作者机构：
[Chuli, Xiao; Li, Huang; Ying, Lu] The Brain Cognition and Brain Disease Branch, Pu Ai Medical School, Shaoyang University, 422000, Shaoyang, China;[Wan, Fu] The First Affiliated Hospital, Department of neurology, Hengyang Medical School, University of South China, 421001, Hengyang, Hunan, China;[Shiqiao, Kang] The First Affiliated Hospital, Department of Critical Care Medicine, Hengyang Medical School, University of South China, 421001, Hengyang, Hunan, China;[Yijie, Fang] School of Nursing, Hengyang Medical School, University of South China, 421001, Hengyang, Hunan, China;[Xudong, Yu] The Brain Cognition and Brain Disease Branch, Pu Ai Medical School, Shaoyang University, 422000, Shaoyang, China. Electronic address: yxd_neuro@163.com
通讯机构：
[Xinhong, Yin] S;[Zhiyong, Xiao; Xudong, Yu] T;The Brain Cognition and Brain Disease Branch, Pu Ai Medical School, Shaoyang University, 422000, Shaoyang, China. Electronic address:;School of Nursing, Hengyang Medical School, University of South China, 421001, Hengyang, Hunan, China. Electronic address:;The First Affiliated Hospital, Department of Critical Care Medicine, Hengyang Medical School, University of South China, 421001, Hengyang, Hunan, China. Electronic address:
摘要：
Esketamine, the right-handed optical isomer of racemic ketamine, is a rapidly acting antidepressant approved by the FDA for treatment-resistant depression in 2019. However, few studies have investigated esketamine's role in learning and memory, particularly in the context of memory reconsolidation. Herein, we evaluated esketamine's role in memory reconsolidation in 7-week-old male Institute of Cancer Research mice subjected to the novel object recognition (NOR) memory task. The NOR reconsolidation procedure comprised three phases: sampling, reactivation, and testing. Esketamine-enhanced NOR memory performance when injected into mice 0 h after reactivation rather than following a 6 h delay. Conversely, administering esketamine 24 h after sampling without reactivation did not enhance NOR memory performance. Notably, esketamine exhibited no discernible effects on nonspecific responses, such as locomotor activity and exploratory behavior. Furthermore, the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type receptor antagonist NBQX effectively blocked the esketamine-induced enhancement of memory reconsolidation. In conclusion, esketamine treatment markedly improves memory reconsolidation in NOR tasks, and this effect is linked to AMPA receptor activity.
作者机构：
[Lv, Yun-Cheng; Tang, Yan-Yan; Xie, Wei; Li, Yuan; Lan, Gan; Zhang, Min; Zhang, Chi; Shi, Jin-Feng; Yin, Wei-Dong; Tang, Chao-Ke] Institute of Cardiovascular Research, Key Laboratory for Atherosclerology of Hunan Province, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang, Hunan, 421001, China;Yongzhou Vocational and Technical College, Yongzhou, Hunan, 425000, China;School of Nursing, University of South China, Hengyang, Hunan, 421001, China;[Liu, Xiang-Yu] Department of Biochemistry and Molecular Biology, School of Life Sciences and Technology, University of South, Hengyang, Hunan, 421001, China;[Zheng, Xi-Long] Department of Biochemistry and Molecular Biology, The Libin Cardiovascular Institute of Alberta, Cumming School of Medicine, The University of Calgary, 3330 Hospital Dr NW, Calgary, Alberta, T2N 4N1, Canada
摘要：
This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/policies/article-withdrawal). This article has been retracted at the request of the Editor-in-Chief. Concerns raised by Dr. Sander Kersten in PubPeer pointed out that Figs.6.1B and 6.2B of this paper were different figures but the legends and Western blots were identical; the quantification was also seen to be different between the two figures. Shortly afterwards, the authors asked to publish a corrigendum for part B of Fig.6.1, including images of western blots and associated bar plots. Subsequently, the journal conducted an investigation and found evidence that there had been improper manipulation and duplication of images in Fig.2 E, 6.2 B, 5 A and and 6.2 D, as shown by the reuse of several western blot bands with approximately 180° rotation in each case. After raising the complaint with the authors, the corresponding author agreed that the paper should be retracted. The authors apologise to the readers of the journal.
摘要：
Background: This study was performed to investigate the compliance and rehabilitation effects of Zheng's supine rehabilitation exercise (ZSRE) performed at home in patients with chronic obstructive pulmonary disease (COPD).Methods: We performed telephone interviews with 157 patients with COPD who were hospitalized on the 26th floor of the National Clinical Research Center for Respiratory Disease and who received COPD education and ZSRE training from 1 September 2015 to 31 August 2016. We retrospectively analyzed the patients' compliance with performing ZSRE at home after discharge and the frequency of hospitalization for treatment of acute exacerbation in both the previous and subsequent years.Results: Among the 157 patients, 66 failed to complete home ZSRE after discharge (non-rehabilitation group), 41 performed home ZSRE once a day after discharge (one-session rehabilitation group), and 50 performed home ZSRE at least twice a day after discharge (multiple-session rehabilitation group). The home ZSRE compliance rate was 57.96% (91/157). There were no significant differences in the mean number of hospitalizations in the year prior to receiving COPD education and ZSRE training among the non-rehabilitation group (1.06 +/- 0.75), one-sessi on rehabilitation group (1.27 +/- 0.78), and multiple-session rehabilitation group (1.16 +/- 0.91). However, there was a significant difference in the mean number of hospitalizations among the groups in the year following discharge (1.44 +/- 1.17, 0.78 +/- 0.82, and 0.66 +/- 0.75, respectively). The number of hospitalizations significantly increased in the non-rehabilitation group and significantly decreased in the one-and multiple-session rehabilitation groups.Conclusions: Home ZSRE can be performed with high compliance by elderly patients with severe or extremely severe COPD and can reduce the number of readmissions.
期刊：
Public Health Nursing,2023年40(5):782-789 ISSN：0737-1209
通讯作者：
Zeng, Y
作者机构：
[Huang, Yu-ting; Yue, Qian-qian; Tang, Tian; Zeng, Ying; Hu, Li-feng; Sun, Ying-xue; Zou, Jin-yu] Univ South China, Hengyang Med Sch, Dept Int & Humanist Nursing, Sch Nursing,Hunan Sci Popularizat Educ Base, Hengyang, Peoples R China.;[Zeng, Ying; Zeng, Xi] Univ South China, Canc Res Inst, Hengyang Med Sch, Key Lab Tumor Cellular & Mol Pathol, Hengyang, Peoples R China.;[Zeng, Ying] Univ South China, Hengyang Med Sch, Sch Nursing, Dept Int & Humanist Nursing, Hengyang, Peoples R China.
通讯机构：
[Zeng, Y ] U;Univ South China, Canc Res Inst, Hengyang Med Sch, Key Lab Tumor Cellular & Mol Pathol, Hengyang, Peoples R China.;Univ South China, Hengyang Med Sch, Sch Nursing, Dept Int & Humanist Nursing, Hengyang, Peoples R China.
摘要：
INTRODUCTION: Colorectal cancer (CRC) is associated with a high incidence and mortality rate. Fecal occult blood test (FOBT) is effective in the prevention of CRC. OBJECTIVE: This study aimed to assess knowledge and beliefs regarding FOBT-based screening. METHODS: This study used PubMed, Cochrane Library, MEDLINE Complete, and Web of Science to search for articles. Original full-text studies in English language focusing on knowledge and beliefs of FOBT screening were included. RESULTS: A total of 32 articles were included. This study indicated that the population in most studies had inadequate knowledge and lacked beliefs toward FOBT-based screening. Most of the extracted studies showed that less than half of the participants had heard of FOBT-based screening. Six studies showed that less than 50% of participants had knowledge of FOBT age. Three studies found that less than 40% of participants were aware of the screening interval. Some participants perceived the benefits of FOBT-based screening, while others perceived many barriers to the test. CONCLUSION: Participants' knowledge and belief in FOBT-based screening were insufficient. This review highlights the importance of educational programs to increase knowledge and beliefs regarding FOBT-based screening. It is important to include FOBT-based screening in the health care system to promote the secondary prevention of CRC.
作者机构：
[Li, W.; Wu, Y.; Liu, F.] Univ South China, Affiliated Hosp 1, Cardiac Intervent Imaging Ctr, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.;[Liu, F.; You, Z.; Liao, L.] Univ South China, Sch Nursing, Hengyang, Hunan, Peoples R China.;[Raja, Z.; Suthakorn, W.; Liu, F.] Chiang Mai Univ, Fac Nursing, Chiang Mai, Thailand.;[Raja, Z.] Dr Ruth KM Pfau Civil Hosp, Dept Plast & Reconstruct Surg, Karachi, Pakistan.;[Wang, J.] Hengyang Tradit Chinese Med Hosp, Occupat Hlth Dept, Hengyang, Hunan, Peoples R China.
通讯机构：
[Liu, F ] U;Univ South China, Affiliated Hosp 1, Cardiac Intervent Imaging Ctr, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.;Univ South China, Sch Nursing, Hengyang, Hunan, Peoples R China.;Chiang Mai Univ, Fac Nursing, Chiang Mai, Thailand.
摘要：
<b>Background:<b/> The ionising radiation generated in percutaneous coronary intervention has the largest hazard to medical staff among all interventional procedures, and thus has gained the attention of various researchers. Radioprotective shielding equipment is an effective measure; however, it has poor applicability to diverse interventional procedures. The aim of this study was to develop a new radioprotective shielding equipment for percutaneous coronary intervention and determine its effectiveness and applicability. <b>Methods:<b/> This study developed a radioprotective cabin for percutaneous coronary intervention and used fluoroscopy and cine models of a digital subtraction angiography machine to compare the effectiveness of experimental (radioprotective cabin) and control (current radioprotection strategies) groups. Radiation equivalent dose rates were measured at 231 data points: 210 points were distributed on four vertical planes around the therapy bed and 21 points were evenly distributed around the thyroid, head, and gonad areas of a standardised patient. <b>Results:<b/> Based on the cine model, there were statistically significant differences in the radiation equivalent dose rates between the control and experimental groups in the left plane, right plane, foot plane, head area, and gonad area (<i>Z<i/> = −6.645, −5.615, −6.204, −2.647, −2.882, respectively; <i>P<i/> < 0.05). Based on the fluoroscopy model, there were statistically significant differences in the radiation equivalent dose rates between the two groups in the left plane, right plane, foot plane, and gonad area (<i>Z<i/> = −6.060, −5.083, −5.203, −2.887, respectively; <i>P<i/> < 0.05). <b>Conclusion:<b/> The radioprotective cabin developed in this study can effectively reduce the radiation equivalent dose rates in the standing area of medical staff and radiation-sensitive areas of patients without affecting the operation, which can be promoted and applied in percutaneous coronary intervention.
