期刊：
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association,2024年34(1):108104
通讯作者：
Liang, Cong;Wang, Rong
作者机构：
[Zhang, Pei; Liang, Cong] School of Nursing, University of South China, Heng Yang, 421001, China;[Liang, Cong] Yellow River Centre Hospital of the Yellow River Conservancy Commission, Zheng Zhou, 450000, China. Electronic address: 983849974@qq.com;[Huang, Xinlin] The Hong Kong Polytechnic University, Hong Kong, China;[Pu, Yucui] Chongqing Preschool Education College, Chong Qing, China;[Wang, Rong] School of Nursing, University of South China, Heng Yang, 421001, China. Electronic address: wwrr77@163.com
通讯机构：
[Wang, Rong] S;[Liang, Cong] Y;Yellow River Centre Hospital of the Yellow River Conservancy Commission, Zheng Zhou, 450000, China. Electronic address:;School of Nursing, University of South China, Heng Yang, 421001, China. Electronic address:
关键词：
Genome-wide association study;Mendelian randomization;Stroke;Walking pace
摘要：
BACKGROUND: Walking pace (WP), a simple physiological indicator, has been found to be strongly associated with a variety of health outcomes in recent years. Among them, the relationship between walking pace and stroke is of particular interest. Given the high morbidity, disability and mortality associated with stroke, identifying modifiable indicators of health, such as walking pace, could help in stroke prevention strategies. However, the causal relationship between WP and stroke risk remains unclear. This study aims to determine the causal relationship between walking pace and risk of stroke using a two-sample Mendelian randomization approach in a European-ancestry population. METHODS: In order to evaluate the potential for a causal relationship between WP and stroke in people of European heritage, a two-sample Mendelian randomization (MR) study was carried out. Statistics about the association of single nucleotide polymorphisms (SNPs) with stroke were taken from FinnGen (R8) (n = 284,040), while the UK Biobank genome-wide association studies (GWAS) provided the summary data on the association of SNPs with WP (n = 459,915). The inverse-variance weighted (IVW) method was utilised as the primary strategy to examine the causal connection between WP and stroke. Additionally, complementary analyses were conducted using the MR-Egger and weighted median. In order to identify the potential directional pleiotropy and heterogeneity, the MR-Egger intercept test, the MR-PRESSO test, and Cochran's Q statistic were all carried out. This connection was evaluated using OR with 95% confidence intervals (CIs). RESULTS: A total of 48 SNPs were identified as valid instrumental variables in our two-sample MR analysis. The result showed that a slower walking pace is associated with a higher risk of stroke (OR = 0.573; 95% CI, 0.383-0.858, P = 0.007). The "leave-one-out" analysis demonstrated that the absence of a single SNP did not affect the robustness of our results. The MR-Egger intercept test indicated that genetic pleiotropy did not introduce bias into the results [intercept = -2.9E-03, SE = 0.008, P = 0.719] and Cochran's Q test revealed no heterogeneity. Therefore, the sensitivity analyses yielded comparable results. Consequently, the results of the sensitivity analyses were consistent. CONCLUSION: Our MR study revealed that WP is inversely associated with risk of stroke. These results provided evidence that slower WP causally increased the risk of stroke, recommending that patients with lower WP should have a prompt physical examination and targeted interventions to reduce their risk of stroke and enhance their quality of life.
摘要：
目的:分析国际急性心肌梗死就医延迟的研究趋势和研究热点,为国内心肌梗死就医延迟研究提供参考.方法:借助CiteSpace 6.2.R4可视化分析软件对 Web of Science(WoS)数据库中2002年1月1日-2022年12月31日急性心肌梗死就医延迟的相关研究文献进行分析.结果:共纳入310篇文献,发文量总体呈上升趋势,发文量最多的国家是美国,主要研究机构为高等院校,各机构间合作紧密.结论:急性心肌梗死就医延迟研究领域主要集中于治疗方法和性别差异,未来研究热点可能是急性心肌梗死的质量管理.
关键词：
Fear of cancer recurrence;Meaning in life;Experiential avoidance;Death anxiety;Serial mediation model
摘要：
This study aims to investigate the association between fear of cancer recurrence (FCR) and death anxiety (DA) among Chinese cancer patients, while considering the mediating effects of experiential avoidance (EA) and meaning in life (MIL). From February to June 2023, convenience sampling was used to select newly diagnosed cancer patients in a tertiary Cancer Hospital in Chinese Hunan Province as the survey objects. A total of 436 cancer patients completed the Fear of Cancer Recurrence Inventory, the Meaning in Life Questionnaire, the Acceptance and Action Questionnaire-II, and the Templer’s death anxiety scale. Descriptive analysis and Pearson correlation analysis were conducted using SPSS 28.0 software. Serial mediation analysis was performed by Hayes’ PROCESS macro. Gender, age, educational level, marital status, residence, occupation, per capita monthly household income, tumor type, and cancer stage were controlled in the model. The results revealed that fear of cancer recurrence had a significant direct effect on death anxiety (Effect = 0.075, 95% CI: 0.064 to 0.087). Additionally, three indirect pathways were identified: (1) through experiential avoidance (Effect = 0.037, 95% CI: 0.026 to 0.049), (2) through meaning in life (Effect = 0.022, 95% CI: 0.014 to 0.031), and (3) through the serial mediators involving meaning in life and experiential avoidance (Effect = 0.016, 95% CI: 0.010 to 0.023). The total indirect effect of the three mediation paths was 63.56%. Fear of cancer recurrence is a significant psychological distress experienced by cancer patients, which not only directly contributes to death anxiety but also may triggers changes, such as experiential avoidance and meaning in life. Ultimately, this comprehensive psychological distress leads to death anxiety.
关键词：
Death anxiety;Meaning in life;Experiential avoidance;Cancer patients;Mediation effect
摘要：
Death anxiety is thought to cause a range of mental disorders among cancer patients, which may affect their mental health and even quality of life. This study sought to investigate experiential avoidance, meaning in life, and death anxiety among Chinese cancer patients and then explore the relationship between these 3 variables. A total of 300 cancer patients recruited from a tertiary cancer hospital participated in this study from October to December 2021. A cross-sectional survey was conducted using a demographic and clinical characteristics questionnaire, the Acceptance and Action Questionnaire II, the Meaning in Life Questionnaire, and Templer’s Death Anxiety Scale. Correlation analysis, hierarchical regression analysis, and mediating effect analysis were used to analyze the relationship among experiential avoidance, meaning in life (including 2 dimensions: presence of meaning and search for meaning), and death anxiety. A total of 315 questionnaires were distributed, and 300 valid questionnaires were returned, resulting in a valid response rate of 95.2%. Experiential avoidance (r = 0.552, p < 0.01) was moderately positively correlated with death anxiety. Presence of meaning (r = − 0.400, p < 0.01) was moderately negatively correlated with death anxiety, while search for meaning (r = − 0.151, p < 0.01) was weakly negatively correlated with death anxiety. Regression analysis showed that experiential avoidance (β = 0.464) and presence of meaning (β = −0.228) were predictors of death anxiety. Mediating effect analysis revealed that presence of meaning either completely or partially mediated the effect of experiential avoidance and death anxiety, and the indirect effect accounted for 14.52% of the total effect. Overall, experiential avoidance predicts death anxiety in cancer patients, and meaning in life can mediate this effect. The results of this study provide a new path for studying the mechanism of death anxiety and suggest a more positive and promising strategy for its management.
期刊：
JOURNAL OF MULTIDISCIPLINARY HEALTHCARE,2024年17:4781-4789 ISSN：1178-2390
通讯作者：
Gong, YW
作者机构：
[Gong, YW; Gong, Youwen] Cent South Univ, Changde Hosp, Peoples Hosp Changde City 1, Xiangya Sch Med,Dept Nursing, Changde, Peoples R China.;[Chen, Yongyi] Hunan Canc Hosp, Dept Nursing, Changsha, Peoples R China.;[Liu, Yang] Univ South China, Sch Nursing, Hengyang, Peoples R China.
通讯机构：
[Gong, YW ] C;Cent South Univ, Changde Hosp, Peoples Hosp Changde City 1, Xiangya Sch Med,Dept Nursing, Changde, Peoples R China.
关键词：
death attitudes;death competence;death education;oncology nurses
摘要：
PURPOSE: To identify the factors affecting Chinese oncology nurses' competency in coping with death, and their relationship with death attitudes and educational needs. METHODS: A national cross-sectional descriptive study was conducted using an online survey of Chinese oncology nurses. Data were collected using the Coping with Death, Death Attitude Profile-Revised, and Death Education Needs Scales. A Pearson's correlation analysis was used to examine the relationships among the research variables. A multiple linear regression analysis was used to analyze the factors influencing coping with death. RESULTS: The total score of coping with death was 133.57±26.78, showing a moderate coping level among Chinese oncology nurses. The Pearson's correlation analysis showed that death attitude was significantly and positively correlated with coping with death competence, and there was a statistically significant positive relationship between coping with death competence and death education needs. Years of oncology care experience, bereavement experience, death attitude, and death education needs were identified as statistically significant factors influencing competency in coping with death. These factors explained 30.6% of the differences in coping with death. CONCLUSION: This study found that oncology nurses in China exhibited moderate levels of death coping competence, which needs to be improved to provide higher-quality end-of-life care. Further, death attitude and education needs were important factors affecting participants' coping with death competence. Tailored death education programs and continuing education on death should be provided for oncology nurses, to encourage them to actively participate in death competence-related training and promote an attitude of natural acceptance of death and positive care for terminally ill patients. In the future, virtual reality technology could complete course implementation designs with immersive, conceptual, and interactive characteristics, to enhance the death-coping education program. Nurses with less experience in oncology care and bereavement should improve their competency in coping with death.
摘要：
目的综合分析国内外头颈癌患者张口困难相关评估工具,为头颈癌患者张口困难评估提供参考。方法系统检索PubMed、Web of Science、CINAHL、Medline、SinoMed、中国知网、万方及维普数据库,追溯参...展开更多 目的综合分析国内外头颈癌患者张口困难相关评估工具,为头颈癌患者张口困难评估提供参考。方法系统检索PubMed、Web of Science、CINAHL、Medline、SinoMed、中国知网、万方及维普数据库,追溯参考文献并补充检索灰色文献数据库OpenGrey。检索时限为建库至2024年5月18日。结果纳入18篇文献,汇总出11种头颈癌患者张口困难相关评估工具,其中5种已在中国进行本土化。评估角度分为客观角度、主观角度以及主客观相结合角度;评估目的分为张口困难严重程度、张口困难相关生活质量、康复锻炼。结论现有张口困难相关评估工具较多,特征各异,选择时应综合考虑。未来应对相关评估工具进一步验证与完善,也可应用人工智能技术优化或开发新的张口困难评估工具。收起
通讯机构：
[Yin, XH ] U;Univ South China, Sch Nursing, Hengyang, Hunan, Peoples R China.
关键词：
Prehabilitation;Frailty;Aged;Meta-analysis
摘要：
Objective: The study investigates the impact of preoperative rehabilitation on the surgical prognosis of frail older patients. Method: The effect sizes of all studies retrieved and included by the nine databases were analyzed and expressed as RR and WMD. Results: 8 studies with 902 participants met the criteria for inclusion. A significant reduction in total complications (RR = 0.84, 95 % CI = 0.73 to 0.97, P = 0.021) and the 6MWT after surgery (WMD = 74.76, 95 % CI = 44.75 to 104.77, P = 0.000) was observed in the prehabilitation group. But it had no differences in mortality(RR = 1.89, 95 % CI = 0.75 to 4.72, P = 0.176), readmission rates(RR = 1.04, 95 % CI = 0.56 to 1.91, P = 0.906) and LOS(WMD = -0.24, 95 % CI = -1.00 to 0.52, P = 0.540). Conclusions: Prehabilitation had positive effect on postoperative complications and functional recovery in frail older patients. (c) 2023 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
作者机构：
[Wang, Jiani] Univ South China, Sch Nursing, Hengyang 421001, Peoples R China.;[Rao, Qin] Univ South China, Changsha Cent Hosp, Dept Pulm TB, Changsha 410004, Peoples R China.;[Zhou, Lan] Univ South China, Dept Drug Resistant TB, Changsha Cent Hosp, Changsha 410004, Peoples R China.;[Xiang, Lingling] Univ South China, Dept Extrapulm TB, Changsha Cent Hosp, Changsha 410004, Peoples R China.;[Xi, Mingxia; Xi, MX] Univ South China, Dept Nursing, Changsha Cent Hosp, Changsha 410004, Peoples R China.
通讯机构：
[Xi, MX ] U;Univ South China, Dept Nursing, Changsha Cent Hosp, Changsha 410004, Peoples R China.
关键词：
Continuing care services;Cross-sectional study;Need survey;Pulmonary tuberculosis
摘要：
OBJECTIVE: To understand the relationship between the need for continuing care services and influencing factors, social support, readiness for discharge among discharged pulmonary tuberculosis (PTB) patients. METHODS: A cross-sectional study was conducted among 170 patients from a database of discharged patients with PTB from September 2023 to January 2024. A demographic and disease characteristics questionnaire, continuing care services basic modality questionnaire, continuing care services need questionnaire, the Social Support Rating Scale (SSRS), and the Readiness for Hospital Discharge Scale (RHDS) were used for this investigation. Univariate analysis and multiple linear regression analysis were used to analyze the associated factors. RESULTS: The mean total score for the need for continuing care services among patients with PTB discharged from the hospital was (121.61±22.98). The dimension with the highest score was health education guidance need. Compared to the the original hospital medical personnel, the primary source of care information after discharge was the local medical institutions was statistically significant and negatively correlated with continuing care service need (P=0.005). Social support was positively associated with need for continuing care services (P=0.042). CONCLUSION: Discharged PTB patients had a high degree of continuing care service need. Factors influencing the need for continuing care services are the primary source of care information after discharge was the local medical institutions, the social support. Medical staff need to provide targeted continuing care services based on relevant influencing factors to meet the discharge needs of patients.
