classes of patients with stroke were highly heterogeneous, with women having more severe symptom characteristics and demographic differences.
This study found that the latent classes of patients with stroke were highly heterogeneous, with women having more severe symptom characteristics and demographic differences.
期刊：
FRONTIERS IN ENDOCRINOLOGY,2025年16:1504609 ISSN：1664-2392
通讯作者：
Gao, Hong;Wu, BY;Gao, H
作者机构：
[Gao, Hong; Wu, Baoyu] Univ South China, Affiliated Hosp 2, Hengyang Med Sch, Dept Nursing, Hengyang, Hunan, Peoples R China.;[Gao, Hong] Ottawa Hosp, Res Inst, Ottawa, ON, Canada.;[Liang, Bingyan; Xiao, Jing] Univ South China, Sch Nursing, Hengyang, Hunan, Peoples R China.;[Li, Genlin; Wang, Xiaolan] Univ South China, Affiliated Hosp 1, Ctr Combinat Obstet & Gynecol & Reprod Med, Hengyang Med Sch, Hengyang, Hunan, Peoples R China.;[Li, Huanhuan] Univ South China, Affiliated Hosp 2, Hengyang Med Sch, Dept Gynecol, Hengyang, Hunan, Peoples R China.
通讯机构：
[Gao, H ] O;[Wu, BY ; Gao, H] U;Univ South China, Affiliated Hosp 2, Hengyang Med Sch, Dept Nursing, Hengyang, Hunan, Peoples R China.;Ottawa Hosp, Res Inst, Ottawa, ON, Canada.
摘要：
INTRODUCTION: Recurrent implantation failure (RIF) is a major challenge in reproductive medicine, and emerging evidence suggests that alterations in the endometrial microbiota may play a critical role in its pathogenesis. To identify the main differential endometrial microbiota associated with RIF and to establish threshold values for their relative abundance. METHODS: This case-control study was conducted in the Departments of Obstetrics, Gynecology, and Reproductive Medicine at two large hospitals. From March to December 2023, the study recruited 17 infertile patients with RIF (Group A, cases), 19 healthy non-pregnant women (Group B, controls), and 20 healthy pregnant women (Group C, controls). Demographic information, medication history, clinical data, and endometrial tissue samples were collected. Endometrial microbiota of all participants was profiled using 16S rRNA gene sequencing. RESULTS: The richness of endometrial microbiota in Group A was significantly lower compared to both control groups (P=0.013, P=0.022, respectively). The diversity of endometrial microbiota in Group A and B was significantly higher compared to Group C (P=0.043, P=0.002, respectively). The composition of endometrial microbiota in Group A differed significantly from both control groups, whereas only minor differences were observed between the two control groups (PERMANOVA, P=0.001). Methyloversatilis, Lactobacillus, Sphingomonas, Faecalibacterium, Escherichia-Shigella, Bacteroides, and Aeromonas were identified as the main differential endometrial microbiota associated with RIF, with threshold relative abundances of 3.807%, 6.606%, 0.192%, 0.193% , 0.618%, 2.411%, and 0.019%, respectively. In Group A, Lactobacillus was positively correlated with Sphingomonas (r=0.64, P=0.005). DISCUSSION: Methyloversatilis, Lactobacillus, Sphingomonas, Faecalibacterium, Escherichia-Shigella, Bacteroides, and Aeromonas were the main differential endometrial microbes associated with RIF. Preliminary threshold values for their relative abundances were established.
摘要：
China is experiencing an increasingly serious aging population. Cognitive function is an important factor and guarantee for the quality of life of older people. Therefore, to achieve healthy aging, this study aimed to examine the sequential multiple mediating effects of indoor ventilation frequency and cognitive function on anxiety and self-rated health in the Chinese older people population. Using the 2018 China Longitudinal Health and Longevity Survey (CLHLS) dataset, we finally selected 10,372 Chinese seniors over the age of 65. First, we describe the basic socio-demographic information of the sample population. Second, Spearman correlation analysis was used to determine whether there was a correlation between indoor ventilation frequency, anxiety, self-rated health, and cognitive function among Chinese older people. Finally, the SPSS macro process program was used to complete the sequence multiple mediation analysis. Indoor ventilation frequency, anxiety, self-rated health and cognitive function were significantly correlated (p < 0.01). Indoor ventilation frequency not only has a direct positive impact on the cognitive function of older people (effect = 0.1427; Standard error = 0.0201; 95%CI: LL = 0.1034, UL = 0.1821), but also indirectly affected cognitive function through three pathways: independent mediation of anxiety (effect = 0.0078; Standard error = 0.0021; 95%CI: LL = 0.0041, UL = 0.0121), independent mediating effect of self-rated health (effect = 0.0154; Standard error = 0.0030; 95%CI: LL = 0.0098, UL = 0.0215), and the chain mediating effect between anxiety and self-rated health (effect = 0.0046; Standard error = 0.0009; 95%CI: LL = 0.0029, UL = 0.0065). All projects are self-reported and some results may be biased. In the future, it may be more inspiring to explore more detailed and specific effects of indoor air quality on cognitive function in older people. Studies have shown that indoor ventilation frequency can improve cognitive function by reducing anxiety and improving self-rated health in older people Chinese. Encouraging older adults to increase the frequency of indoor ventilation will benefit their mental health and cognitive function. This study provides empirical evidence for the association between indoor ventilation frequency and cognitive function in older people Chinese adults. We used nationally representative data to investigate the relationship between indoor ventilation frequency and cognitive function and further explored the mediating role of anxiety and self-rated health in Chinese older adults. Indoor ventilation frequency can not only directly affect cognitive function in older people, but also indirectly affect cognitive function through anxiety and self-rated health. Anxiety and self-rated health have a series of mediating effects between indoor ventilation frequency and cognitive function.
摘要：
INTRODUCTION: Although chronic endometritis (CE) is strongly associated with infertility and adverse pregnancy outcomes, the specific microbiome of women with CE who can conceive remain unclear. METHODS: This study recruited 100 participants aged 18 to 45 years with spontaneously conceived pregnancy who opted for pregnancy termination, detected their endometrial microbiome by 16S rRNA, and made a diagnosis of CE. RESULTS: Among them, 19 were diagnosed with CE. There was a comparable microbial composition within the endometrium between women with and without CE. The relative abundance of Sphingomonas (21%) and Pseudomonas (8%) were the same in both groups. Compared to women without CE, women with CE exhibited higher abundance of Faecalibacterium (6.5% vs 3.8%), Escherichia-Shigella (3.3% vs 2.6%), Akkermansia (1.65% vs 1.1%), and lower abundance of Lactobacillus (10% vs 14%), and Corynebacterium (1.35% vs 2.15%) at the genus level. Streptococcus, Escherichia-Shigella, Akkermansia and Finegoldia exhibited significant interactions with other microbiome in participants with CE. DISCUSSION: In women with CE, reproductive potential may be associated with the compositional stability of the endometrial microbiome, whereas an imbalance in the abundance of these microbes may be linked to their pregnancy outcomes.
期刊：
FRONTIERS IN ONCOLOGY,2025年15:1515502 ISSN：2234-943X
通讯作者：
Yan, YY
作者机构：
[Mo, Wenjuan; Li, Mengnan] Univ South China, Sch Nursing, Hengyang Med Sch, Hengyang, Hunan, Peoples R China.;[Yan, YY; Yan, Yuanyuan; Fu, Guang] Univ South China, Affiliated Hosp 1, Dept Gastrointestinal Surg, Hengyang, Peoples R China.
通讯机构：
[Yan, YY ] U;Univ South China, Affiliated Hosp 1, Dept Gastrointestinal Surg, Hengyang, Peoples R China.
关键词：
best evidence;gastric cancer;intervention strategies;prevention;pulmonary complications
摘要：
BACKGROUND: Postoperative pulmonary complications in gastric cancer surgery significantly impact patient recovery and prognosis. These complications, including infections, can increase hospital stays and costs, and even lead to death. Numerous risk factors are involved, such as age, smoking history, and lung function. Although preventive measures exist, a unified and effective strategy is lacking. Therefore, researching and implementing effective prevention measures is crucial for improving patients' postoperative quality of life and survival rates. AIM: To collate and summarize the best available evidence for the prevention of pulmonary complications in patients undergoing gastric cancer surgery, thereby providing a reference for the clinical development of relevant intervention strategies. METHODS: A literature search was conducted in databases including BMJ Best Practice, UpToDate, JBI, Cochrane Library, PubMed, Embase, the Ontario Nurses Registration Network, the U.S. National Clinical Practice Guidelines, and MedLine, for documents related to the prevention of pulmonary complications in gastric cancer surgery patients. The search period extended from the inception of these databases to July 25, 2024. The quality of the literature was evaluated according to the standards of the Joanna Briggs Institute (JBI) Evidence-Based Health Care Center, and evidence was extracted from the included documents. RESULTS: A total of 27 documents were ultimately included. The extracted content encompassed three areas: preoperative assessment, risk prevention and intervention measures, totaling 31 best evidences across five categories. The findings of our study underscore the significance of comprehensive preoperative assessments, such as the ARISCAT index for pulmonary risk evaluation, and stress the importance of preoperative interventions like inspiratory muscle training, smoking cessation, and oral care in mitigating postoperative pulmonary complications (PPCs) following gastric cancer surgery. We also advocate for the adoption of protective lung ventilation strategies during surgery and continuous pulse oximetry monitoring postoperatively, along with targeted treatments for specific complications. CONCLUSION: The best evidence extracted for the prevention of complications in gastric cancer surgery patients serves as a basis for evidence-based practice for the prevention of pulmonary complications in this patient group. Further research topics on pulmonary complications of gastric cancer, we recommend further optimization of preoperative assessment tools, investigation into the efficacy of smoking cessation programs, comparative studies on intraoperative ventilation strategies, development of postoperative rehabilitation programs, and research into culturally and resource-sensitive interventions to broaden the global applicability of these practices.
摘要：
OBJECTIVE: While growing evidence supports the Geriatric Nutritional Risk Index (GNRI) as a prognostic indicator for various cancers, its predictive value in pancreatic cancer remains unclear. This meta-analysis systematically evaluates GNRI's ability to predict postoperative complications and long-term outcomes in pancreatic cancer patients. METHODS: We conducted a comprehensive literature search across nine databases (Web of Science, PubMed, Embase, Cochrane Library, Scopus, WanFang, CNKI, VIP, and SinoMed) through June 1, 2025. Hazard ratios (HRs) with 95% confidence intervals (CIs) were used to assess overall survival (OS), while risk ratios (RRs) with 95% CIs evaluated postoperative complications. RESULTS: From 233 initially identified studies, 10 met inclusion criteria (n = 2,003 patients). Pooled analysis revealed that lower GNRI significantly predicted worse OS (HR = 1.92, 95% CI 1.54-2.41, p < 0.0001) and higher postoperative pancreatic fistula (POPF) incidence (RR = 0.18, 95% CI 0.08-0.43, p < 0.001). No significant association was found between GNRI and post-pancreatectomy hemorrhage (PPH) (RR = 0.21, 95% CI 0.03-1.53, p = 0.13). CONCLUSION: GNRI shows promise as a clinically useful predictor of OS and POPF in pancreatic cancer patients. However, these findings require validation through prospective multicenter studies. SYSTEMATIC REVIEW REGISTRATION: Identifier CRD42023409362.
摘要：
Aims
Although anxiety and depression are frequently linked to coronary heart disease, a network analysis of comorbid anxiety and depression and their association with quality of life in patients undergoing percutaneous coronary intervention (PCI) remains unclear from the perspective of symptom interactions. We aimed to investigate the network structure and symptom patterns of anxiety and depression, and their relationship with quality of life in patients undergoing PCI.
Methods and Results
This study included 528 patients undergoing PCI. The seven-item Generalized Anxiety Disorder Scale, nine-item Patient Health Questionnaire, and World Health Organization Quality of Life Questionnaire-Brief Version were used as measurement tools. The R software was used to construct and interpret the network structure. The symptoms “sleep disturbance,” “irritability,” and “uncontrollable worry” showed the highest expected influence centrality. Three bridge symptoms were identified: “sleep disturbance,” “excessive worry,” and “trouble relaxing.” Among the three strongest edges, two were associated with anxiety and depressive symptoms. Ten symptoms were directly associated with quality of life, with “fatigue” showing the strongest relationship. In the network comparison test, significant differences in global strength were observed between the male and female groups.
Conclusion
“Sleep disturbance,” plays a critical role in the current network, while “excessive worry,” “trouble relaxing,” and “fatigue” were identified as key priorities owing to their high correlation with “sleep disturbance” and quality of life. Focusing on these symptoms may help mitigate the risk of multiple-symptom interactions and provide tailored intervention measures for patients undergoing PCI.
Registration
Chinese Clinical Trial Registry ChiCTR230007581
摘要：
Background and objectives To reach the goal of a 95 % reduction in Tuberculosis (TB) mortality by 2035 compared to 2015, it may be necessary for different regions to create specific intervention strategies tailored to their respective TB mortality components. This study aimed to investigate the causes of death among TB patients in China's developed cities.
To reach the goal of a 95 % reduction in Tuberculosis (TB) mortality by 2035 compared to 2015, it may be necessary for different regions to create specific intervention strategies tailored to their respective TB mortality components. This study aimed to investigate the causes of death among TB patients in China's developed cities.
Methods This retrospective cohort study included 8851TB patients registered at Shenzhen's largest TB-designated hospital between 2017 and 2022. The primary causes of death were categorized, and multivariable logistic regression was used to identify independent risk factors for TB mortality.
This retrospective cohort study included 8851TB patients registered at Shenzhen's largest TB-designated hospital between 2017 and 2022. The primary causes of death were categorized, and multivariable logistic regression was used to identify independent risk factors for TB mortality.
Results The study revealed a TB mortality rate of 1.6 % during the treatment period. Independent risk factors for TB mortality included male gender, older age, lower body mass index (BMI), anemia, and the presence of tumors. Notably, poor treatment adherence was significant contributors to mortality, even in this well-resourced urban environment. Additionally, the progression of the chronic disease emerged as a critical factor in TB-related deaths, particularly among patients with severe underlying conditions.
The study revealed a TB mortality rate of 1.6 % during the treatment period. Independent risk factors for TB mortality included male gender, older age, lower body mass index (BMI), anemia, and the presence of tumors. Notably, poor treatment adherence was significant contributors to mortality, even in this well-resourced urban environment. Additionally, the progression of the chronic disease emerged as a critical factor in TB-related deaths, particularly among patients with severe underlying conditions.
Conclusion This study underscores the importance of addressing treatment adherence and healthcare accessibility to reduce TB mortality, even in urban settings with robust healthcare infrastructure. The findings also highlight the need for integrated management of TB and chronic diseases, as well as early identification and management of underlying disease to improve patient outcomes. These insights are crucial for developing targeted interventions that can enhance TB care and reduce mortality in similar urban populations.
This study underscores the importance of addressing treatment adherence and healthcare accessibility to reduce TB mortality, even in urban settings with robust healthcare infrastructure. The findings also highlight the need for integrated management of TB and chronic diseases, as well as early identification and management of underlying disease to improve patient outcomes. These insights are crucial for developing targeted interventions that can enhance TB care and reduce mortality in similar urban populations.
摘要：
Genital tract Chlamydia trachomatis (Ct) infection is one of the most prevalent sexually transmitted infections (STIs) worldwide. However, its clinical progression is often insidious and prolonged. Understanding the mechanisms by which Ct influences cell death pathways is crucial for elucidating the pathogenic processes of this intracellular bacterium. Ferroptosis, a newly identified form of programmed cell death, is characterized by the iron-dependent accumulation of lipid peroxides. Despite its relevance, the interaction between Ct and ferroptosis remains poorly studied. In the present study, we first performed bioinformatics analysis based on RNA sequencing data under an in vitro model of Ct acute infection. Bioinformatics analysis revealed significant enrichment of differentially expressed genes in ferroptosis and p53 signaling pathways. Subsequently, we validated the hypothesis that Ct inhibits host ferroptosis by expression assays of ferroptosis-related proteins. Further cell proliferation, intracellular ferrous iron fluorescence, and lipid peroxidation assays multifaceted observations of the phenotype. Mechanistically, we found that Ct inhibition of ferroptosis acts by regulating the host p53/SLC7A11 pathway. Finally, indirect immunofluorescence assays demonstrated that ferroptosis decreases inclusion forming units (IFUs) of Ct progeny and thus affects its reproduction, which partly explains Ct 's survival strategy of resisting host ferroptosis.
Genital tract Chlamydia trachomatis (Ct) infection is one of the most prevalent sexually transmitted infections (STIs) worldwide. However, its clinical progression is often insidious and prolonged. Understanding the mechanisms by which Ct influences cell death pathways is crucial for elucidating the pathogenic processes of this intracellular bacterium. Ferroptosis, a newly identified form of programmed cell death, is characterized by the iron-dependent accumulation of lipid peroxides. Despite its relevance, the interaction between Ct and ferroptosis remains poorly studied. In the present study, we first performed bioinformatics analysis based on RNA sequencing data under an in vitro model of Ct acute infection. Bioinformatics analysis revealed significant enrichment of differentially expressed genes in ferroptosis and p53 signaling pathways. Subsequently, we validated the hypothesis that Ct inhibits host ferroptosis by expression assays of ferroptosis-related proteins. Further cell proliferation, intracellular ferrous iron fluorescence, and lipid peroxidation assays multifaceted observations of the phenotype. Mechanistically, we found that Ct inhibition of ferroptosis acts by regulating the host p53/SLC7A11 pathway. Finally, indirect immunofluorescence assays demonstrated that ferroptosis decreases inclusion forming units (IFUs) of Ct progeny and thus affects its reproduction, which partly explains Ct 's survival strategy of resisting host ferroptosis.
作者机构：
[Li, C.; Hu, A.; You, Z.] Jinhua Univ Vocat Technol, Sch Med, Jinhua 321000, Zhejiang, Peoples R China.;[Liu, X.; Liu, Y.; Liu, F.; Liao, L.] Univ South China, Sch Nursing, Hengyang 421001, Hunan, Peoples R China.;[Li, W.; Liu, F.] Univ South China, Affiliated Hosp 1, Cardiac Intervent Imaging Ctr, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.;[Liu, F.] Chiang Mai Univ, Fac Nursing, PhD Degree Program, Chiang Mai 50000, Thailand.
通讯机构：
[Liu, F ] U;Univ South China, Sch Nursing, Hengyang 421001, Hunan, Peoples R China.;Univ South China, Affiliated Hosp 1, Cardiac Intervent Imaging Ctr, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.;Chiang Mai Univ, Fac Nursing, PhD Degree Program, Chiang Mai 50000, Thailand.
摘要：
objective: To assess the variations in radiation dose at different areas in the cardiac catheterization room during cardiac catheterization interventions. methods:To simulate the conventional operation in cardiac catheterization interventions, perform angiography on standard manikins ,the radiation dose was collected from 22 areas in the cardiac catheterization room under 8 projection angles, and each area was repeated 5 times, and the collected data was analyzed using one-way ANOVA and independent sample t-test. results:Analysis of the radiation dose in 22 areas under 8 projection angles revealed that the lowest radiation dose was found in the area at the end of the operating table in the cardiac catheterization room (p < 0.05), and the highest radiation dose was found in the area on the left and right sides of the X-ray tube (p < 0.05); the radiation dose in the area on the right side of the X-ray tube of the DSA machine was greater than that in the conventional standing area of the first operator (p < 0.05)，and the radiation dose in the conventional standing area of the second operator was greater than that in the conventional standing area of the first operator (p < 0.05); the radiation dose in the standing area of the first operator was highest in the cephalic position (CRA 30°) (p < 0.05), and the radiation dose in the standing area of the second operator was highest in the left anterior oblique position (LAO 45°) (p < 0.05); in the angle of RAO projection, the radiation dose in the right area of the X-ray tube was greater than that in the left area of the X-ray tube (p < 0.05). Under the RAO projection angle, the radiation dose from the right side of the X-ray tube of the DSA machine was greater than that from the left side (p<0.05), and the result was reversed at the projection angle of the LAO. conclusion:The radiation dose during cardiac catheterization interventions is lowest in the area at the end of the operating table, which can be used as a standing area for nurses and as an area for the placement of surgical equipment and supplies. At the same time, it is necessary to pay attention to the radiation dose to the second operator and to further improve the radiation protection measures for the second operator, and additional measures are needed to minimize the radiation dose to the operators in the cephalic position (CRA 30°) and in the left anterior oblique position (LAO 45°).
摘要：
Hypoxia is a common feature of solid tumors, and activation of hypoxia-inducing factors in the tumor hypoxia microenvironment can lead to complex reprogramming of glucose metabolism in tumor cells. In particular, the unique glucose metabolism pattern of tumor cells, mainly glycolysis pathway, provides conditions for tumor growth, metastasis, immune escape and drug resistance. Drug development for glycolysis-related targets is more targeted and safer than traditional chemotherapy drugs, and drug delivery systems offer favorable strategies for improving the targeted therapy of these drugs in vivo. Here, we review drug delivery systems that target tumor glycolysis, including specific small molecule inhibitors, siRNA, and other nanodelivery systems that affect glycolysis, and note the multifunctional anti-tumor nanodelivery systems that combine multiple therapeutic modalities including chemotherapy, photothermal, photodynamic, sonodynamic, chemodynamic therapies, as well as photoacoustic, magnetic resonance imaging. Several major challenges and future directions in the development and transformation of anti-tumor nanostrategies for glycolysis are discussed. The development of innovative anti-tumor nanodelivery systems related to tumor glycolysis could provide powerful weapons against tumor progression in the foreseeable future.
Hypoxia is a common feature of solid tumors, and activation of hypoxia-inducing factors in the tumor hypoxia microenvironment can lead to complex reprogramming of glucose metabolism in tumor cells. In particular, the unique glucose metabolism pattern of tumor cells, mainly glycolysis pathway, provides conditions for tumor growth, metastasis, immune escape and drug resistance. Drug development for glycolysis-related targets is more targeted and safer than traditional chemotherapy drugs, and drug delivery systems offer favorable strategies for improving the targeted therapy of these drugs in vivo. Here, we review drug delivery systems that target tumor glycolysis, including specific small molecule inhibitors, siRNA, and other nanodelivery systems that affect glycolysis, and note the multifunctional anti-tumor nanodelivery systems that combine multiple therapeutic modalities including chemotherapy, photothermal, photodynamic, sonodynamic, chemodynamic therapies, as well as photoacoustic, magnetic resonance imaging. Several major challenges and future directions in the development and transformation of anti-tumor nanostrategies for glycolysis are discussed. The development of innovative anti-tumor nanodelivery systems related to tumor glycolysis could provide powerful weapons against tumor progression in the foreseeable future.
摘要：
BACKGROUND: To investigate the association between indoor ventilation frequency and symptoms of depression and anxiety in older persons. METHODS: A binary logistic regression model was used to analyze the effects of indoor ventilation frequency on depression and anxiety by using data from the 2018 Chinese longitudinal healthy longevity survey (CLHLS). RESULTS: A total of 9,690 older persons with an average age of (83.20 ± 11.27) years were included, including 4,458 males (46.0%) and 5,232 females (54.0%). The average score of indoor ventilation frequency was (6.06 ± 1.98) points, including 770 people (7.9%) with low frequency, 3,066 people (31.6%) with medium frequency, and 5,854 people (60.4%) with high frequency. 842 (8.7%) had symptoms of depression and 204 (2.1%) had symptoms of anxiety. Compared with the older persons with low indoor ventilation frequency, the older persons with higher ventilation frequency had a lower incidence of depression (OR(95%CI) = 1.92 (1.50 ∼ 2.46), 1.51 (1.27 ∼ 1.79); P < 0.001). However indoor ventilation frequency was not associated with anxiety symptoms. CONCLUSION: Indoor ventilation frequency is related to depressive symptoms in older persons. Communities and families should pay more attention to indoor ventilation and intervene in time to promote and improve the mental health of older persons.
作者机构：
[Zhai, Da-Hong; Zhang, Ya-Juan] Department of Nursing, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China;[Li, Xiao-Shan; Zeng, Gu-Qing] School of Nursing, University of South China, Hengyang 421001, China
摘要：
OBJECTIVE: This study aims to systematically evaluate the risk factors associated with the development of postoperative lower extremity deep venous thrombosis (LEDVT) in patients with severe traumatic brain injury (sTBI). METHODS: A systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Comprehensive searches of Chinese and English databases, including PubMed, Cochrane Library, Embase, China National Knowledge Infrastructure, and Wanfang, were conducted from inception to December 12, 2024. Two researchers independently screened articles and extracted relevant data. Study quality was assessed using the Newcastle-Ottawa Scale and the Agency for Healthcare Research and Quality criteria. Meta-analyses were performed using RevMan 5.3, applying a random-effects model to combine effect sizes, with subsequent sensitivity analyses and assessments for publication bias. The review was registered in PROSPERO (CRD42024629624). RESULTS: A total of 13 studies (n = 777,327) were included, comprising 8 case-control studies, 2 cohort studies, and 3 cross-sectional studies. Eleven significant risk factors for postoperative LEDVT were identified: advanced age (odds ratio [OR] = 1.12, 95% confidence interval [CI]: 1.10-1.14), use of dehydrant (OR = 2.04, 95% CI: 1.38-3.04), mechanical ventilation (OR = 1.01, 95% CI: 1.01-1.02), elevated D-dimer level (OR = 1.19, 95% CI: 1.11-1.27), polytrauma (OR = 1.63, 95% CI: 1.29-2.03), hypertension (OR = 1.11, 95% CI: 1.07-1.15), surgical duration (OR = 1.60, 95% CI: 1.06-2.42), elevated body mass index (OR = 1.30, 95% CI: 1.16-1.45), deep venous catheterization (OR = 1.36, 95% CI: 1.15-1.60), length of hospital stay (OR = 1.36, 95% CI: 1.18-1.56), and blood transfusion (OR = 3.56, 95% CI: 1.91-6.63), with all p values <0.05. No statistically significant associations were observed for Glasgow Coma Scale score (OR = 1.12, 95% CI: 0.98-1.28) or diabetes mellitus (OR = 1.02, 95% CI: 0.97-1.07). CONCLUSIONS: Eleven variables were identified as significant risk factors for postoperative LEDVT among patients with sTBI. These findings underscore the importance of implementing individualized preventive strategies for patients identified as high risk.
摘要：
BACKGROUND: Good adherence to pre-exposure prophylaxis (PrEP) is critical for effective HIV prevention. Despite the growing awareness of PrEP, many individuals remain at a preliminary understanding stage and struggle to achieve sustained adherence. mHealth (mobile Health) technology is emerging as one of the promising tools in the HIV prevention cascade. While research on mHealth applications for HIV prevention is rapidly advancing, their effectiveness in promoting robust PrEP adherence and optimizing cascade outcomes remains inconclusive, with fragmented evidence limiting scalable implementation. OBJECTIVE: To evaluate the efficacy of mHealth tools in optimizing the HIV prevention cascade (from risk identification to PrEP adherence) among key populations (including men who have sex with men, bisexual individuals, sex workers, transgender populations and some other groups who at elevated risk of HIV acquisition). METHODS: We searched in PubMed, Cochrane Library, Web of Science, Embase, Ovid and CINAHL (EBSCO) from the inception to February 3, 2025. Our inclusion criteria focused on randomized controlled trials (RCTs). Literature screening and data extraction were performed independently by two authors. Methodological quality was assessed using Cochrane's Risk of Bias in Randomized Controlled Trials tool. The primary outcome was adherence to PrEP and secondary outcomes included PrEP use, HIV testing and number of condomless sex events. Analyses were performed using standardized mean difference (SMD) and 95% confidence interval (CI) for continuous variables and using odds ratios (OR) and 95% CI for categorical variables. Data analysis and forest plotting were carried out using R Statistical Software version 4.4.0. RESULTS: 16 RCT studies met the inclusion criteria. The results of the meta-analysis showed that mHealth interventions significantly promoted PrEP adherence (OR = 1.60, 95% CI [1.09, 2.35], ρ = 0.016) and HIV testing (OR = 1.63, 95% CI [1.39, 1.90], ρ < 0.01). It had also shown some effectiveness in promoting the use of PrEP. However, there were no significant effects on reducing the number of condomless sex events during the entire follow-up period. CONCLUSION: mHealth effectively enhances specific stages of the prevention cascade. However, further optimization of technology design and intervention is needed to address complex difficulties. SYSTEMATIC REVIEW REGISTRATION: https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=533772, identifier PROSPERO CRD42024533772.
期刊：
Asia-Pacific Journal of Oncology Nursing,2025年12:100702 ISSN：2347-5625
通讯作者：
Chen, YY
作者机构：
[Guo, Junchen; Xu, Xianghua; Chen, Yongyi; Hu, Yonghong] Hunan Canc Hosp, Dept Palliat Care, Changsha, Peoples R China.;[Guo, Junchen] Univ Wollongong, Sch Nursing, Wollongong, NSW, Australia.;[Zeng, Linghao] Univ South China, Sch Nursing, Hengyang, Peoples R China.;[Dai, Yunyun] Univ Wollongong, Hlth Serv Res Inst, Wollongong, NSW, Australia.
通讯机构：
[Chen, YY ] H;Hunan Canc Hosp, Dept Palliat Care, Changsha, Peoples R China.
关键词：
Palliative care;Shared-care management;Delphi technique;End of life care
摘要：
Objective Shared-care management (SCM) in palliative care is a collaborative model where shared care teams work in partnership with patients' original healthcare providers, employing multimodal strategies including consultations and coordinated referrals to enhance quality of care for patients. The evidence regarding its implementation remains fragmented and lacks detailed explanations, which impedes its application in clinical practice. This study aimed to develop a SCM standard of palliative care in adults in mainland regions of China.
Shared-care management (SCM) in palliative care is a collaborative model where shared care teams work in partnership with patients' original healthcare providers, employing multimodal strategies including consultations and coordinated referrals to enhance quality of care for patients. The evidence regarding its implementation remains fragmented and lacks detailed explanations, which impedes its application in clinical practice. This study aimed to develop a SCM standard of palliative care in adults in mainland regions of China.
Methods Initial standard framework identification was achieved via literature evidence summary. From April to August 2024, two rounds of Delphi method was conducted with the purposes of modifying the standard. To establish consensus, items with a mean importance score > 3.50 and the coefficient of variation of item scores < 0.25 were retained.
Initial standard framework identification was achieved via literature evidence summary. From April to August 2024, two rounds of Delphi method was conducted with the purposes of modifying the standard. To establish consensus, items with a mean importance score > 3.50 and the coefficient of variation of item scores < 0.25 were retained.
Results The first round involved 35 experts, with a follow-up participation of 33 in the second round. The Kendall concordance coefficients of the two rounds of experts consultation were 0.128 and 0.134, respectively (all P < 0.001), indicating consensus among the experts. At the end of the second round, the average importance score of each item was 4.73-5.00. A total of 8 modules including SCM team, applicable population, process of SCM, contents of SCM, start time, precautions, effectiveness evaluation and quality control, and the corresponding 22 items were finally identified in this standard.
The first round involved 35 experts, with a follow-up participation of 33 in the second round. The Kendall concordance coefficients of the two rounds of experts consultation were 0.128 and 0.134, respectively (all P < 0.001), indicating consensus among the experts. At the end of the second round, the average importance score of each item was 4.73-5.00. A total of 8 modules including SCM team, applicable population, process of SCM, contents of SCM, start time, precautions, effectiveness evaluation and quality control, and the corresponding 22 items were finally identified in this standard.
Conclusions The establishment of the standard in this study provides a critical framework that can be adopted by healthcare institutions to ensure that SCM services are delivered uniformly and effectively in mainland regions of China.
The establishment of the standard in this study provides a critical framework that can be adopted by healthcare institutions to ensure that SCM services are delivered uniformly and effectively in mainland regions of China.
